Hepatic mitochondrial DNA/Toll-like receptor 9/MicroRNA-223 forms a negative feedback loop to limit neutrophil overactivation and acetaminophen hepatotoxicity in mice

The novel TLR9 antagonist COV08-0064 protects from ischemia/reperfusion injury in non-steatotic and steatotic mice livers

(2016) Mohamed E. Shaker et al.   BIOCHEMICAL PHARMACOLOGY

CD205-TLR9-IL-12 axis contributes to CpG-induced oversensitive liver injury in HBsAg transgenic mice by promoting the interaction of NKT cells with Kupffer cells

(2016) Xin Hou et al.   Cellular & Molecular Immunology

The emerging role of miR-223 as novel potential diagnostic and therapeutic target for inflammatory disorders

(2016) Faisal Aziz   CELLULAR IMMUNOLOGY

MicroRNA-223 ameliorates alcoholic liver injury by inhibiting the IL-6–p47 phox –oxidative stress pathway in neutrophils

(2016) Man Li et al.   GUT

Chemokine (C-C motif) receptor 2-positive monocytes aggravate the early phase of acetaminophen-induced acute liver injury

(2016) Jana C. Mossanen et al.   HEPATOLOGY

c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src

(2016) Sanda Win et al.   HEPATOLOGY

A novel high mobility group box 1 neutralizing chimeric antibody attenuates drug-induced liver injury and postinjury inflammation in mice

(2016) Peter Lundbäck et al.   HEPATOLOGY

Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9

(2016) Irma Garcia-Martinez et al.   JOURNAL OF CLINICAL INVESTIGATION

miR-223 Deficiency Protects against Fas-Induced Hepatocyte Apoptosis and Liver Injury through Targeting Insulin-Like Growth Factor 1 Receptor

(2015) Ximena V. Qadir et al.   AMERICAN JOURNAL OF PATHOLOGY

TLR2 and TLR9 contribute to alcohol-mediated liver injury through induction of CXCL1 and neutrophil infiltration

(2015) Yoon Seok Roh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Acetaminophen: Dose-Dependent Drug Hepatotoxicity and Acute Liver Failure in Patients

(2015) Hartmut Jaeschke   DIGESTIVE DISEASES

Damage-associated molecular pattern-activated neutrophil extracellular trap exacerbates sterile inflammatory liver injury

(2015) Hai Huang et al.   HEPATOLOGY

Hepatic DNA deposition drives drug-induced liver injury and inflammation in mice

(2014) Pedro Elias Marques et al.   HEPATOLOGY

MicroRNA-223 coordinates cholesterol homeostasis

(2014) Kasey C. Vickers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating microRNA profiles in human patients with acetaminophen hepatotoxicity or ischemic hepatitis

(2014) J. Ward et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophil activation during acetaminophen hepatotoxicity and repair in mice and humans

(2014) C. David Williams et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Acetaminophen-related Hepatotoxicity

(2013) Chalermrat Bunchorntavakul et al.   Clinics in Liver Disease

Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital

(2013) Daniel J. Antoine et al.   HEPATOLOGY

MicroRNA-223 controls susceptibility to tuberculosis by regulating lung neutrophil recruitment

(2013) Anca Dorhoi et al.   JOURNAL OF CLINICAL INVESTIGATION

Toll Like Receptor 3 Plays a Critical Role in the Progression and Severity of Acetaminophen-Induced Hepatotoxicity

(2013) Karen A. Cavassani et al.   PLoS One

Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases

(2012) Shashi Bala et al.   HEPATOLOGY

Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure

(2012) Pedro E. Marques et al.   HEPATOLOGY

Increased susceptibility of natural killer T-cell-deficient mice to acetaminophen-induced liver injury

(2012) Brittany V. Martin-Murphy et al.   HEPATOLOGY

G-CSF-activated STAT3 enhances production of the chemokine MIP-2 in bone marrow neutrophils

(2012) Hoainam T. Nguyen-Jackson et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Circulating microRNAs as potential markers of human drug-induced liver injury

(2011) Philip J. Starkey Lewis et al.   HEPATOLOGY

Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity

(2011) Hartmut Jaeschke et al.   LIVER INTERNATIONAL

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

MicroRNAs modulate the noncanonical transcription factor NF-κB pathway by regulating expression of the kinase IKKα during macrophage differentiation

(2010) Tao Li et al.   NATURE IMMUNOLOGY

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Role of NF-κB in the Regulation of Cytochrome P450 Enzymes

(2009) Beshay Zordoky et al.   CURRENT DRUG METABOLISM

Toll-like receptor 9 inhibition confers protection from liver ischemia-reperfusion injury

(2009) Zubin M. Bamboat et al.   HEPATOLOGY

Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation

(2009) Yanming Wang et al.   JOURNAL OF CELL BIOLOGY

Innate immunity turned inside-out: antimicrobial defense by phagocyte extracellular traps

(2009) Maren von Köckritz-Blickwede et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Toll-like receptor 9 agonists up-regulates the expression of cyclooxygenase-2 via activation of NF-κB in prostate cancer cells

(2009) Jin Ming Di et al.   MOLECULAR BIOLOGY REPORTS

Circulating microRNAs, potential biomarkers for drug-induced liver injury

(2009) K. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The IKK Complex, a Central Regulator of NF- B Activation

(2009) A. Israel   Cold Spring Harbor Perspectives in Biology

MicroRNA-223 Is Commonly Repressed in Hepatocellular Carcinoma and Potentiates Expression of Stathmin1

(2008) Queenie W.–L. Wong et al.   GASTROENTEROLOGY

Regulation of progenitor cell proliferation and granulocyte function by microRNA-223

(2008) Jonathan B. Johnnidis et al.   NATURE