Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency

Insights into Cytokine–Receptor Interactions from Cytokine Engineering

(2015) Jamie B. Spangler et al.   Annual Review of Immunology

Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands

(2015) Ignacio Moraga et al.   CELL

Selective IL-2 Responsiveness of Regulatory T Cells Through Multiple Intrinsic Mechanisms Supports the Use of Low-Dose IL-2 Therapy in Type 1 Diabetes

(2015) Aixin Yu et al.   DIABETES

Receptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signaling

(2015) Stephan Wilmes et al.   JOURNAL OF CELL BIOLOGY

Dynamics and Interaction of Interleukin-4 Receptor Subunits in Living Cells

(2014) Hetvi Gandhi et al.   BIOPHYSICAL JOURNAL

Low-dose inhalation of interleukin-2 bio-chemotherapy for the treatment of pulmonary metastases in melanoma patients

(2014) C Posch et al.   BRITISH JOURNAL OF CANCER

Ultra Low-Dose IL-2 for GVHD Prophylaxis after Allogeneic Hematopoietic Stem Cell Transplantation Mediates Expansion of Regulatory T Cells without Diminishing Antiviral and Antileukemic Activity

(2014) A. A. Kennedy-Nasser et al.   CLINICAL CANCER RESEARCH

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Monofunctional Stealth Nanoparticle for Unbiased Single Molecule Tracking Inside Living Cells

(2014) Domenik Liße et al.   NANO LETTERS

Structural and dynamic determinants of type I interferon receptor assembly and their functional interpretation

(2012) Jacob Piehler et al.   IMMUNOLOGICAL REVIEWS

Epstein-Barr Virus IL-10 Engages IL-10R1 by a Two-step Mechanism Leading to Altered Signaling Properties

(2012) Sung Il Yoon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Contribution of Alternatively Activated Macrophages to Allergic Lung Inflammation: A Tale of Mice and Men

(2012) Preeta Dasgupta et al.   Journal of Innate Immunity

Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines

(2012) Ilkka S Junttila et al.   Nature Chemical Biology

Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15

(2012) Aaron M Ring et al.   NATURE IMMUNOLOGY

Quantification of Biological Interactions with Particle Image Cross-Correlation Spectroscopy (PICCS)

(2011) Stefan Semrau et al.   BIOPHYSICAL JOURNAL

Structural Linkage between Ligand Discrimination and Receptor Activation by Type I Interferons

(2011) Christoph Thomas et al.   CELL

Stochastic Receptor Expression Determines Cell Fate upon Interferon Treatment

(2011) D. Levin et al.   MOLECULAR AND CELLULAR BIOLOGY

Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity

(2011) Hong-Erh Liang et al.   NATURE IMMUNOLOGY

USP18-Based Negative Feedback Control Is Induced by Type I and Type III Interferons and Specifically Inactivates Interferon α Response

(2011) Véronique François-Newton et al.   PLoS One

Functional Immobilization and Patterning of Proteins by an Enzymatic Transfer Reaction

(2010) Sharon Waichman et al.   ANALYTICAL CHEMISTRY

Differentiation of Effector CD4 T Cell Populations

(2010) Jinfang Zhu et al.   Annual Review of Immunology

Receptor Density Is Key to the Alpha2/Beta Interferon Differential Activities

(2009) I. Moraga et al.   MOLECULAR AND CELLULAR BIOLOGY

A Reducing and Oxidizing System Minimizes Photobleaching and Blinking of Fluorescent Dyes

(2008) Jan Vogelsang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System

(2008) Sherry L. LaPorte et al.   CELL

The Stability of the Ternary Interferon-Receptor Complex Rather than the Affinity to the Individual Subunits Dictates Differential Biological Activities

(2008) Eyal Kalie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tuning sensitivity to IL-4 and IL-13: differential expression of IL-4Rα, IL-13Rα1, and γc regulates relative cytokine sensitivity

(2008) Ilkka S. Junttila et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dynamic multiple-target tracing to probe spatiotemporal cartography of cell membranes

(2008) Arnauld Sergé et al.   NATURE METHODS

Highly inclined thin illumination enables clear single-molecule imaging in cells

(2008) Makio Tokunaga et al.   NATURE METHODS

Type I IL-4Rs Selectively Activate IRS-2 to Induce Target Gene Expression in Macrophages

(2008) N. M. Heller et al.   Science Signaling

Structural Biology of Shared Cytokine Receptors

(2007) Xinquan Wang et al.   Annual Review of Immunology