Kinetics of cytokine receptor trafficking determine signaling and functional selectivity

A molecular assembly phase transition and kinetic proofreading modulate Ras activation by SOS

(2019) William Y. C. Huang et al.   SCIENCE

Structure and dynamics of GPCR signaling complexes

(2018) Daniel Hilger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure and dynamics of GPCR signaling complexes

(2018) Daniel Hilger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanisms of signalling and biased agonism in G protein-coupled receptors

(2018) Denise Wootten et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mapping Determinants of Cytokine Signaling via Protein Engineering

(2018) Claire Gorby et al.   Frontiers in Immunology

The IFN-λ-IFN-λR1-IL-10Rβ Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity

(2017) Juan L. Mendoza et al.   IMMUNITY

Signal processing by the endosomal system

(2016) Roberto Villaseñor et al.   CURRENT OPINION IN CELL BIOLOGY

Endocytic regulation of cytokine receptor signaling

(2016) Jaroslaw Cendrowski et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells

(2016) Sylvia Heink et al.   NATURE IMMUNOLOGY

Phosphotyrosine-mediated LAT assembly on membranes drives kinetic bifurcation in recruitment dynamics of the Ras activator SOS

(2016) William Y. C. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Receptor dimer stabilization by hierarchical plasma membrane microcompartments regulates cytokine signaling

(2016) C. You et al.   Science Advances

Insights into Cytokine–Receptor Interactions from Cytokine Engineering

(2015) Jamie B. Spangler et al.   Annual Review of Immunology

Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands

(2015) Ignacio Moraga et al.   CELL

Interleukin-2 Activity Can Be Fine Tuned with Engineered Receptor Signaling Clamps

(2015) Suman Mitra et al.   IMMUNITY

Type I Interferon Signaling Is Decoupled from Specific Receptor Orientation through Lenient Requirements of the Transmembrane Domain

(2015) Nanaocha Sharma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Receptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signaling

(2015) Stephan Wilmes et al.   JOURNAL OF CELL BIOLOGY

IL-6 as a keystone cytokine in health and disease

(2015) Christopher A Hunter et al.   NATURE IMMUNOLOGY

Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency

(2015) Ignacio Moraga et al.   Science Signaling

Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency

(2015) Ignacio Moraga et al.   Science Signaling

Dynamics and Interaction of Interleukin-4 Receptor Subunits in Living Cells

(2014) Hetvi Gandhi et al.   BIOPHYSICAL JOURNAL

A Conserved IFN-  Receptor Tyrosine Motif Directs the Biological Response to Type I IFNs

(2014) W. Zhao et al.   JOURNAL OF IMMUNOLOGY

Noise estimation for off-axis electron holography

(2014) Falk Röder et al.   ULTRAMICROSCOPY

Structural and dynamic determinants of type I interferon receptor assembly and their functional interpretation

(2012) Jacob Piehler et al.   IMMUNOLOGICAL REVIEWS

Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15

(2012) Aaron M Ring et al.   NATURE IMMUNOLOGY

STAT1:DNA sequence-dependent binding modulation by phosphorylation, protein:protein interactions and small-molecule inhibition

(2012) Andrew J. Bonham et al.   NUCLEIC ACIDS RESEARCH

The STAT3 beacon: IL-6 recurrently activates STAT 3 from endosomal structures

(2011) Christopher L. German et al.   EXPERIMENTAL CELL RESEARCH

T-cell tolerance and the multi-functional role of IL-2R signaling in T-regulatory cells

(2011) Guoyan Cheng et al.   IMMUNOLOGICAL REVIEWS

Inhibition of Classic Signaling Is a Novel Function of Soluble Glycoprotein 130 (sgp130), Which Is Controlled by the Ratio of Interleukin 6 and Soluble Interleukin 6 Receptor

(2011) Christoph Garbers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane trafficking and signaling: Two sides of the same coin

(2011) Pauline Gonnord et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Functional Immobilization and Patterning of Proteins by an Enzymatic Transfer Reaction

(2010) Sharon Waichman et al.   ANALYTICAL CHEMISTRY

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

IL-6: Regulator of Treg/Th17 balance

(2010) Akihiro Kimura et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Ubiquitination Regulates the Internalization, Endolysosomal Sorting, and Signaling of the Erythropoietin Receptor

(2010) Gamze Betul Bulut et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of CD4 + T Cell IL-6R Expression during Inflammation Underlines a Role for IL-6 Trans Signaling in the Local Maintenance of Th17 Cells

(2010) Gareth W. Jones et al.   JOURNAL OF IMMUNOLOGY

A role for IL-27p28 as an antagonist of gp130-mediated signaling

(2010) Jason S Stumhofer et al.   NATURE IMMUNOLOGY

Covering a Broad Dynamic Range: Information Processing at the Erythropoietin Receptor

(2010) V. Becker et al.   SCIENCE

Development and function of TH17 cells in health and disease

(2009) Jennifer Louten et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Biochemical Monitoring of the Early Endocytic Traffic of the Type I Interferon Receptor

(2009) Béatrice Payelle-Brogard et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Modulation of protein properties in living cells using nanobodies

(2009) Axel Kirchhofer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Reducing and Oxidizing System Minimizes Photobleaching and Blinking of Fluorescent Dyes

(2008) Jan Vogelsang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System

(2008) Sherry L. LaPorte et al.   CELL

c-Cbl-Dependent Monoubiquitination and Lysosomal Degradation of gp130

(2008) Y. Tanaka et al.   MOLECULAR AND CELLULAR BIOLOGY

Priming for T helper type 2 differentiation by interleukin 2–mediated induction of interleukin 4 receptor α-chain expression

(2008) Wei Liao et al.   NATURE IMMUNOLOGY

Dynamic multiple-target tracing to probe spatiotemporal cartography of cell membranes

(2008) Arnauld Sergé et al.   NATURE METHODS

IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells

(2008) T. Korn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type I IL-4Rs Selectively Activate IRS-2 to Induce Target Gene Expression in Macrophages

(2008) N. M. Heller et al.   Science Signaling

Structural Biology of Shared Cytokine Receptors

(2007) Xinquan Wang et al.   Annual Review of Immunology