DNA methylation analysis in constitutional disorders: Clinical implications of the epigenome

Induction of DNA Methylation by Artificial piRNA Production in Male Germ Cells

(2015) Daisuke Itou et al.   CURRENT BIOLOGY

Cultural relativism: maintenance of genomic imprints in pluripotent stem cell culture systems

(2015) Maxim VC Greenberg et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

What Do You Mean, “Epigenetic”?

(2015) Carrie Deans et al.   GENETICS

Maternal gestational diabetes is associated with genome-wide DNA methylation variation in placenta and cord blood of exposed offspring

(2015) Sarah Finer et al.   HUMAN MOLECULAR GENETICS

Altering 5-hydroxymethylcytosine modification impacts ischemic brain injury

(2015) Zhigang Miao et al.   HUMAN MOLECULAR GENETICS

Integrative analysis of 111 reference human epigenomes

(2015) Anshul Kundaje et al.   NATURE

Disruption of DNA-methylation-dependent long gene repression in Rett syndrome

(2015) Harrison W. Gabel et al.   NATURE

Integrative analysis of haplotype-resolved epigenomes across human tissues

(2015) Danny Leung et al.   NATURE

Genomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation

(2015) Tuncay Baubec et al.   NATURE

RNA-mediated epigenetic regulation of gene expression

(2015) Daniel Holoch et al.   NATURE REVIEWS GENETICS

Characterization of global loss of imprinting in fetal overgrowth syndrome induced by assisted reproduction

(2015) Zhiyuan Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MeCP2 binds to non-CG methylated DNA as neurons mature, influencing transcription and the timing of onset for Rett syndrome

(2015) Lin Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A statistical method for single sample analysis of HumanMethylation450 array data: genome-wide methylation analysis of patients with imprinting disorders

(2015) Faisal I Rezwan et al.   Clinical Epigenetics

Genome-wide DNA hypomethylation and RNA:DNA hybrid accumulation in Aicardi–Goutières syndrome

(2015) Yoong Wearn Lim et al.   eLife

What Do You Mean, “Epigenetic”?

(2015) Carrie Deans et al.   GENETICS

An analysis of DNA methylation in human adipose tissue reveals differential modification of obesity genes before and after gastric bypass and weight loss

(2015) Miles C Benton et al.   GENOME BIOLOGY

A Comparison of Genome-Wide DNA Methylation Patterns between Different Vascular Tissues from Patients with Coronary Heart Disease

(2015) Maria S. Nazarenko et al.   PLoS One

GeMes, Clusters of DNA Methylation under Genetic Control, Can Inform Genetic and Epigenetic Analysis of Disease

(2014) Yun Liu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Increased methylation at differentially methylated region of GNASin infants born to gestational diabetes

(2014) Danqing Chen et al.   BMC Medical Genetics

Genomics and epigenomics in pediatric oncology and clinical laboratory genetics

(2014) Bekim Sadikovic et al.   CLINICAL BIOCHEMISTRY

5-Hydroxymethylcytosine: A stable or transient DNA modification?

(2014) Maria A. Hahn et al.   GENOMICS

Epigenetics and imprinting in human disease

(2014) Jennifer M. Kalish et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Genome-wide DNA methylation analysis of patients with imprinting disorders identifies differentially methylated regions associated with novel candidate imprinted genes

(2014) Louise E Docherty et al.   JOURNAL OF MEDICAL GENETICS

DNA methylation and body-mass index: a genome-wide analysis

(2014) Katherine J Dick et al.   LANCET

5-Hydroxymethylcytosine is a predominantly stable DNA modification

(2014) Martin Bachman et al.   Nature Chemistry

Epigenetics: The neglected key to minimize learning and memory deficits in Down syndrome

(2014) Alain D. Dekker et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

An update on epigenetics and childhood respiratory diseases

(2014) Olena Gruzieva et al.   Paediatric Respiratory Reviews

Allele-Specific Methylation Occurs at Genetic Variants Associated with Complex Disease

(2014) John N. Hutchinson et al.   PLoS One

Notes on the role of dynamic DNA methylation in mammalian development

(2014) Timothy H. Bestor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effectiveness of exome and genome sequencing guided by acuity of illness for diagnosis of neurodevelopmental disorders

(2014) S. E. Soden et al.   Science Translational Medicine

The PEG13-DMR and brain-specific enhancers dictate imprinted expression within the 8q24 intellectual disability risk locus

(2014) Franck Court et al.   Epigenetics & Chromatin

Large hypomethylated blocks as a universal defining epigenetic alteration in human solid tumors

(2014) Winston Timp et al.   Genome Medicine

Transcription-Associated R-Loop Formation across the Human FMR1 CGG-Repeat Region

(2014) Erick W. Loomis et al.   PLoS Genetics

Whole-genome analysis of 5-hydroxymethylcytosine and 5-methylcytosine at base resolution in the human brain

(2014) Lu Wen et al.   GENOME BIOLOGY

DNA Methyltransferases: A Novel Target for Prevention and Therapy

(2014) Dharmalingam Subramaniam et al.   Frontiers in Oncology

Weaver syndrome andEZH2mutations: Clarifying the clinical phenotype

(2013) Katrina Tatton-Brown et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Genetics and the investigation of developmental delay/intellectual disability

(2013) M. Srour et al.   ARCHIVES OF DISEASE IN CHILDHOOD

Genome-wide analysis validates aberrant methylation in fragile X syndrome is specific to the FMR1locus

(2013) Reid S Alisch et al.   BMC Medical Genetics

Multilocus loss of DNA methylation in individuals with mutations in the histone H3 Lysine 4 Demethylase KDM5C

(2013) Daria Grafodatskaya et al.   BMC Medical Genomics

Interplay between the Cancer Genome and Epigenome

(2013) Hui Shen et al.   CELL

Chromatin: Receiver and Quarterback for Cellular Signals

(2013) David G. Johnson et al.   CELL

Epigenetic regulation by long noncoding RNAs in plants

(2013) Jae Bok Heo et al.   CHROMOSOME RESEARCH

Epigenetic dysregulation of SHANK3 in brain tissues from individuals with autism spectrum disorders

(2013) Li Zhu et al.   HUMAN MOLECULAR GENETICS

Targeted Next-Generation Sequencing can Replace Sanger Sequencing in Clinical Diagnostics

(2013) Birgit Sikkema-Raddatz et al.   HUMAN MUTATION

DNA methylation profiles in type 1 diabetes twins point to strong epigenetic effects on etiology

(2013) Mihaela Stefan et al.   JOURNAL OF AUTOIMMUNITY

Quantitative analysis of methylation status at 11p15 and 7q21 for the genetic diagnosis of Beckwith–Wiedemann syndrome and Silver–Russell syndrome

(2013) Beom Hee Lee et al.   JOURNAL OF HUMAN GENETICS

Truncating mutations of MAGEL2 cause Prader-Willi phenotypes and autism

(2013) Christian P Schaaf et al.   NATURE GENETICS

Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain

(2013) Junjie U Guo et al.   NATURE NEUROSCIENCE

Dynamic causal modeling suggests serial processing of tactile vibratory stimuli in the human somatosensory cortex—An fMRI study

(2013) Christian Kalberlah et al.   NEUROIMAGE

DNMT1 mutation hot spot causes varied phenotypes of HSAN1 with dementia and hearing loss

(2013) C. J. Klein et al.   NEUROLOGY

Elucidating the Landscape of Aberrant DNA Methylation in Hepatocellular Carcinoma

(2013) Min-Ae Song et al.   PLoS One

Tobacco Smoking Leads to Extensive Genome-Wide Changes in DNA Methylation

(2013) Sonja Zeilinger et al.   PLoS One

Childhood maltreatment is associated with distinct genomic and epigenetic profiles in posttraumatic stress disorder

(2013) D. Mehta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global Epigenomic Reconfiguration During Mammalian Brain Development

(2013) R. Lister et al.   SCIENCE

Potential functional roles of DNA demethylation intermediates

(2013) Chun-Xiao Song et al.   TRENDS IN BIOCHEMICAL SCIENCES

A Six Months Exercise Intervention Influences the Genome-wide DNA Methylation Pattern in Human Adipose Tissue

(2013) Tina Rönn et al.   PLoS Genetics

Interaction of prenatal maternal smoking, interleukin 13 genetic variants and DNA methylation influencing airflow and airway reactivity

(2013) Veeresh K Patil et al.   Clinical Epigenetics

The interaction of genetic variants and DNA methylation of the interleukin-4 receptor gene increase the risk of asthma at age 18 years

(2013) Nelís Soto-Ramírez et al.   Clinical Epigenetics

Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates

(2013) Hannah K Long et al.   eLife

A screen for hydroxymethylcytosine and formylcytosine binding proteins suggests functions in transcription and chromatin regulation

(2013) Mario Iurlaro et al.   GENOME BIOLOGY

A genetic association study of DNA methylation levels in the DRD4 gene region finds associations with nearby SNPs

(2012) Sophia J Docherty et al.   Behavioral and Brain Functions

Epigenetics in asthma and COPD

(2012) Michael Kabesch et al.   BIOCHIMIE

A small molecule regulates hairpin structures in d(CGG) trinucleotide repeats

(2012) Masaki Hagihara et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

SHANK3 as an autism spectrum disorder-associated gene

(2012) Shigeo Uchino et al.   BRAIN & DEVELOPMENT

Base-Resolution Analyses of Sequence and Parent-of-Origin Dependent DNA Methylation in the Mouse Genome

(2012) Wei Xie et al.   CELL

Cancer Epigenetics: From Mechanism to Therapy

(2012) Mark A. Dawson et al.   CELL

Impact of an Exercise Intervention on DNA Methylation in Skeletal Muscle From First-Degree Relatives of Patients With Type 2 Diabetes

(2012) M. D. Nitert et al.   DIABETES

DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients

(2012) Michael Volkmar et al.   EMBO JOURNAL

Exploring genome-wide DNA methylation profiles altered in hepatocellular carcinoma using Infinium HumanMethylation 450 BeadChips

(2012) Jing Shen et al.   Epigenetics

Targeted next generation sequencing as a diagnostic tool in epileptic disorders

(2012) Johannes R. Lemke et al.   EPILEPSIA

Prevalence of SHANK3 variants in patients with different subtypes of autism spectrum disorders

(2012) Luigi Boccuto et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Age-associated DNA methylation in pediatric populations

(2012) R. S. Alisch et al.   GENOME RESEARCH

Epigenome-wide association study in the European Prospective Investigation into Cancer and Nutrition (EPIC-Turin) identifies novel genetic loci associated with smoking

(2012) Natalie S. Shenker et al.   HUMAN MOLECULAR GENETICS

Latent Regulatory Potential of Human-Specific Repetitive Elements

(2012) Michelle C. Ward et al.   MOLECULAR CELL

Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates

(2012) Gregory Hannum et al.   MOLECULAR CELL

The rs3743205 SNP Is Important for the Regulation of the Dyslexia Candidate GeneDYX1C1by Estrogen Receptor β and DNA Methylation

(2012) Kristiina Tammimies et al.   MOLECULAR ENDOCRINOLOGY

Functions of DNA methylation: islands, start sites, gene bodies and beyond

(2012) Peter A. Jones   NATURE REVIEWS GENETICS

Diagnostic Exome Sequencing in Persons with Severe Intellectual Disability

(2012) Joep de Ligt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Association of the CpG Methylation Pattern of the Proximal Insulin Gene Promoter with Type 1 Diabetes

(2012) Delphine Fradin et al.   PLoS One

Genomic landscape of human allele-specific DNA methylation

(2012) F. Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Updates in the Genetic Evaluation of the Child with Global Developmental Delay or Intellectual Disability

(2012) Leigh Anne Flore et al.   Seminars in Pediatric Neurology

Alcohol Alters DNA Methylation Patterns and Inhibits Neural Stem Cell Differentiation

(2011) Feng C. Zhou et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Variable DNA Methylation Is Associated with Chronic Obstructive Pulmonary Disease and Lung Function

(2011) Weiliang Qiu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Genetic and Epigenetic Networks in Intellectual Disabilities

(2011) Hans van Bokhoven   Annual Review of Genetics

Whole exome and whole genome sequencing

(2011) David Bick et al.   CURRENT OPINION IN PEDIATRICS

Regulation of mammalian DNA methyltransferases: a route to new mechanisms

(2011) Hélène Denis et al.   EMBO REPORTS

DNA methylation ofIGF2,GNASAS,INSIGFandLEPand being born small for gestational age

(2011) Elmar W. Tobi et al.   Epigenetics

Multiple sclerosis etiology: beyond genes and environment

(2011) Rosella Mechelli et al.   Expert Review of Clinical Immunology

Directional DNA Methylation Changes and Complex Intermediate States Accompany Lineage Specificity in the Adult Hematopoietic Compartment

(2011) Emily Hodges et al.   MOLECULAR CELL

Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss

(2011) Christopher J Klein et al.   NATURE GENETICS

HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants

(2011) L. D. Ward et al.   NUCLEIC ACIDS RESEARCH

Genomic Distribution and Inter-Sample Variation of Non-CpG Methylation across Human Cell Types

(2011) Michael J. Ziller et al.   PLoS Genetics

Identification of Type 1 Diabetes–Associated DNA Methylation Variable Positions That Precede Disease Diagnosis

(2011) Vardhman K. Rakyan et al.   PLoS Genetics

5-Hydroxymethylcytosine is associated with enhancers and gene bodies in human embryonic stem cells

(2011) Hume Stroud et al.   GENOME BIOLOGY

Haploinsufficiency of HDAC4 Causes Brachydactyly Mental Retardation Syndrome, with Brachydactyly Type E, Developmental Delays, and Behavioral Problems

(2010) Stephen R. Williams et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genetic Control of Individual Differences in Gene-Specific Methylation in Human Brain

(2010) Dandan Zhang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Uniparental disomy and human disease: An overview

(2010) Kazuki Yamazawa et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

Genetics Talks to Epigenetics? The Interplay Between Sequence Variants and Chromatin Structure

(2010) Silvio Zaina et al.   CURRENT GENOMICS

RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage

(2010) M. Schaefer et al.   GENES & DEVELOPMENT

Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer

(2010) A. E. Teschendorff et al.   GENOME RESEARCH

AutoMeDIP-seq: A high-throughput, whole genome, DNA methylation assay

(2010) Lee M. Butcher et al.   METHODS

Epigenetic modifications and human disease

(2010) Anna Portela et al.   NATURE BIOTECHNOLOGY

Principles and challenges of genome-wide DNA methylation analysis

(2010) Peter W. Laird   NATURE REVIEWS GENETICS

Identification of Genetic and Epigenetic Marks Involved in Population Structure

(2010) Jingyu Liu et al.   PLoS One

Integrated Genetic and Epigenetic Analysis Identifies Haplotype-Specific Methylation in the FTO Type 2 Diabetes and Obesity Susceptibility Locus

(2010) Christopher G. Bell et al.   PLoS One

Tissue Distribution of 5-Hydroxymethylcytosine and Search for Active Demethylation Intermediates

(2010) Daniel Globisch et al.   PLoS One

De novo mutations in the gene encoding the synaptic scaffolding proteinSHANK3in patients ascertained for schizophrenia

(2010) Julie Gauthier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Signals of Epigenetic States

(2010) Roberto Bonasio et al.   SCIENCE

A Small-RNA Perspective on Gametogenesis, Fertilization, and Early Zygotic Development

(2010) Déborah Bourc’his et al.   SCIENCE

Personalized Epigenomic Signatures That Are Stable Over Time and Covary with Body Mass Index

(2010) A. P. Feinberg et al.   Science Translational Medicine

Genome-scale DNA methylation analysis

(2010) Shaun D Fouse et al.   Epigenomics

Inter- and Intra-Individual Variation in Allele-Specific DNA Methylation and Gene Expression in Children Conceived using Assisted Reproductive Technology

(2010) Nahid Turan et al.   PLoS Genetics

Fetal Alcohol Spectrum Disorders: The Epigenetic Perspective1

(2009) Philip C. Haycock   BIOLOGY OF REPRODUCTION

Imprinting disorders and assisted reproductive technology

(2009) Somjate Manipalviratn et al.   FERTILITY AND STERILITY

An operational definition of epigenetics

(2009) S. L. Berger et al.   GENES & DEVELOPMENT

Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus

(2009) B. M. Javierre et al.   GENOME RESEARCH

Gene-body hypermethylation of ATM in peripheral blood DNA of bilateral breast cancer patients

(2009) James M. Flanagan et al.   HUMAN MOLECULAR GENETICS

Interplay between DNA methylation, histone modification and chromatin remodeling in stem cells and during development

(2009) Kohta Ikegami et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores

(2009) Rafael A Irizarry et al.   NATURE GENETICS

Rethinking how DNA methylation patterns are maintained

(2009) Peter A. Jones et al.   NATURE REVIEWS GENETICS

DNA methylation and gene expression

(2009) Zahava Siegfried et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Germline Mutation in NLRP2 (NALP2) in a Familial Imprinting Disorder (Beckwith-Wiedemann Syndrome)

(2009) Esther Meyer et al.   PLoS Genetics

Cause and Consequences of Genetic and Epigenetic Alterations in Human Cancer

(2008) B. Sadikovic et al.   CURRENT GENOMICS

Hypomethylation at multiple maternally methylated imprinted regions including PLAGL1 and GNAS loci in Beckwith–Wiedemann syndrome

(2008) Jet Bliek et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Low frequency of imprinting defects in ICSI children born small for gestational age

(2008) Deniz Kanber et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Prader–Willi syndrome

(2008) Suzanne B Cassidy et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Clinical and molecular genetic features of Beckwith-Wiedemann syndrome associated with assisted reproductive technologies

(2008) D. Lim et al.   HUMAN REPRODUCTION

Decline in genomic DNA methylation through aging in a cohort of elderly subjects

(2008) Valentina Bollati et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Genomic surveys by methylation-sensitive SNP analysis identify sequence-dependent allele-specific DNA methylation

(2008) Kristi Kerkel et al.   NATURE GENETICS

Global Developmental Delay and Mental Retardation or Intellectual Disability: Conceptualization, Evaluation, and Etiology

(2008) Michael Shevell   PEDIATRIC CLINICS OF NORTH AMERICA

Discovery of bisulfite-mediated cytosine conversion to uracil, the key reaction for DNA methylation analysis — A personal account

(2008) Hikoya HAYATSU   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES