Targeting tumor hypoxia and mitochondrial metabolism with anti-parasitic drugs to improve radiation response in high-grade gliomas

Ivermectin suppresses tumour growth and metastasis through degradation of PAK1 in oesophageal squamous cell carcinoma

(2020) Liang Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Disruption of Endolysosomal RAB5/7 Efficiently Eliminates Colorectal Cancer Stem Cells

(2019) Mitsunobu Takeda et al.   CANCER RESEARCH

The kinase inhibitor SI113 induces autophagy and synergizes with quinacrine in hindering the growth of human glioblastoma multiforme cells

(2019) Silvia Matteoni et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Oxidative phosphorylation as a potential therapeutic target for cancer therapy

(2019) Valentina Sica et al.   INTERNATIONAL JOURNAL OF CANCER

Repurposing quinacrine for treatment-refractory cancer

(2019) Derek B. Oien et al.   SEMINARS IN CANCER BIOLOGY

The anti-malarial atovaquone selectively increases chemosensitivity in retinoblastoma via mitochondrial dysfunction-dependent oxidative damage and Akt/AMPK/mTOR inhibition

(2018) Feng Ke et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Antibiotic ivermectin selectively induces apoptosis in chronic myeloid leukemia through inducing mitochondrial dysfunction and oxidative stress

(2018) Jiaqiao Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting mitochondrial respiration as a therapeutic strategy for cervical cancer

(2018) Shenglan Tian et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lactic acid induces lactate transport and glycolysis/OXPHOS interconversion in glioblastoma

(2018) Ke Duan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Clinical trials targeting hypoxia

(2018) Hannah Tharmalingham et al.   BRITISH JOURNAL OF RADIOLOGY

Antimalarial drug mefloquine inhibits nuclear factor kappa B signaling and induces apoptosis in colorectal cancer cells

(2018) Xin Xu et al.   CANCER SCIENCE

Oxidative Phosphorylation as an Emerging Target in Cancer Therapy

(2018) Thomas M. Ashton et al.   CLINICAL CANCER RESEARCH

Targeting mitochondria by anthelmintic drug atovaquone sensitizes renal cell carcinoma to chemotherapy and immunotherapy

(2018) Dehong Chen et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Atovaquone enhances doxorubicin’s efficacy via inhibiting mitochondrial respiration and STAT3 in aggressive thyroid cancer

(2018) Zhuo Lv et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Notch1 signaling in melanoma cells promoted tumor-induced immunosuppression via upregulation of TGF-β1

(2018) Zike Yang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Antimalarial drugs trigger lysosome-mediated cell death in chronic lymphocytic leukemia (CLL) cells

(2018) Subhadip Das et al.   LEUKEMIA RESEARCH

Mefloquine targets β -catenin pathway and thus can play a role in the treatment of liver cancer

(2018) Yu-Hui Li et al.   MICROBIAL PATHOGENESIS

A Repurposed Drug for Brain Cancer: Enhanced Atovaquone Amorphous Solid Dispersion by Combining a Spontaneously Emulsifying Component with a Polymer Carrier

(2018) Hiroyuki Takabe et al.   Pharmaceutics

Effects of Biguanides on Growth and Glycolysis of Bladder and Colon Cancer Cells

(2018) MICHAEL A. LEA et al.   ANTICANCER RESEARCH

Ivermectin inhibits the growth of glioma cells by inducing cell cycle arrest and apoptosis in vitro and in vivo

(2018) Dandan Song et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Suppressing ROS-TFE3-dependent autophagy enhances ivermectin-induced apoptosis in human melanoma cells

(2018) Faming Deng et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Papaverine and its derivatives radiosensitize solid tumors by inhibiting mitochondrial metabolism

(2018) Martin Benej et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ivermectin induces cell cycle arrest and apoptosis of HeLa cells via mitochondrial pathway

(2018) Ping Zhang et al.   CELL PROLIFERATION

Quinacrine in endometrial cancer: Repurposing an old antimalarial drug

(2017) Eleftheria Kalogera et al.   GYNECOLOGIC ONCOLOGY

The functional curcumin liposomes induce apoptosis in C6 glioblastoma cells and C6 glioblastoma stem cells in vitro and in animals

(2017) Yahua Wang et al.   International Journal of Nanomedicine

Therapeutic strategies of drug repositioning targeting autophagy to induce cancer cell death: from pathophysiology to treatment

(2017) Go J. Yoshida   Journal of Hematology & Oncology

HGG-12. HYPOXIA SEEMS TO BE FREQUENTLY UPREGULATED IN THE PEDIATRIC HIGH GRADE GLIOMA AND DIPG

(2017) Anne-Florence Blandin et al.   NEURO-ONCOLOGY

Cancer acidity: An ultimate frontier of tumor immune escape and a novel target of immunomodulation

(2017) Veronica Huber et al.   SEMINARS IN CANCER BIOLOGY

Coordinated regulation of growth, activity and transcription in natural populations of the unicellular nitrogen-fixing cyanobacterium Crocosphaera

(2017) Samuel T. Wilson et al.   Nature Microbiology

Mefloquine effectively targets gastric cancer cells through phosphatase-dependent inhibition of PI3K/Akt/mTOR signaling pathway

(2016) Yanwei Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Anthelmintic drug ivermectin inhibits angiogenesis, growth and survival of glioblastoma through inducing mitochondrial dysfunction and oxidative stress

(2016) Yingying Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Gene expression-based discovery of atovaquone as a STAT3 inhibitor and anticancer agent

(2016) M. Xiang et al.   BLOOD

Targeting the hypoxic fraction of tumours using hypoxia-activated prodrugs

(2016) Roger M. Phillips   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Ivermectin Induces Cytostatic Autophagy by Blocking the PAK1/Akt Axis in Breast Cancer

(2016) Q. Dou et al.   CANCER RESEARCH

Eco-toxicological effects of the avermectin family with a focus on abamectin and ivermectin

(2016) Shahla Hosseini Bai et al.   CHEMOSPHERE

Sorafenib and Quinacrine Target Anti-Apoptotic Protein MCL1: A Poor Prognostic Marker in Anaplastic Thyroid Cancer (ATC)

(2016) J. Abdulghani et al.   CLINICAL CANCER RESEARCH

Targeting hypoxia to overcome radiation resistance in head & neck cancers: real challenge or clinical fairytale?

(2016) René Baumann et al.   Expert Review of Anticancer Therapy

Therapeutic Strategy for Targeting Aggressive Malignant Gliomas by Disrupting Their Energy Balance

(2016) Ahmed M. Hegazy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diffuse Intrinsic Pontine Glioma

(2016) Tammy Hennika et al.   JOURNAL OF CHILD NEUROLOGY

The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia

(2016) Thomas M. Ashton et al.   Nature Communications

Repurposing atovaquone: Targeting mitochondrial complex III and OXPHOS to eradicate cancer stem cells

(2016) Marco Fiorillo et al.   Oncotarget

Hypoxia and metabolic adaptation of cancer cells

(2016) K L Eales et al.   Oncogenesis

Therapeutic strategies targeting cancer stem cells

(2015) Go J. Yoshida et al.   CANCER SCIENCE

A Lactate-Induced Response to Hypoxia

(2015) Dong Chul Lee et al.   CELL

A Novel Dual AMPK Activator/mTOR Inhibitor Inhibits Thyroid Cancer Cell Growth

(2015) Robert L. Plews et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Metabolic reprogramming: the emerging concept and associated therapeutic strategies

(2015) Go J. Yoshida   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H+ symporters

(2015) Ibtissam Marchiq et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Citrate concentrations increase with hypoperfusion in pediatric diffuse intrinsic pontine glioma

(2015) Kristen W. Yeom et al.   JOURNAL OF NEURO-ONCOLOGY

Biomedical briefing

(2015)   NATURE MEDICINE

Inhibition of Lactate Dehydrogenase to Treat Epilepsy

(2015) Jong M. Rho   NEW ENGLAND JOURNAL OF MEDICINE

Quinacrine induces apoptosis in human leukemia K562 cells via p38 MAPK-elicited BCL2 down-regulation and suppression of ERK/c-Jun-mediated BCL2L1 expression

(2015) Jung-Jung Changchien et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Clinicopathology of diffuse intrinsic pontine glioma and its redefined genomic and epigenomic landscape

(2015) Eshini Panditharatna et al.   Cancer Genetics

Mitochondrial biogenesis is required for the anchorage-independent survival and propagation of stem-like cancer cells

(2015) Arianna De Luca et al.   Oncotarget

Quinacrine promotes autophagic cell death and chemosensitivity in ovarian cancer and attenuates tumor growth

(2015) Ashwani Khurana et al.   Oncotarget

DIPG in Children – What Can We Learn from the Past?

(2015) Magimairajan Issai Vanan et al.   Frontiers in Oncology

Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria

(2014) Hannah R. Bridges et al.   BIOCHEMICAL JOURNAL

Osteopontin-CD44 Signaling in the Glioma Perivascular Niche Enhances Cancer Stem Cell Phenotypes and Promotes Aggressive Tumor Growth

(2014) Alexander Pietras et al.   Cell Stem Cell

The river blindness drug Ivermectin and related macrocyclic lactones inhibit WNT-TCF pathway responses in human cancer

(2014) A. Melotti et al.   EMBO Molecular Medicine

Hypoxia sustains glioblastoma radioresistance through ERKs/DNA-PKcs/HIF-1α functional interplay

(2014) FRANCESCO MARAMPON et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Diffuse intrinsic pontine glioma: a reassessment

(2014) Nathan J. Robison et al.   JOURNAL OF NEURO-ONCOLOGY

Quinacrine Overcomes Resistance to Erlotinib by Inhibiting FACT, NF- B, and Cell-Cycle Progression in Non-Small Cell Lung Cancer

(2014) J. K. T. Dermawan et al.   MOLECULAR CANCER THERAPEUTICS

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

(2014) Andrea Viale et al.   NATURE

Quinacrine for extremity melanoma in a mouse model of isolated limb perfusion (ILP)

(2014) Minhyung Kim et al.   SURGERY TODAY

Chloroquine in Cancer Therapy: A Double-Edged Sword of Autophagy

(2013) T. Kimura et al.   CANCER RESEARCH

Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response

(2013) V. E. Zannella et al.   CLINICAL CANCER RESEARCH

In Vitro Drug Response and Efflux Transporters Associated with Drug Resistance in Pediatric High Grade Glioma and Diffuse Intrinsic Pontine Glioma

(2013) Susanna J. E. Veringa et al.   PLoS One

Mefloquine exerts anticancer activity in prostate cancer cells via ROS-mediated modulation of Akt, ERK, JNK and AMPK signaling

(2013) KUN-HUANG YAN et al.   Oncology Letters

Management of Diffuse Pontine Gliomas in Children: Recent Developments

(2013) Rejin Kebudi et al.   PEDIATRIC DRUGS

Inhibition of autophagy and induction of breast cancer cell death by mefloquine, an antimalarial agent

(2012) Natasha Sharma et al.   CANCER LETTERS

Quinacrine Inhibits Cell Growth and Induces Apoptosis in Human Gastric Cancer Cell Line SGC-7901

(2012) Xiaoyang Wu et al.   CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL

Effects of hypoxia and HIFs on cancer metabolism

(2012) Vera Mucaj et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors

(2012) Mahadeo A. Sukhai et al.   JOURNAL OF CLINICAL INVESTIGATION

Metabolic symbiosis in cancer: Refocusing the Warburg lens

(2012) Erica C. Nakajima et al.   MOLECULAR CARCINOGENESIS

Quinacrine-Mediated Autophagy and Apoptosis in Colon Cancer Cells Is Through a p53- and p21-Dependent Mechanism

(2012) Purusottam Mohapatra et al.   ONCOLOGY RESEARCH

Targeting the Lactate Transporter MCT1 in Endothelial Cells Inhibits Lactate-Induced HIF-1 Activation and Tumor Angiogenesis

(2012) Pierre Sonveaux et al.   PLoS One

Lactate Activates HIF-1 in Oxidative but Not in Warburg-Phenotype Human Tumor Cells

(2012) Christophe J. De Saedeleer et al.   PLoS One

Energy metabolism of cancer: Glycolysis versus oxidative phosphorylation (Review)

(2012) JIE ZHENG   Oncology Letters

Diffuse intrinsic pontine glioma: poised for progress

(2012) Katherine E. Warren   Frontiers in Oncology

Quinacrine synergizes with 5-fluorouracil and other therapies in colorectal cancer

(2011) Jean-Nicolas Gallant et al.   CANCER BIOLOGY & THERAPY

Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF- B/IL-8 Pathway that Drives Tumor Angiogenesis

(2011) F. Vegran et al.   CANCER RESEARCH

Beyond DNA binding - a review of the potential mechanisms mediating quinacrine's therapeutic activities in parasitic infections, inflammation, and cancers

(2011) Reza Ehsanian et al.   Cell Communication and Signaling

Quinacrine has anticancer activity in breast cancer cells through inhibition of topoisomerase activity

(2011) Ranjan Preet et al.   INTERNATIONAL JOURNAL OF CANCER

Metabolic Alterations in Highly Tumorigenic Glioblastoma Cells

(2011) Yunfei Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic state of glioma stem cells and nontumorigenic cells

(2011) E. Vlashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aberrant Signaling Pathways in Glioma

(2011) Mitsutoshi Nakada et al.   Cancers

The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells

(2010) S. Sharmeen et al.   BLOOD

HIF-1α inhibition by siRNA or chetomin in human malignant glioma cells: effects on hypoxic radioresistance and monitoring via CA9 expression

(2010) Jacqueline Kessler et al.   BMC CANCER

The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype

(2010) John M. Heddleston et al.   CELL CYCLE

Quinacrine Enhances Cisplatin-Induced Cytotoxicity in Four Cancer Cell Lines

(2010) Yixiang Wang et al.   CHEMOTHERAPY

Inhibition of NF-κB Signaling by Quinacrine Is Cytotoxic to Human Colon Carcinoma Cell Lines and Is Synergistic in Combination with Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) or Oxaliplatin

(2010) Tanvi S. Jani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reversal of P-glycoprotein-mediated multidrug resistancein vitroby doramectin and nemadectin

(2010) Aili Gao et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Bevacizumab in recurrent high-grade pediatric gliomas

(2010) A. Narayana et al.   NEURO-ONCOLOGY

Cancer stem cells in glioblastoma—molecular signaling and therapeutic targeting

(2010) Zhi Huang et al.   Protein & Cell

Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells

(2009) Zhizhong Li et al.   CANCER CELL

MYC-Induced Cancer Cell Energy Metabolism and Therapeutic Opportunities

(2009) C. V. Dang et al.   CLINICAL CANCER RESEARCH

Direct control of mitochondrial function by mTOR

(2009) Arvind Ramanathan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regional Hypoxia in Glioblastoma Multiforme Quantified with [18F]Fluoromisonidazole Positron Emission Tomography before Radiotherapy: Correlation with Time to Progression and Survival

(2008) A. M. Spence et al.   CLINICAL CANCER RESEARCH

Malignant Gliomas in Adults

(2008) Patrick Y. Wen et al.   NEW ENGLAND JOURNAL OF MEDICINE