Sepsis-associated encephalopathy and septic encephalitis: an update

Fulminant encephalopathy in a child with hyperferritinemic sepsis: a case report

(2020) Lilin Huang et al.   BMC Neurology

Initial experience with [18F]DPA-714 TSPO-PET to image inflammation in primary angiitis of the central nervous system

(2020) Philipp Backhaus et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Antimicrobial-associated harm in critical care: a narrative review

(2020) Nishkantha Arulkumaran et al.   INTENSIVE CARE MEDICINE

Sepsis-associated encephalopathy: a vicious cycle of immunosuppression

(2020) Chao Ren et al.   Journal of Neuroinflammation

Mitochondrial dysfunction mediated through dynamin-related protein 1 (Drp1) propagates impairment in blood brain barrier in septic encephalopathy

(2020) Bereketeab Haileselassie et al.   Journal of Neuroinflammation

Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study

(2020) Kristina E Rudd et al.   LANCET

Sepsis-Associated Encephalopathy: From Delirium to Dementia?

(2020) Ha-Yeun Chung et al.   Journal of Clinical Medicine

Sepsis therapies: learning from 30 years of failure of translational research to propose new leads

(2020) Jean‐Marc Cavaillon et al.   EMBO Molecular Medicine

Therapeutic effects of recombinant human brain natriuretic peptide on sepsis-associated encephalopathy in mice

(2020) Nan Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

CXCR5 Knockdown Attenuates Hippocampal Neurogenesis Deficits and Cognitive Impairment in a Mouse Model of Sepsis-associated Encephalopathy

(2020) Yanan Shen et al.   NEUROSCIENCE

COVID ‐19: A Global Threat to the Nervous System

(2020) Igor J. Koralnik et al.   ANNALS OF NEUROLOGY

Cerebrovascular disease in patients with COVID-19: neuroimaging, histological and clinical description

(2020) Francisco Hernández-Fernández et al.   BRAIN

Glycemic control with insulin attenuates sepsis-associated encephalopathy by inhibiting glial activation via the suppression of the nuclear factor kappa B and mitogen-activated protein kinase signaling pathways in septic rats

(2020) Chun-Ta Huang et al.   BRAIN RESEARCH

Small dose of L-dopa/Benserazide hydrochloride improved sepsis-induced neuroinflammation and long-term cognitive dysfunction in sepsis mice

(2020) Fan Li et al.   BRAIN RESEARCH

Effectiveness of Melatonin for the Prevention of Intensive Care Unit Delirium

(2019) Laura Baumgartner et al.   PHARMACOTHERAPY

The prognostic value of neurofilament levels in patients with sepsis-associated encephalopathy – A prospective, pilot observational study

(2019) Johannes Ehler et al.   PLoS One

Astroglia in Sepsis Associated Encephalopathy

(2019) Tatyana Shulyatnikova et al.   NEUROCHEMICAL RESEARCH

Short-Term Effects of Sepsis and the Impact of Aging on the Transcriptional Profile of Different Brain Regions

(2019) Mike Yoshio Hamasaki et al.   INFLAMMATION

Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis

(2019) Christopher W. Seymour et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Acute Ischemic Stroke Therapy in Infective Endocarditis: Case Series and Systematic Review

(2019) Robert J. Marquardt et al.   Journal of Stroke & Cerebrovascular Diseases

Microglial Cells Depletion Increases Inflammation and Modifies Microglial Phenotypes in an Animal Model of Severe Sepsis

(2019) Monique Michels et al.   MOLECULAR NEUROBIOLOGY

Prophylactic use of exogenous melatonin and melatonin receptor agonists to improve sleep and delirium in the intensive care units: a systematic review and meta-analysis of randomized controlled trials

(2019) Qingyu Zhang et al.   Sleep and Breathing

Association between Elevated Serum Tau Protein Level and Sepsis-Associated Encephalopathy in Patients with Severe Sepsis

(2019) Teng Zhao et al.   Canadian Journal of Infectious Diseases & Medical Microbiology

Neurological and Psychiatric Adverse Effects of Antimicrobials

(2019) Madison K. Bangert et al.   CNS DRUGS

Systemic infection and microglia activation: a prospective postmortem study in sepsis patients

(2019) D. Westhoff et al.   Immunity & Ageing

Serum glial fibrillary acidic protein and ubiquitin C-terminal hydrolase-L1 for diagnosis of sepsis-associated encephalopathy and outcome prognostication

(2019) Long Wu et al.   JOURNAL OF CRITICAL CARE

Clinical course of infectious intracranial aneurysm undergoing antibiotic treatment

(2019) Cory J. Rice et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Atorvastatin Relieves Cognitive Disorder After Sepsis Through Reverting Inflammatory Cytokines, Oxidative Stress, and Neuronal Apoptosis in Hippocampus

(2019) Jianmei Tian et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Regulation of hippocampal neuronal apoptosis and autophagy in mice with sepsis‐associated encephalopathy by immunity‐related GTPase M1

(2019) Rui‐Xi Zhou et al.   CNS Neuroscience & Therapeutics

Characterization and modulation of microglial phenotypes in an animal model of severe sepsis

(2019) Monique Michels et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Low-dose Dexamethasone Increases Autophagy in Cerebral Cortical Neurons of Juvenile Rats with Sepsis Associated Encephalopathy

(2019) Ruixi Zhou et al.   NEUROSCIENCE

Plasma miR-370-3p As a Biomarker of Sepsis-Associated Encephalopathy, The Transcriptomic Profiling Analysis of Microrna-Arrays From Mouse Brains

(2019) Peerapat Visitchanakun et al.   SHOCK

Dexmedetomidine Attenuates Neuroinflammation In LPS-Stimulated BV2 Microglia Cells Through Upregulation Of miR-340

(2019) Yang Bao et al.   Drug Design Development and Therapy

Subcutaneous administration of β-hydroxybutyrate improves learning and memory of sepsis surviving mice

(2019) Xueqin Wang et al.   Neurotherapeutics

Mitochondrial dynamics and protective effects of a mitochondrial division inhibitor, Mdivi-1, in lipopolysaccharide-induced brain damage

(2018) Songyun Deng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Population-Based Cohort Study on the Drug-Specific Effect of Statins on Sepsis Outcome

(2018) Chien-Chang Lee et al.   CHEST

Neural pathways involved in infection-induced inflammation: recent insights and clinical implications

(2018) Marion Griton et al.   CLINICAL AUTONOMIC RESEARCH

Endocrine and Metabolic Alterations in Sepsis and Implications for Treatment

(2018) Catherine Ingels et al.   CRITICAL CARE CLINICS

Early Evidence of Sepsis-Associated Hyperperfusion—A Study of Cerebral Blood Flow Measured With MRI Arterial Spin Labeling in Critically Ill Septic Patients and Control Subjects*

(2018) Marie-Hélène Masse et al.   CRITICAL CARE MEDICINE

Circulating biomarkers may be unable to detect infection at the early phase of sepsis in ICU patients: the CAPTAIN prospective multicenter cohort study

(2018) Marianna Parlato et al.   INTENSIVE CARE MEDICINE

Evaluation of Brain Nuclear Medicine Imaging Tracers in a Murine Model of Sepsis-Associated Encephalopathy

(2018) Dávid Szöllősi et al.   MOLECULAR IMAGING AND BIOLOGY

Intestinal microbiota impact sepsis associated encephalopathy via the vagus nerve

(2018) Suyan Li et al.   NEUROSCIENCE LETTERS

Hydrocortisone plus Fludrocortisone for Adults with Septic Shock

(2018) Djillali Annane et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cerebral blood flow and serum neuron-specific enolase in early-onset neonatal sepsis

(2018) Mohammed S. El Shimy et al.   PEDIATRIC RESEARCH

Assessing long-term neuroinflammatory responses to encephalopathy using MRI approaches in a rat endotoxemia model

(2018) Rheal A. Towner et al.   GeroScience

Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU

(2018) John W. Devlin et al.   CRITICAL CARE MEDICINE

Emerging PET Radiotracers and Targets for Imaging of Neuroinflammation in Neurodegenerative Diseases: Outlook Beyond TSPO

(2018) Vidya Narayanaswami et al.   Molecular Imaging

Systematic Review of Endovascular, Surgical, and Conservative Options for Infectious Intracranial Aneurysms and Cardiac Considerations

(2018) Ranjan Ragulojan et al.   Journal of Stroke & Cerebrovascular Diseases

MRI Presentation of Infectious Intracranial Aneurysms in Infective Endocarditis

(2018) Ibrahim Migdady et al.   Neurocritical Care

Diagnostic value of NT-proCNP compared to NSE and S100B in cerebrospinal fluid and plasma of patients with sepsis-associated encephalopathy

(2018) Johannes Ehler et al.   NEUROSCIENCE LETTERS

Association of Corticosteroid Treatment With Outcomes in Adult Patients With Sepsis

(2018) Fang Fang et al.   JAMA Internal Medicine

Prophylactic Palmitoylethanolamide Prolongs Survival and Decreases Detrimental Inflammation in Aged Mice With Bacterial Meningitis

(2018) Ev Christin Heide et al.   Frontiers in Immunology

Short- and Long-Term Protective Effects of Melatonin in a Mouse Model of Sepsis-Associated Encephalopathy

(2017) Mu-huo Ji et al.   INFLAMMATION

Incidence and Trends of Sepsis in US Hospitals Using Clinical vs Claims Data, 2009-2014

(2017) Chanu Rhee et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Alteration of sphingolipid metabolism as a putative mechanism underlying LPS-induced BBB disruption

(2017) Rajkumar Vutukuri et al.   JOURNAL OF NEUROCHEMISTRY

Neurodegenerative changes and neuroapoptosis induced by systemic lipopolysaccharide administration are reversed by dexmedetomidine treatment in mice

(2017) Qiaoqing Ning et al.   NEUROLOGICAL RESEARCH

FTY720-Induced Lymphopenia Does Not Aggravate Mortality in a Murine Model of Polymicrobial Abdominal Sepsis

(2017) Jana Enderes et al.   SHOCK

Minocycline Prevents the Impairment of Hippocampal Long-Term Potentiation in the Septic Mouse

(2017) Koji Hoshino et al.   SHOCK

Sepsis-Associated Encephalopathy: The Blood–Brain Barrier and the Sphingolipid Rheostat

(2017) Stephen J. Kuperberg et al.   Frontiers in Immunology

In Vivo Imaging of Human Neuroinflammation

(2016) Daniel S. Albrecht et al.   ACS Chemical Neuroscience

Focal epileptic seizures, electroencephalography and outcome of sepsis associated encephalopathy—A pilot study

(2016) I.I. Berisavac et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Septic encephalopathy and septic encephalitis‬‬

(2016) Simone C. Tauber et al.   Expert Review of Anti-Infective Therapy

Clinical management of infectious cerebral vasculitides

(2016) Francisco Javier Carod Artal   Expert Review of Neurotherapeutics

Assessment of Clinical Criteria for Sepsis

(2016) Christopher W. Seymour et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Activation of the hypothalamic-pituitary-adrenal (HPA) axis contributes to the immunosuppression of mice infected with Angiostrongylus cantonensis

(2016) Ai-ling Chen et al.   Journal of Neuroinflammation

Biomarkers of Delirium in a Low-Risk Community-Acquired Pneumonia-Induced Sepsis

(2016) Cristiane Damiani Tomasi et al.   MOLECULAR NEUROBIOLOGY

Brain Oxidative Stress During Experimental Sepsis Is Attenuated by Simvastatin Administration

(2016) Carlos Henrique Rocha Catalão et al.   MOLECULAR NEUROBIOLOGY

Antibiotic-associated encephalopathy

(2016) Shamik Bhattacharyya et al.   NEUROLOGY

Peripheral T-lymphocyte and natural killer cell population imbalance is associated with septic encephalopathy in patients with severe sepsis

(2016) CHENG-XIANG LU et al.   Experimental and Therapeutic Medicine

Das posteriore reversible Enzephalopathiesyndrom

(2016) M. Fischer et al.   Medizinische Klinik-Intensivmedizin und Notfallmedizin

Clinical management of infectious cerebral vasculitides

(2016) Francisco Javier Carod Artal   Expert Review of Neurotherapeutics

A Young Man With Severe and Disabling Complications of Septic Shock

(2015) L. E. M. Haas et al.   AMERICAN JOURNAL OF CRITICAL CARE

Bacterial meningitis: an update of new treatment options

(2015) Roland Nau et al.   Expert Review of Anti-Infective Therapy

Acute brain failure in severe sepsis: a prospective study in the medical intensive care unit utilizing continuous EEG monitoring

(2015) Emily J. Gilmore et al.   INTENSIVE CARE MEDICINE

Successful Treatment of Multifoci Nocardial Brain Abscesses

(2015) Qingsheng Xu et al.   MEDICINE

The role of adrenal gland microenvironment in the HPA axis function and dysfunction during sepsis

(2015) Waldemar Kanczkowski et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease

(2015) Yun-Hee Youm et al.   NATURE MEDICINE

Early Standard Electroencephalogram Abnormalities Predict Mortality in Septic Intensive Care Unit Patients

(2015) Eric Azabou et al.   PLoS One

Outcome of delirium in critically ill patients: systematic review and meta-analysis

(2015) J. I. F. Salluh et al.   BMJ-British Medical Journal

Outcome of delirium in critically ill patients: systematic review and meta-analysis

(2015) J. I. F. Salluh et al.   BMJ-British Medical Journal

New aspects in fenestrated capillary and tissue dynamics in the sensory circumventricular organs of adult brains

(2015) Seiji Miyata   Frontiers in Neuroscience

3D-CAM: Derivation and Validation of a 3-Minute Diagnostic Interview for CAM-Defined Delirium

(2014) Edward R. Marcantonio et al.   ANNALS OF INTERNAL MEDICINE

The DSM-5 criteria, level of arousal and delirium diagnosis: inclusiveness is safer

(2014) et al.   BMC Medicine

Empiric Antibiotic Treatment Reduces Mortality in Severe Sepsis and Septic Shock From the First Hour

(2014) Ricard Ferrer et al.   CRITICAL CARE MEDICINE

Neuroinflammation: Microglial Activation During Sepsis

(2014) Monique Michels et al.   CURRENT NEUROVASCULAR RESEARCH

Palmitoylethanolamide stimulates phagocytosis of Escherichia coli K1 by macrophages and increases the resistance of mice against infections

(2014) Sandra Redlich et al.   Journal of Neuroinflammation

Long-term cerebral consequences of sepsis

(2014) Catherine N Widmann et al.   LANCET NEUROLOGY

Block of GABAA receptor ion channel by penicillin: Electrophysiological and modeling insights toward the mechanism

(2014) Alexey V. Rossokhin et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Delirium in the ICU and Subsequent Long-Term Disability Among Survivors of Mechanical Ventilation*

(2013) Nathan E. Brummel et al.   CRITICAL CARE MEDICINE

Association between Endothelial Dysfunction and Acute Brain Dysfunction during Critical Illness

(2012) Christopher G. Hughes et al.   ANESTHESIOLOGY

Sepsis-associated encephalopathy

(2012) Teneille E. Gofton et al.   Nature Reviews Neurology

Septic encephalopathy: Inflammation in man and mouse

(2011) Alexander Jacob et al.   NEUROCHEMISTRY INTERNATIONAL

Septic metastatic encephalitis: coexistence of brain damage and repair

(2011) S. C. Tauber et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Different assessment tools for intensive care unit delirium: Which score to use?*

(2010) Alawi Luetz et al.   CRITICAL CARE MEDICINE

Long-term Cognitive Impairment and Functional Disability Among Survivors of Severe Sepsis

(2010) Theodore J. Iwashyna et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Minimal penetration of lipopolysaccharide across the murine blood–brain barrier

(2009) William A. Banks et al.   BRAIN BEHAVIOR AND IMMUNITY

Rivastigmine for the prevention of postoperative delirium in elderly patients undergoing elective cardiac surgery—A randomized controlled trial*

(2009) Melanie Gamberini et al.   CRITICAL CARE MEDICINE

Mechanisms of Brain Signaling During Sepsis

(2009) Najla Akrout et al.   Current Neuropharmacology

Pathophysiology of Delirium in the Intensive Care Unit

(2008) Max L. Gunther et al.   CRITICAL CARE CLINICS

The varicella zoster virus vasculopathies: Clinical, CSF, imaging, and virologic features

(2008) M. A. Nagel et al.   NEUROLOGY