Article
Oncology
Nana Xu, Mengmeng Lu, Jiaxin Wang, Yujia Li, Xiaotian Yang, Xiajie Wei, Jiaoyang Si, Jingru Han, Xiaojuan Yao, Juanmei Zhang, Junqi Liu, Yanming Li, Hushan Yang, Dengke Bao
Summary: The study demonstrated that ivermectin significantly inhibits the proliferation of ESCC cells and induces apoptosis. Mechanistically, ivermectin induces mitochondrial dysfunction and apoptosis pathway, leading to apoptosis of ESCC cells.
Article
Multidisciplinary Sciences
Francisco J. Sanchez-Rivera, Jeremy Ryan, Yadira M. Soto-Feliciano, Mary Clare Beytagh, Lucius Xuan, David M. Feldser, Michael T. Hemann, Jesse Zamudio, Nadya Dimitrova, Anthony Letai, Tyler Jacks
Summary: The level of mitochondrial apoptotic priming is a critical determinant of cell fate upon p53 reactivation, with cells having high initial priming tending to undergo apoptosis and cells with low priming tending to survive and arrest in the cell cycle. Manipulating the priming levels through BCL-2 or BCL-XL expression or inhibition can affect the outcome of p53 restoration, highlighting mitochondrial apoptotic priming as a key factor in determining cell fate. Moreover, less primed cells can be forced into apoptotic cell fate following p53 activation using p53-independent drugs that increase apoptotic priming.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Multidisciplinary
Jin-yi Liu, Wei-qi Fu, Xiang-jin Zheng, Wan Li, Li-wen Ren, Jin-hua Wang, Cui Yang, Guan-hua Du
Summary: Avasimibe demonstrated potent anticancer effects on human glioblastoma cells by inhibiting proliferation, inducing apoptosis, and regulating multiple signaling pathways. The drug showed promising potential as a chemotherapy treatment for glioblastoma.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Oncology
Haini Wang, Junli Zuo
Summary: Overexpressed survivin is associated with worse survival of several types of human tumors. In this study, the antitumor activity of shikonin in non-small-cell lung cancer (NSCLC) by regulating survivin pathway was investigated. Result showed that shikonin inhibited the NSCLC H1299 cell proliferation in a dose-dependent manner. Moreover, shikonin fits well with survivin by molecular docking. Shikonin also inhibited the mRNA expression and protein level of survivin in H1299 cells. Shikonin arrested H1299 cell cycle at the G0/G1 phase by regulating CDK/cyclin family members. In addition, shikonin regulated the expression of X-linked inhibitor of apoptosis- (XIAP-) mediated caspases 3 and 9, thus leading to the damage of mitochondrial membrane potential and induction of H1299 cell apoptosis. Overall, shikonin inhibited H1299 cell growth by inducing apoptosis and blocking the cell cycle. The underlying mechanism involves targeting survivin, which subsequently regulates the protein expression of XIAP/caspase 3/9, CDK2/4, and cyclin E/D1. Thus, shikonin, a survivin inhibitor, is a promising therapeutic strategy in NSCLC treatment.
ANALYTICAL CELLULAR PATHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuan Zhang, Tun Sun, Meng Li, Yanling Lin, Yue Liu, Shusheng Tang, Chongshan Dai
Summary: Ivermectin can induce apoptotic cell death in human neuroblastoma cells, promoting ROS production, mitochondrial dysfunction, and autophagy, while inhibiting the Akt/mTOR pathway. Autophagy inhibition improved Ivermectin-induced oxidative stress and apoptotic cell death in these cells.
Article
Biochemistry & Molecular Biology
Zhenyao Yu, Yixue Hou, Wei Zhou, Zizhen Zhao, Zesheng Liu, Ailing Fu
Summary: Mitochondrial transplantation therapy has been actively researched as a treatment for mitochondria-associated diseases, including malignant melanoma. This study investigated the signal mechanism and gender differences in the anti-tumor activity of healthy mitochondria. The results showed that intact mitochondria significantly inhibited tumor cell proliferation and showed anti-tumor effects in melanoma-bearing mice, with female mitochondria demonstrating greater efficiency and a possible stronger mitochondria-nuclear communication than male mitochondria.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Oncology
Jie Zhang, Gulimire Buranjiang, Zuohelaguli Mutalifu, Hua Jin, Liyan Yao
Summary: This study found that KIF14 plays a role in promoting cell proliferation, migration, and invasion in cervical cancer, and causes cell cycle arrest by inhibiting p27 degradation. These findings provide a new therapeutic target for cervical cancer.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Hong-Li Li, Yan Cheng, Zi-Wei Zhou, Hui-Zhi Long, Hong-Yu Luo, Dan-Dan Wen, Lin Cheng, Li-Chen Gao
Summary: Isoliensinine, an alkaloid derived from lotus, has been found to have various anti-cancer properties, and in this study, it was shown to induce cell cycle arrest and apoptosis in cervical cancer cells by inhibiting the AKT/GSK3α pathway.
Article
Pharmacology & Pharmacy
Haina Wang, Rui Wang, Dan Huang, Sihan Li, Beibei Gao, Zhijie Kang, Bo Tang, Jiajun Xie, Fanzhi Yan, Rui Liang, Hua Li, Jinsong Yan
Summary: The study demonstrates that HHT can inhibit the growth and spread of HCC cells through various pathways, including reducing cell proliferation, inhibiting colony formation, preventing cell invasion and migration, inducing cell cycle arrest, and promoting apoptosis. The apoptosis induced by HHT is mainly achieved through the activation of the Hippo pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiang Wang, Jian Wang, Ping Zhang, Cheng Zhang, Weiguo Wang, Mengqi Wu, Wenping Xu, Liming Tao, Zhong Li, Yang Zhang
Summary: The widespread and excessive use of ivermectin can lead to environmental pollution and affect the metabolism of exposed humans and mammals. It inhibits cell proliferation and induces cytotoxicity in RAW264.7 cells. Ivermectin activates the AMPK/mTOR signaling pathway, resulting in cell cycle arrest and induction of autophagy.
Article
Pharmacology & Pharmacy
Shican Zhou, Hang Wu, Wenjuan Ning, Xiao Wu, Xiaoxiao Xu, Yuanqiao Ma, Xingwang Li, Junhong Hu, Chenyu Wang, Junpeng Wang
Summary: Ivermectin inhibits colorectal cancer cell growth by promoting ROS-mediated mitochondrial apoptosis pathway and inducing S phase arrest, suggesting its potential as a novel anticancer drug therapy for human colorectal cancer and other cancers.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kate L. Hertweck, Kunwar S. Vikramdeo, Jose N. Galeas, Stephen M. Marbut, Paramahansa Pramanik, Furhan Yunus, Seema Singh, Ajay P. Singh, Santanu Dasgupta
Summary: In this study, the authors identified a unique set of mitochondria-targeted genes that are differentially expressed in non-small-cell lung cancer subtypes. Altered expression of certain genes, such as SLC25A4, was associated with poor patient survival. These findings highlight the potential of these genes as biomarkers and therapeutic targets for lung cancer.
Article
Chemistry, Physical
Peihua Li, Shiming Pu, Chao Lin, Liu He, Hongxia Zhao, Cheng Yang, Ziqi Guo, Shisan Xu, Zuping Zhou
Summary: Curcumin exhibits anti-colon cancer properties by inhibiting cell proliferation and inducing apoptosis through p53-mediated mechanisms.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Toxicology
Yang Liu, Xian-Ji Piao, Wan-Ting Xu, Yu Zhang, Tong Zhang, Hui Xue, Yan-Nan Li, Wen-Bo Zuo, Geng Sun, Zhong-Ren Fu, Ying-Hua Luo, Cheng-Hao Jin
Summary: Calycosin exhibited anti-proliferation effects on HCC cells and had less cytotoxicity in normal cells. It induced apoptosis by regulating various signaling pathways and caused cell cycle arrest in the G0/G1 phase. Additionally, calycosin reduced the expression of certain proteins and induced cellular events through ROS-mediated pathways.
TOXICOLOGY IN VITRO
(2021)
Article
Pharmacology & Pharmacy
Luya Pu, Qingyu Meng, Shuai Li, Bin Liu, Fan Li
Summary: Icariin can inhibit the proliferation of FLSs by interfering with the cell cycle process and inducing cell apoptosis, indicating its potential for the treatment of RA.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)