Mechanoactivation of NOX2-generated ROS elicits persistent TRPM8 Ca2+signals that are inhibited by oncogenic KRas

Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel

(2019) Ying Yin et al.   SCIENCE

Dynamically stiffened matrix promotes malignant transformation of mammary epithelial cells via collective mechanical signaling

(2019) Matthew G. Ondeck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and mechanistic insights into mechanoactivation of focal adhesion kinase

(2019) Magnus Sebastian Bauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dihydrotanshinone-Induced NOX5 Activation Inhibits Breast Cancer Stem Cell through the ROS/Stat3 Signaling Pathway

(2019) Su-Lim Kim et al.   Oxidative Medicine and Cellular Longevity

ROCK isoforms differentially modulate cancer cell motility by mechanosensing the substrate stiffness

(2019) Yueting Peng et al.   Acta Biomaterialia

A microfluidic assay for the quantification of the metastatic propensity of breast cancer specimens

(2019) Christopher L. Yankaskas et al.   Nature Biomedical Engineering

Mechanosensitive ion channels push cancer progression

(2019) Zoltán Pethő et al.   CELL CALCIUM

Mammalian TRP ion channels are insensitive to membrane stretch

(2019) Yury A. Nikolaev et al.   JOURNAL OF CELL SCIENCE

A Soft Microenvironment Protects from Failure of Midbody Abscission and Multinucleation Downstream of the EMT-Promoting Transcription Factor Snail

(2018) Allison K. Simi et al.   CANCER RESEARCH

Mechanosensitive adhesion complexes in epithelial architecture and cancer onset

(2018) Minerva Bosch-Fortea et al.   CURRENT OPINION IN CELL BIOLOGY

Quantifying solid stress and elastic energy from excised or in situ tumors

(2018) Hadi T Nia et al.   Nature Protocols

Real-time scratch assay reveals mechanisms of early calcium signaling in breast cancer cells in response to wounding

(2018) Stephen J.P. Pratt et al.   Oncotarget

Validation of miRNA prognostic power in hepatocellular carcinoma using expression data of independent datasets

(2018) Ádám Nagy et al.   Scientific Reports

Sustained Morphine Administration Induces TRPM8-Dependent Cold Hyperalgesia

(2017) Kerui Gong et al.   JOURNAL OF PAIN

Molecular mechanisms of tumour invasion: regulation by calcium signals

(2017) Oksana Iamshanova et al.   JOURNAL OF PHYSIOLOGY-LONDON

Single and collective cell migration: the mechanics of adhesions

(2017) Chiara De Pascalis et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanobiology of collective cell behaviours

(2017) Benoit Ladoux et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Piezos thrive under pressure: mechanically activated ion channels in health and disease

(2017) Swetha E. Murthy et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation

(2017) Chrystelle Aillaud et al.   SCIENCE

Vasohibins encode tubulin detyrosinating activity

(2017) Joppe Nieuwenhuis et al.   SCIENCE

Microtubules tune mechanotransduction through NOX2 and TRPV4 to decrease sclerostin abundance in osteocytes

(2017) James S. Lyons et al.   Science Signaling

Microtubules tune mechanotransduction through NOX2 and TRPV4 to decrease sclerostin abundance in osteocytes

(2017) James S. Lyons et al.   Science Signaling

Mechanical stability of talin rod controls cell migration and substrate sensing

(2017) Rolle Rahikainen et al.   Scientific Reports

Alterations of calcium homeostasis in cancer cells

(2016) Saverio Marchi et al.   CURRENT OPINION IN PHARMACOLOGY

Forcing through Tumor Metastasis: The Interplay between Tissue Rigidity and Epithelial–Mesenchymal Transition

(2016) Spencer C. Wei et al.   TRENDS IN CELL BIOLOGY

Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension

(2016) Charles D. Cox et al.   Nature Communications

The mechanical response of talin

(2016) Mingxi Yao et al.   Nature Communications

Solid stress and elastic energy as measures of tumour mechanopathology

(2016) Hadi T. Nia et al.   Nature Biomedical Engineering

Biphasic response of cell invasion to matrix stiffness in three-dimensional biopolymer networks

(2015) Nadine R. Lang et al.   Acta Biomaterialia

Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration

(2015) I. Acerbi et al.   Integrative Biology

Matrix stiffness drives epithelial–mesenchymal transition and tumour metastasis through a TWIST1–G3BP2 mechanotransduction pathway

(2015) Spencer C. Wei et al.   NATURE CELL BIOLOGY

Detyrosinated microtubules modulate mechanotransduction in heart and skeletal muscle

(2015) Jaclyn P. Kerr et al.   Nature Communications

The combinatorial activation of the PI3K and Ras/MAPK pathways is sufficient for aggressive tumor formation, while individual pathway activation supports cell persistence

(2015) Keyata N. Thompson et al.   Oncotarget

Mechanical sensitivity of Piezo1 ion channels can be tuned by cellular membrane tension

(2015) Amanda H Lewis et al.   eLife

Redox-modulating agents target NOX2-dependent IKKε oncogenic kinase expression and proliferation in human breast cancer cell lines

(2015) Espérance Mukawera et al.   Redox Biology

Ionic Selectivity and Permeation Properties of Human PIEZO1 Channels

(2015) Radhakrishnan Gnanasambandam et al.   PLoS One

Identification of a novel 2-pyridyl-benzensulfonamide derivative, RQ-00203078, as a selective and orally active TRPM8 antagonist

(2014) Masashi Ohmi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Neighborly relations during collective migration

(2014) Sandrine Etienne-Manneville   CURRENT OPINION IN CELL BIOLOGY

Piezo1 integration of vascular architecture with physiological force

(2014) Jing Li et al.   NATURE

Extracellular matrix stiffness and composition jointly regulate the induction of malignant phenotypes in mammary epithelium

(2014) Ovijit Chaudhuri et al.   NATURE MATERIALS

Evidence That Breast Tissue Stiffness Is Associated with Risk of Breast Cancer

(2014) Norman F. Boyd et al.   PLoS One

Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells

(2014) Medha M. Pathak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Piezo1, a mechanically activated ion channel, is required for vascular development in mice

(2014) S. S. Ranade et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation

(2014) Mingxi Yao et al.   Scientific Reports

Quantification of surface tension and internal pressure generated by single mitotic cells

(2014) Elisabeth Fischer-Friedrich et al.   Scientific Reports

X-ROS signaling in the heart and skeletal muscle: Stretch-dependent local ROS regulates [Ca2+]i

(2012) Benjamin L. Prosser et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Piezo proteins are pore-forming subunits of mechanically activated channels

(2012) Bertrand Coste et al.   NATURE

Independent regulation of tumor cell migration by matrix stiffness and confinement

(2012) A. Pathak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Invasive Breast Cancer: Relationship between Shear-wave Elastographic Findings and Histologic Prognostic Factors

(2012) Andrew Evans et al.   RADIOLOGY

Microtubules Underlie Dysfunction in Duchenne Muscular Dystrophy

(2012) R. J. Khairallah et al.   Science Signaling

High Expression of Transient Receptor Potential Channels in Human Breast Cancer Epithelial Cells and Tissues: Correlation with Pathological Parameters

(2011) Isabelle Dhennin-Duthille et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

TRPM channels: same ballpark, different players, and different rules in immunogenetics

(2011) Ammad Ahmad Farooqi et al.   IMMUNOGENETICS

In situ force mapping of mammary gland transformation

(2011) Jose I. Lopez et al.   Integrative Biology

Cell-ECM traction force modulates endogenous tension at cell-cell contacts

(2011) V. Maruthamuthu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

X-ROS Signaling: Rapid Mechano-Chemo Transduction in Heart

(2011) B. L. Prosser et al.   SCIENCE

Estrogen regulation of TRPM8 expression in breast cancer cells

(2010) Dechen Chodon et al.   BMC CANCER

Epithelial-to-Mesenchymal Transition Promotes Tubulin Detyrosination and Microtentacles that Enhance Endothelial Engagement

(2010) R. A. Whipple et al.   CANCER RESEARCH

Reactive oxygen species in cancer

(2010) Geou-Yarh Liou et al.   FREE RADICAL RESEARCH

Matrix Rigidity Regulates Cancer Cell Growth and Cellular Phenotype

(2010) Robert W. Tilghman et al.   PLoS One

An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients

(2009) Balazs Györffy et al.   BREAST CANCER RESEARCH AND TREATMENT

Deletion of PTEN Promotes Tumorigenic Signaling, Resistance to Anoikis, and Altered Response to Chemotherapeutic Agents in Human Mammary Epithelial Cells

(2009) M. I. Vitolo et al.   CANCER RESEARCH

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Mechanotransduction by TRP Channels: General Concepts and Specific Role in the Vasculature

(2009) Jun Yin et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Expression of NADPH oxidase homologues and accessory genes in human cancer cell lines, tumours and adjacent normal tissues

(2009) Agnes Juhasz et al.   FREE RADICAL RESEARCH

Sclerostin Mediates Bone Response to Mechanical Unloading Through Antagonizing Wnt/β-Catenin Signaling

(2009) Chuwen Lin et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Collagen density promotes mammary tumor initiation and progression

(2008) Paolo P Provenzano et al.   BMC Medicine