Identification of novel functional and spatial associations between sphingosine kinase 1, sphingosine 1-phosphate receptors and other signaling proteins that affect prognostic outcome in estrogen receptor-positive breast cancer

Sphingosine-1-Phosphate Produced by Sphingosine Kinase 1 Promotes Breast Cancer Progression by Stimulating Angiogenesis and Lymphangiogenesis

(2012) M. Nagahashi et al.   CANCER RESEARCH

Sphingosine Kinase Inhibitors and Cancer: Seeking the Golden Sword of Hercules

(2011) S. Pyne et al.   CANCER RESEARCH

BACE1 Activity Is Modulated by Cell-Associated Sphingosine-1-Phosphate

(2011) N. Takasugi et al.   JOURNAL OF NEUROSCIENCE

Ablation of Sphingosine Kinase-2 Inhibits Tumor Cell Proliferation and Migration

(2011) P. Gao et al.   MOLECULAR CANCER RESEARCH

Defining a role for sphingosine kinase 1 in p53-dependent tumors

(2011) L A Heffernan-Stroud et al.   ONCOGENE

High Expression of Sphingosine 1-Phosphate Receptors, S1P1 and S1P3, Sphingosine Kinase 1, and Extracellular Signal-Regulated Kinase-1/2 Is Associated with Development of Tamoxifen Resistance in Estrogen Receptor-Positive Breast Cancer Patients

(2010) Carol Watson et al.   AMERICAN JOURNAL OF PATHOLOGY

Breast cancer patients’ clinical outcome measures are associated with Src kinase family member expression

(2010) B Elsberger et al.   BRITISH JOURNAL OF CANCER

LYN Is a Mediator of Epithelial-Mesenchymal Transition and a Target of Dasatinib in Breast Cancer

(2010) Y.-L. Choi et al.   CANCER RESEARCH

Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration

(2010) Graham M. Strub et al.   FASEB JOURNAL

A critical role for the protein phosphatase 2A B′α regulatory subunit in dephosphorylation of sphingosine kinase 1

(2010) Melissa R. Pitman et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Sphingosine 1-Phosphate Receptor 4 Uses HER2 (ERBB2) to Regulate Extracellular Signal Regulated Kinase-1/2 in MDA-MB-453 Breast Cancer Cells

(2010) Jaclyn S. Long et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine Kinase 1 Induces Tolerance to Human Epidermal Growth Factor Receptor 2 and Prevents Formation of a Migratory Phenotype in Response to Sphingosine 1-Phosphate in Estrogen Receptor-Positive Breast Cancer Cells

(2010) J. S. Long et al.   MOLECULAR AND CELLULAR BIOLOGY

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

(2010) Sergio E. Alvarez et al.   NATURE

Guanine nucleotides regulate sphingosine kinase 1 activation by eukaryotic elongation factor 1A and provide a mechanism for eEF1A-associated oncogenesis

(2010) T M Leclercq et al.   ONCOGENE

Ras/Raf-1/MAPK Pathway Mediates Response to Tamoxifen but not Chemotherapy in Breast Cancer Patients

(2009) L. M. McGlynn et al.   CLINICAL CANCER RESEARCH

Sphingosine-1-phosphate: a potential therapeutic agent against human breast cancer

(2009) Binbing Ling et al.   INVESTIGATIONAL NEW DRUGS

Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

(2009) N. C. Hait et al.   SCIENCE

A tumor suppressor role for PP2A-B56α through negative regulation of c-Myc and other key oncoproteins

(2008) Hugh K. Arnold et al.   CANCER AND METASTASIS REVIEWS

Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease

(2008) S PYNE et al.   CELLULAR SIGNALLING

Deactivation of Sphingosine Kinase 1 by Protein Phosphatase 2A

(2008) Renae K. Barr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Filamin A Links Sphingosine Kinase 1 and Sphingosine-1-Phosphate Receptor 1 at Lamellipodia To Orchestrate Cell Migration

(2008) M. Maceyka et al.   MOLECULAR AND CELLULAR BIOLOGY

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY