MONITORING THE EFFECTS OF VARIOUS COMBINATION OF SPECIFIC DRUG THERAPIES AT DIFFERENT STAGES OF ALZHEIMER'S DEMENTIA

We have studied the effects of various combinations of specific drug therapies on patients with Alzheimer's dementia. The study was conducted over a 12-week period, with initial, after 4, 8, and 12-weeks assessment. A number of 140 patients with Alzheimer's dementia were assessed observing the clinical manifestations, the therapeutic measures that were applied and the changes in the response to treatment. Mini-Mental State Examination (MMSE) was used to monitor the cognitive functionality evolution of the studied patients. The depreciation of the MMSE score was observed in 2.94% of the patients registering a mild impairment, in 6.02% - a moderate impairment and 17.39% - a severe impairment. The greatest depreciation effect was achieved with memantine in monotherapy (ES = 0.24), and the lowest - with donepezil therapy in combination with memantine (ES = 0.24). Our results prove that specific anti-dementia treatment is effective for the treatment of cognitive impairment, especially if it is instituted at the onset of the disease.