Clinical relevance of autophagic therapy in cancer: Investigating the current trends, challenges, and future prospects

Autophagic Markers BECLIN 1 and LC3 Are Associated with Prognosis of Multiple Myeloma

(2015) Geunyoung Jung et al.   ACTA HAEMATOLOGICA

AutomiRDB: a web resource connecting microRNAs and autophagy in cancer

(2015) Yi Chen et al.   APOPTOSIS

Global cancer statistics, 2012

(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Interaction of autophagy with microRNAs and their potential therapeutic implications in human cancers

(2015) Zhao Jing et al.   CANCER LETTERS

Pre-clinical evaluation of AZD-2014, a novel mTORC1/2 dual inhibitor, against renal cell carcinoma

(2015) Bing Zheng et al.   CANCER LETTERS

Expression pattern of autophagy-related markers in non-metastatic clear cell renal cell carcinoma: association with disease recurrence following radical nephrectomy

(2015) Masatomo Nishikawa et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Methods to analyze SNARE-dependent vesicular fusion events that regulate autophagosome biogenesis

(2015) Kevin Moreau et al.   METHODS

mTORC1 Phosphorylates UVRAG to Negatively Regulate Autophagosome and Endosome Maturation

(2015) Young-Mi Kim et al.   MOLECULAR CELL

MicroRNA-423-5p Promotes Autophagy in Cancer Cells and Is Increased in Serum From Hepatocarcinoma Patients Treated With Sorafenib

(2015) Paola Stiuso et al.   Molecular Therapy-Nucleic Acids

Selective targeting of human colon cancer stem-like cells by the mTOR inhibitor Torin-1

(2015) Maria Giovanna Francipane et al.   Oncotarget

The Dual PI3K/mTOR Inhibitor NVP-BEZ235 Is a Potent Inhibitor of ATM- and DNA-PKCs-Mediated DNA Damage Responses

(2015) Bipasha Mukherjee et al.   NEOPLASIA

Removal of the BH4 Domain from Bcl-2 Protein Triggers an Autophagic Process that Impairs Tumor Growth

(2015) Daniela Trisciuoglio et al.   NEOPLASIA

NVP-BEZ235, a dual PI3K/mTOR inhibitor, induces cell death through alternate routes in prostate cancer cells depending on the PTEN genotype

(2014) Seung-Woo Hong et al.   APOPTOSIS

Silencing of Bcl-2 expression by small interfering RNA induces autophagic cell death in MCF-7 breast cancer cells

(2014) Ugur Akar et al.   Autophagy

Nelfinavir, a new anti-cancer drug with pleiotropic effects and many paths to autophagy

(2014) Joell J. Gills et al.   Autophagy

Bcl-2 family members: Dual regulators of apoptosis and autophagy

(2014) Beth Levine et al.   Autophagy

Atg1 kinase organizes autophagosome formation by phosphorylating Atg9

(2014) Daniel Papinski et al.   Autophagy

Inhibition of autophagy attenuates pancreatic cancer growth independent ofTP53/TRP53status

(2014) Annan Yang et al.   Autophagy

Acidic extracellular pH neutralizes the autophagy-inhibiting activity of chloroquine

(2014) Paola Pellegrini et al.   Autophagy

Combined autophagy and proteasome inhibition

(2014) Dan T Vogl et al.   Autophagy

Prognostic significance of p62/SQSTM1 subcellular localization and LC3B in oral squamous cell carcinoma

(2014) J-L Liu et al.   BRITISH JOURNAL OF CANCER

Induction of autophagy contributes to crizotinib resistance in ALK-positive lung cancer

(2014) Cheng Ji et al.   CANCER BIOLOGY & THERAPY

Tumor Vessel Normalization by Chloroquine Independent of Autophagy

(2014) Hannelore Maes et al.   CANCER CELL

Autophagy in cancer stem/progenitor cells

(2014) Yi-Hui Lin et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

To Be or Not to Be? How Selective Autophagy and Cell Death Govern Cell Fate

(2014) Douglas R. Green et al.   CELL

LAMP3 is involved in tamoxifen resistance in breast cancer cells through the modulation of autophagy

(2014) Anika Nagelkerke et al.   ENDOCRINE-RELATED CANCER

Involvement of miR-29b signaling in the sensitivity to chemotherapy in patients with ovarian carcinoma

(2014) Furong Dai et al.   HUMAN PATHOLOGY

Role of Autophagy in Cisplatin Resistance in Ovarian Cancer Cells

(2014) Juan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phase I Dose-Escalation Study of 5-Day Intermittent Oral Lapatinib Therapy in Patients With Human Epidermal Growth Factor Receptor 2–Overexpressing Breast Cancer

(2014) A. Jo Chien et al.   JOURNAL OF CLINICAL ONCOLOGY

Tyrosine Kinase Inhibitor Sorafenib Decreases 111In-Girentuximab Uptake in Patients with Clear Cell Renal Cell Carcinoma

(2014) C. H. J. Muselaers et al.   JOURNAL OF NUCLEAR MEDICINE

Inhibition of Grade Dependent Autophagy in Urothelial Carcinoma Increases Cell Death under Nutritional Limiting Condition and Potentiates the Cytotoxicity of Chemotherapeutic Agent

(2014) Rani Ojha et al.   JOURNAL OF UROLOGY

Metformin decreases lung cancer risk in diabetic patients in a dose-dependent manner

(2014) Ming-Ju Tsai et al.   LUNG CANCER

Interaction of the HOPS complex with Syntaxin 17 mediates autophagosome clearance in Drosophila

(2014) Szabolcs Takáts et al.   MOLECULAR BIOLOGY OF THE CELL

Histone deacetylase inhibition synergistically enhances pemetrexed cytotoxicity through induction of apoptosis and autophagy in non-small cell lung cancer

(2014) Donatella Del Bufalo et al.   Molecular Cancer

The AMPK Inhibitor Compound C Is a Potent AMPK-Independent Antiglioma Agent

(2014) X. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Early Steps in Autophagy Depend on Direct Phosphorylation of Atg9 by the Atg1 Kinase

(2014) Daniel Papinski et al.   MOLECULAR CELL

PI3K and cancer: lessons, challenges and opportunities

(2014) David A. Fruman et al.   NATURE REVIEWS DRUG DISCOVERY

Chloroquine enhances temozolomide cytotoxicity in malignant gliomas by blocking autophagy

(2014) Encouse B. Golden et al.   Neurosurgical Focus

Enzalutamide in Metastatic Prostate Cancer before Chemotherapy

(2014) Tomasz M. Beer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting autophagy overcomes Enzalutamide resistance in castration-resistant prostate cancer cells and improves therapeutic response in a xenograft model

(2014) H G Nguyen et al.   ONCOGENE

Phase II and Pharmacodynamic Study of Autophagy Inhibition Using Hydroxychloroquine in Patients With Metastatic Pancreatic Adenocarcinoma

(2014) B. M. Wolpin et al.   ONCOLOGIST

Inhibition of Beclin 1 Expression Enhances Cisplatin-Induced Apoptosis Through a Mitochondrial-Dependent Pathway in Human Ovarian Cancer SKOV3/DDP Cells

(2014) Yang Sun et al.   ONCOLOGY RESEARCH

Metformin Reduces Thyroid Cancer Risk in Taiwanese Patients with Type 2 Diabetes

(2014) Chin-Hsiao Tseng   PLoS One

Is Autophagy Rather Than Apoptosis the Regression Driver in Imatinib-Treated Gastrointestinal Stromal Tumors?

(2014) Francesca Miselli et al.   Translational Oncology

Suppression of autophagy by chloroquine sensitizes 5-fluorouracil-mediated cell death in gallbladder carcinoma cells

(2014) Xiao Liang et al.   Cell and Bioscience

Atypical presentation of fever as hypersensitivity reaction to oxaliplatin

(2014) Arushi Khurana et al.   JOURNAL OF ONCOLOGY PHARMACY PRACTICE

Autophagy modulation as a target for anticancer drug discovery

(2013) Xin Li et al.   ACTA PHARMACOLOGICA SINICA

Syntaxin 17

(2013) Eisuke Itakura et al.   Autophagy

ATG16L1 meets ATG9 in recycling endosomes

(2013) Claudia Puri et al.   Autophagy

Inhibition of the autophagic flux by salinomycin in breast cancer stem-like/progenitor cells interferes with their maintenance

(2013) Wen Yue et al.   Autophagy

Autophagy of cancer stem cells is involved with chemoresistance of colon cancer cells

(2013) Shaobin Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Prognostic impact of Beclin 1, p62/sequestosome 1 and LC3 protein expression in colon carcinomas from patients receiving 5-fluorouracil as adjuvant chemotherapy

(2013) Jae Myung Park et al.   CANCER BIOLOGY & THERAPY

Inhibiting Autophagy

(2013) Michael T. Lotze et al.   CANCER JOURNAL

Chloroquine in Cancer Therapy: A Double-Edged Sword of Autophagy

(2013) T. Kimura et al.   CANCER RESEARCH

Historical landmarks of autophagy research

(2013) Yoshinori Ohsumi   CELL RESEARCH

Autophagy Inhibition Sensitizes Colon Cancer Cells to Antiangiogenic and Cytotoxic Therapy

(2013) M. Selvakumaran et al.   CLINICAL CANCER RESEARCH

Autophagy in Chronic Myeloid Leukaemia: Stem Cell Survival and Implication in Therapy

(2013) Gudmundur Helgason et al.   CURRENT CANCER DRUG TARGETS

From Bortezomib to other Inhibitors of the Proteasome and Beyond

(2013) Daniela Buac et al.   CURRENT PHARMACEUTICAL DESIGN

MK-2206, an AKT Inhibitor, Promotes Caspase-Independent Cell Death and Inhibits Leiomyoma Growth

(2013) Elizabeth C. Sefton et al.   ENDOCRINOLOGY

Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis

(2013) J. Y. Guo et al.   GENES & DEVELOPMENT

Dual mTORC1/2 inhibition in a preclinical xenograft tumor model of endometrial cancer

(2013) Sharmilee Bansal Korets et al.   GYNECOLOGIC ONCOLOGY

Autophagy and Cellular Immune Responses

(2013) Yuting Ma et al.   IMMUNITY

Nilotinib Induces Autophagy in Hepatocellular Carcinoma through AMPK Activation

(2013) Hui-Chuan Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy stimulates apoptosis in HER2-overexpressing breast cancers treated by lapatinib

(2013) Xingmei Zhu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

MicroRNA-101 inhibits human hepatocellular carcinoma progression through EZH2 downregulation and increased cytostatic drug sensitivity

(2013) Leibo Xu et al.   JOURNAL OF HEPATOLOGY

Mechanism of temozolomide-induced antitumour effects on glioma cells

(2013) Wei Shen et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Inhibition of autophagy enhances apoptosis induced by proteasome inhibitor bortezomib in human glioblastoma U87 and U251 cells

(2013) Xudong Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Combination treatment with ABT-737 and chloroquine in preclinical models of small cell lung cancer

(2013) Rebekah L Zinn et al.   Molecular Cancer

Differential and Common DNA Repair Pathways for Topoisomerase I- and II-Targeted Drugs in a Genetic DT40 Repair Cell Screen Panel

(2013) Y. Maede et al.   MOLECULAR CANCER THERAPEUTICS

Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy

(2013) Yoshinobu Ichimura et al.   MOLECULAR CELL

p53 status determines the role of autophagy in pancreatic tumour development

(2013) Mathias T. Rosenfeldt et al.   NATURE

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

Relevance of cancer initiating/stem cells in carcinogenesis and therapy resistance in oral cancer

(2013) Niharika Sinha et al.   ORAL ONCOLOGY

Autophagy Inhibition Promotes 5-Fluorouraci-Induced Apoptosis by Stimulating ROS Formation in Human Non-Small Cell Lung Cancer A549 Cells

(2013) Xiaohong Pan et al.   PLoS One

Thymoquinone Inhibits Autophagy and Induces Cathepsin-Mediated, Caspase-Independent Cell Death in Glioblastoma Cells

(2013) Ira O. Racoma et al.   PLoS One

Induction of Autophagy Is an Early Response to Gefitinib and a Potential Therapeutic Target in Breast Cancer

(2013) Wieslawa H. Dragowska et al.   PLoS One

Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia

(2013) Y. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Connections between SNAREs and autophagy

(2013) Kevin Moreau et al.   TRENDS IN BIOCHEMICAL SCIENCES

Increased activation of PI3K/AKT signaling pathway is associated with cholangiocarcinoma metastasis and PI3K/mTOR inhibition presents a possible therapeutic strategy

(2013) Supak Yothaisong et al.   TUMOR BIOLOGY

Retinoblastoma protein regulates the crosstalk between autophagy and apoptosis and favors glioblastoma resistance to etoposide

(2013) D Biasoli et al.   Cell Death & Disease

Vorinostat-induced autophagy switches from a death-promoting to a cytoprotective signal to drive acquired resistance

(2013) D Dupéré-Richer et al.   Cell Death & Disease

Cannabinoids inhibit energetic metabolism and induce AMPK-dependent autophagy in pancreatic cancer cells

(2013) I Dando et al.   Cell Death & Disease

Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment

(2013) X Sui et al.   Cell Death & Disease

Autophagy Opposes p53-Mediated Tumor Barrier to Facilitate Tumorigenesis in a Model of PALB2-Associated Hereditary Breast Cancer

(2013) Y. Huo et al.   Cancer Discovery

The VMP1-Beclin 1 interaction regulates autophagy induction

(2013) Maria I. Molejon et al.   Scientific Reports

Perifosine induces protective autophagy and upregulation of ATG5 in human chronic myelogenous leukemia cells in vitro

(2012) Yin Tong et al.   ACTA PHARMACOLOGICA SINICA

MAPK14/p38α confers irinotecan resistance to TP53-defective cells by inducing survival autophagy

(2012) Salome Paillas et al.   Autophagy

Aurora kinase A inhibition-induced autophagy triggers drug resistance in breast cancer cells

(2012) Zhengzhi Zou et al.   Autophagy

Lys05

(2012) Ravi K. Amaravadi et al.   Autophagy

Dual functions of autophagy in the response of breast tumor cells to radiation

(2012) Molly L. Bristol et al.   Autophagy

Rapamycin inhibits the growth of glioblastoma

(2012) Antonietta Arcella et al.   BRAIN RESEARCH

Inhibiting Systemic Autophagy during Interleukin 2 Immunotherapy Promotes Long-term Tumor Regression

(2012) X. Liang et al.   CANCER RESEARCH

Inhibition of autophagy enhances apoptosis induced by the PI3K/AKT/mTor inhibitor NVP-BEZ235 in renal cell carcinoma cells

(2012) Hongyan Li et al.   CELL BIOCHEMISTRY AND FUNCTION

Oncophagy: harnessing regulation of autophagy in cancer therapy

(2012) Justin S Gundara et al.   ENDOCRINE-RELATED CANCER

Autophagy and cancer

(2012) Kyeong Sook Choi   EXPERIMENTAL AND MOLECULAR MEDICINE

Autophagic tumor stroma: Mechanisms and roles in tumor growth and progression

(2012) Xianda Zhao et al.   INTERNATIONAL JOURNAL OF CANCER

Inhibition of autophagy enhances anticancer effects of bevacizumab in hepatocarcinoma

(2012) Xian-ling Guo et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Limitations of targeted therapy with sorafenib in elderly high-risk myelodysplastic syndrome and acute myeloid leukemia

(2012) Andrew Wei et al.   LEUKEMIA & LYMPHOMA

Combination of Pan-Histone Deacetylase Inhibitor and Autophagy Inhibitor Exerts Superior Efficacy against Triple-Negative Human Breast Cancer Cells

(2012) R. Rao et al.   MOLECULAR CANCER THERAPEUTICS

Clathrin and phosphatidylinositol-4,5-bisphosphate regulate autophagic lysosome reformation

(2012) Yueguang Rong et al.   NATURE CELL BIOLOGY

Beclin 1 and autophagy are required for the tumorigenicity of breast cancer stem-like/progenitor cells

(2012) C Gong et al.   ONCOGENE

Quinacrine-Mediated Autophagy and Apoptosis in Colon Cancer Cells Is Through a p53- and p21-Dependent Mechanism

(2012) Purusottam Mohapatra et al.   ONCOLOGY RESEARCH

Blocking Autophagy Prevents Bortezomib-Induced NF-κB Activation by Reducing I-κBα Degradation in Lymphoma Cells

(2012) Li Jia et al.   PLoS One

The Inhibition of Autophagy Sensitises Colon Cancer Cells with Wild-Type p53 but Not Mutant p53 to Topotecan Treatment

(2012) Dan-Dan Li et al.   PLoS One

Autophagy Protects against Oxaliplatin-Induced Cell Death via ER Stress and ROS in Caco-2 Cells

(2012) Yan Shi et al.   PLoS One

Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency

(2012) Q. McAfee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of dual inhibition of apoptosis and autophagy in prostate cancer

(2012) Ahamed Saleem et al.   PROSTATE

New Targets for Acetylation in Autophagy

(2012) A. Hamai et al.   Science Signaling

Autophagic activation potentiates the antiproliferative effects of tyrosine kinase inhibitors in medullary thyroid cancer

(2012) Chi-Iou Lin et al.   SURGERY

Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy

(2012) W-Y Shi et al.   Cell Death & Disease

Temsirolimus in the treatment of relapsed and/or refractory mantle cell lymphoma

(2012) Sara Galimberti   Cancer Management and Research

High Mobility Group Box 1 (HMGB1) Activates an Autophagic Response to Oxidative Stress

(2011) Daolin Tang et al.   ANTIOXIDANTS & REDOX SIGNALING

ULK1 inhibits the kinase activity of mTORC1 and cell proliferation

(2011) Chang Hwa Jung et al.   Autophagy

Distinct cellular and therapeutic effects of obatoclax in rituximab-sensitive and -resistant lymphomas

(2011) Elizabeth A. Brem et al.   BRITISH JOURNAL OF HAEMATOLOGY

Fangchinoline induces autophagic cell death via p53/sestrin2/AMPK signalling in human hepatocellular carcinoma cells

(2011) Ning Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Autophagy inhibition promotes paclitaxel-induced apoptosis in cancer cells

(2011) Guangmin Xi et al.   CANCER LETTERS

Inhibition of autophagy enhances cisplatin cytotoxicity through endoplasmic reticulum stress in human cervical cancer cells

(2011) Ye Xu et al.   CANCER LETTERS

Abstract 5109: Doxorubicin-induced autophagy functions as a pro-survival pathway in breast cancer cells

(2011) Didem Cosan et al.   CANCER RESEARCH

SNARE Proteins Are Required for Macroautophagy

(2011) Usha Nair et al.   CELL

Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13

(2011) Junli Liu et al.   CELL

Cancer cells metabolically "fertilize" the tumor microenvironment with hydrogen peroxide, driving the Warburg effect

(2011) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Autophagy positively regulates the CD44+CD24-/lowbreast cancer stem-like phenotype

(2011) Sílvia Cufí et al.   CELL CYCLE

The AMPK stress response pathway mediates anoikis resistance through inhibition of mTOR and suppression of protein synthesis

(2011) T L Ng et al.   CELL DEATH AND DIFFERENTIATION

MicroRNA Profiling of Sporadic and Hereditary Medullary Thyroid Cancer Identifies Predictors of Nodal Metastasis, Prognosis, and Potential Therapeutic Targets

(2011) D. Abraham et al.   CLINICAL CANCER RESEARCH

Autophagy Activation in Hepatocellular Carcinoma Contributes to the Tolerance of Oxaliplatin via Reactive Oxygen Species Modulation

(2011) Z.-B. Ding et al.   CLINICAL CANCER RESEARCH

The dynamic nature of autophagy in cancer

(2011) A. C. Kimmelman   GENES & DEVELOPMENT

Imatinib induces autophagy throughBECLIN‐1andATG5genes in chronic myeloid leukemia cells

(2011) Geylani Can et al.   Hematology

Beclin 1 expression predicts favorable clinical outcome in patients with diffuse large B-cell lymphoma treated with R-CHOP

(2011) Jia-Jia Huang et al.   HUMAN PATHOLOGY

The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance

(2011) Monika Mortensen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autophagy facilitates the Lapatinib resistance of HER2 positive breast cancer cells

(2011) Suning Chen et al.   MEDICAL HYPOTHESES

The Role of Autophagy in Cancer: Therapeutic Implications

(2011) Z. J. Yang et al.   MOLECULAR CANCER THERAPEUTICS

Autophagy as a target for anticancer therapy

(2011) Filip Janku et al.   Nature Reviews Clinical Oncology

Omeprazole Inhibits Proliferation and Modulates Autophagy in Pancreatic Cancer Cells

(2011) Andrej Udelnow et al.   PLoS One

Autophagosome targeting and membrane curvature sensing by Barkor/Atg14(L)

(2011) W. Fan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy-related proteins Beclin-1 and LC3 predict cetuximab efficacy in advanced colorectal cancer

(2011) Gui-Fang Guo   WORLD JOURNAL OF GASTROENTEROLOGY

The role of reactive oxygen species and autophagy in safingol-induced cell death

(2011) L-U Ling et al.   Cell Death & Disease

Roles of autophagy in cetuximab-mediated cancer therapy against EGFR

(2010) Xinqun Li et al.   Autophagy

miR-183 inhibits TGF-β1-induced apoptosis by downregulation of PDCD4 expression in human hepatocellular carcinoma cells

(2010) Jipeng Li et al.   BMC CANCER

Dasatinib induces autophagic cell death in human ovarian cancer

(2010) Xiao-Feng Le et al.   CANCER

Autophagy induced by farnesyltransferase inhibitors in cancer cells

(2010) Jingxuan Pan et al.   CANCER BIOLOGY & THERAPY

Inhibition of MCL-1 enhances Lapatinib toxicity and overcomes lapatinib resistance via BAK-dependent autophagy

(2010) Aditi Pandya Martin et al.   CANCER BIOLOGY & THERAPY

2-Deoxy-d-glucose activates autophagy via endoplasmic reticulum stress rather than ATP depletion

(2010) Haibin Xi et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

A Dual PI3K/mTOR Inhibitor, PI-103, Cooperates with Stem Cell-Delivered TRAIL in Experimental Glioma Models

(2010) T. Bagci-Onder et al.   CANCER RESEARCH

Inhibition of Autophagy Enhances Anticancer Effects of Atorvastatin in Digestive Malignancies

(2010) P.-M. Yang et al.   CANCER RESEARCH

The autophagic tumor stroma model of cancer

(2010) Stephanos Pavlides et al.   CELL CYCLE

Regulation of autophagy by phosphatidylinositol 3-phosphate

(2010) Chloe Burman et al.   FEBS LETTERS

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Lucanthone Is a Novel Inhibitor of Autophagy That Induces Cathepsin D-mediated Apoptosis

(2010) Jennifer S. Carew et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acquisition of Temozolomide Chemoresistance in Gliomas Leads to Remodeling of Mitochondrial Electron Transport Chain

(2010) Claudia R. Oliva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Bcl-2 Homology Domain 3 Mimetic Gossypol Induces Both Beclin 1-dependent and Beclin 1-independent Cytoprotective Autophagy in Cancer Cells

(2010) Ping Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Preclinical testing of the Akt inhibitor triciribine in T-cell acute lymphoblastic leukemia

(2010) Camilla Evangelisti et al.   JOURNAL OF CELLULAR PHYSIOLOGY

p53 and autophagy contribute to dasatinib resistance in primary CLL lymphocytes

(2010) Lilian Amrein et al.   LEUKEMIA RESEARCH

Termination of autophagy and reformation of lysosomes regulated by mTOR

(2010) Li Yu et al.   NATURE

Astrocyte elevated gene-1 induces protective autophagy

(2010) S. K. Bhutia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy inhibition and antimalarials promote cell death in gastrointestinal stromal tumor (GIST)

(2010) A. Gupta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Beclin 1–VPS34 complex – at the crossroads of autophagy and beyond

(2010) Sarah F. Funderburk et al.   TRENDS IN CELL BIOLOGY

GX15-070 (obatoclax) overcomes glucocorticoid resistance in acute lymphoblastic leukemia through induction of apoptosis and autophagy

(2010) N Heidari et al.   Cell Death & Disease

Inhibition of Autophagy by 3-MA Enhances the Effect of 5-FU-Induced Apoptosis in Colon Cancer Cells

(2009) Jie Li et al.   ANNALS OF SURGICAL ONCOLOGY

Autophagy facilitates the progression of ERα-positive breast cancer cells to antiestrogen resistance

(2009) Patricia V. Schoenlein et al.   Autophagy

Inhibition of macroautophagy by bafilomycin A1 lowers proliferation and induces apoptosis in colon cancer cells

(2009) Ya Chun Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Involvement of macroautophagy in the caspase-independent killing of Burkitt lymphoma cell lines by rituximab

(2009) Julie Turzanski et al.   BRITISH JOURNAL OF HAEMATOLOGY

Cancer Prevention and Treatment with Resveratrol: From Rodent Studies to Clinical Trials

(2009) A. Bishayee   Cancer Prevention Research

AZD8055 Is a Potent, Selective, and Orally Bioavailable ATP-Competitive Mammalian Target of Rapamycin Kinase Inhibitor with In vitro and In vivo Antitumor Activity

(2009) C. M. Chresta et al.   CANCER RESEARCH

Autophagy Suppresses Tumorigenesis through Elimination of p62

(2009) Robin Mathew et al.   CELL

The late stages of autophagy: how does the end begin?

(2009) T Noda et al.   CELL DEATH AND DIFFERENTIATION

Atg32 Is a Mitochondrial Protein that Confers Selectivity during Mitophagy

(2009) Tomotake Kanki et al.   DEVELOPMENTAL CELL

Predictors of Competing Mortality in Advanced Head and Neck Cancer

(2009) Loren K. Mell et al.   JOURNAL OF CLINICAL ONCOLOGY

Inhibition of autophagy by 3-MA potentiates cisplatin-induced apoptosis in esophageal squamous cell carcinoma cells

(2009) Donglei Liu et al.   MEDICAL ONCOLOGY

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

(2009) Chang Hwa Jung et al.   MOLECULAR BIOLOGY OF THE CELL

Proteasome inhibitors activate autophagy as a cytoprotective response in human prostate cancer cells

(2009) K Zhu et al.   ONCOGENE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Class I phosphatidylinositol 3-kinase inhibitor LY294002 activates autophagy and induces apoptosis through p53 pathway in gastric cancer cell line SGC7901

(2008) Chungen Xing et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Pharmacokinetic characteristics and anticancer effects of 5-Fluorouracil loaded nanoparticles

(2008) Su Li et al.   BMC CANCER

A Molecule Targeting VHL-Deficient Renal Cell Carcinoma that Induces Autophagy

(2008) Sandra Turcotte et al.   CANCER CELL

Prevention of cisplatin nephrotoxicity: state of the art and recommendations from the European Society of Clinical Pharmacy Special Interest Group on Cancer Care

(2008) Vincent Launay-Vacher et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Therapeutic Efficacy of ABT-737, a Selective Inhibitor of BCL-2, in Small Cell Lung Cancer

(2008) C. L. Hann et al.   CANCER RESEARCH

Bone marrow aplasia following acute poisoning with chloroquine-proguanil

(2008) Christine Payen et al.   CLINICAL TOXICOLOGY

Mechanisms of proteasome inhibitor action and resistance in cancer

(2008) David J. McConkey et al.   DRUG RESISTANCE UPDATES

HAMLET (human α-lactalbumin made lethal to tumor cells) triggers autophagic tumor cell death

(2008) Sonja Aits et al.   INTERNATIONAL JOURNAL OF CANCER

Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

(2008) S.-M. Maira et al.   MOLECULAR CANCER THERAPEUTICS

Regulation of autophagy by cytoplasmic p53

(2008) Ezgi Tasdemir et al.   NATURE CELL BIOLOGY