The mycobacterial cell envelope — a moving target

Sequential assembly of the septal cell envelope prior to V snapping in Corynebacterium glutamicum

(2019) Xiaoxue Zhou et al.   Nature Chemical Biology

Path‐seq identifies an essential mycolate remodeling program for mycobacterial host adaptation

(2019) Eliza JR Peterson et al.   Molecular Systems Biology

Imaging mycobacterial growth and division with a fluorogenic probe

(2018) Heather L. Hodges et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stress-Induced Reorganization of the Mycobacterial Membrane Domain

(2018) Jennifer M. Hayashi et al.   mBio

Multisystem Analysis of Mycobacterium tuberculosis Reveals Kinase-Dependent Remodeling of the Pathogen-Environment Interface

(2018) Xavier Carette et al.   mBio

Two Faces of CwlM, an Essential PknB Substrate, in Mycobacterium tuberculosis

(2018) Obolbek Turapov et al.   Cell Reports

Maturing Mycobacterium smegmatis peptidoglycan requires non-canonical crosslinks to maintain shape

(2018) Catherine Baranowski et al.   eLife

Protein kinase G confers survival advantage toMycobacterium tuberculosisduring latency-like conditions

(2017) Mehak Zahoor Khan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deletion of a mycobacterial divisome factor collapses single-cell phenotypic heterogeneity

(2017) E. Hesper Rego et al.   NATURE

Mycobacterium tuberculosisinhibits human innate immune responses via the production of TLR2 antagonist glycolipids

(2017) Landry Blanc et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD1b-restricted GEM T cell responses are modulated byMycobacterium tuberculosismycolic acid meromycolate chains

(2017) Andrew Chancellor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MmpL3 is the flippase for mycolic acids in mycobacteria

(2017) Zhujun Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mycobacterial ESX-1 secretion system mediates host cell lysis through bacterium contact-dependent gross membrane disruptions

(2017) William H. Conrad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct Spatiotemporal Dynamics of Peptidoglycan Synthesis between Mycobacterium smegmatis and Mycobacterium tuberculosis

(2017) Helene Botella et al.   mBio

The Cell Wall Lipid PDIM Contributes to Phagosomal Escape and Host Cell Exit of Mycobacterium tuberculosis

(2017) Jeff Quigley et al.   mBio

Mycobacterium tuberculosis universal stress protein Rv2623 interacts with the putative ATP binding cassette (ABC) transporter Rv1747 to regulate mycobacterial growth

(2017) Lisa N. Glass et al.   PLoS Pathogens

Systematic, multiparametric analysis of Mycobacterium tuberculosis intracellular infection offers insight into coordinated virulence

(2017) Amy K. Barczak et al.   PLoS Pathogens

Metabolic anticipation in Mycobacterium tuberculosis

(2017) Hyungjin Eoh et al.   Nature Microbiology

Division site selection linked to inherited cell surface wave troughs in mycobacteria

(2017) Haig A. Eskandarian et al.   Nature Microbiology

Lipoarabinomannan-Responsive Polycytotoxic T Cells Are Associated with Protection in Human Tuberculosis

(2016) Martin Busch et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Therapeutic Potential of the Mycobacterium tuberculosis Mycolic Acid Transporter, MmpL3

(2016) Wei Li et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Indole-2-carboxamide-based MmpL3 Inhibitors Show Exceptional Antitubercular Activity in an Animal Model of Tuberculosis Infection

(2016) Jozef Stec et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Serine/threonine kinase PknL , is involved in the adaptive response of Mycobacterium tuberculosis

(2016) Ahmed Kabir Refaya et al.   MICROBIOLOGICAL RESEARCH

Persisting positron emission tomography lesion activity and Mycobacterium tuberculosis mRNA after tuberculosis cure

(2016) Stephanus T Malherbe et al.   NATURE MEDICINE

Spatially distinct and metabolically active membrane domain in mycobacteria

(2016) Jennifer M. Hayashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A cytoplasmic peptidoglycan amidase homologue controls mycobacterial cell wall synthesis

(2016) Cara C Boutte et al.   eLife

Mild Nutrient Starvation Triggers the Development of a Small-Cell Survival Morphotype in Mycobacteria

(2016) Mu-Lu Wu et al.   Frontiers in Microbiology

Suppression of autophagy and antigen presentation by Mycobacterium tuberculosis PE_PGRS47

(2016) Neeraj K. Saini et al.   Nature Microbiology

Mycobacterium tuberculosis EsxH inhibits ESCRT-dependent CD4+ T-cell activation

(2016) Cynthia Portal-Celhay et al.   Nature Microbiology

Absolute Proteome Composition and Dynamics during Dormancy and Resuscitation of Mycobacterium tuberculosis

(2015) Olga T. Schubert et al.   Cell Host & Microbe

Freund's adjuvant, NOD2 and mycobacteria

(2015) Marcel A Behr et al.   CURRENT OPINION IN MICROBIOLOGY

Peptidoglycan synthesis inMycobacterium tuberculosisis organized into networks with varying drug susceptibility

(2015) Karen J. Kieser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of EspB from the ESX-1 Type VII Secretion System and Insights into its Export Mechanism

(2015) Matthew Solomonson et al.   STRUCTURE

The Mycobacterial Cell Wall—Peptidoglycan and Arabinogalactan

(2015) Luke J. Alderwick et al.   Cold Spring Harbor Perspectives in Medicine

Phosphorylation of the Peptidoglycan Synthase PonA1 Governs the Rate of Polar Elongation in Mycobacteria

(2015) Karen J. Kieser et al.   PLoS Pathogens

Variability in Tuberculosis Granuloma T Cell Responses Exists, but a Balance of Pro- and Anti-inflammatory Cytokines Is Associated with Sterilization

(2015) Hannah Priyadarshini Gideon et al.   PLoS Pathogens

Novel Insights into the Mechanism of Inhibition of MmpL3, a Target of Multiple Pharmacophores in Mycobacterium tuberculosis

(2014) Wei Li et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Host Evasion and Exploitation Schemes of Mycobacterium tuberculosis

(2014) C.J. Cambier et al.   CELL

Mycolic Acids: Structures, Biosynthesis, and Beyond

(2014) Hedia Marrakchi et al.   CHEMISTRY & BIOLOGY

Biochemical and Spatial Coincidence in the Provisional Ser/Thr Protein Kinase Interaction Network ofMycobacterium tuberculosis

(2014) Christina E. Baer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mannan Chain Length Controls Lipoglycans Signaling via and Binding to TLR2

(2014) J. Nigou et al.   JOURNAL OF IMMUNOLOGY

Synthesis of fluorescent D-amino acids and their use for probing peptidoglycan synthesis and bacterial growth in situ

(2014) Erkin Kuru et al.   Nature Protocols

How sisters grow apart: mycobacterial growth and division

(2014) Karen J. Kieser et al.   NATURE REVIEWS MICROBIOLOGY

A Trial of Mass Isoniazid Preventive Therapy for Tuberculosis Control

(2014) Gavin J. Churchyard et al.   NEW ENGLAND JOURNAL OF MEDICINE

Non-Replicating Mycobacterium tuberculosis Elicits a Reduced Infectivity Profile with Corresponding Modifications to the Cell Wall and Extracellular Matrix

(2014) Joanna Bacon et al.   PLoS One

Mycobacterium tuberculosis Proteins Involved in Mycolic Acid Synthesis and Transport Localize Dynamically to the Old Growing Pole and Septum

(2014) Clément Carel et al.   PLoS One

Molecular basis of mycobacterial lipid antigen presentation by CD1c and its recognition by    T cells

(2014) S. Roy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mycobacterial outer membrane is a lipid bilayer and the inner membrane is unusually rich in diacyl phosphatidylinositol dimannosides

(2014) Ritu Bansal-Mutalik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Subpolar addition of new cell wall is directed by DivIVA in mycobacteria

(2014) X. Meniche et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of BCG vaccination against Mycobacterium tuberculosis infection in children: systematic review and meta-analysis

(2014) A. Roy et al.   BMJ-British Medical Journal

Mycobacterium Tuberculosis Proteome Microarray for Global Studies of Protein Function and Immunogenicity

(2014) Jiaoyu Deng et al.   Cell Reports

Mycobacterium tuberculosis Ser/Thr Protein Kinase B Mediates an Oxygen-Dependent Replication Switch

(2014) Corrie Ortega et al.   PLOS BIOLOGY

Correction: Mycobacterium tuberculosis Universal Stress Protein Rv2623 Regulates Bacillary Growth by ATP-Binding: Requirement for Establishing Chronic Persistent Infection

(2014) Joshua E. Drumm et al.   PLoS Pathogens

Phosphorylation of KasB Regulates Virulence and Acid-Fastness in Mycobacterium tuberculosis

(2014) Catherine Vilchèze et al.   PLoS Pathogens

The Immune Response in Tuberculosis

(2013) Anne O'Garra et al.   Annual Review of Immunology

Reduced Drug Uptake in Phenotypically Resistant Nutrient-Starved Nonreplicating Mycobacterium tuberculosis

(2013) Jansy Sarathy et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Tryptophan Biosynthesis Protects Mycobacteria from CD4 T-Cell-Mediated Killing

(2013) Yanjia J. Zhang et al.   CELL

Identification of a New Tuberculosis Antigen Recognized by γδ T Cell Receptor

(2013) Xueyan Xi et al.   Clinical and Vaccine Immunology

Asymmetric growth and division inMycobacteriumspp.: compensatory mechanisms for non-medial septa

(2013) Bhupender Singh et al.   MOLECULAR MICROBIOLOGY

The Mycobacterium tuberculosis regulatory network and hypoxia

(2013) James E. Galagan et al.   NATURE

Mycobacteria manipulate macrophage recruitment through coordinated use of membrane lipids

(2013) C. J. Cambier et al.   NATURE

A conserved human T cell population targets mycobacterial antigens presented by CD1b

(2013) Ildiko Van Rhijn et al.   NATURE IMMUNOLOGY

Sterilization of granulomas is common in active and latent tuberculosis despite within-host variability in bacterial killing

(2013) Philana Ling Lin et al.   NATURE MEDICINE

Improved BM212 MmpL3 Inhibitor Analogue Shows Efficacy in Acute Murine Model of Tuberculosis Infection

(2013) Giovanna Poce et al.   PLoS One

Osmosensory signaling in Mycobacterium tuberculosis mediated by a eukaryotic-like Ser/Thr protein kinase

(2013) S. K. Hatzios et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32

(2013) S. A. Stanley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Keto-Mycolic Acid-Dependent Pellicle Formation Confers Tolerance to Drug-Sensitive Mycobacterium tuberculosis

(2013) D. Sambandan et al.   mBio

Critical Roles for Lipomannan and Lipoarabinomannan in Cell Wall Integrity of Mycobacteria and Pathogenesis of Tuberculosis

(2013) T. Fukuda et al.   mBio

Inactivation of Mycobacterium tuberculosis l,d-Transpeptidase LdtMt1by Carbapenems and Cephalosporins

(2012) Vincent Dubée et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Identification of theMycobacterium tuberculosisprotein PE-PGRS62 as a novel effector that functions to block phagosome maturation and inhibit iNOS expression

(2012) Emily P. Thi et al.   CELLULAR MICROBIOLOGY

ESX-1-mediated translocation to the cytosol controls virulence of mycobacteria

(2012) Diane Houben et al.   CELLULAR MICROBIOLOGY

Phosphorylation of Mycobacterial PcaA Inhibits Mycolic Acid Cyclopropanation

(2012) Rosa Milagros Corrales et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Meropenem inhibits D,D-carboxypeptidase activity inMycobacterium tuberculosis

(2012) Pradeep Kumar et al.   MOLECULAR MICROBIOLOGY

Cell Division Site Placement and Asymmetric Growth in Mycobacteria

(2012) Graham Joyce et al.   PLoS One

Negative regulation by Ser/Thr phosphorylation of HadAB and HadBC dehydratases from Mycobacterium tuberculosis type II fatty acid synthase system

(2011) Nawel Slama et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of Polar Peptidoglycan Biosynthesis by Wag31 Phosphorylation in Mycobacteria

(2011) Charul Jani et al.   BMC MICROBIOLOGY

Downregulation of katG expression is associated with isoniazid resistance in Mycobacterium tuberculosis

(2011) Hiroki Ando et al.   MOLECULAR MICROBIOLOGY

Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection

(2011) Christopher B Ford et al.   NATURE GENETICS

Asymmetry and Aging of Mycobacterial Cells Lead to Variable Growth and Antibiotic Susceptibility

(2011) B. B. Aldridge et al.   SCIENCE

Time-kill kinetics of anti-tuberculosis drugs, and emergence of resistance, in relation to metabolic activity of Mycobacterium tuberculosis

(2010) J. E. M. de Steenwinkel et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Phosphorylation of Enoyl-Acyl Carrier Protein Reductase InhA Impacts Mycobacterial Growth and Survival

(2010) Shazia Khan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of theMycobacterium tuberculosisβ-Ketoacyl-Acyl Carrier Protein Reductase MabA Regulates Mycolic Acid Biosynthesis

(2010) Romain Veyron-Churlet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Basis of Phosphatidyl-myo-inositol Mannoside Biosynthesis and Regulation in Mycobacteria

(2010) Marcelo E. Guerin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Mycobacterium tuberculosis protein LdtMt2 is a nonclassical transpeptidase required for virulence and resistance to amoxicillin

(2010) Radhika Gupta et al.   NATURE MEDICINE

Regulation of antigen presentation by Mycobacterium tuberculosis: a role for Toll-like receptors

(2010) Clifford V. Harding et al.   NATURE REVIEWS MICROBIOLOGY

The Arabinosyltransferase EmbC Is Inhibited by Ethambutol in Mycobacterium tuberculosis

(2009) R. Goude et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mycobacterial survival strategies in the phagosome: defence against host stresses

(2009) Sabine Ehrt et al.   CELLULAR MICROBIOLOGY

How B cells shape the immune response againstMycobacterium tuberculosis

(2009) Paul J. Maglione et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Mycobacterium tuberculosis Sigma Factor  B Is Required for Full Response to Cell Envelope Stress and Hypoxia In Vitro, but It Is Dispensable for In Vivo Growth

(2009) P. A. Fontan et al.   JOURNAL OF BACTERIOLOGY

Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle

(2009) Eri Ishikawa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Degradation-resistant protein domains limit host cell processing and immune detection of mycobacteria

(2009) Kah Wee Koh et al.   MOLECULAR IMMUNOLOGY

A replication clock for Mycobacterium tuberculosis

(2009) Wendy P Gill et al.   NATURE MEDICINE

Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis

(2009) V. Makarov et al.   SCIENCE

Mutations in pimE Restore Lipoarabinomannan Synthesis and Growth in a Mycobacterium smegmatis lpqW Mutant

(2008) P. K. Crellin et al.   JOURNAL OF BACTERIOLOGY

Direct Visualization of the Outer Membrane of Mycobacteria and Corynebacteria in Their Native State

(2008) B. Zuber et al.   JOURNAL OF BACTERIOLOGY

Wag31, a homologue of the cell division protein DivIVA, regulates growth, morphology and polar cell wall synthesis in mycobacteria

(2008) C.-M. Kang et al.   MICROBIOLOGY-SGM

The Enduring Hypoxic Response of Mycobacterium tuberculosis

(2008) Tige R. Rustad et al.   PLoS One

Disclosure of the mycobacterial outer membrane: Cryo-electron tomography and vitreous sections reveal the lipid bilayer structure

(2008) C. Hoffmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA