Mitochondrial Quality Control Mechanisms and the PHB (Prohibitin) Complex

Mitochondrial adventures at the organelle society

(2018) Cátia V. Diogo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Combined flow cytometry and high-throughput image analysis for the study of essential genes in Caenorhabditis elegans

(2018) Blanca Hernando-Rodríguez et al.   BMC BIOLOGY

PINK1 import regulation; a fine system to convey mitochondrial stress to the cytosol

(2018) Shiori Sekine et al.   BMC BIOLOGY

Prohibitin: A new player in immunometabolism and in linking obesity and inflammation with cancer

(2018) Yang Xin Zi Xu et al.   CANCER LETTERS

Mitochondrial Translation Efficiency Controls Cytoplasmic Protein Homeostasis

(2018) Tamara Suhm et al.   Cell Metabolism

Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

(2018) Sarah Pickles et al.   CURRENT BIOLOGY

The expression pattern and potential functions of PHB in the spermiogenesis of Phascolosoma esculenta

(2018) Cong-Cong Hou et al.   GENE

ATAD3 controls mitochondrial cristae structure in mouse muscle, influencing mtDNA replication and cholesterol levels

(2018) Susana Peralta et al.   JOURNAL OF CELL SCIENCE

The different axes of the mammalian mitochondrial unfolded protein response

(2018) Christian Münch   BMC BIOLOGY

The Mitochondrial Unfolded Protein Response Is Mediated Cell-Non-autonomously by Retromer-Dependent Wnt Signaling

(2018) Qian Zhang et al.   CELL

USP14 inhibition corrects an in vivo model of impaired mitophagy

(2018) Joy Chakraborty et al.   EMBO Molecular Medicine

Sphingosine Kinase Activates the Mitochondrial Unfolded Protein Response and Is Targeted to Mitochondria by Stress

(2018) Sungjin Kim et al.   Cell Reports

Prohibitin – At the crossroads of obesity-linked diabetes and cancer

(2017) Suresh Mishra et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Mitochondrial prohibitin and its ubiquitination during spermatogenesis of the swimming crab Charybdis japonica

(2017) Ya-Ru Xu et al.   GENE

Deficiency of PHB complex impairs respiratory supercomplex formation and activates mitochondrial flashes

(2017) Chongshu Jian et al.   JOURNAL OF CELL SCIENCE

Newly born peroxisomes are a hybrid of mitochondrial and ER-derived pre-peroxisomes

(2017) Ayumu Sugiura et al.   NATURE

Increased mitochondrial fusion allows the survival of older animals in diverse C. elegans longevity pathways

(2017) Snehal N. Chaudhari et al.   Nature Communications

Mitochondrial metabolites: undercover signalling molecules

(2017) Christian Frezza   Interface Focus

Accumulation of prohibitin is a common cellular response to different stressing stimuli and protects melanoma cells from ER stress and chemotherapy-induced cell death

(2017) Tharcisio Citrangulo Tortelli Junior et al.   Oncotarget

Prohibitin-mediated mitochondrial ubiquitination during spermiogenesis in Chinese mitten crab Eriocheir sinensis

(2017) Cong-Cong Hou et al.   Oncotarget

Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity

(2016) Carsten Merkwirth et al.   CELL

Mitochondrial Stress Induces Chromatin Reorganization to Promote Longevity and UPR mt

(2016) Ye Tian et al.   CELL

Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response

(2016) Hyun-Eui Kim et al.   CELL

Neuroendocrine Coordination of Mitochondrial Stress Signaling and Proteostasis

(2016) Kristen M. Berendzen et al.   CELL

Neuropeptide signals cell non-autonomous mitochondrial unfolded protein response

(2016) Li-Wa Shao et al.   CELL RESEARCH

A Tether Is a Tether Is a Tether: Tethering at Membrane Contact Sites

(2016) Michal Eisenberg-Bord et al.   DEVELOPMENTAL CELL

Prohibitin confers cytoprotection against ISO-induced hypertrophy in H9c2 cells via attenuation of oxidative stress and modulation of Akt/Gsk-3β signaling

(2016) Debabrata Chowdhury et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response

(2016) Yi-Fan Lin et al.   NATURE

Mitonuclear communication in homeostasis and stress

(2016) Pedro M. Quirós et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

(2016) H. Zhang et al.   SCIENCE

ER-mitochondria contacts couple mtDNA synthesis with mitochondrial division in human cells

(2016) Samantha C. Lewis et al.   SCIENCE

Mitochondrial endonuclease G mediates breakdown of paternal mitochondria upon fertilization

(2016) Q. Zhou et al.   SCIENCE

Ubiquitin-Dependent And Independent Signals In Selective Autophagy

(2016) Aliaksandr Khaminets et al.   TRENDS IN CELL BIOLOGY

The Mitochondria-Regulated Immune Pathway Activated in the C. elegans Intestine Is Neuroprotective

(2016) Madhusudana Rao Chikka et al.   Cell Reports

The BCL-2–like protein CED-9 ofC. eleganspromotes FZO-1/Mfn1,2– and EAT-3/Opa1–dependent mitochondrial fusion

(2016) Stéphane G. Rolland et al.   JOURNAL OF CELL BIOLOGY

Ca2+ homeostasis and endoplasmic reticulum (ER) stress: An integrated view of calcium signaling

(2015) Joachim Krebs et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Analysis of the effect of the mitochondrial prohibitin complex, a context-dependent modulator of longevity, on the C. elegans metabolome

(2015) Artur B. Lourenço et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

UPRmt-mediated cytoprotection and organismal aging

(2015) Anna M. Schulz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Iron-Starvation-Induced Mitophagy Mediates Lifespan Extension upon Mitochondrial Stress in C. elegans

(2015) Alfonso Schiavi et al.   CURRENT BIOLOGY

The mitochondrial unfolded protein response—synchronizing genomes

(2015) Virginija Jovaisaite et al.   CURRENT OPINION IN CELL BIOLOGY

Stomatin-Like Protein 2 Is Required forIn VivoMitochondrial Respiratory Chain Supercomplex Formation and Optimal Cell Function

(2015) Panagiotis Mitsopoulos et al.   MOLECULAR AND CELLULAR BIOLOGY

Mitochondrial and Nuclear Accumulation of the Transcription Factor ATFS-1 Promotes OXPHOS Recovery during the UPRmt

(2015) Amrita M. Nargund et al.   MOLECULAR CELL

Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

(2015) Konstantinos Palikaras et al.   NATURE

A cytosolic network suppressing mitochondria-mediated proteostatic stress and cell death

(2015) Xiaowen Wang et al.   NATURE

Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol

(2015) Lidia Wrobel et al.   NATURE

Mitochondrial Morphology and Fundamental Parameters of the Mitochondrial Respiratory Chain Are Altered in Caenorhabditis elegans Strains Deficient in Mitochondrial Dynamics and Homeostasis Processes

(2015) Anthony L. Luz et al.   PLoS One

Mitophagy confers resistance to siderophore-mediated killing byPseudomonas aeruginosa

(2015) Natalia V. Kirienko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interaction of MDM33 with mitochondrial inner membrane homeostasis pathways in yeast

(2015) Till Klecker et al.   Scientific Reports

Human Mitochondrial DNA-Protein Complexes Attach to a Cholesterol-Rich Membrane Structure

(2015) Joachim M. Gerhold et al.   Scientific Reports

Mitochondrial dynamics and mitochondrial quality control

(2015) Hong-Min Ni et al.   Redox Biology

A Trifluorinated Thiazoline Scaffold Leading to Pro-apoptotic Agents Targeting Prohibitins

(2014) Alba Pérez-Perarnau et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

DNAJC19, a Mitochondrial Cochaperone Associated with Cardiomyopathy, Forms a Complex with Prohibitins to Regulate Cardiolipin Remodeling

(2014) Ricarda Richter-Dennerlein et al.   Cell Metabolism

The Protein Import Machinery of Mitochondria—A Regulatory Hub in Metabolism, Stress, and Disease

(2014) Angelika B. Harbauer et al.   Cell Metabolism

Paternal Mitochondrial Destruction after Fertilization Is Mediated by a Common Endocytic and Autophagic Pathway in Drosophila

(2014) Yoav Politi et al.   DEVELOPMENTAL CELL

Caenorhabditis elegans pathways that surveil and defend mitochondria

(2014) Ying Liu et al.   NATURE

Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection

(2014) Mark W. Pellegrino et al.   NATURE

Prohibitin-Mediated Lifespan and Mitochondrial Stress Implicate SGK-1, Insulin/IGF and mTORC2 in C. elegans

(2014) Roxani Gatsi et al.   PLoS One

Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans

(2014) Christopher F. Bennett et al.   Nature Communications

Low abundance of the matrix arm of complex I in mitochondria predicts longevity in mice

(2014) Satomi Miwa et al.   Nature Communications

Molecular mechanisms underlying genotype-dependent responses to dietary restriction

(2013) Jennifer Schleit et al.   AGING CELL

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Muscle Mitohormesis Promotes Longevity via Systemic Repression of Insulin Signaling

(2013) Edward Owusu-Ansah et al.   CELL

Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure

(2013) Marc Liesa et al.   Cell Metabolism

Prohibitin Ligands in Cell Death and Survival: Mode of Action and Therapeutic Potential

(2013) Frédéric Thuaud et al.   CHEMISTRY & BIOLOGY

The ire-1 ER stress-response pathway is required for normal secretory-protein metabolism in C. elegans

(2013) M. Safra et al.   JOURNAL OF CELL SCIENCE

Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

(2013) Shireen A. Sarraf et al.   NATURE

Mitonuclear protein imbalance as a conserved longevity mechanism

(2013) Riekelt H. Houtkooper et al.   NATURE

Mitochondrial lipid trafficking

(2013) Takashi Tatsuta et al.   TRENDS IN CELL BIOLOGY

Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses

(2012) Justine A. Melo et al.   CELL

Heteroplasmy of Mouse mtDNA Is Genetically Unstable and Results in Altered Behavior and Cognition

(2012) Mark S. Sharpley et al.   CELL

C. elegans Detects Pathogen-Induced Translational Inhibition to Activate Immune Signaling

(2012) Tiffany L. Dunbar et al.   Cell Host & Microbe

Barriers to Male Transmission of Mitochondrial DNA in Sperm Development

(2012) Steven Z. DeLuca et al.   DEVELOPMENTAL CELL

Biogenesis of iron-sulfur clusters in mammalian cells: new insights and relevance to human disease

(2012) T. A. Rouault   Disease Models & Mechanisms

Identification of Core Components and Transient Interactors of the Peroxisomal Importomer by Dual-Track Stable Isotope Labeling with Amino Acids in Cell Culture Analysis

(2012) Silke Oeljeklaus et al.   JOURNAL OF PROTEOME RESEARCH

Mitochondrial nucleoid interacting proteins support mitochondrial protein synthesis

(2012) J. He et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

(2012) A. M. Nargund et al.   SCIENCE

Role of MINOS in mitochondrial membrane architecture and biogenesis

(2012) Martin van der Laan et al.   TRENDS IN CELL BIOLOGY

Loss of Prohibitin Membrane Scaffolds Impairs Mitochondrial Architecture and Leads to Tau Hyperphosphorylation and Neurodegeneration

(2012) Carsten Merkwirth et al.   PLoS Genetics

Protective Coupling of Mitochondrial Function and Protein Synthesis via the eIF2α Kinase GCN-2

(2012) Brooke M. Baker et al.   PLoS Genetics

The dynamin-related protein DRP-1 and the insulin signaling pathway cooperate to modulate Caenorhabditis elegans longevity

(2011) Christine C. Yang et al.   AGING CELL

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

(2011) Jenni Durieux et al.   CELL

Degradation of Paternal Mitochondria by Fertilization-Triggered Autophagy in C. elegans Embryos

(2011) M. Sato et al.   SCIENCE

Postfertilization Autophagy of Sperm Organelles Prevents Paternal Mitochondrial DNA Transmission

(2011) S. Al Rawi et al.   SCIENCE

Taking a “good” look at free radicals in the aging process

(2011) Siegfried Hekimi et al.   TRENDS IN CELL BIOLOGY

Histone Methyl Transferases and Demethylases; Can They Link Metabolism and Transcription?

(2010) Raffaele Teperino et al.   Cell Metabolism

Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration

(2010) Graham M. Strub et al.   FASEB JOURNAL

The Matrix Peptide Exporter HAF-1 Signals a Mitochondrial UPR by Activating the Transcription Factor ZC376.7 in C. elegans

(2010) Cole M. Haynes et al.   MOLECULAR CELL

The genetic interactome of prohibitins: coordinated control of cardiolipin and phosphatidylethanolamine by conserved regulators in mitochondria

(2009) Christof Osman et al.   JOURNAL OF CELL BIOLOGY

Dual Functions of Mss51 Couple Synthesis of Cox1 to Assembly of Cytochrome c Oxidase in Saccharomyces cerevisiae Mitochondria

(2009) Xochitl Perez-Martinez et al.   MOLECULAR BIOLOGY OF THE CELL

Prohibitin couples diapause signalling to mitochondrial metabolism during ageing in C. elegans

(2009) Marta Artal-Sanz et al.   NATURE

An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen

(2009) Benoît Kornmann et al.   SCIENCE

Prohibitin and mitochondrial biology

(2009) Marta Artal-Sanz et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Deletion of the Mitochondrial Superoxide Dismutase sod-2 Extends Lifespan in Caenorhabditis elegans

(2009) Jeremy M. Van Raamsdonk et al.   PLoS Genetics

Prohibitin function within mitochondria: Essential roles for cell proliferation and cristae morphogenesis

(2008) Carsten Merkwirth et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Human prohibitin 1 maintains the organization and stability of the mitochondrial nucleoids

(2008) Katsumi Kasashima et al.   EXPERIMENTAL CELL RESEARCH

Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondria

(2008) C. Merkwirth et al.   GENES & DEVELOPMENT

Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence

(2008) Michael Schleicher et al.   JOURNAL OF CELL BIOLOGY

The C. elegans Opa1 Homologue EAT-3 Is Essential for Resistance to Free Radicals

(2008) Takayuki Kanazawa et al.   PLoS Genetics

A structure for the yeast prohibitin complex: Structure prediction and evidence from chemical crosslinking and mass spectrometry

(2002) Jaap W. Back et al.   PROTEIN SCIENCE