COVID-19 and RAS: Unravelling an Unclear Relationship

Angiotensin receptor blockers as tentative SARS‐CoV‐2 therapeutics

(2020) David Gurwitz   DRUG DEVELOPMENT RESEARCH

The Other Angiotensin II Receptor: AT2R as a Therapeutic Target

(2020) Lucienne Juillerat-Jeanneret   JOURNAL OF MEDICINAL CHEMISTRY

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

COVID-19 and the cardiovascular system

(2020) Ying-Ying Zheng et al.   Nature Reviews Cardiology

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

COVID‐19 patients' clinical characteristics, discharge rate, and fatality rate of meta‐analysis

(2020) Long‐quan Li et al.   JOURNAL OF MEDICAL VIROLOGY

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

Adipocyte deficiency of ACE2 increases systolic blood pressures of obese female C57BL/6 mice

(2019) Robin Shoemaker et al.   Biology of Sex Differences

Targeting the renin–angiotensin system as novel therapeutic strategy for pulmonary diseases

(2018) Wan Shun Daniel Tan et al.   CURRENT OPINION IN PHARMACOLOGY

Angiotensin-Converting Enzyme Inhibitors in Hypertension

(2018) Franz H. Messerli et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The ACE2/Angiotensin-(1–7)/MAS Axis of the Renin-Angiotensin System: Focus on Angiotensin-(1–7)

(2018) Robson Augusto Souza Santos et al.   PHYSIOLOGICAL REVIEWS

Protective regulation of the ACE2/ACE gene expression by estrogen in human atrial tissue from elderly men

(2017) A Bukowska et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Biochemical evaluation of the renin-angiotensin system: the good, bad, and absolute?

(2016) Mark C. Chappell   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Pulmonary Angiotensin-Converting Enzyme 2 (ACE2) and Inflammatory Lung Disease

(2016) Hongpeng Jia   SHOCK

Perinatally administered losartan augments renal ACE2 expression but not cardiac or renal Mas receptor in spontaneously hypertensive rats

(2015) Jan Klimas et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Angiotensin-Converting Enzyme Inhibition Attenuates Lipopolysaccharide-Induced Lung Injury by Regulating the Balance Between Angiotensin-Converting Enzyme and Angiotensin-Converting Enzyme 2 and Inhibiting Mitogen-Activated Protein Kinase Activation

(2015) Yingchuan Li et al.   SHOCK

Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections

(2014) Zhen Zou et al.   Nature Communications

Agonists of MAS oncogene and angiotensin II type 2 receptors attenuate cardiopulmonary disease in rats with neonatal hyperoxia-induced lung injury

(2013) Gerry T. M. Wagenaar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Multiple Functions of Angiotensin-Converting Enzyme 2 and Its Relevance in Cardiovascular Diseases

(2013) Keiji Kuba et al.   CIRCULATION JOURNAL

Angiotensin-(1–7) Protects From Experimental Acute Lung Injury

(2013) Nadine Klein et al.   CRITICAL CARE MEDICINE

ACE2 – From the renin–angiotensin system to gut microbiota and malnutrition

(2013) Thomas Perlot et al.   MICROBES AND INFECTION

Three key proteases – angiotensin-I-converting enzyme (ACE), ACE2 and renin – within and beyond the renin-angiotensin system

(2012) Cuie Guang et al.   Archives of Cardiovascular Diseases

Angiotensin Converting Enzyme 2 Contributes to Sex Differences in the Development of Obesity Hypertension in C57BL/6 Mice

(2012) Manisha Gupte et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Angiotensin-converting enzyme 2, angiotensin-(1–7) and Mas: new players of the renin–angiotensin system

(2012) Robson A S Santos et al.   JOURNAL OF ENDOCRINOLOGY

Acute respiratory distress syndrome leads to reduced ratio of ACE/ACE2 activities and is prevented by angiotensin-(1-7) or an angiotensin II receptor antagonist

(2011) Roelie M Wösten-van Asperen et al.   JOURNAL OF PATHOLOGY

Ventilator-Induced Inflammatory Response in Lipopolysaccharide-Exposed Rat Lung Is Mediated by Angiotensin-Converting Enzyme

(2010) Roelie M. Wösten-van Asperen et al.   AMERICAN JOURNAL OF PATHOLOGY

Gender and the renin-angiotensin-aldosterone system

(2010) Kimiaki Komukai et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Trilogy of ACE2: A peptidase in the renin–angiotensin system, a SARS receptor, and a partner for amino acid transporters

(2010) Keiji Kuba et al.   PHARMACOLOGY & THERAPEUTICS

Onset of Experimental Severe Cardiac Fibrosis Is Mediated by Overexpression of Angiotensin-Converting Enzyme 2

(2009) Rachel Masson et al.   HYPERTENSION

Cardiac Overexpression of Angiotensin Converting Enzyme 2 Protects the Heart From Ischemia-Induced Pathophysiology

(2008) Shant Der Sarkissian et al.   HYPERTENSION

Transgenic Angiotensin-Converting Enzyme 2 Overexpression in Vessels of SHRSP Rats Reduces Blood Pressure and Improves Endothelial Function

(2008) Brit Rentzsch et al.   HYPERTENSION

Candesartan Ameliorates Cardiac Dysfunction Observed in Angiotensin-Converting Enzyme 2-Deficient Mice

(2008) Kazuto Nakamura et al.   HYPERTENSION RESEARCH

AT2 receptors: Functional relevance in cardiovascular disease

(2008) Emma S. Jones et al.   PHARMACOLOGY & THERAPEUTICS

Angiotensin AT2 receptors: control of renal sodium excretion and blood pressure

(2008) Robert M. Carey et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM