MmpL3 Inhibition: A New Approach to Treat Nontuberculous Mycobacterial Infections

Beyond antibiotics for pulmonary nontuberculous mycobacterial disease

(2020) Grant Waterer   CURRENT OPINION IN PULMONARY MEDICINE

Non-tuberculous mycobacteria and the rise of Mycobacterium abscessus

(2020) Matt D. Johansen et al.   NATURE REVIEWS MICROBIOLOGY

Macrophage Signaling Pathways in Pulmonary Nontuberculous Mycobacteria Infections

(2020) Zohra Prasla et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Identification and drug susceptibility testing for nontuberculous mycobacteria

(2020) Wei-Chang Huang et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

New tuberculosis drug targets, their inhibitors, and potential therapeutic impact

(2020) Gauri S. Shetye et al.   Translational Research

Structure‐Based Design and Synthesis of Piperidinol‐Containing Molecules as New Mycobacterium abscessus Inhibitors

(2020) Jérôme Ruyck et al.   ChemistryOpen

Potency Increase of Spiroketal Analogs of Membrane Inserting Indolyl Mannich Base Antimycobacterials Is Due to Acquisition of MmpL3 Inhibition

(2020) Ming Li et al.   ACS Infectious Diseases

Treatment of Nontuberculous Mycobacterial Pulmonary Disease: An Official ATS/ERS/ESCMID/IDSA Clinical Practice Guideline: Executive Summary

(2020) Charles L Daley et al.   CLINICAL INFECTIOUS DISEASES

Direct Inhibition of MmpL3 by Novel Antitubercular Compounds

(2019) Wei Li et al.   ACS Infectious Diseases

Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against Mycobacterium tuberculosis. Part II

(2019) Wei Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mycobacterium abscessus pulmonary disease: individual patient data meta-analysis

(2019) Nakwon Kwak et al.   EUROPEAN RESPIRATORY JOURNAL

Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target

(2019) Bing Zhang et al.   CELL

Advancing the therapeutic potential of indoleamides for tuberculosis

(2019) Shichun Lun et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

MmpL3 is a lipid transporter that binds trehalose monomycolate and phosphatidylethanolamine

(2019) Chih-Chia Su et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemical disarming of isoniazid resistance in Mycobacterium tuberculosis

(2019) Kelly Flentie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

1H-benzo[d]imidazole derivatives affect MmpL3 in Mycobacterium tuberculosis

(2019) Małgorzata Korycka-Machała et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Bedaquiline Eliminates Bactericidal Activity of β-Lactams against Mycobacterium abscessus

(2019) Marissa Lindman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antimycobacterial Susceptibility Testing of Nontuberculous Mycobacteria

(2019) Barbara A. Brown-Elliott et al.   JOURNAL OF CLINICAL MICROBIOLOGY

The MmpL3 interactome reveals a complex crosstalk between cell envelope biosynthesis and cell elongation and division in mycobacteria

(2019) Juan Manuel Belardinelli et al.   Scientific Reports

Editorial: NTM—The New Uber-Bugs

(2019) Veronique Dartois et al.   Frontiers in Microbiology

Identification of New MmpL3 Inhibitors by Untargeted and Targeted Mutant Screens Defines MmpL3 Domains with Differential Resistance

(2019) John T. Williams et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Novel Pyrazole-Containing Compounds Active against Mycobacterium tuberculosis

(2019) Giovanna Poce et al.   ACS Medicinal Chemistry Letters

Mycobacterium abscessus, an Emerging and Worrisome Pathogen among Cystic Fibrosis Patients

(2019) Degiacomi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A piperidinol-containing molecule is active against Mycobacterium tuberculosis by inhibiting the mycolic acid flippase activity of MmpL3

(2019) Christian Dupont et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of novel scaffolds targeting Mycobacterium tuberculosis

(2019) Michael Dal Molin et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The mycobacterial cell envelope — a moving target

(2019) Charles L. Dulberger et al.   NATURE REVIEWS MICROBIOLOGY

Electrochemistry of ring-substituted 1-hydroxynaphthalene-2-carboxanilides: Relation to structure and biological activity

(2019) Július Gajdár et al.   ELECTROCHIMICA ACTA

Active Benzimidazole Derivatives Targeting the MmpL3 Transporter in Mycobacterium abscessus

(2019) Clément Raynaud et al.   ACS Infectious Diseases

Rifabutin acts in synergy and is bactericidal with frontline Mycobacterium abscessus antibiotics clarithromycin and tigecycline, suggesting a potent treatment combination

(2018) Mark Pryjma et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

HC2091 Kills Mycobacterium tuberculosis by Targeting the MmpL3 Mycolic Acid Transporter

(2018) Huiqing Zheng et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

NTM drug discovery: status, gaps and the way forward

(2018) Mu-Lu Wu et al.   DRUG DISCOVERY TODAY

Indolyl Azaspiroketal Mannich Bases Are Potent Antimycobacterial Agents with Selective Membrane Permeabilizing Effects and in Vivo Activity

(2018) Samuel Agyei Nyantakyi et al.   JOURNAL OF MEDICINAL CHEMISTRY

NonTuberculous Mycobacteria infection and lung transplantation in cystic fibrosis: a worldwide survey of clinical practice

(2018) Adrien Tissot et al.   BMC Pulmonary Medicine

MmpL3 as a Target for the Treatment of Drug-Resistant Nontuberculous Mycobacterial Infections

(2018) Wei Li et al.   Frontiers in Microbiology

Discovery of benzothiazole amides as potent antimycobacterial agents

(2018) James Graham et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of heterocyclic replacements for the coumarin core of anti-tubercular FadD32 inhibitors

(2018) Chao Fang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Optimization and Lead Selection of Benzothiazole Amide Analogs Toward a Novel Antimycobacterial Agent

(2018) Mary A. De Groote et al.   Frontiers in Microbiology

A description of Mycobacterium chelonae subsp. gwanakae subsp. nov., a rapidly growing mycobacterium with a smooth colony phenotype due to glycopeptidolipids

(2018) Byoung-Jun Kim et al.   INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY

Novel Acetamide Indirectly Targets Mycobacterial Transporter MmpL3 by Proton Motive Force Disruption

(2018) Annanya Shetty et al.   Frontiers in Microbiology

Disinfectant Susceptibility Profiling of Glutaraldehyde-Resistant Nontuberculous Mycobacteria

(2017) Winona Burgess et al.   INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY

The new phylogeny of the genus Mycobacterium : The old and the news

(2017) Enrico Tortoli et al.   INFECTION GENETICS AND EVOLUTION

Targeting Mycolic Acid Transport by Indole-2-carboxamides for the Treatment of Mycobacterium abscessus Infections

(2017) Alan P. Kozikowski et al.   JOURNAL OF MEDICINAL CHEMISTRY

Amphiphilic Indole Derivatives as Antimycobacterial Agents: Structure–Activity Relationships and Membrane Targeting Properties

(2017) Tianming Yang et al.   JOURNAL OF MEDICINAL CHEMISTRY

MmpL3 is the flippase for mycolic acids in mycobacteria

(2017) Zhujun Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reversion of antibiotic resistance inMycobacterium tuberculosisby spiroisoxazoline SMARt-420

(2017) Nicolas Blondiaux et al.   SCIENCE

Genomic Insight into Mechanisms of Reversion of Antibiotic Resistance in Multidrug Resistant Mycobacterium tuberculosis Induced by a Nanomolecular Iodine-Containing Complex FS-1

(2017) Aleksandr I. Ilin et al.   Frontiers in Cellular and Infection Microbiology

Screening of TB Actives for Activity against Nontuberculous Mycobacteria Delivers High Hit Rates

(2017) Jian Liang Low et al.   Frontiers in Microbiology

Essentiality of mmpL3 and impact of its silencing on Mycobacterium tuberculosis gene expression

(2017) Giulia Degiacomi et al.   Scientific Reports

Tigecycline Potentiates Clarithromycin Activity against Mycobacterium avium In Vitro

(2016) Hannelore I. Bax et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Therapeutic Potential of the Mycobacterium tuberculosis Mycolic Acid Transporter, MmpL3

(2016) Wei Li et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Progression and Treatment Outcomes of Lung Disease Caused byMycobacterium abscessusandMycobacterium massiliense

(2016) Jimyung Park et al.   CLINICAL INFECTIOUS DISEASES

Mycobacterial Characteristics and Treatment Outcomes inMycobacterium abscessusLung Disease

(2016) Won-Jung Koh et al.   CLINICAL INFECTIOUS DISEASES

Indole-2-carboxamide-based MmpL3 Inhibitors Show Exceptional Antitubercular Activity in an Animal Model of Tuberculosis Infection

(2016) Jozef Stec et al.   JOURNAL OF MEDICINAL CHEMISTRY

A new piperidinol derivative targeting mycolic acid transport inMycobacterium abscessus

(2016) Christian Dupont et al.   MOLECULAR MICROBIOLOGY

Structure of the Essential Mtb FadD32 Enzyme: A Promising Drug Target for Treating Tuberculosis

(2016) Misty L. Kuhn et al.   ACS Infectious Diseases

Structure–Function Profile of MmpL3, the Essential Mycolic Acid Transporter from Mycobacterium tuberculosis

(2016) Juan Manuel Belardinelli et al.   ACS Infectious Diseases

Risk Factors for Recurrence after Successful Treatment of Mycobacterium avium Complex Lung Disease

(2015) Bo Young Lee et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Clofazimine Prevents the Regrowth of Mycobacterium abscessus and Mycobacterium avium Type Strains Exposed to Amikacin and Clarithromycin

(2015) Beatriz E. Ferro et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthesis and evaluation of in vitro antimycobacterial activity of novel 1H-benzo[d]imidazole derivatives and analogues

(2015) Katarzyna Gobis et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Nontuberculous Mycobacteria in Cystic Fibrosis and Non–Cystic Fibrosis Bronchiectasis

(2015) In Park et al.   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

Novel Insights into the Mechanism of Inhibition of MmpL3, a Target of Multiple Pharmacophores in Mycobacterium tuberculosis

(2014) Wei Li et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mycolic Acids: Structures, Biosynthesis, and Beyond

(2014) Hedia Marrakchi et al.   CHEMISTRY & BIOLOGY

New Approaches to Target the Mycolic Acid Biosynthesis Pathway for the Development of Tuberculosis Therapeutics

(2014) E. North et al.   CURRENT PHARMACEUTICAL DESIGN

N-Arylalkylbenzo[d]thiazole-2-carboxamides as anti-mycobacterial agents: design, new methods of synthesis and biological evaluation

(2014) Parth Shah et al.   MedChemComm

Fueling Open-Source Drug Discovery: 177 Small-Molecule Leads against Tuberculosis

(2013) Lluís Ballell et al.   ChemMedChem

Preliminary Structure–Activity Relationships and Biological Evaluation of Novel Antitubercular Indolecarboxamide Derivatives Against Drug-Susceptible and Drug-Resistant Mycobacterium tuberculosis Strains

(2013) Oluseye K. Onajole et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Biological Evaluation of Indole-2-carboxamides: A Promising Class of Antituberculosis Agents

(2013) Ravinder Reddy Kondreddi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis

(2013) Regina Wilson et al.   Nature Chemical Biology

Improved BM212 MmpL3 Inhibitor Analogue Shows Efficacy in Acute Murine Model of Tuberculosis Infection

(2013) Giovanna Poce et al.   PLoS One

Tetrahydropyrazolo[1,5-a]Pyrimidine-3-Carboxamide and N-Benzyl-6′,7′-Dihydrospiro[Piperidine-4,4′-Thieno[3,2-c]Pyran] Analogues with Bactericidal Efficacy against Mycobacterium tuberculosis Targeting MmpL3

(2013) Modesto J. Remuiñán et al.   PLoS One

Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32

(2013) S. A. Stanley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Indolcarboxamide Is a Preclinical Candidate for Treating Multidrug-Resistant Tuberculosis

(2013) S. P. S. Rao et al.   Science Translational Medicine

Indoleamides are active against drug-resistant Mycobacterium tuberculosis

(2013) Shichun Lun et al.   Nature Communications

Identification of Novel Inhibitors of M. tuberculosis Growth Using Whole Cell Based High-Throughput Screening

(2012) Sarah A. Stanley et al.   ACS Chemical Biology

SQ109 Targets MmpL3, a Membrane Transporter of Trehalose Monomycolate Involved in Mycolic Acid Donation to the Cell Wall Core of Mycobacterium tuberculosis

(2012) Kapil Tahlan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane

(2012) Anna E Grzegorzewicz et al.   Nature Chemical Biology

Chronic respiratory disease, inhaled corticosteroids and risk of non-tuberculous mycobacteriosis

(2012) Claire Andréjak et al.   THORAX

Investigations of genotoxic activity of antimicrobial/antiviral agent FS-1 in human lymphocytes and tumor cell

(2011) A. Nersesyan et al.   Cytology and Genetics

Bacterial Growth and Cell Division: a Mycobacterial Perspective

(2008) E. C. Hett et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS