MmpL3 as a Target for the Treatment of Drug-Resistant Nontuberculous Mycobacterial Infections

In vivo potent BM635 analogue with improved drug-like properties

(2018) Giovanna Poce et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Targeting Mycolic Acid Transport by Indole-2-carboxamides for the Treatment of Mycobacterium abscessus Infections

(2017) Alan P. Kozikowski et al.   JOURNAL OF MEDICINAL CHEMISTRY

MmpL3 is the flippase for mycolic acids in mycobacteria

(2017) Zhujun Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Screening of TB Actives for Activity against Nontuberculous Mycobacteria Delivers High Hit Rates

(2017) Jian Liang Low et al.   Frontiers in Microbiology

Essentiality of mmpL3 and impact of its silencing on Mycobacterium tuberculosis gene expression

(2017) Giulia Degiacomi et al.   Scientific Reports

Therapeutic Potential of the Mycobacterium tuberculosis Mycolic Acid Transporter, MmpL3

(2016) Wei Li et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Nontuberculous Mycobacterial Infections in Cystic Fibrosis

(2016) Stacey L. Martiniano et al.   CLINICS IN CHEST MEDICINE

Indole-2-carboxamide-based MmpL3 Inhibitors Show Exceptional Antitubercular Activity in an Animal Model of Tuberculosis Infection

(2016) Jozef Stec et al.   JOURNAL OF MEDICINAL CHEMISTRY

MmpL3 Inhibitors: Diverse Chemical Scaffolds Inhibit the Same Target

(2016) Giovanna Poce et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

A new piperidinol derivative targeting mycolic acid transport inMycobacterium abscessus

(2016) Christian Dupont et al.   MOLECULAR MICROBIOLOGY

Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium

(2016) Josephine M. Bryant et al.   SCIENCE

Diphenylether-Modified 1,2-Diamines with Improved Drug Properties for Development against Mycobacterium tuberculosis

(2016) Marie H. Foss et al.   ACS Infectious Diseases

Structure–Function Profile of MmpL3, the Essential Mycolic Acid Transporter from Mycobacterium tuberculosis

(2016) Juan Manuel Belardinelli et al.   ACS Infectious Diseases

THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria

(2016) Jonathan A. G. Cox et al.   Nature Microbiology

Emerging bacterial pathogens and changing concepts of bacterial pathogenesis in cystic fibrosis

(2015) Michael D. Parkins et al.   Journal of Cystic Fibrosis

The I-TASSER Suite: protein structure and function prediction

(2015) Jianyi Yang et al.   NATURE METHODS

Antiinfectives targeting enzymes and the proton motive force

(2015) Xinxin Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nontuberculous Mycobacteria in Cystic Fibrosis and Non–Cystic Fibrosis Bronchiectasis

(2015) In Park et al.   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

US Cystic Fibrosis Foundation and European Cystic Fibrosis Society consensus recommendations for the management of non-tuberculous mycobacteria in individuals with cystic fibrosis: executive summary

(2015) R Andres Floto et al.   THORAX

Novel Insights into the Mechanism of Inhibition of MmpL3, a Target of Multiple Pharmacophores in Mycobacterium tuberculosis

(2014) Wei Li et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Lack of Antimicrobial Bactericidal Activity in Mycobacterium abscessus

(2014) Florian P. Maurer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Multitarget Drug Discovery for Tuberculosis and Other Infectious Diseases

(2014) Kai Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and anti-tuberculosis activity of 1-adamantyl-3-heteroaryl ureas with improved in vitro pharmacokinetic properties

(2013) E. Jeffrey North et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Preliminary Structure–Activity Relationships and Biological Evaluation of Novel Antitubercular Indolecarboxamide Derivatives Against Drug-Susceptible and Drug-Resistant Mycobacterium tuberculosis Strains

(2013) Oluseye K. Onajole et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Biological Evaluation of Indole-2-carboxamides: A Promising Class of Antituberculosis Agents

(2013) Ravinder Reddy Kondreddi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tetrahydropyrazolo[1,5-a]Pyrimidine-3-Carboxamide and N-Benzyl-6′,7′-Dihydrospiro[Piperidine-4,4′-Thieno[3,2-c]Pyran] Analogues with Bactericidal Efficacy against Mycobacterium tuberculosis Targeting MmpL3

(2013) Modesto J. Remuiñán et al.   PLoS One

Indolcarboxamide Is a Preclinical Candidate for Treating Multidrug-Resistant Tuberculosis

(2013) S. P. S. Rao et al.   Science Translational Medicine

Discovery of Tetrahydropyrazolopyrimidine Carboxamide Derivatives As Potent and Orally Active Antitubercular Agents

(2013) Fumiaki Yokokawa et al.   ACS Medicinal Chemistry Letters

Indoleamides are active against drug-resistant Mycobacterium tuberculosis

(2013) Shichun Lun et al.   Nature Communications

SQ109 Targets MmpL3, a Membrane Transporter of Trehalose Monomycolate Involved in Mycolic Acid Donation to the Cell Wall Core of Mycobacterium tuberculosis

(2012) Kapil Tahlan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Screening a library of 1600 adamantyl ureas for anti-Mycobacterium tuberculosis activity in vitro and for better physical chemical properties for bioavailability

(2012) Michael S. Scherman et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Accurate multiple sequence alignment of transmembrane proteins with PSI-Coffee

(2012) Jia-Ming Chang et al.   BMC BIOINFORMATICS

Antimicrobial Susceptibility Testing, Drug Resistance Mechanisms, and Therapy of Infections with Nontuberculous Mycobacteria

(2012) B. A. Brown-Elliott et al.   CLINICAL MICROBIOLOGY REVIEWS

Discovery and development of SQ109: a new antitubercular drug with a novel mechanism of action

(2012) Katherine A Sacksteder et al.   Future Microbiology

Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane

(2012) Anna E Grzegorzewicz et al.   Nature Chemical Biology

MmpL3 Is the Cellular Target of the Antitubercular Pyrrole Derivative BM212

(2011) Valentina La Rosa et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The structure–activity relationship of urea derivatives as anti-tuberculosis agents

(2011) Joshua R. Brown et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Clinical and Microbiologic Outcomes in Patients Receiving Treatment for Mycobacterium abscessus Pulmonary Disease

(2011) Julie Jarand et al.   CLINICAL INFECTIOUS DISEASES

Synthesis and evaluation of SQ109 analogues as potential anti-tuberculosis candidates

(2010) Oluseye K. Onajole et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

I-TASSER server for protein 3D structure prediction

(2008) Yang Zhang   BMC BIOINFORMATICS