Revisiting Platelets and Toll-Like Receptors (TLRs): At the Interface of Vascular Immunity and Thrombosis
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Revisiting Platelets and Toll-Like Receptors (TLRs): At the Interface of Vascular Immunity and Thrombosis
Authors
Keywords
-
Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 21, Issue 17, Pages 6150
Publisher
MDPI AG
Online
2020-08-26
DOI
10.3390/ijms21176150
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Ticagrelor Inhibits Toll-Like and Protease-Activated Receptor Mediated Platelet Activation in Acute Coronary Syndromes
- (2020) Patricia P. Wadowski et al. CARDIOVASCULAR DRUGS AND THERAPY
- TLR4-Targeting Therapeutics: Structural Basis and Computer-Aided Drug Discovery Approaches
- (2020) Qurat ul Ain et al. MOLECULES
- Platelet-derived HMGB1: critical mediator of SARs related to transfusion
- (2020) Fabrice Cognasse et al. Annals of Translational Medicine
- Cytokine storm intervention in the early stages of COVID-19 pneumonia
- (2020) Xinjuan Sun et al. CYTOKINE & GROWTH FACTOR REVIEWS
- Platelet Toll-Like Receptors Mediate Thromboinflammatory Responses in Patients With Essential Thrombocythemia
- (2020) Cecilia P. Marín Oyarzún et al. Frontiers in Immunology
- Platelets in Cardiac Ischaemia/Reperfusion Injury – A Promising Therapeutic Target
- (2019) Melanie Ziegler et al. CARDIOVASCULAR RESEARCH
- Platelet‐derived extracellular vesicles convey mitochondrial DAMPs in platelet concentrates and their levels are associated with adverse reactions
- (2019) Genevieve Marcoux et al. TRANSFUSION
- The Interaction Between Two Worlds: MicroRNAs and Toll-Like Receptors
- (2019) Recep Bayraktar et al. Frontiers in Immunology
- Platelet Inflammatory Response to Stress
- (2019) Fabrice Cognasse et al. Frontiers in Immunology
- Platelets in Sepsis: An Update on Experimental Models and Clinical Data
- (2019) Alice Assinger et al. Frontiers in Immunology
- Platelets and Immune Responses During Thromboinflammation
- (2019) Matthias Mezger et al. Frontiers in Immunology
- Toll-Like Receptors and Relevant Emerging Therapeutics with Reference to Delivery Methods
- (2019) Javaid et al. Pharmaceutics
- Platelets modulate multiple markers of neutrophil function in response to in vitro Toll-like receptor stimulation
- (2019) Kathryn E. Hally et al. PLoS One
- Inflammation in acute coronary syndrome: Expression of TLR2 mRNA is increased in platelets of patients with ACS
- (2019) Lukas Andreas Heger et al. PLoS One
- Fungal Chitin Reduces Platelet Activation Mediated via TLR8 Stimulation
- (2019) Jordan Leroy et al. Frontiers in Cellular and Infection Microbiology
- Internalization of microparticles by platelets is partially mediated by toll-like receptor 4 and enhances platelet thrombogenicity
- (2019) Didac Jerez-Dolz et al. ATHEROSCLEROSIS
- Platelet-derived miRNAs as determinants of the antiplatelet response in clopidogrel-treated patients with ACS
- (2019) Jun Liu et al. THROMBOSIS RESEARCH
- Emerging Role of Mitochondrial DNA as a Major Driver of Inflammation and Disease Progression
- (2019) Fei Zhong et al. TRENDS IN IMMUNOLOGY
- Effect of ultrapure lipopolysaccharides derived from diverse bacterial species on the modulation of platelet activation
- (2019) Thomas M. Vallance et al. Scientific Reports
- Platelet Toll-like receptor and its ligand HMGB-1 expression is increased in the left atrium of atrial fibrillation patients
- (2018) Kadri Murat Gurses et al. CYTOKINE
- Exploring the biological functional mechanism of the HMGB1/TLR4/MD-2 complex by surface plasmon resonance
- (2018) Mingzhu He et al. MOLECULAR MEDICINE
- Platelet Toll-like receptor expression and activation induced by lipopolysaccharide and sepsis
- (2018) Theodora A.M. Claushuis et al. PLATELETS
- The effects of aspirin and ticagrelor on Toll-like receptor (TLR)-mediated platelet activation: results of a randomized, cross-over trial
- (2018) Kathryn E Hally et al. PLATELETS
- Role of matrix metalloproteinases 2 and 9, toll-like receptor 4 and platelet-leukocyte aggregate formation in sepsis-associated thrombocytopenia
- (2018) Caroline M. Larkin et al. PLoS One
- Localization of lipopolysaccharide from Escherichia Coli into human atherosclerotic plaque
- (2018) Roberto Carnevale et al. Scientific Reports
- MicroRNA-223 Suppresses the Canonical NF-κB Pathway in Basal Keratinocytes to Dampen Neutrophilic Inflammation
- (2018) Wenqing Zhou et al. Cell Reports
- New mitochondrial DNA synthesis enables NLRP3 inflammasome activation
- (2018) Zhenyu Zhong et al. NATURE
- Role of platelets and platelet receptors in cancer metastasis
- (2018) Martin Schlesinger Journal of Hematology & Oncology
- Recent clinical trends in Toll-like receptor targeting therapeutics
- (2018) Muhammad Ayaz Anwar et al. MEDICINAL RESEARCH REVIEWS
- Role of Platelets in Leukocyte Recruitment and Resolution of Inflammation
- (2018) Jan Rossaint et al. Frontiers in Immunology
- Hepatic mitochondrial DNA/Toll-like receptor 9/MicroRNA-223 forms a negative feedback loop to limit neutrophil overactivation and acetaminophen hepatotoxicity in mice
- (2017) Yong He et al. HEPATOLOGY
- Toll-like receptors: Significance, ligands, signaling pathways, and functions in mammals
- (2017) Mallenahally Kusha Vidya et al. INTERNATIONAL REVIEWS OF IMMUNOLOGY
- Downregulated expression of miR-223 promotes Toll-like receptor-activated inflammatory responses in macrophages by targeting RhoB
- (2017) Ningjie Zhang et al. MOLECULAR IMMUNOLOGY
- Lipopolysaccharide as trigger of platelet aggregation via eicosanoid over-production
- (2017) Simona Bartimoccia et al. THROMBOSIS AND HAEMOSTASIS
- Small but mighty: Platelets as central effectors of host defense
- (2017) Ishikawa-Ankerhold Hellen et al. THROMBOSIS AND HAEMOSTASIS
- Platelet Toll-like receptor (TLR) expression and TLR-mediated platelet activation in acute myocardial infarction
- (2017) Kathryn E. Hally et al. THROMBOSIS RESEARCH
- The Toll-Like Receptor 4 Antagonist Eritoran Protects Mice from Lethal Filovirus Challenge
- (2017) Patrick Younan et al. mBio
- Cytomegalovirus Infection and Relative Risk of Cardiovascular Disease (Ischemic Heart Disease, Stroke, and Cardiovascular Death): A Meta‐Analysis of Prospective Studies Up to 2016
- (2017) Haoran Wang et al. Journal of the American Heart Association
- Inhibition of Toll-Like Receptor Signaling as a Promising Therapy for Inflammatory Diseases: A Journey from Molecular to Nano Therapeutics
- (2017) Wei Gao et al. Frontiers in Physiology
- NF-κB Links TLR2 and PAR1 to Soluble Immunomodulator Factor Secretion in Human Platelets
- (2017) Pauline Damien et al. Frontiers in Immunology
- Human platelet interaction with E. coli O111 promotes tissue-factor-dependent procoagulant activity, involving Toll like receptor 4
- (2017) Valeria Matus et al. PLoS One
- Lipopolysaccharide potentiates platelet responses via toll-like receptor 4-stimulated Akt-Erk-PLA2 signalling
- (2017) Maria E. Lopes Pires et al. PLoS One
- Platelet-derived high-mobility group box 1 promotes recruitment and suppresses apoptosis of monocytes
- (2016) Sebastian Vogel et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Disulfide HMGB1 derived from platelets coordinates venous thrombosis in mice
- (2016) K. Stark et al. BLOOD
- Thrombosis and platelets: an update
- (2016) Milka Koupenova et al. EUROPEAN HEART JOURNAL
- Platelets Toll-like receptor-4 in Crohns disease
- (2016) Werner Schmid et al. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
- Long noncoding RNAs as regulators of Toll-like receptor signaling and innate immunity
- (2016) Michael B. Murphy et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Toll-Like Receptor Signalling Is Not Involved in Platelet Response to Streptococcus pneumoniae In Vitro or In Vivo
- (2016) Sacha F. de Stoppelaar et al. PLoS One
- Platelets Guide Leukocytes to Their Sites of Extravasation
- (2016) Gabriele Zuchtriegel et al. PLOS BIOLOGY
- Metformin Uniquely Prevents Thrombosis by Inhibiting Platelet Activation and mtDNA Release
- (2016) Guang Xin et al. Scientific Reports
- Enhanced Platelet Toll-like Receptor 2 and 4 Expression in Acute Coronary Syndrome and Stable Angina Pectoris
- (2015) Kadri Murat Gurses et al. AMERICAN JOURNAL OF CARDIOLOGY
- Sex Differences in Platelet Toll-Like Receptors and Their Association With Cardiovascular Risk FactorsSignificance
- (2015) Milka Koupenova et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- LPS stimulation of purified human platelets is partly dependent on plasma soluble CD14 to secrete their main secreted product, soluble-CD40-Ligand
- (2015) Pauline Damien et al. BMC IMMUNOLOGY
- Dicer Cleavage by Calpain Determines Platelet microRNA Levels and Function in DiabetesNovelty and Significance
- (2015) Amro Elgheznawy et al. CIRCULATION RESEARCH
- Potent irreversible P2Y12 inhibition does not reduce LPS-induced coagulation activation in a randomized, double-blind, placebo-controlled trial
- (2015) C. Schoergenhofer et al. CLINICAL SCIENCE
- Mediators and molecular pathways involved in the regulation of neutrophil extracellular trap formation mediated by activated platelets
- (2015) Agostina Carestia et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Expression and functionality of Toll-like receptor 3 in the megakaryocytic lineage
- (2015) L. P. D'Atri et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- Crosstalk between platelets and PBMC: New evidence in wound healing
- (2015) Niccolò Nami et al. PLATELETS
- Differential effects of platelets and platelet inhibition by ticagrelor on TLR2- and TLR4-mediated inflammatory responses
- (2015) Andre J. van der Ven et al. THROMBOSIS AND HAEMOSTASIS
- Platelet components associated with adverse reactions: predictive value of mitochondrial DNA relative to biological response modifiers
- (2015) Fabrice Cognasse et al. TRANSFUSION
- Platelets in Inflammation: Regulation of Leukocyte Activities and Vascular Repair
- (2015) Angèle Gros et al. Frontiers in Immunology
- Platelet Transfusion – The New Immunology of an Old Therapy
- (2015) Moritz Stolla et al. Frontiers in Immunology
- Breaking the Mold: Transcription Factors in the Anucleate Platelet and Platelet-Derived Microparticles
- (2015) Katie L. Lannan et al. Frontiers in Immunology
- Inhibition of Glycoprotein VI Clustering by Collagen as a Mechanism of Inhibiting Collagen-Induced Platelet Responses: The Example of Losartan
- (2015) Peng Jiang et al. PLoS One
- Mitochondria in lung biology and pathology: more than just a powerhouse
- (2014) Paul T. Schumacker et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Human Cytomegalovirus–Platelet Interaction Triggers Toll-Like Receptor 2–Dependent Proinflammatory and Proangiogenic Responses
- (2014) Alice Assinger et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Toll like receptor 2/1 mediated platelet adhesion and activation on bacterial mimetic surfaces is dependent on src/Syk-signaling and purinergic receptor P2X1 and P2Y12 activation
- (2014) Kristin Klarström Engström et al. Biointerphases
- Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation
- (2014) L. H. Boudreau et al. BLOOD
- Platelet-TLR7 mediates host survival and platelet count during viral infection in the absence of platelet-dependent thrombosis
- (2014) M. Koupenova et al. BLOOD
- The Balancing Act of Neutrophils
- (2014) Bart W. Bardoel et al. Cell Host & Microbe
- Human platelets express Toll-like receptor 3 and respond to poly I:C
- (2014) Antonio-Santos Anabel et al. HUMAN IMMUNOLOGY
- The Signaling Role of CD40 Ligand in Platelet Biology and in Platelet Component Transfusion
- (2014) Chaker Aloui et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Activated platelets present high mobility group box 1 to neutrophils, inducing autophagy and promoting the extrusion of neutrophil extracellular traps
- (2014) N. Maugeri et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- Association of plasma miR-223 and platelet reactivity in patients with coronary artery disease on dual antiplatelet therapy: A preliminary report
- (2014) Bernadeta Chyrchel et al. PLATELETS
- Maresin 1 biosynthesis during platelet–neutrophil interactions is organ-protective
- (2014) Raja-Elie E. Abdulnour et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Neutrophils scan for activated platelets to initiate inflammation
- (2014) Vinatha Sreeramkumar et al. SCIENCE
- Neutrophil Elastase Causes Tissue Damage That Decreases Host Tolerance to Lung Infection with Burkholderia Species
- (2014) Manoranjan Sahoo et al. PLoS Pathogens
- Toll-Like Receptor Signaling Pathways
- (2014) Takumi Kawasaki et al. Frontiers in Immunology
- HMGB1 promotes neutrophil extracellular trap formation through interactions with Toll-like receptor 4
- (2013) Jean-Marc Tadie et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patients With Severe Sepsis
- (2013) Steven M. Opal et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Activated Platelets Enhance IL-10 Secretion and Reduce TNF- Secretion by Monocytes
- (2013) S. Gudbrandsdottir et al. JOURNAL OF IMMUNOLOGY
- Distinct effects of Re- and S-forms of LPS on modulating platelet activation
- (2013) J. Kappelmayer et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- Decreased circulating microRNA-223 level predicts high on-treatment platelet reactivity in patients with troponin-negative non-ST elevation acute coronary syndrome
- (2013) Ying-Ying Zhang et al. JOURNAL OF THROMBOSIS AND THROMBOLYSIS
- The TLR4 antagonist Eritoran protects mice from lethal influenza infection
- (2013) Kari Ann Shirey et al. NATURE
- Mitochondrial DAMPs Increase Endothelial Permeability through Neutrophil Dependent and Independent Pathways
- (2013) Shiqin Sun et al. PLoS One
- Decreased platelet miR-223 expression is associated with high on-clopidogrel platelet reactivity
- (2013) Rui Shi et al. THROMBOSIS RESEARCH
- Regulation of platelet responses triggered by Toll-like receptor 2 and 4 ligands is another non-genomic role of nuclear factor-kappaB
- (2013) Leonardo Rivadeneyra et al. THROMBOSIS RESEARCH
- Platelet secretion is kinetically heterogeneous in an agonist-responsive manner
- (2012) D. Jonnalagadda et al. BLOOD
- Engagement of Platelet Toll-Like Receptor 9 by Novel Endogenous Ligands Promotes Platelet Hyperreactivity and Thrombosis
- (2012) Soumya Panigrahi et al. CIRCULATION RESEARCH
- Human platelets can discriminate between various bacterial LPS isoforms via TLR4 signaling and differential cytokine secretion
- (2012) Julien Berthet et al. CLINICAL IMMUNOLOGY
- Cytokine Secretion from Human Monocytes Potentiated by P-Selectin-Mediated Cell Adhesion
- (2012) Junsuke Suzuki et al. INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
- T granules in human platelets function in TLR9 organization and signaling
- (2012) Jonathan N. Thon et al. JOURNAL OF CELL BIOLOGY
- Inducible MicroRNA-223 Down-Regulation Promotes TLR-Triggered IL-6 and IL-1β Production in Macrophages by Targeting STAT3
- (2012) Qingyun Chen et al. PLoS One
- Periodontopathogens induce expression of CD40L on human platelets via TLR2 and TLR4
- (2012) Alice Assinger et al. THROMBOSIS RESEARCH
- Quantitative immunofluorescence mapping reveals little functional coclustering of proteins within platelet -granules
- (2011) J. Kamykowski et al. BLOOD
- Microparticles (Ectosomes) Shed by Stored Human Platelets Downregulate Macrophages and Modify the Development of Dendritic Cells
- (2011) S. Sadallah et al. JOURNAL OF IMMUNOLOGY
- Lipopolysaccharide Signaling without a Nucleus: Kinase Cascades Stimulate Platelet Shedding of Proinflammatory IL-1 -Rich Microparticles
- (2011) G. T. Brown et al. JOURNAL OF IMMUNOLOGY
- Efficient phagocytosis of periodontopathogens by neutrophils requires plasma factors, platelets and TLR2
- (2011) A. ASSINGER et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- Cardiovascular disease and the role of oral bacteria
- (2011) Shaneen J. Leishman et al. Journal of Oral Microbiology
- Platelet, Not Endothelial, P-Selectin Expression Contributes to Generation of Immunity in Cutaneous Contact Hypersensitivity
- (2010) Ralf J. Ludwig et al. AMERICAN JOURNAL OF PATHOLOGY
- Direct Angiotensin II Type 2 Receptor Stimulation Acts Anti-Inflammatory Through Epoxyeicosatrienoic Acid and Inhibition of Nuclear Factor κB
- (2010) Franziska Rompe et al. HYPERTENSION
- Losartan inhibits LPS-induced inflammatory signaling through a PPARγ-dependent mechanism in human THP-1 macrophages
- (2010) Jianbo An et al. HYPERTENSION RESEARCH
- Invasive Streptococcus pneumoniae trigger platelet activation via Toll-like receptor 2
- (2010) C. KEANE et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- Circulating mitochondrial DAMPs cause inflammatory responses to injury
- (2010) Qin Zhang et al. NATURE
- Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
- (2010) Kiichi Nakahira et al. NATURE IMMUNOLOGY
- A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release
- (2010) H. Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Nuclear Emancipation: A Platelet Tour de Force
- (2010) S. L. Spinelli et al. Science Signaling
- MITOCHONDRIAL DNA IS RELEASED BY SHOCK AND ACTIVATES NEUTROPHILS VIA P38 MAP KINASE
- (2010) Qin Zhang et al. SHOCK
- Platelets and Megakaryocytes Contain Functional Nuclear Factor-κB
- (2009) Sherry L. Spinelli et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury
- (2009) Mark R. Looney et al. JOURNAL OF CLINICAL INVESTIGATION
- Lipopolysaccharide Stimulates Platelet Secretion and Potentiates Platelet Aggregation via TLR4/MyD88 and the cGMP-Dependent Protein Kinase Pathway
- (2009) G. Zhang et al. JOURNAL OF IMMUNOLOGY
- NF-κB inhibitors impair platelet activation responses
- (2009) E. MALAVER et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- Existence of a microRNA pathway in anucleate platelets
- (2009) Patricia Landry et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Preliminary evidence for a matrix metalloproteinase-2 (MMP-2)-dependent shedding of soluble CD40 ligand (sCD40L) from activated platelets
- (2009) Stephan Reinboldt et al. PLATELETS
- Immune versus thrombotic stimulation of platelets differentially regulates signalling pathways, intracellular protein-protein interactions, and α-granule release
- (2009) Sybille Rex et al. THROMBOSIS AND HAEMOSTASIS
- Toll-like receptor 2 stimulation of platelets is mediated by purinergic P2X1-dependent Ca2+ mobilisation, cyclooxygenase and purinergic P2Y1 and P2Y12 receptor activation
- (2009) Caroline Skoglund et al. THROMBOSIS AND HAEMOSTASIS
- Defective circulating CD25 regulatory T cells in patients with chronic immune thrombocytopenic purpura
- (2008) J. Yu et al. BLOOD
- Stimulation of Toll-Like Receptor 2 in Human Platelets Induces a Thromboinflammatory Response Through Activation of Phosphoinositide 3-Kinase
- (2008) Price Blair et al. CIRCULATION RESEARCH
- The platelet release reaction: just when you thought platelet secretion was simple
- (2008) Qiansheng Ren et al. CURRENT OPINION IN HEMATOLOGY
- Differential expression of microRNAs in hematopoietic cell lineages
- (2008) Michaela Merkerova et al. EUROPEAN JOURNAL OF HAEMATOLOGY
- A systematic review and meta-analyses on C-reactive protein in relation to periodontitis
- (2008) Spiros Paraskevas et al. JOURNAL OF CLINICAL PERIODONTOLOGY
- Induction of inflammatory and immune responses by HMGB1–nucleosome complexes: implications for the pathogenesis of SLE
- (2008) Vilma Urbonaviciute et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The periodontal pathogenPorphyromonas gingivalissensitises human blood platelets to epinephrine
- (2008) M. Nylander et al. PLATELETS
- Donor platelets stored for at least 3 days can elicit activation marker expression by the recipient's blood mononuclear cells: an in vitrostudy
- (2008) Fabrice Cognasse et al. TRANSFUSION
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started