Multiple sclerosis etiology: beyond genes and environment

Altered expression of miR-17-5p in CD4+lymphocytes of relapsing-remitting multiple sclerosis patients

(2010) Raija L. P. Lindberg et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Epigenetics and autoimmunity

(2010) Wesley H. Brooks et al.   JOURNAL OF AUTOIMMUNITY

MGAT5 alters the severity of multiple sclerosis

(2010) B. Brynedal et al.   JOURNAL OF NEUROIMMUNOLOGY

Regulation of Alternative Splicing by Histone Modifications

(2010) R. F. Luco et al.   SCIENCE

Prediction of acute multiple sclerosis relapses by transcription levels of peripheral blood cells

(2009) Michael Gurevich et al.   BMC Medical Genomics

Epstein–Barr virus infection is not a characteristic feature of multiple sclerosis brain

(2009) Simon N. Willis et al.   BRAIN

Switching on Epigenetic Therapy

(2009) Sascha Karberg   CELL

MicroRNAs and cancer epigenetics: a macrorevolution

(2009) Veronica Davalos et al.   CURRENT OPINION IN ONCOLOGY

Identification of new sensitive biomarkers for thein vivoresponse to interferon-β treatment in multiple sclerosis using DNA-array evaluation

(2009) F. Sellebjerg et al.   EUROPEAN JOURNAL OF NEUROLOGY

Comprehensive follow-up of the first genome-wide association study of multiple sclerosis identifies KIF21B and TMEM39A as susceptibility loci

(2009) et al.   HUMAN MOLECULAR GENETICS

Pathway and network-based analysis of genome-wide association studies in multiple sclerosis

(2009) S. E. Baranzini et al.   HUMAN MOLECULAR GENETICS

PARP-1 Deficiency Increases the Severity of Disease in a Mouse Model of Multiple Sclerosis

(2009) Vimal Selvaraj et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parent-of-origin of HLA-DRB1*1501 and age of onset of multiple sclerosis

(2009) Sreeram V Ramagopalan et al.   JOURNAL OF HUMAN GENETICS

Therapeutic activities of intravenous immunoglobulins in multiple sclerosis involve modulation of chemokine expression

(2009) Nadine Pigard et al.   JOURNAL OF NEUROIMMUNOLOGY

Less is more: therapeutic exon skipping for Duchenne muscular dystrophy

(2009) Annemieke Aartsma-Rus et al.   LANCET NEUROLOGY

Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score

(2009) Philip L De Jager et al.   LANCET NEUROLOGY

Local restoration of dystrophin expression with the morpholino oligomer AVI-4658 in Duchenne muscular dystrophy: a single-blind, placebo-controlled, dose-escalation, proof-of-concept study

(2009) Maria Kinali et al.   LANCET NEUROLOGY

Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies

(2009) Rocio G Urdinguio et al.   LANCET NEUROLOGY

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Parental origin of sequence variants associated with complex diseases

(2009) Augustine Kong et al.   NATURE

Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20

(2009) Melanie Bahlo et al.   NATURE GENETICS

Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

(2009) Philip L De Jager et al.   NATURE GENETICS

Toll-like receptor 2 and poly(ADP-ribose) polymerase 1 promote central nervous system neuroinflammation in progressive EAE

(2009) Mauricio F Farez et al.   NATURE IMMUNOLOGY

Alternative splicing and biological heterogeneity in prostate cancer

(2009) Prabhakar Rajan et al.   Nature Reviews Urology

Nucleosome positioning as a determinant of exon recognition

(2009) Hagen Tilgner et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Chromatin organization marks exon-intron structure

(2009) Schraga Schwartz et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Gene expression profiling in multiple sclerosis: A disease of the central nervous system, but with relapses triggered in the periphery?

(2009) Boel Brynedal et al.   NEUROBIOLOGY OF DISEASE

Common Genetic Variation and Human Traits

(2009) David B. Goldstein   NEW ENGLAND JOURNAL OF MEDICINE

Differential Micro RNA Expression in PBMC from Multiple Sclerosis Patients

(2009) David Otaegui et al.   PLoS One

Alternative Splicing and Transcriptome Profiling of Experimental Autoimmune Encephalomyelitis Using Genome-Wide Exon Arrays

(2009) Alan Gillett et al.   PLoS One

Multiple Sclerosis: MicroRNA Expression Profiles Accurately Differentiate Patients with Relapsing-Remitting Disease from Healthy Controls

(2009) Andreas Keller et al.   PLoS One

Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases

(2009) et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene expression profiling: Decoding breast cancer

(2009) Femke de Snoo et al.   SURGICAL ONCOLOGY-OXFORD

Epigenetics: molecular mechanisms and implications for disease

(2009) Adam E. Handel et al.   TRENDS IN MOLECULAR MEDICINE

Aging and Environmental Exposures Alter Tissue-Specific DNA Methylation Dependent upon CpG Island Context

(2009) Brock C. Christensen et al.   PLoS Genetics

Expression of the Multiple Sclerosis-Associated MHC Class II Allele HLA-DRB1*1501 Is Regulated by Vitamin D

(2009) Sreeram V. Ramagopalan et al.   PLoS Genetics

Methylation of class II transactivator gene promoter IV is not associated with susceptibility to Multiple Sclerosis

(2008) Sreeram V Ramagopalan et al.   BMC Medical Genetics

Strong EBV-specific CD8+ T-cell response in patients with early multiple sclerosis

(2008) Samantha Jilek et al.   BRAIN

MicroRNAs (miRNAs) in Neurodegenerative Diseases

(2008) Peter T. Nelson et al.   BRAIN PATHOLOGY

CCCTC-binding Factor Activates PARP-1 Affecting DNA Methylation Machinery

(2008) Tiziana Guastafierro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

EBNA1-specific T cells from patients with multiple sclerosis cross react with myelin antigens and co-produce IFN-γ and IL-2

(2008) Jan D. Lünemann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IFN-β1b Induces Transient and Variable Gene Expression in Relapsing-Remitting Multiple Sclerosis Patients Independent of Neutralizing Antibodies or Changes in IFN Receptor RNA Expression

(2008) Anthony T. Reder et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Relapses in multiple sclerosis are associated with increased CD8+ T-cell mediated cytotoxicity in CSF

(2008) C MALMESTROM et al.   JOURNAL OF NEUROIMMUNOLOGY

Decreased T cell reactivity to Epstein-Barr virus infected lymphoblastoid cell lines in multiple sclerosis

(2008) M P Pender et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Multiple sclerosis

(2008) Alastair Compston et al.   LANCET

Environmental factors and multiple sclerosis

(2008) George C Ebers   LANCET NEUROLOGY

Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes

(2008) Changchun Xiao et al.   NATURE IMMUNOLOGY

MicroRNAs: new regulators of immune cell development and function

(2008) David Baltimore et al.   NATURE IMMUNOLOGY