The current landscape of coronavirus-host protein–protein interactions

Type I and Type III Interferons – Induction, Signaling, Evasion, and Application to Combat COVID-19

(2020) Annsea Park et al.   Cell Host & Microbe

Repurposing chlorpromazine to treat COVID-19: The reCoVery study

(2020) M. Plaze et al.   ENCEPHALE-REVUE DE PSYCHIATRIE CLINIQUE BIOLOGIQUE ET THERAPEUTIQUE

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

Prohibitin 2 deficiency impairs cardiac fatty acid oxidation and causes heart failure

(2020) Dechao Wu et al.   Cell Death & Disease

Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2

(2020) Yadi Zhou et al.   Cell Discovery

Characterization of the Lipidomic Profile of Human Coronavirus-Infected Cells: Implications for Lipid Metabolism Remodeling upon Coronavirus Replication

(2019) Bingpeng Yan et al.   Viruses-Basel

SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target

(2019) Shuofeng Yuan et al.   Nature Communications

Determination of host proteins composing the microenvironment of coronavirus replicase complexes by proximity-labeling

(2019) Philip V'kovski et al.   eLife

High-throughput Screening and Identification of Potent Broad-spectrum Inhibitors of Coronaviruses

(2019) Liang Shen et al.   JOURNAL OF VIROLOGY

Ribonucleotide reductase M2 promotes RNA replication of hepatitis C virus by protecting NS5B protein from hPLIC1-dependent proteasomal degradation

(2019) Bouchra Kitab et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SARS coronavirus protein nsp1 disrupts localization of Nup93 from the nuclear pore complex

(2019) Garret N. Gomez et al.   Biochemistry and Cell Biology

Porcine deltacoronavirus nucleocapsid protein antagonizes IFN-β production by impairing dsRNA and PACT binding to RIG-I

(2019) Jun Chen et al.   VIRUS GENES

Porcine Epidemic Diarrhea Virus (PEDV) ORF3 Interactome Reveals Inhibition of Virus Replication by Cellular VPS36 Protein

(2019) Challika Kaewborisuth et al.   Viruses-Basel

Human Coronavirus: Host-Pathogen Interaction

(2019) To Sing Fung et al.   Annual Review of Microbiology

Differential Proteomics Reveals Discrete Functions of Proteins Interacting with Hypo- versus Hyper-phosphorylated NS5A of the Hepatitis C Virus

(2019) Ting-Chun Pan et al.   JOURNAL OF PROTEOME RESEARCH

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

(2019) Yingyao Zhou et al.   Nature Communications

Porcine Deltacoronavirus Nucleocapsid Protein Suppressed IFN-β Production by Interfering Porcine RIG-I dsRNA-Binding and K63-Linked Polyubiquitination

(2019) Ji Likai et al.   Frontiers in Immunology

KEGG Mapper for inferring cellular functions from protein sequences

(2019) Minoru Kanehisa et al.   PROTEIN SCIENCE

The microRNAs miR-302b and miR-372 regulate mitochondrial metabolism via the SLC25A12 transporter, which controls MAVS-mediated antiviral innate immunity

(2019) Kai Yasukawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Porcine Deltacoronavirus Accessory Protein NS6 Antagonizes Interferon Beta Production by Interfering with the Binding of RIG-I/MDA5 to Double-Stranded RNA

(2018) Puxian Fang et al.   JOURNAL OF VIROLOGY

Accessory proteins 8b and 8ab of severe acute respiratory syndrome coronavirus suppress the interferon signaling pathway by mediating ubiquitin-dependent rapid degradation of interferon regulatory factor 3

(2018) Hui Hui Wong et al.   VIROLOGY

Gemcitabine and Nucleos(t)ide Synthesis Inhibitors Are Broad-Spectrum Antiviral Drugs that Activate Innate Immunity

(2018) Hye Shin et al.   Viruses-Basel

Saracatinib Inhibits Middle East Respiratory Syndrome-Coronavirus Replication In Vitro

(2018) Jin Shin et al.   Viruses-Basel

The Gene Ontology Resource: 20 years and still GOing strong

(2018)   NUCLEIC ACIDS RESEARCH

Mitochondrial Quality Control Mechanisms and the PHB (Prohibitin) Complex

(2018) Blanca Hernando-Rodríguez et al.   Cells

Phage display technique identifies the interaction of severe acute respiratory syndrome coronavirus open reading frame 6 protein with nuclear pore complex interacting protein NPIPB3 in modulating Type I interferon antagonism

(2017) Su-Hua Huang et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

Structural Insights into the Interaction of Coronavirus Papain-Like Proteases and Interferon-Stimulated Gene Product 15 from Different Species

(2017) Courtney M. Daczkowski et al.   JOURNAL OF MOLECULAR BIOLOGY

The Drug Repurposing Hub: a next-generation drug library and information resource

(2017) Steven M Corsello et al.   NATURE MEDICINE

The nucleocapsid proteins of mouse hepatitis virus and severe acute respiratory syndrome coronavirus share the same IFN-β antagonizing mechanism: attenuation of PACT-mediated RIG-I/ MDA5 activation

(2017) Zhen Ding et al.   Oncotarget

Cellular RNA Helicase DDX1 Is Involved in Transmissible Gastroenteritis Virus nsp14-Induced Interferon-Beta Production

(2017) Yanrong Zhou et al.   Frontiers in Immunology

Proteomic approaches to uncovering virus–host protein interactions during the progression of viral infection

(2016) Krystal K Lum et al.   Expert Review of Proteomics

Binding of the Methyl Donor S -Adenosyl-l-Methionine to Middle East Respiratory Syndrome Coronavirus 2′- O -Methyltransferase nsp16 Promotes Recruitment of the Allosteric Activator nsp10

(2016) Wahiba Aouadi et al.   JOURNAL OF VIROLOGY

p53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PLprovia E3 ubiquitin ligase RCHY1

(2016) Yue Ma-Lauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Porcine Epidemic Diarrhea Virus 3C-Like Protease Regulates Its Interferon Antagonism by Cleaving NEMO

(2015) Dang Wang et al.   JOURNAL OF VIROLOGY

Viral activation of cellular metabolism

(2015) Erica L. Sanchez et al.   VIROLOGY

Middle East respiratory syndrome coronavirus ORF4b protein inhibits type I interferon production through both cytoplasmic and nuclear targets

(2015) Yang Yang et al.   Scientific Reports

Screening of an FDA-Approved Compound Library Identifies Four Small-Molecule Inhibitors of Middle East Respiratory Syndrome Coronavirus Replication in Cell Culture

(2014) Adriaan H. de Wilde et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Repurposing of Clinically Developed Drugs for Treatment of Middle East Respiratory Syndrome Coronavirus Infection

(2014) Julie Dyall et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Nucleocapsid Phosphorylation and RNA Helicase DDX1 Recruitment Enables Coronavirus Transition from Discontinuous to Continuous Transcription

(2014) Chia-Hsin Wu et al.   Cell Host & Microbe

Suppression of innate antiviral response by severe acute respiratory syndrome coronavirus M protein is mediated through the first transmembrane domain

(2014) Kam-Leung Siu et al.   Cellular & Molecular Immunology

Prohibitin Overexpression in Adipocytes Induces Mitochondrial Biogenesis, Leads to Obesity Development, and Affects Glucose Homeostasis in a Sex-Specific Manner

(2014) Sudharsana R. Ande et al.   DIABETES

Mitochondrial dynamics and the innate antiviral immune response

(2014) Marie Pourcelot et al.   FEBS Journal

SARS-Coronavirus Open Reading Frame-9b Suppresses Innate Immunity by Targeting Mitochondria and the MAVS/TRAF3/TRAF6 Signalosome

(2014) Chong-Shan Shi et al.   JOURNAL OF IMMUNOLOGY

Porcine Epidemic Diarrhea Virus Nucleocapsid Protein Antagonizes Beta Interferon Production by Sequestering the Interaction between IRF3 and TBK1

(2014) Z. Ding et al.   JOURNAL OF VIROLOGY

Middle East Respiratory Syndrome Coronavirus 4a Protein Is a Double-Stranded RNA-Binding Protein That Suppresses PACT-Induced Activation of RIG-I and MDA5 in the Innate Antiviral Response

(2014) K.-L. Siu et al.   JOURNAL OF VIROLOGY

Coronavirus-induced ER stress response and its involvement in regulation of coronavirus–host interactions

(2014) To Sing Fung et al.   VIRUS RESEARCH

Virus-host interactomics: new insights and opportunities for antiviral drug discovery

(2014) Benoît de Chassey et al.   Genome Medicine

Structural Basis for the Ubiquitin-Linkage Specificity and deISGylating Activity of SARS-CoV Papain-Like Protease

(2014) Kiira Ratia et al.   PLoS Pathogens

SARS coronavirus papain-like protease inhibits the type I interferon signaling pathway through interaction with the STING-TRAF3-TBK1 complex

(2014) Xiaojuan Chen et al.   Protein & Cell

Inside-out Signaling Promotes Dynamic Changes in the Carcinoembryonic Antigen-related Cellular Adhesion Molecule 1 (CEACAM1) Oligomeric State to Control Its Cell Adhesion Properties

(2013) Prerna C. Patel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Cellular Interactome of the Coronavirus Infectious Bronchitis Virus Nucleocapsid Protein and Functional Implications for Virus Biology

(2013) E. Emmott et al.   JOURNAL OF VIROLOGY

Human Coronavirus OC43 Nucleocapsid Protein Binds MicroRNA 9 and Potentiates NF- B Activation

(2013) F. W. Lai et al.   JOURNAL OF VIROLOGY

Nuclear Imprisonment: Viral Strategies to Arrest Host mRNA Nuclear Export

(2013) Sharon Kuss et al.   Viruses-Basel

Chemoproteomic Profiling Identifies Changes in DNA-PK as Markers of Early Dengue Virus Infection

(2012) Michael L. Vetter et al.   ACS Chemical Biology

A Novel 4EHP-GIGYF2 Translational Repressor Complex Is Essential for Mammalian Development

(2012) M. Morita et al.   MOLECULAR AND CELLULAR BIOLOGY

Coronavirus Papain-like Proteases Negatively Regulate Antiviral Innate Immune Response through Disruption of STING-Mediated Signaling

(2012) Li Sun et al.   PLoS One

Biogenesis and Dynamics of the Coronavirus Replicative Structures

(2012) Marne Hagemeijer et al.   Viruses-Basel

CoronavirusInfection Induces DNA Replication Stress Partly through Interaction of Its Nonstructural Protein 13 with the p125 Subunit of DNA Polymerase δ

(2011) Ling Hui Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PLP2 of Mouse Hepatitis Virus A59 (MHV-A59) Targets TBK1 to Negatively Regulate Cellular Type I Interferon Signaling Pathway

(2011) Gang Wang et al.   PLoS One

Coronavirus Gene 7 Counteracts Host Defenses and Modulates Virus Virulence

(2011) Jazmina L. G. Cruz et al.   PLoS Pathogens

The SARS-Coronavirus-Host Interactome: Identification of Cyclophilins as Target for Pan-Coronavirus Inhibitors

(2011) Susanne Pfefferle et al.   PLoS Pathogens

The Cellular RNA Helicase DDX1 Interacts with Coronavirus Nonstructural Protein 14 and Enhances Viral Replication

(2010) L. Xu et al.   JOURNAL OF VIROLOGY

Interaction between SARS-CoV helicase and a multifunctional cellular protein (Ddx5) revealed by yeast and mammalian cell two-hybrid systems

(2009) Jin-Yan Chen et al.   ARCHIVES OF VIROLOGY

The Identification of a Calmodulin-Binding Domain within the Cytoplasmic Tail of Angiotensin-Converting Enzyme-2

(2009) Zon W. Lai et al.   ENDOCRINOLOGY

Circos: An information aesthetic for comparative genomics

(2009) M. Krzywinski et al.   GENOME RESEARCH

Severe Acute Respiratory Syndrome Coronavirus M Protein Inhibits Type I Interferon Production by Impeding the Formation of TRAF3·TANK·TBK1/IKKϵ Complex

(2009) Kam-Leung Siu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Severe Acute Respiratory Syndrome Coronavirus Nonstructural Protein 2 Interacts with a Host Protein Complex Involved in Mitochondrial Biogenesis and Intracellular Signaling

(2009) C. T. Cornillez-Ty et al.   JOURNAL OF VIROLOGY

PLP2, a potent deubiquitinase from murine hepatitis virus, strongly inhibits cellular type I interferon production

(2008) Dahai Zheng et al.   CELL RESEARCH

Glycogen Synthase Kinase-3 Regulates the Phosphorylation of Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Protein and Viral Replication

(2008) Chia-Hsin Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coronavirus Spike Protein Inhibits Host Cell Translation by Interaction with eIF3f

(2008) Han Xiao et al.   PLoS One