Recent advances in the role of sphingosine 1‐phosphate in cancer

Sphingosine kinase‐2 is overexpressed in large granular lymphocyte leukaemia and promotes survival through Mcl‐1

(2020) Francis R. LeBlanc et al.   BRITISH JOURNAL OF HAEMATOLOGY

Long noncoding RNA LINC00520 accelerates progression of papillary thyroid carcinoma by serving as a competing endogenous RNA of microRNA-577 to increase Sphk2 expression

(2020) Yu Sun et al.   CELL CYCLE

Modulating sphingosine‐1‐phosphate receptors to improve chemotherapy efficacy against Ewing sarcoma

(2020) Enrica Marmonti et al.   INTERNATIONAL JOURNAL OF CANCER

Discovery of a Small Side Cavity in Sphingosine Kinase 2 that Enhances Inhibitor Potency and Selectivity

(2020) Christopher D. Sibley et al.   JOURNAL OF MEDICINAL CHEMISTRY

Endothelial sphingosine 1-phosphate receptors promote vascular normalization and antitumor therapy

(2020) Andreane Cartier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resistance of melanoma to immune checkpoint inhibitors is overcome by targeting the sphingosine kinase-1

(2020) Caroline Imbert et al.   Nature Communications

Targeting the Sphingolipid System as a Therapeutic Direction for Glioblastoma

(2020) Melinda N. Tea et al.   Cancers

Interleukin-22 Mediates the Chemotactic Migration of Breast Cancer Cells and Macrophage Infiltration of the Bone Microenvironment by Potentiating S1P/SIPR Signaling

(2020) Eun-Young Kim et al.   Cells

Discovery and Characterization of Peptide Inhibitors for Calcium and Integrin Binding Protein 1

(2020) Ana C. Puhl et al.   ACS Chemical Biology

Repression of sphingosine kinase (SK)-interacting protein (SKIP) in acute myeloid leukemia diminishes SK activity and its re-expression restores SK function

(2020) Essam A. Ghazaly et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-wide Screening Identifies SFMBT1 as an Oncogenic Driver in Cancer with VHL Loss

(2020) Xijuan Liu et al.   MOLECULAR CELL

Sphingosine Kinase 1 Regulates the Survival of Breast Cancer Stem Cells and Non-stem Breast Cancer Cells by Suppression of STAT1

(2020) Ling-Wei Hii et al.   Cells

Sphingosine Kinase Blockade Leads to Increased Natural Killer T Cell Responses to Mantle Cell Lymphoma

(2020) Michael S. Lee et al.   Cells

PIWI-Interacting RNA-004800 Is Regulated by S1P Receptor Signaling Pathway to Keep Myeloma Cell Survival

(2020) Huanxin Ma et al.   Frontiers in Oncology

Fifty years of lyase and a moment of truth: Sphingosine phosphate lyase from discovery to disease

(2019) Julie D. Saba   JOURNAL OF LIPID RESEARCH

New insights into functions of the sphingosine-1-phosphate transporter SPNS2

(2019) Sarah Spiegel et al.   JOURNAL OF LIPID RESEARCH

SPHK1 is a novel target of metformin in ovarian cancer

(2019) Peter C Hart et al.   MOLECULAR CANCER RESEARCH

Sphingosine 1 phosphate receptor-1 (S1P1) promotes tumor-associated regulatory T cell expansion: leading to poor survival in bladder cancer

(2019) Yi-Na Liu et al.   Cell Death & Disease

Cancer-induced inflammation and inflammation-induced cancer in colon: a role for S1P lyase

(2019) Anja Schwiebs et al.   ONCOGENE

A Designed Small Molecule Inhibitor of a Non-Coding RNA Sensitizes HER2 Negative Cancers to Herceptin

(2019) Matthew G. Costales et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Topographical Mapping of Isoform-Selectivity Determinants for J-Channel-Binding Inhibitors of Sphingosine Kinases 1 and 2

(2019) David R. Adams et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sphingosine 1–phosphate signaling induces SNAI2 expression to promote cell invasion in breast cancer cells

(2019) Wei Wang et al.   FASEB JOURNAL

Increased Sphingosine Kinase 1 Expression Predicts Distant Metastasis and Poor Outcome in Patients With Colorectal Cancer

(2019) GO EUN BAE et al.   ANTICANCER RESEARCH

Sphingosine-1-phosphate signalling drives an angiogenic transcriptional programme in diffuse large B cell lymphoma

(2019) Lauren Lupino et al.   LEUKEMIA

Sphingosine-1-phosphate (S1P) in ovarian physiology and disease

(2019) CG Hernández-Coronado et al.   ANNALES D ENDOCRINOLOGIE

Sphingosine-kinase-1 signaling promotes metastasis of triple-negative breast cancer

(2019) Sunil Acharya et al.   CANCER RESEARCH

Activation of sphingosine kinase by lipopolysaccharide promotes prostate cancer cell invasion and metastasis via SphK1/S1PR4/matriptase

(2019) Cheng-Fan Lee et al.   ONCOGENE

Silencing of microRNA-708 promotes cell growth and epithelial-to-mesenchymal transition by activating the SPHK2/AKT/β-catenin pathway in glioma

(2019) Yan Chen et al.   Cell Death & Disease

Sphingosine kinase 1 overexpression induces MFN2 fragmentation and alters mitochondrial matrix Ca2+ handling in HeLa cells

(2019) I. Pulli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

SGPL1321 mutation: one main trigger for invasiveness of pediatric alveolar rhabdomyosarcoma

(2019) Anna Adamus et al.   CANCER GENE THERAPY

β3-adrenoreceptor blockade reduces tumor growth and increases neuronal differentiation in neuroblastoma via SK2/S1P2 modulation

(2019) Gennaro Bruno et al.   ONCOGENE

Pro-Survival Lipid Sphingosine-1-Phosphate Metabolically Programs T Cells to Limit Anti-tumor Activity

(2019) Paramita Chakraborty et al.   Cell Reports

Kelch-like protein 5-mediated ubiquitination of lysine 183 promotes proteasomal degradation of sphingosine kinase 1

(2019) Jason A. Powell et al.   BIOCHEMICAL JOURNAL

Sphingolipids and the unfolded protein response

(2019) Melissa K. Bennett et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Prognostic roles of the expression of sphingosine-1-phosphate metabolism enzymes in non-small cell lung cancer

(2019) Yingqin Wang et al.   Translational Lung Cancer Research

Activation of sphingosine 1-phosphate receptor 2 attenuates chemotherapy-induced neuropathy

(2019) Wei Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine kinase and sphingosine-1-phosphate receptor signaling pathway in inflammatory gastrointestinal disease and cancers: A novel therapeutic target

(2019) Olga A. Sukocheva et al.   PHARMACOLOGY & THERAPEUTICS

Sphingosine-1-Phosphate Receptor 1 Activity Promotes Tumor Growth by Amplifying VEGF-VEGFR2 Angiogenic Signaling

(2019) Vijay Avin Balaji Ragunathrao et al.   Cell Reports

ABCC1-Exported Sphingosine-1-phosphate, Produced by Sphingosine Kinase 1, Shortens Survival of Mice and Patients with Breast Cancer

(2018) Akimitsu Yamada et al.   MOLECULAR CANCER RESEARCH

S1P Stimulates Proliferation by Up-regulating CTGF Expression through S1PR2-mediated YAP Activation

(2018) Jung-Chien Cheng et al.   MOLECULAR CANCER RESEARCH

YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene expression, are critical for glioblastoma tumorigenicity

(2018) Olivia M. Yu et al.   ONCOGENE

Deletion of sphingosine kinase 1 inhibits liver tumorigenesis in diethylnitrosamine-treated mice

(2018) Jinbiao Chen et al.   Oncotarget

The sphingosine 1-phosphate receptor 2 is shed in exosomes from breast cancer cells and is N-terminally processed to a short constitutively active form that promotes extracellular signal regulated kinase activation and DNA synthesis in fibroblasts

(2018) Ashref El Buri et al.   Oncotarget

Targeting S1PR1/STAT3 loop abrogates desmoplasia and chemosensitizes pancreatic cancer to gemcitabine

(2018) Manendra Babu Lankadasari et al.   Theranostics

Triple Negative Breast Cancer Depends on Sphingosine Kinase 1 (SphK1)/Sphingosine-1-Phosphate (S1P)/Sphingosine 1-Phosphate Receptor 3 (S1PR3)/Notch Signaling for Metastasis

(2018) Shushu Wang et al.   MEDICAL SCIENCE MONITOR

Cytoplasmic dynein regulates the subcellular localization of sphingosine kinase 2 to elicit tumor-suppressive functions in glioblastoma

(2018) Heidi A. Neubauer et al.   ONCOGENE

Sphingosine kinase 1 activation by estrogen receptor α36 contributes to tamoxifen resistance in breast cancer

(2018) Melissa A. Maczis et al.   JOURNAL OF LIPID RESEARCH

Sphingosine 1-phosphate (S1P) reduces hepatocyte growth factor-induced migration of hepatocellular carcinoma cells via S1P receptor 2

(2018) Rie Matsushima-Nishiwaki et al.   PLoS One

S1P/S1PR3 axis promotes aerobic glycolysis by YAP/c-MYC/PGAM1 axis in osteosarcoma

(2018) Yifei Shen et al.   EBioMedicine

Runx1 Orchestrates Sphingolipid Metabolism and Glucocorticoid Resistance in Lymphomagenesis

(2017) A. Kilbey et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Genome-wide in vivo screen identifies novel host regulators of metastatic colonization

(2017) Louise van der Weyden et al.   NATURE

Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets

(2017) Thiet M. Vu et al.   NATURE

Sphingosine kinase 2 inhibition synergises with bortezomib to target myeloma by enhancing endoplasmic reticulum stress

(2017) Craig T. Wallington-Beddoe et al.   Oncotarget

The hematopoietic oncoprotein FOXP1 promotes tumor cell survival in diffuse large B-cell lymphoma by repressing S1PR2 signaling

(2016) M. Flori et al.   BLOOD

A role of the sphingosine-1-phosphate (S1P)–S1P receptor 2 pathway in epithelial defense against cancer (EDAC)

(2016) Sayaka Yamamoto et al.   MOLECULAR BIOLOGY OF THE CELL

CIB1 contributes to oncogenic signalling by Ras via modulating the subcellular localisation of sphingosine kinase 1

(2016) W Zhu et al.   ONCOGENE

Sphingosine 1-phosphate and sphingosine kinases in health and disease: Recent advances

(2016) Susan Pyne et al.   PROGRESS IN LIPID RESEARCH

Sphingosine Kinases: Emerging Structure–Function Insights

(2016) David R. Adams et al.   TRENDS IN BIOCHEMICAL SCIENCES

An oncogenic role for sphingosine kinase 2

(2016) Heidi A. Neubauer et al.   Oncotarget

Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androgen-independent LNCaP-AI prostate cancer cells

(2016) Melissa McNaughton et al.   Oncotarget

MicroRNA-613 inhibits cell growth, migration and invasion of papillary thyroid carcinoma by regulating SphK2

(2016) Wangwang Qiu et al.   Oncotarget

Abnormal Expression of miR-21 and miR-95 in Cancer Stem-Like Cells is Associated with Radioresistance of Lung Cancer

(2015) Jinghui Zhang et al.   CANCER INVESTIGATION

Sphingosine 1-phosphate is a ligand for peroxisome proliferator-activated receptor-γ that regulates neoangiogenesis

(2015) Kate A. Parham et al.   FASEB JOURNAL

Intracellular sphingosine kinase 2–derived sphingosine-1-phosphate mediates epidermal growth factor–induced ezrin-radixin-moesin phosphorylation and cancer cell invasion

(2015) Mohamad M. Adada et al.   FASEB JOURNAL

A novel role of sphingosine kinase-1 in the invasion and angiogenesis of VHL mutant clear cell renal cell carcinoma

(2015) Mohamed F. Salama et al.   FASEB JOURNAL

Activation of sphingosine kinase 2 by endoplasmic reticulum stress ameliorates hepatic steatosis and insulin resistance in mice

(2015) Su-Yeon Lee et al.   HEPATOLOGY

Increased SPHK2 Transcription of Human Colon Cancer Cells in Serum-Depleted Culture: The Involvement of CREB Transcription Factor

(2015) Naoki Mizutani et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation

(2015) Shanmugam Panneer Selvam et al.   Science Signaling

HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1to limit vascular inflammation

(2015) Sylvain Galvani et al.   Science Signaling

Long non-coding RNA HULC promotes tumor angiogenesis in liver cancer by up-regulating sphingosine kinase 1 (SPHK1)

(2015) Zhanping Lu et al.   Oncotarget

TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1

(2015) Nima Etemadi et al.   eLife

Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation

(2015) Shanmugam Panneer Selvam et al.   Science Signaling

HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1to limit vascular inflammation

(2015) Sylvain Galvani et al.   Science Signaling

The phosphorylated prodrug FTY720 is a histone deacetylase inhibitor that reactivates ERα expression and enhances hormonal therapy for breast cancer

(2015) N C Hait et al.   Oncogenesis

Sphingosine Kinase 2 Promotes Acute Lymphoblastic Leukemia by Enhancing MYC Expression

(2014) C. T. Wallington-Beddoe et al.   CANCER RESEARCH

A Novel E2F/Sphingosine Kinase 1 Axis Regulates Anthracycline Response in Squamous Cell Carcinoma

(2014) M. Hazar-Rethinam et al.   CLINICAL CANCER RESEARCH

Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs

(2014) Emilie Degagné et al.   JOURNAL OF CLINICAL INVESTIGATION

Coupling between endocytosis and sphingosine kinase 1 recruitment

(2014) Hongying Shen et al.   NATURE CELL BIOLOGY

The role of sphingosine kinase isoforms and receptors S1P1, S1P2, S1P3, and S1P5 in primary, secondary, and recurrent glioblastomas

(2014) Karl Quint et al.   TUMOR BIOLOGY

miRNA-95 Mediates Radioresistance in Tumors by Targeting the Sphingolipid Phosphatase SGPP1

(2013) X. Huang et al.   CANCER RESEARCH

Roles, regulation and inhibitors of sphingosine kinase 2

(2013) Heidi A. Neubauer et al.   FEBS Journal

Dual role of sphingosine kinase-1 in promoting the differentiation of dermal fibroblasts and the dissemination of melanoma cells

(2013) V Albinet et al.   ONCOGENE

Enhanced expression of transferrin receptor 1 contributes to oncogenic signalling by sphingosine kinase 1

(2013) D H Pham et al.   ONCOGENE

Prognostic significance of sphingosine kinase 2 expression in non-small cell lung cancer

(2013) Qiushi Wang et al.   TUMOR BIOLOGY

Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1

(2012) Mark E. Schnute et al.   BIOCHEMICAL JOURNAL

Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer

(2012) Jie Liang et al.   CANCER CELL

Sphingolipid Metabolism Cooperates with BAK and BAX to Promote the Mitochondrial Pathway of Apoptosis

(2012) Jerry E. Chipuk et al.   CELL

Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis

(2012) Suriyan Ponnusamy et al.   EMBO Molecular Medicine

Identification of novel functional and spatial associations between sphingosine kinase 1, sphingosine 1-phosphate receptors and other signaling proteins that affect prognostic outcome in estrogen receptor-positive breast cancer

(2012) Jan Ohotski et al.   INTERNATIONAL JOURNAL OF CANCER

Oncogenic K-Ras Regulates Bioactive Sphingolipids in a Sphingosine Kinase 1-dependent Manner

(2012) Christopher R. Gault et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mouse SPNS2 Functions as a Sphingosine-1-Phosphate Transporter in Vascular Endothelial Cells

(2012) Yu Hisano et al.   PLoS One

Crystal Structure of a Lipid G Protein-Coupled Receptor

(2012) M. A. Hanson et al.   SCIENCE

The sphingosine 1-phosphate receptor S1P2 maintains the homeostasis of germinal center B cells and promotes niche confinement

(2011) Jesse A Green et al.   NATURE IMMUNOLOGY

High Expression of Sphingosine 1-Phosphate Receptors, S1P1 and S1P3, Sphingosine Kinase 1, and Extracellular Signal-Regulated Kinase-1/2 Is Associated with Development of Tamoxifen Resistance in Estrogen Receptor-Positive Breast Cancer Patients

(2010) Carol Watson et al.   AMERICAN JOURNAL OF PATHOLOGY

Runx Regulation of Sphingolipid Metabolism and Survival Signaling

(2010) A. Kilbey et al.   CANCER RESEARCH

Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy

(2010) S Lépine et al.   CELL DEATH AND DIFFERENTIATION

FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells

(2010) Francesca Tonelli et al.   CELLULAR SIGNALLING

Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration

(2010) Graham M. Strub et al.   FASEB JOURNAL

The Sphingosine Kinase 1 Inhibitor 2-(p-Hydroxyanilino)-4-(p-chlorophenyl)thiazole Induces Proteasomal Degradation of Sphingosine Kinase 1 in Mammalian Cells

(2010) Carolyn Loveridge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine Kinase 1 Induces Tolerance to Human Epidermal Growth Factor Receptor 2 and Prevents Formation of a Migratory Phenotype in Response to Sphingosine 1-Phosphate in Estrogen Receptor-Positive Breast Cancer Cells

(2010) J. S. Long et al.   MOLECULAR AND CELLULAR BIOLOGY

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

(2010) Sergio E. Alvarez et al.   NATURE

Targeted Disruption of the S1P2 Sphingosine 1-Phosphate Receptor Gene Leads to Diffuse Large B-Cell Lymphoma Formation

(2009) G. Cattoretti et al.   CANCER RESEARCH

Sprouty4deficiency potentiates Ras-independent angiogenic signals and tumor growth

(2009) Koji Taniguchi et al.   CANCER SCIENCE

Translocation of Sphingosine Kinase 1 to the Plasma Membrane Is Mediated by Calcium- and Integrin-binding Protein 1

(2009) Kate E. Jarman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

(2009) N. C. Hait et al.   SCIENCE