Neurodegenerative changes and neuroapoptosis induced by systemic lipopolysaccharide administration are reversed by dexmedetomidine treatment in mice

Dexmedetomidine attenuates acute lung injury induced by lipopolysaccharide in mouse through inhibition of MAPK pathway

(2015) Yingzhen Xu et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Systemic Lipopolysaccharide Administration-Induced Cognitive Impairments are Reversed by Erythropoietin Treatment in Mice

(2015) Rong Gao et al.   INFLAMMATION

Sedation and Delirium in the Intensive Care Unit

(2014) Michael C. Reade et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dexmedetomidine Reduces Isoflurane-Induced Neuroapoptosis Partly by Preserving PI3K/Akt Pathway in the Hippocampus of Neonatal Rats

(2014) Yujuan Li et al.   PLoS One

Neuroprotective Effects of Dexmedetomidine against Glutamate Agonist-induced Neuronal Cell Death Are Related to Increased Astrocyte Brain-derived Neurotrophic Factor Expression

(2013) Vincent Degos et al.   ANESTHESIOLOGY

Two Decades of Mortality Trends Among Patients With Severe Sepsis

(2013) Elizabeth K. Stevenson et al.   CRITICAL CARE MEDICINE

Class I Histone Deacetylase Inhibitor Valproic Acid Reverses Cognitive Deficits in a Mouse Model of Septic Encephalopathy

(2013) Jing Wu et al.   NEUROCHEMICAL RESEARCH

Dexmedetomidine is neuroprotective in an in vitro model for traumatic brain injury

(2012) Marc Schoeler et al.   BMC Neurology

Preventing Delirium in the Intensive Care Unit

(2012) Nathan E. Brummel et al.   CRITICAL CARE CLINICS

Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the Intensive Care Unit

(2012) Juliana Barr et al.   CRITICAL CARE MEDICINE

Persistent cognitive impairment, hippocampal atrophy and EEG changes in sepsis survivors

(2012) Alexander Semmler et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Sepsis-associated encephalopathy

(2012) Teneille E. Gofton et al.   Nature Reviews Neurology

Neurodegenerative Evidence in Mice Brains with Cecal Ligation and Puncture-Induced Sepsis: Preventive Effect of the Free Radical Scavenger Edaravone

(2012) Hiroki Yokoo et al.   PLoS One

Mitochondrial Dysfunction during Sepsis

(2012) Luciano Cesar Pontes Azevedo   Endocrine Metabolic & Immune Disorders-Drug Targets

Neuro-oxidative-nitrosative stress in sepsis

(2011) Ronan MG Berg et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The neutrophil in vascular inflammation

(2011) Mia Phillipson et al.   NATURE MEDICINE

Ghrelin prevents neuronal apoptosis and cognitive impairments in sepsis-associated encephalopathy

(2011) Guobin Wang et al.   NEUROREPORT

Interleukin-1β causes long-term potentiation deficiency in a mouse model of septic encephalopathy

(2011) Y. Imamura et al.   NEUROSCIENCE

Role of analgesics, sedatives, neuromuscular blockers, and delirium

(2010) Jesse B. Hall et al.   CRITICAL CARE MEDICINE

Long-term Cognitive Impairment and Functional Disability Among Survivors of Severe Sepsis

(2010) Theodore J. Iwashyna et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Sepsis Associated Encephalopathy Studied by MRI and Cerebral Spinal Fluid S100B Measurement

(2009) Ornella Piazza et al.   NEUROCHEMICAL RESEARCH

When apoptosis meets autophagy: deciding cell fate after trauma and sepsis

(2009) Ya-Ching Hsieh et al.   TRENDS IN MOLECULAR MEDICINE

Detachment of Brain Pericytes from the Basal Lamina is Involved in Disruption of the Blood–Brain Barrier Caused by Lipopolysaccharide-Induced Sepsis in Mice

(2008) Tsuyoshi Nishioku et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Sepsis induces brain mitochondrial dysfunction

(2008) Joana da Costa P. d’Avila et al.   CRITICAL CARE MEDICINE

Oxidative Stress and Iron Homeostasis: Mechanistic and Health Aspects

(2008) Dimitrios Galaris et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

The Effects of Riluzole on Neurological, Brain Biochemical, and Histological Changes in Early and Late Term of Sepsis in Rats

(2008) Hale Z. Toklu et al.   JOURNAL OF SURGICAL RESEARCH

Mechanisms of microbial traversal of the blood–brain barrier

(2008) Kwang Sik Kim   NATURE REVIEWS MICROBIOLOGY