A chemoproteomic portrait of the oncometabolite fumarate

CRISPR Approaches to Small Molecule Target Identification

(2018) Marco Jost et al.   ACS Chemical Biology

SWI/SNF protein expression status in fumarate hydratase–deficient renal cell carcinoma: immunohistochemical analysis of 32 tumors from 28 patients

(2018) Abbas Agaimy et al.   HUMAN PATHOLOGY

Features and regulation of non-enzymatic post-translational modifications

(2018) Robert Harmel et al.   Nature Chemical Biology

Structural Insights into BAF47 and BAF155 Complex Formation

(2017) Li Yan et al.   JOURNAL OF MOLECULAR BIOLOGY

Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes

(2017) Julie Adam et al.   Cell Reports

Co-opting a Bioorthogonal Reaction for Oncometabolite Detection

(2016) Thomas T. Zengeya et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition

(2016) Marco Sciacovelli et al.   NATURE

Proteome-wide covalent ligand discovery in native biological systems

(2016) Keriann M. Backus et al.   NATURE

Chemical proteomic map of dimethyl fumarate–sensitive cysteines in primary human T cells

(2016) Megan M. Blewett et al.   Science Signaling

Chemical proteomic map of dimethyl fumarate–sensitive cysteines in primary human T cells

(2016) Megan M. Blewett et al.   Science Signaling

The basics of thiols and cysteines in redox biology and chemistry

(2015) Leslie B. Poole   FREE RADICAL BIOLOGY AND MEDICINE

ProLuCID: An improved SEQUEST-like algorithm with enhanced sensitivity and specificity

(2015) T. Xu et al.   Journal of Proteomics

Succination is Increased on Select Proteins in the Brainstem of the NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) Knockout Mouse, a Model of Leigh Syndrome

(2015) Gerardo G. Piroli et al.   MOLECULAR & CELLULAR PROTEOMICS

Fumarate induces redox-dependent senescence by modifying glutathione metabolism

(2015) Liang Zheng et al.   Nature Communications

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

Site-specific mapping and quantification of protein S-sulphenylation in cells

(2014) Jing Yang et al.   Nature Communications

Metabolic Mechanisms of Epigenetic Regulation

(2013) Jordan L. Meier   ACS Chemical Biology

PBRM1 and BAP1 as Novel Targets for Renal Cell Carcinoma

(2013) James Brugarolas   CANCER JOURNAL

Thiol-blocking electrophiles interfere with labeling and detection of protein sulfenic acids

(2013) Julie A. Reisz et al.   FEBS Journal

The Proto-oncometabolite Fumarate Binds Glutathione to Amplify ROS-Dependent Signaling

(2013) Lucas B. Sullivan et al.   MOLECULAR CELL

A chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles

(2013) Chu Wang et al.   NATURE METHODS

Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2

(2013) S. K. Knutson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Mitochondrial Aconitase by Succination in Fumarate Hydratase Deficiency

(2013) Nicola Ternette et al.   Cell Reports

Mitochondrial stress causes increased succination of proteins in adipocytes in response to glucotoxicity

(2012) Norma Frizzell et al.   BIOCHEMICAL JOURNAL

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Improving Proteomics Mass Accuracy by Dynamic Offline Lock Mass

(2011) Ying Zhang et al.   ANALYTICAL CHEMISTRY

Succination of Keap1 and Activation of Nrf2-Dependent Antioxidant Pathways in FH-Deficient Papillary Renal Cell Carcinoma Type 2

(2011) Lisa Kinch et al.   CANCER CELL

Identification of a core member of the SWI/SNF complex, BAF155/SMARCC1, as a human tumor suppressor gene

(2011) Jessica DelBove et al.   Epigenetics

Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status

(2011) Chiara Bardella et al.   JOURNAL OF PATHOLOGY

Itaconic Acid Is a Mammalian Metabolite Induced during Macrophage Activation

(2011) Cheryl L. Strelko et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Predicting the functional impact of protein mutations: application to cancer genomics

(2011) Boris Reva et al.   NUCLEIC ACIDS RESEARCH

Refinements to Label Free Proteome Quantitation: How to Deal with Peptides Shared by Multiple Proteins

(2010) Ying Zhang et al.   ANALYTICAL CHEMISTRY

Ubiquitin-dependent and Ubiquitin-independent Control of Subunit Stoichiometry in the SWI/SNF Complex

(2010) Brian R. Keppler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative reactivity profiling predicts functional cysteines in proteomes

(2010) Eranthie Weerapana et al.   NATURE

Effect of Dynamic Exclusion Duration on Spectral Count Based Quantitative Proteomics

(2009) Ying Zhang et al.   ANALYTICAL CHEMISTRY

UOK 262 cell line, fumarate hydratase deficient (FH−/FH−) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer

(2009) Youfeng Yang et al.   CANCER GENETICS AND CYTOGENETICS

Fumarate Hydratase Deficiency in Renal Cancer Induces Glycolytic Addiction and Hypoxia-Inducible Transcription Factor 1  Stabilization by Glucose-Dependent Generation of Reactive Oxygen Species

(2009) S. Sudarshan et al.   MOLECULAR AND CELLULAR BIOLOGY

Expanding the functional diversity of proteins through cysteine oxidation

(2008) Khalilah G Reddie et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Thiol chemistry and specificity in redox signaling

(2008) Christine C. Winterbourn et al.   FREE RADICAL BIOLOGY AND MEDICINE