Applications of Genetically Modified Immunobiotics with High Immunoregulatory Capacity for Treatment of Inflammatory Bowel Diseases

Secretion of an immunoreactive single-chain variable fragment antibody against mouse interleukin 6 by Lactococcus lactis

(2016) Suguru Shigemori et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Genetic engineering of probiotic Escherichia coli Nissle 1917 for clinical application

(2016) Bingming Ou et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Recombinant Lactococcus lactis expressing porcine insulin-like growth factor I ameliorates DSS-induced colitis in mice

(2016) Shujie Liu et al.   BMC BIOTECHNOLOGY

Oral delivery of Bifidobacterium longum expressing α-melanocyte-stimulating hormone to combat ulcerative colitis

(2016)   JOURNAL OF MEDICAL MICROBIOLOGY

Evaluation of the biosafety of recombinant lactic acid bacteria designed to prevent and treat colitis

(2016) Alejandra de Moreno de LeBlanc et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Escherichia coli strain Nissle 1917 ameliorates experimental colitis by modulating intestinal permeability, the inflammatory response and clinical signs in a faecal transplantation model

(2016) Éricka L. Souza et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Lactic acid bacteria—20 years exploring their potential as live vectors for mucosal vaccination

(2015) Agnieszka Wyszyńska et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Milk Fermented with a 15-Lipoxygenase-1-Producing Lactococcus Lactis Alleviates Symptoms of colitis in a Murine Model

(2015) Tessalia Saraiva et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Efficacy of probiotic treatment withBifidobacterium longum 536for induction of remission in active ulcerative colitis: A randomized, double-blinded, placebo-controlled multicenter trial

(2015) Hiroyuki Tamaki et al.   Digestive Endoscopy

OralBifidobacterium longumexpressing alpha-melanocyte-stimulating hormone to fight experimental colitis

(2015) Pijin Wei et al.   DRUG DELIVERY

Interleukin-10 gene-carrying bifidobacteria ameliorate murine ulcerative colitis by regulating regulatory T cell/T helper 17 cell pathway

(2015) Dingguo Zhang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Identification of an anti-inflammatory protein fromFaecalibacterium prausnitzii, a commensal bacterium deficient in Crohn’s disease

(2015) E Quévrain et al.   GUT

IL-6 as a keystone cytokine in health and disease

(2015) Christopher A Hunter et al.   NATURE IMMUNOLOGY

Immunopathogenesis of IBD: current state of the art

(2015) Heitor S. P. de Souza et al.   Nature Reviews Gastroenterology & Hepatology

Current Review of Genetically Modified Lactic Acid Bacteria for the Prevention and Treatment of Colitis Using Murine Models

(2015) Alejandra de Moreno de LeBlanc et al.   Gastroenterology Research and Practice

Bifidobacterium longum CCM 7952 Promotes Epithelial Barrier Function and Prevents Acute DSS-Induced Colitis in Strictly Strain-Specific Manner

(2015) Dagmar Srutkova et al.   PLoS One

The Treatment-Naive Microbiome in New-Onset Crohn’s Disease

(2014) Dirk Gevers et al.   Cell Host & Microbe

Superoxide dismutase recombinantLactobacillus fermentumameliorates intestinal oxidative stress through inhibiting NF-κB activation in a trinitrobenzene sulphonic acid-induced colitis mouse model

(2014) C.L. Hou et al.   JOURNAL OF APPLIED MICROBIOLOGY

Heme Oxygenase-1 Ameliorates Dextran Sulfate Sodium-induced Acute Murine Colitis by Regulating Th17/Treg Cell Balance

(2014) Liya Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protective Effects of Lactococci Strains Delivering Either IL-10 Protein or cDNA in a TNBS-induced Chronic Colitis Model

(2014) Silvina del Carmen et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

A Helminth Immunomodulator Reduces Allergic and Inflammatory Responses by Induction of IL-10-Producing Macrophages

(2014) C. Schnoeller et al.   JOURNAL OF IMMUNOLOGY

Recombinant Lactococcus lactis can make the difference in antigen-specific immune tolerance induction, the Type 1 Diabetes case

(2014) Sofie Robert et al.   Microbial Cell Factories

A Transgenic Probiotic Secreting a Parasite Immunomodulator for Site-Directed Treatment of Gut Inflammation

(2014) Rose A Whelan et al.   MOLECULAR THERAPY

The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic

(2014) Colin Hill et al.   Nature Reviews Gastroenterology & Hepatology

Review article: the role of oxidative stress in pathogenesis and treatment of inflammatory bowel diseases

(2014) Aleksandra Piechota-Polanczyk et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Immunosuppressive therapies for inflammatory bowel disease

(2014) Talia Zenlea   WORLD JOURNAL OF GASTROENTEROLOGY

rBet v 1 immunotherapy of sensitized mice with Streptococcus thermophilus as vehicle and adjuvant

(2014) Claudia Petrarca et al.   Human Vaccines & Immunotherapeutics

Alpha-Melanocyte Stimulating Hormone: An Emerging Anti-Inflammatory Antimicrobial Peptide

(2014) Madhuri Singh et al.   Biomed Research International

Regulation of Toll-Like Receptors-Mediated Inflammation by Immunobiotics in Bovine Intestinal Epitheliocytes: Role of Signaling Pathways and Negative Regulators

(2014) Julio Villena et al.   Frontiers in Immunology

Modulation of Respiratory TLR3-Anti-Viral Response by Probiotic Microorganisms: Lessons Learned from Lactobacillus rhamnosus CRL1505

(2014) Haruki Kitazawa et al.   Frontiers in Immunology

Modulation of Intestinal TLR4-Inflammatory Signaling Pathways by Probiotic Microorganisms: Lessons Learned from Lactobacillus jensenii TL2937

(2014) Julio Villena et al.   Frontiers in Immunology

Genetically Engineered Immunomodulatory Streptococcus thermophilus Strains Producing Antioxidant Enzymes Exhibit Enhanced Anti-Inflammatory Activities

(2013) Silvina del Carmen et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Phase 1b, multicenter, single blinded, placebo-controlled, sequential dose escalation study to assess the safety and tolerability of topically applied AG013 in subjects with locally advanced head and neck cancer receiving induction chemotherapy

(2013) Sewanti Atul Limaye et al.   CANCER

Oral Delivery of IL-27 Recombinant Bacteria Attenuates Immune Colitis in Mice

(2013) Miranda L. Hanson et al.   GASTROENTEROLOGY

A nematode immunomodulator suppresses grass pollen-specific allergic responses by controlling excessive Th2 inflammation

(2012) Emilia Daniłowicz-Luebert et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

World Gastroenterology Organisation Global Guidelines

(2012) Francisco Guarner et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Effect of recombinantLactobacillus caseiexpressing interleukin-10 in dextran sulfate sodium-induced colitis mice

(2012) Zhi Bing Qiu et al.   Journal of Digestive Diseases

Protective effects of cathelicidin-encoding Lactococcus lactis in murine ulcerative colitis

(2012) Clover Ching Man Wong et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Food-Grade Bacteria Expressing Elafin Protect Against Inflammation and Restore Colon Homeostasis

(2012) J.-P. Motta et al.   Science Translational Medicine

Mucosal Vaccination and Therapy with Genetically Modified Lactic Acid Bacteria

(2012) Jerry Wells   Annual Review of Food Science and Technology

Probiotic Bifidobacterium breve Induces IL-10-Producing Tr1 Cells in the Colon

(2012) Seong Gyu Jeon et al.   PLoS Pathogens

Randomised clinical trial: the effectiveness of Lactobacillus reuteri ATCC 55730 rectal enema in children with active distal ulcerative colitis

(2011) S. Oliva et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Lactobacillus rhamnosus GG and Streptococcus thermophilus induce suppressor of cytokine signalling 3 (SOCS3) gene expression directly and indirectly via interleukin-10 in human primary macrophages

(2011) S. Latvala et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Cytokine profile and induction of T helper type 17 and regulatory T cells by human peripheral mononuclear cells after microbial exposure

(2011) O. N. Donkor et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review

(2011) Natalie A. Molodecky et al.   GASTROENTEROLOGY

Bifidobacterium infantis35624 administration induces Foxp3 T regulatory cells in human peripheral blood: potential role for myeloid and plasmacytoid dendritic cells

(2011) Patrycja Konieczna et al.   GUT

Suppression of Th17 response by Streptococcus thermophilus ST28 through induction of IFN-γ

(2011) Soichi Tanabe   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Streptococcus thermophilusST28 Ameliorates Colitis in Mice Partially by Suppression of Inflammatory Th17 Cells

(2011) Tasuku Ogita et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Treatment of Mice with Dextran Sulfate Sodium-Induced Colitis with Human Interleukin 10 Secreted by TransformedBifidobacterium longum

(2011) Jun Yao et al.   MOLECULAR PHARMACEUTICS

A Helminth Immunomodulator Exploits Host Signaling Events to Regulate Cytokine Production in Macrophages

(2011) Christian Klotz et al.   PLoS Pathogens

Treatment of Relapsing Mild-to-Moderate Ulcerative Colitis With the Probiotic VSL#3 as Adjunctive to a Standard Pharmaceutical Treatment: A Double-Blind, Randomized, Placebo-Controlled Study

(2010) Antonio Tursi et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Treatment with IL-27 attenuates experimental colitis through the suppression of the development of IL-17-producing T helper cells

(2010) Tetsumasa Sasaoka et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

CpG oligodeoxynucleotides induce strong up-regulation of interleukin 33 via Toll-like receptor 9

(2010) Takeshi Shimosato et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Intragastric administration of a superoxide dismutase-producing recombinant Lactobacillus casei BL23 strain attenuates DSS colitis in mice

(2010) Laurie Watterlot et al.   INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY

Use of superoxide dismutase and catalase producing lactic acid bacteria in TNBS induced Crohn's disease in mice

(2010) Jean Guy LeBlanc et al.   JOURNAL OF BIOTECHNOLOGY

Infant colitis—it's in the genes

(2010) Erik-Oliver Glocker et al.   LANCET

Probiotics and the gut microbiota in intestinal health and disease

(2010) Mélanie G. Gareau et al.   Nature Reviews Gastroenterology & Hepatology

Bifidobacterium animalis subsp. lactis fermented milk product reduces inflammation by altering a niche for colitogenic microbes

(2010) P. Veiga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of a Probiotic Preparation (VSL#3) on Induction and Maintenance of Remission in Children With Ulcerative Colitis

(2009) Erasmo Miele et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Identification of a potent immunostimulatory oligodeoxynucleotide fromStreptococcus thermophilus lacZ

(2009) Takeshi SHIMOSATO et al.   ANIMAL SCIENCE JOURNAL

The Probiotic Preparation, VSL#3 Induces Remission in Patients With Mild-to-Moderately Active Ulcerative Colitis

(2009) Ajit Sood et al.   Clinical Gastroenterology and Hepatology

Upregulation of T-bet and tight junction molecules by Bifidobactrium longum improves colonic inflammation of ulcerative colitis

(2009) Yasuhiro Takeda et al.   INFLAMMATORY BOWEL DISEASES

Split immune response after oral vaccination of mice with recombinant Escherichia coli Nissle 1917 expressing fimbrial adhesin K88

(2009) Katharina A. Remer et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Orally administered L. lactis secreting an anti-TNF Nanobody demonstrate efficacy in chronic colitis

(2009) K Vandenbroucke et al.   Mucosal Immunology

Common variants at five new loci associated with early-onset inflammatory bowel disease

(2009) Marcin Imielinski et al.   NATURE GENETICS

Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor

(2009) Erik-Oliver Glocker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mucosal delivery of therapeutic and prophylactic molecules using lactic acid bacteria

(2008) Jerry M. Wells et al.   NATURE REVIEWS MICROBIOLOGY

Pharmacological and Clinical Aspects of Heme Oxygenase

(2008) N. G. Abraham et al.   PHARMACOLOGICAL REVIEWS

Commensal-Induced Regulatory T Cells Mediate Protection against Pathogen-Stimulated NF-κB Activation

(2008) Caitlin O'Mahony et al.   PLoS Pathogens

Paracellular entry of interleukin-10 producing Lactococcus lactis in inflamed intestinal mucosa in mice

(2007) Anouk Waeytens et al.   INFLAMMATORY BOWEL DISEASES

Development of a tripartite vector system for live oral immunization using a Gram-negative probiotic carrier

(2007) Christian Buddenborg et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY