SARS-CoV-2/Renin–Angiotensin System: Deciphering the Clues for a Couple with Potentially Harmful Effects on Skeletal Muscle

Angiotensin receptor blockers as tentative SARS‐CoV‐2 therapeutics

(2020) David Gurwitz   DRUG DEVELOPMENT RESEARCH

Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China

(2020) Zunyou Wu et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Recent insights into 2019-nCoV: a brief but comprehensive review

(2020) Qingmei Han et al.   JOURNAL OF INFECTION

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2

(2020) Renhong Yan et al.   SCIENCE

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

Emerging novel coronavirus (2019-nCoV)—current scenario, evolutionary perspective based on genome analysis and recent developments

(2020) Yashpal Singh Malik et al.   VETERINARY QUARTERLY

Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study

(2020) Xiaobo Yang et al.   Lancet Respiratory Medicine

The Stanford Hall consensus statement for post-COVID-19 rehabilitation

(2020) Robert M Barker-Davies et al.   BRITISH JOURNAL OF SPORTS MEDICINE

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Understanding the Renin-Angiotensin-Aldosterone-SARS-CoV-Axis: A Comprehensive Review

(2020) Nicholas E. Ingraham et al.   EUROPEAN RESPIRATORY JOURNAL

Interactions of coronaviruses with ACE2, angiotensin II, and RAS inhibitors—lessons from available evidence and insights into COVID-19

(2020) Hisashi Kai et al.   HYPERTENSION RESEARCH

COVID-19 and RAS: Unravelling an Unclear Relationship

(2020) Damiano D’Ardes et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Characteristics and Outcomes of 21 Critically Ill Patients With COVID-19 in Washington State

(2020) Matt Arentz et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19)

(2020) James M. Sanders et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Musculoskeletal Consequences of COVID-19

(2020) Nathaniel P. Disser et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Can angiotensin receptor-blocking drugs perhaps be harmful in the COVID-19 pandemic?

(2020) Murray Esler et al.   JOURNAL OF HYPERTENSION

From SARS and MERS CoVs to SARS‐CoV‐2: Moving toward more biased codon usage in viral structural and nonstructural genes

(2020) Mahmoud Kandeel et al.   JOURNAL OF MEDICAL VIROLOGY

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

Structural basis of receptor recognition by SARS-CoV-2

(2020) Jian Shang et al.   NATURE

The proximal origin of SARS-CoV-2

(2020) Kristian G. Andersen et al.   NATURE MEDICINE

Inhibitors of the Renin–Angiotensin–Aldosterone System and Covid-19

(2020) John A. Jarcho et al.   NEW ENGLAND JOURNAL OF MEDICINE

Renin–Angiotensin–Aldosterone System Blockers and the Risk of Covid-19

(2020) Giuseppe Mancia et al.   NEW ENGLAND JOURNAL OF MEDICINE

Renin–Angiotensin–Aldosterone System Inhibitors and Risk of Covid-19

(2020) Harmony R. Reynolds et al.   NEW ENGLAND JOURNAL OF MEDICINE

Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection?

(2020) Lei Fang et al.   Lancet Respiratory Medicine

Respiratory rehabilitation in elderly patients with COVID-19: A randomized controlled study

(2020) Kai Liu et al.   Complementary Therapies in Clinical Practice

Cardiac Involvement in a Patient With Coronavirus Disease 2019 (COVID-19)

(2020) Riccardo M. Inciardi et al.   JAMA Cardiology

Covid-19: the renin–angiotensin system imbalance hypothesis

(2020) Katharina Lanza et al.   CLINICAL SCIENCE

Pulmonary function in patients surviving to COVID-19 pneumonia

(2020) Alessia Fumagalli et al.   INFECTION

Protective Effect of Angiotensin 1–7 on Sarcopenia Induced by Chronic Liver Disease in Mice

(2020) Francisco Aguirre et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Persistent Symptoms in Patients After Acute COVID-19

(2020) Angelo Carfì et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The molecular virology of Coronaviruses

(2020) Ella Hartenian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lung, Heart, Vascular, and Diaphragm Ultrasound Examination of COVID-19 Patients: A Comprehensive Approach

(2020) Fabio Guarracino et al.   JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA

Biological, clinical and epidemiological features of COVID-19, SARS and MERS and AutoDock simulation of ACE2

(2020) Xue-Yan Zhang et al.   Infectious Diseases of Poverty

SARS-CoV-2 and ACE2: The biology and clinical data settling the ARB and ACEI controversy

(2020) Mina K. Chung et al.   EBioMedicine

Molecular mechanisms involved in the positive effects of physical activity on coping with COVID-19

(2020) Ersilia Nigro et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

ULTRASOUND IMAGING FOR DIAPHRAGM DYSFUNCTION: A NARRATIVE LITERATURE REVIEW

(2019) Luigi Vetrugno et al.   JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA

From SARS to MERS, Thrusting Coronaviruses into the Spotlight

(2019) Zhiqi Song et al.   Viruses-Basel

Aging of the musculoskeletal system: How the loss of estrogen impacts muscle strength

(2019) Brittany C. Collins et al.   BONE

Sarcopenia: revised European consensus on definition and diagnosis

(2019) Alfonso J Cruz-Jentoft et al.   AGE AND AGEING

Mitochondrial Dysfunction in Skeletal Muscle Pathologies

(2019) Johanna Abrigo et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Muscle wasting: A review of exercise, classical and non‐classical RAS axes

(2019) Mark A. Winslow et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

N-Acetyl Cysteine attenuates the sarcopenia and muscle apoptosis induced by chronic liver disease

(2019) Johanna Abrigo et al.   CURRENT MOLECULAR MEDICINE

Exercise Training Modalities for People with Chronic Obstructive Pulmonary Disease

(2019) Claire M. Nolan et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Diaphragm Dysfunction in Critical Illness

(2018) Gerald S. Supinski et al.   CHEST

Angiotensin-Converting Enzyme Inhibitors in Hypertension

(2018) Franz H. Messerli et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The ACE2/Angiotensin-(1–7)/MAS Axis of the Renin-Angiotensin System: Focus on Angiotensin-(1–7)

(2018) Robson Augusto Souza Santos et al.   PHYSIOLOGICAL REVIEWS

Modulation of the renin–angiotensin system in white adipose tissue and skeletal muscle: focus on exercise training

(2018) Eliete Dalla Corte Frantz et al.   CLINICAL SCIENCE

Ventilator-induced diaphragm dysfunction in critical illness

(2018) Yung-Yang Liu et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Intensive Care Unit–Acquired Weakness

(2017) Christopher L. Kramer   NEUROLOGIC CLINICS

Physical Exercise and ACE2-Angiotensin-(1-7)-Mas Receptor Axis of the Renin Angiotensin System

(2017) Albena Nunes-Silva et al.   PROTEIN AND PEPTIDE LETTERS

Angiotensin-II-induced Muscle Wasting is Mediated by 25-Hydroxycholesterol via GSK3β Signaling Pathway

(2017) Congcong Shen et al.   EBioMedicine

Angiotensin-(1-7) Prevents Skeletal Muscle Atrophy Induced by Transforming Growth Factor Type Beta (TGF-β) via Mas Receptor Activation

(2016) Johanna Ábrigo et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

ICU-Acquired Weakness

(2016) Sarah E. Jolley et al.   CHEST

Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas

(2016) María Gabriela Morales et al.   Disease Models & Mechanisms

Recovery and outcomes after the acute respiratory distress syndrome (ARDS) in patients and their family caregivers

(2016) Margaret S. Herridge et al.   INTENSIVE CARE MEDICINE

Skeletal muscle insulin resistance in salt-sensitive hypertension: role of angiotensin II activation of NFκB

(2015) Ming-Sheng Zhou et al.   Cardiovascular Diabetology

Endotoxin-induced skeletal muscle wasting is prevented by angiotensin-(1–7) through a p38 MAPK-dependent mechanism

(2015) María Gabriela Morales et al.   CLINICAL SCIENCE

Angiotensin-(1–7) decreases skeletal muscle atrophy induced by angiotensin II through a Mas receptor-dependent mechanism

(2015) Franco Cisternas et al.   CLINICAL SCIENCE

AT1 receptor blocker losartan protects against mechanical ventilation-induced diaphragmatic dysfunction

(2015) Oh Sung Kwon et al.   JOURNAL OF APPLIED PHYSIOLOGY

Role of Inflammation in Muscle Homeostasis and Myogenesis

(2015) Domiziana Costamagna et al.   MEDIATORS OF INFLAMMATION

Sepsis Is Associated with a Preferential Diaphragmatic Atrophy

(2014) Boris Jung et al.   ANESTHESIOLOGY

Integrative Biology of Exercise

(2014) John A. Hawley et al.   CELL

Angiotensin II Mediates Angiotensin Converting Enzyme Type 2 Internalization and Degradation Through an Angiotensin II Type I Receptor–Dependent Mechanism

(2014) Matthew R. Deshotels et al.   HYPERTENSION

The angiotensin-(1–7)/Mas axis reduces myonuclear apoptosis during recovery from angiotensin II-induced skeletal muscle atrophy in mice

(2014) Carla Meneses et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Effects of Exercise Training on Circulating and Skeletal Muscle Renin-Angiotensin System in Chronic Heart Failure Rats

(2014) Igor Lucas Gomes-Santos et al.   PLoS One

Ventilator-induced diaphragm dysfunction: cause and effect

(2013) Scott K. Powers et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Physical Complications in Acute Lung Injury Survivors

(2013) Eddy Fan et al.   CRITICAL CARE MEDICINE

Molecular mechanisms and signaling pathways of angiotensin II-induced muscle wasting: Potential therapeutic targets for cardiac cachexia

(2013) Tadashi Yoshida et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Angiotensin 1–7 improves insulin sensitivity by increasing skeletal muscle glucose uptake in vivo

(2013) Omar Echeverría-Rodríguez et al.   PEPTIDES

Intensive Care Unit–acquired Weakness

(2012) Jane Batt et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Angiotensin II: Role in Skeletal Muscle Atrophy

(2012) Claudio Cabello-Verrugio et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Angiotensin II-induced pro-fibrotic effects require p38MAPK activity and transforming growth factor beta 1 expression in skeletal muscle cells

(2012) María Gabriela Morales et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Acute respiratory distress syndrome leads to reduced ratio of ACE/ACE2 activities and is prevented by angiotensin-(1-7) or an angiotensin II receptor antagonist

(2011) Roelie M Wösten-van Asperen et al.   JOURNAL OF PATHOLOGY

IGF-1 prevents ANG II-induced skeletal muscle atrophy via Akt- and Foxo-dependent inhibition of the ubiquitin ligase atrogin-1 expression

(2010) Tadashi Yoshida et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Prolonged mechanical ventilation alters diaphragmatic structure and function

(2010) Scott K. Powers et al.   CRITICAL CARE MEDICINE

Alteration of the Piglet Diaphragm Contractility In Vivo and Its Recovery after Acute Hypercapnia

(2009) Samir Jaber et al.   ANESTHESIOLOGY

Ventilator-induced diaphragmatic dysfunction

(2009) Basil J Petrof et al.   Current Opinion in Critical Care

IL-6 and Serum Amyloid A Synergy Mediates Angiotensin II-Induced Muscle Wasting

(2009) L. Zhang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Differential Downregulation of ACE2 by the Spike Proteins of Severe Acute Respiratory Syndrome Coronavirus and Human Coronavirus NL63

(2009) I. Glowacka et al.   JOURNAL OF VIROLOGY

Redox regulation of diaphragm proteolysis during mechanical ventilation

(2008) J. M. McClung et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Rapid Disuse Atrophy of Diaphragm Fibers in Mechanically Ventilated Humans

(2008) Sanford Levine et al.   NEW ENGLAND JOURNAL OF MEDICINE

Modulation of TNF- -converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF-  production and facilitates viral entry

(2008) S. Haga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endocytosis of the receptor-binding domain of SARS-CoV spike protein together with virus receptor ACE2

(2008) Shunxin Wang et al.   VIRUS RESEARCH