Preclinical testing of the Akt inhibitor triciribine in T-cell acute lymphoblastic leukemia

Side-population cells in luminal-type breast cancer have tumour-initiating cell properties and are regulated by HER2 expression and signalling

(2010) T Nakanishi et al.   BRITISH JOURNAL OF CANCER

Evidence for self-renewing lung cancer stem cells and their implications in tumor initiation, progression, and targeted therapy

(2010) James P. Sullivan et al.   CANCER AND METASTASIS REVIEWS

The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane

(2010) N Berndt et al.   CELL DEATH AND DIFFERENTIATION

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Erucylphosphohomocholine, the first intravenously applicable alkylphosphocholine, is cytotoxic to acute myelogenous leukemia cells through JNK- and PP2A-dependent mechanisms

(2010) A M Martelli et al.   LEUKEMIA

Identification of cancer stem cells in a Tax-transgenic (Tax-Tg) mouse model of adult T-cell leukemia/lymphoma

(2009) J. Yamazaki et al.   BLOOD

High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia

(2009) A. Gutierrez et al.   BLOOD

Dual Inhibition of Class IA Phosphatidylinositol 3-Kinase and Mammalian Target of Rapamycin as a New Therapeutic Option for T-Cell Acute Lymphoblastic Leukemia

(2009) F. Chiarini et al.   CANCER RESEARCH

TORC-Specific Phosphorylation of Mammalian Target of Rapamycin (mTOR): Phospho-Ser2481 Is a Marker for Intact mTOR Signaling Complex 2

(2009) J. Copp et al.   CANCER RESEARCH

Perifosine Inhibits Mammalian Target of Rapamycin Signaling through Facilitating Degradation of Major Components in the mTOR Axis and Induces Autophagy

(2009) L. Fu et al.   CANCER RESEARCH

PTEN/PI3K/Akt Pathway Regulates the Side Population Phenotype and ABCG2 Activity in Glioma Tumor Stem-like Cells

(2009) Anne-Marie Bleau et al.   Cell Stem Cell

Targeting the PI3K/AKT/mTOR signaling network in acute myelogenous leukemia

(2009) Alberto M Martelli et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Targeted therapy in T-cell malignancies: dysregulation of the cellular signaling pathways

(2009) W-L Zhao   LEUKEMIA

The impact of NOTCH1, FBW7 and PTEN mutations on prognosis and downstream signaling in pediatric T-cell acute lymphoblastic leukemia: a report from the Children's Oncology Group

(2009) A Larson Gedman et al.   LEUKEMIA

Negative prognostic impact of PTEN mutation in pediatric T-cell acute lymphoblastic leukemia

(2009) P Y Jotta et al.   LEUKEMIA

Targeting the phosphoinositide 3-kinase pathway in cancer

(2009) Pixu Liu et al.   NATURE REVIEWS DRUG DISCOVERY

The nuts and bolts of AGC protein kinases

(2009) Laura R. Pearce et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Perifosine: Update on a novel Akt inhibitor

(2009) Joell J. Gills et al.   Current Oncology Reports

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Targeting the PI3K/Akt/mTOR pathway: Effective combinations and clinical considerations

(2008) J LOPICCOLO et al.   DRUG RESISTANCE UPDATES

PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability

(2008) Ana Silva et al.   JOURNAL OF CLINICAL INVESTIGATION

Acute lymphoblastic leukaemia

(2008) Ching-Hon Pui et al.   LANCET

The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism

(2008) F Chiarini et al.   LEUKEMIA

Surface and inner cell behaviour along skeletal muscle cell in vitro differentiation

(2008) R. Curci et al.   MICRON

It's T-ALL about Notch

(2008) R M Demarest et al.   ONCOGENE

PI3K pathway alterations in cancer: variations on a theme

(2008) T L Yuan et al.   ONCOGENE

Identification of a Small Subpopulation of Candidate Leukemia-Initiating Cells in the Side Population of Patients with Acute Myeloid Leukemia

(2008) Bijan Moshaver et al.   STEM CELLS