Engineered IL-10 variants elicit potent immunomodulatory effects at low ligand doses

Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations

(2020) Stephan Wilmes et al.   SCIENCE

Pegilodecakin combined with pembrolizumab or nivolumab for patients with advanced solid tumours (IVY): a multicentre, multicohort, open-label, phase 1b trial

(2019) Aung Naing et al.   LANCET ONCOLOGY

A strategy for the selection of monovalent antibodies that span protein dimer interfaces

(2019) Jamie B. Spangler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biology and therapeutic potential of interleukin-10

(2019) Margarida Saraiva et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Immune regulation and cytotoxic T cell activation of IL-10 agonists – Preclinical and clinical experience

(2019) Martin Oft   SEMINARS IN IMMUNOLOGY

Kinetics of cytokine receptor trafficking determine signaling and functional selectivity

(2019) Jonathan Martinez-Fabregas et al.   eLife

Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells

(2018) Bertram Bengsch et al.   IMMUNITY

Interleukin-2 shapes the cytotoxic T cell proteome and immune environment–sensing programs

(2018) Christina M. Rollings et al.   Science Signaling

Interleukin-2 shapes the cytotoxic T cell proteome and immune environment–sensing programs

(2018) Christina M. Rollings et al.   Science Signaling

The Dynamics of Interleukin-10-Afforded Protection during Dextran Sulfate Sodium-Induced Colitis

(2018) Ana Cardoso et al.   Frontiers in Immunology

PEGylated IL-10 (Pegilodecakin) Induces Systemic Immune Activation, CD8+ T Cell Invigoration and Polyclonal T Cell Expansion in Cancer Patients

(2018) Aung Naing et al.   CANCER CELL

CML hematopoietic stem cells expressing IL-1RAP can be targeted by chimeric antigen receptor (CAR)-engineered T cells

(2018) Walid Warda et al.   CANCER RESEARCH

The IFN-λ-IFN-λR1-IL-10Rβ Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity

(2017) Juan L. Mendoza et al.   IMMUNITY

Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages

(2017) W. K. Eddie Ip et al.   SCIENCE

Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments

(2017) David Richter et al.   Nature Communications

Applications of Genetically Modified Immunobiotics with High Immunoregulatory Capacity for Treatment of Inflammatory Bowel Diseases

(2017) Suguru Shigemori et al.   Frontiers in Immunology

The paradoxical role of IL-10 in immunity and cancer

(2015) Mark H. Mannino et al.   CANCER LETTERS

Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands

(2015) Ignacio Moraga et al.   CELL

Suppression of antigen presentation by IL-10

(2015) Sharad K Mittal et al.   CURRENT OPINION IN IMMUNOLOGY

Interleukin-10 paradox: A potent immunoregulatory cytokine that has been difficult to harness for immunotherapy

(2015) Ankit Saxena et al.   CYTOKINE

Receptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signaling

(2015) Stephan Wilmes et al.   JOURNAL OF CELL BIOLOGY

Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency

(2015) Ignacio Moraga et al.   Science Signaling

Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency

(2015) Ignacio Moraga et al.   Science Signaling

Serum IL-10 Predicts Worse Outcome in Cancer Patients: A Meta-Analysis

(2015) Shuai Zhao et al.   PLoS One

Evidence for non-neutralizing autoantibodies against IL-10 signalling components in patients with inflammatory bowel disease

(2014) Natalie Frede et al.   BMC IMMUNOLOGY

The activating effect of IFN-γ on monocytes/macrophages is regulated by the LIF–trophoblast–IL-10 axis via Stat1 inhibition and Stat3 activation

(2014) Angham Dallagi et al.   Cellular & Molecular Immunology

Transcription Factor STAT3 and Type I Interferons Are Corepressive Insulators for Differentiation of Follicular Helper and T Helper 1 Cells

(2014) John P. Ray et al.   IMMUNITY

Interleukin-10 Receptor Signaling in Innate Immune Cells Regulates Mucosal Immune Tolerance and Anti-Inflammatory Macrophage Function

(2014) Dror S. Shouval et al.   IMMUNITY

IL-10: Master Switch from Tumor-Promoting Inflammation to Antitumor Immunity

(2014) M. Oft   Cancer Immunology Research

Pegylated IL-10 induces cancer immunity

(2013) John B. Mumm et al.   BIOESSAYS

IL-10 Directly Activates and Expands Tumor-Resident CD8+ T Cells without De Novo Infiltration from Secondary Lymphoid Organs

(2012) J. Emmerich et al.   CANCER RESEARCH

IL-10 Elicits IFNγ-Dependent Tumor Immune Surveillance

(2011) John B. Mumm et al.   CANCER CELL

Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5

(2011) Xiang-Ping Yang et al.   NATURE IMMUNOLOGY

Defective IL-10 production in severe phenotypes of Crohn's disease

(2009) Ismael Correa et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Modulation of protein properties in living cells using nanobodies

(2009) Axel Kirchhofer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System

(2008) Sherry L. LaPorte et al.   CELL

Dynamic multiple-target tracing to probe spatiotemporal cartography of cell membranes

(2008) Arnauld Sergé et al.   NATURE METHODS

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH