Inhibition of Glycoprotein VI Clustering by Collagen as a Mechanism of Inhibiting Collagen-Induced Platelet Responses: The Example of Losartan

Insights into the molecular basis of action of the AT1 antagonist losartan using a combined NMR spectroscopy and computational approach

(2014) Maria Zervou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Discovery of Novel GPVI Receptor Antagonists by Structure-Based Repurposing

(2014) Lewis Taylor et al.   PLoS One

Usefulness of Losartan on the Size of the Ascending Aorta in an Unselected Cohort of Children, Adolescents, and Young Adults With Marfan Syndrome

(2013) Christiane Pees et al.   AMERICAN JOURNAL OF CARDIOLOGY

Modulation of Transforming Growth Factor-  Signaling and Extracellular Matrix Production in Myxomatous Mitral Valves by Angiotensin II Receptor Blockers

(2012) A. Geirsson et al.   CIRCULATION

Constitutive Dimerization of Glycoprotein VI (GPVI) in Resting Platelets Is Essential for Binding to Collagen and Activation in Flowing Blood

(2012) Stephanie M. Jung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design and reshaping of an scFv directed against human platelet glycoprotein VI with diagnostic potential

(2011) Muhammad Zahid et al.   ANALYTICAL BIOCHEMISTRY

Platelet Glycoprotein VI Dimerization, an Active Process Inducing Receptor Competence, Is an Indicator of Platelet Reactivity

(2011) Stéphane Loyau et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Renin–angiotensin system inhibitors reduce the progression of mesangioproliferative glomerulonephritis: 10year follow-up

(2011) Pierangela Presta et al.   European Journal of Internal Medicine

Characterization of the In Vivo Antiplatelet Activity of the Antihypertensive Agent Losartan

(2011) John P. Murad et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Platelet Recruitment to the Inflamed Glomerulus Occurs via an αIIbβ3/GPVI-Dependent Pathway

(2010) Sapna Devi et al.   AMERICAN JOURNAL OF PATHOLOGY

Thromboxane prostanoid receptor stimulation induces shedding of the transmembrane chemokine CX3CL1 yet enhances CX3CL1-dependent leukocyte adhesion

(2010) Soumitra Tole et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Rationale and design of a randomized clinical trial (Marfan Sartan) of angiotensin II receptor blocker therapy versus placebo in individuals with Marfan syndrome

(2010) Delphine Detaint et al.   Archives of Cardiovascular Diseases

Angiotensin II–Mediated Microvascular Thrombosis

(2010) Elena Y. Senchenkova et al.   HYPERTENSION

Structural Basis for Platelet Antiaggregation by Angiotensin II Type 1 Receptor Antagonist Losartan (DuP-753) via Glycoprotein VI

(2010) Katsuki Ono et al.   JOURNAL OF MEDICINAL CHEMISTRY

Diagnostic and Therapeutic Potentials of Platelet Glycoprotein VI

(2010) Boris Bigalke et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Dilation-Dependent Activation of Platelets and Prothrombin in Human Thoracic Ascending Aortic Aneurysm

(2008) Ziad Touat et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Novel mechanistic concept of platelet inhibition

(2008) Alexander B Sigalov   EXPERT OPINION ON THERAPEUTIC TARGETS

Low-Dose Losartan Therapy Reduces Proteinuria in Normotensive Patients with Immunoglobulin A Nephropathy

(2008) Ari SHIMIZU et al.   HYPERTENSION RESEARCH

Angiotensin II Blockade and Aortic-Root Dilation in Marfan's Syndrome

(2008) Benjamin S. Brooke et al.   NEW ENGLAND JOURNAL OF MEDICINE