Cytoplasmic dynein regulates the subcellular localization of sphingosine kinase 2 to elicit tumor-suppressive functions in glioblastoma

Topical Application of Fingolimod Perturbs Cutaneous Inflammation

(2016) Wai Y. Sun et al.   JOURNAL OF IMMUNOLOGY

CIB1 contributes to oncogenic signalling by Ras via modulating the subcellular localisation of sphingosine kinase 1

(2016) W Zhu et al.   ONCOGENE

Expression of S1P metabolizing enzymes and receptors correlate with survival time and regulate cell migration in glioblastoma multiforme

(2016) Sandra Bien-Möller et al.   Oncotarget

Nuclear factor one B (NFIB) encodes a subtype-specific tumour suppressor in glioblastoma

(2016) Brett W. Stringer et al.   Oncotarget

A Negative Regulatory Mechanism Involving 14-3-3ζ Limits Signaling Downstream of ROCK to Regulate Tissue Stiffness in Epidermal Homeostasis

(2015) Jasreen Kular et al.   DEVELOPMENTAL CELL

Revisiting the sphingolipid rheostat: Evolving concepts in cancer therapy

(2015) Jason Newton et al.   EXPERIMENTAL CELL RESEARCH

A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties

(2015) Melissa R. Pitman et al.   Oncotarget

Export of sphingosine-1-phosphate and cancer progression

(2014) Kazuaki Takabe et al.   JOURNAL OF LIPID RESEARCH

The role of sphingosine kinase isoforms and receptors S1P1, S1P2, S1P3, and S1P5 in primary, secondary, and recurrent glioblastomas

(2014) Karl Quint et al.   TUMOR BIOLOGY

Mechanotransduction Pathways Promoting Tumor Progression Are Activated in Invasive Human Squamous Cell Carcinoma

(2013) S. Jan Ibbetson et al.   AMERICAN JOURNAL OF PATHOLOGY

Roles, regulation and inhibitors of sphingosine kinase 2

(2013) Heidi A. Neubauer et al.   FEBS Journal

A Metabolic Shift Favoring Sphingosine 1-Phosphate at the Expense of Ceramide Controls Glioblastoma Angiogenesis

(2013) Hazem J. Abuhusain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingolipid Metabolism Cooperates with BAK and BAX to Promote the Mitochondrial Pathway of Apoptosis

(2012) Jerry E. Chipuk et al.   CELL

The compartmentalization and translocation of the sphingosine kinases: Mechanisms and functions in cell signaling and sphingolipid metabolism

(2011) Deanna Siow et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

Pharmacology and Antitumor Activity of ABC294640, a Selective Inhibitor of Sphingosine Kinase-2

(2010) K. J. French et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Correction: Mouse Cytoplasmic Dynein Intermediate Chains: Identification of New Isoforms, Alternative Splicing and Tissue Distribution of Transcripts

(2010) Anna Kuta et al.   PLoS One

Regulation of sphingosine kinase and sphingolipid signaling

(2010) Stuart M. Pitson   TRENDS IN BIOCHEMICAL SCIENCES

Targeting Sphingosine Kinase 1 Inhibits Akt Signaling, Induces Apoptosis, and Suppresses Growth of Human Glioblastoma Cells and Xenografts

(2009) D. Kapitonov et al.   CANCER RESEARCH

Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti-inflammatory phenotype

(2009) Andreas Weigert et al.   INTERNATIONAL JOURNAL OF CANCER

Translocation of Sphingosine Kinase 1 to the Plasma Membrane Is Mediated by Calcium- and Integrin-binding Protein 1

(2009) Kate E. Jarman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specificity of Cytoplasmic Dynein Subunits in Discrete Membrane-trafficking Steps

(2009) Krysten J. Palmer et al.   MOLECULAR BIOLOGY OF THE CELL

Regulators of the cytoplasmic dynein motor

(2009) Julia R. Kardon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

(2009) N. C. Hait et al.   SCIENCE

Ceramide-induced cell death in malignant cells

(2008) Alexander Carpinteiro et al.   CANCER LETTERS

The CCT/TRiC chaperonin is required for maturation of sphingosine kinase 1

(2008) Julia R. Zebol et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

A neuron-specific cytoplasmic dynein isoform preferentially transports TrkB signaling endosomes

(2008) Junghoon Ha et al.   JOURNAL OF CELL BIOLOGY