Article
Anesthesiology
Alberto Fogagnolo, Fabio S. Taccone, Giulia Benetto, Federico Franchi, Sabino Scolletta, Antonella Cotoia, Iryna Kozhevnikova, Carlo A. Volta, Savino Spadaro
Summary: This study found that PDW and MPV have predictive value for mortality in critically ill patients, especially in septic patients. A combined analysis of platelet morphological indices and lactate can improve the prediction accuracy of mortality.
MINERVA ANESTESIOLOGICA
(2021)
Article
Engineering, Biomedical
Fudan Zheng, Luhao Wang, Yuxian Pang, Zhiguang Chen, Yutong Lu, Yuedong Yang, Jianfeng Wu
Summary: Septic shock has become the leading cause of morbidity and mortality in the ICU. However, currently there is no model to predict the mortality of septic shock patients. We aim to develop such a model.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2023)
Article
Medicine, General & Internal
Qing Li, Jianfeng Xie, Yingzi Huang, Songqiao Liu, Fengmei Guo, Ling Liu, Yi Yang
Summary: Leukocytes play an essential role in immune function during sepsis, and our study showed that lymphocyte counts are associated with survival rates in critically ill patients with septic shock. The dynamics of leukocytes within the first 3 days of ICU admission can serve as a valuable prognostic marker for septic shock patients in the ICU.
Article
Medicine, General & Internal
Yao Tian, Yang Yao, Jing Zhou, Xin Diao, Hui Chen, Kaixia Cai, Xuan Ma, Shengyu Wang
Summary: This study evaluates the accuracy of APACHE II score on different days in predicting the mortality of critically ill patients and identifies the best time point for the score. The results show that the APACHE II score on day 3 has the highest predictive value for hospital mortality of ICU patients.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Ralphe Bou Chebl, Hani Tamim, Musharaf Sadat, Saad Qahtani, Tarek Dabbagh, Yaseen M. Arabi
Summary: Septic cirrhosis patients admitted to ICU have a higher mortality rate, with cirrhosis, elevated INR, hemodialysis, and mechanical ventilation being independent predictors of mortality.
Article
Medicine, General & Internal
Xueyan Zhang, Jianfang Ni, Hongwei Zhang, Mengyuan Diao
Summary: This study retrospectively analyzed data from 1,442 ICU patients with GIB and identified nine independent predictors to establish a predictive model for in-hospital mortality. The model showed excellent predictive value and may be a valuable tool in clinical practice.
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Shengyu Wang, Yao Tian, Yang Yao, Jing Zhou, Hui Chen, Xin Diao
Summary: This study aimed to develop a simplified and accurate scoring system, MNEWS, based on the national early warning score, NEWS, to predict the mortality of ICU patients. The performance of MNEWS, APACHE II, and the original NEWS systems in predicting mortality was evaluated using AUROC analysis. The results showed that MNEWS and APACHE II had better performance than NEWS in predicting hospital mortality and 90-day mortality. MNEWS had a high calibration ability in predicting hospital mortality and was confirmed in the validation cohort. In conclusion, MNEWS is a simple and accurate scoring system for evaluating the severity and predicting outcomes of ICU patients.
POSTGRADUATE MEDICAL JOURNAL
(2023)
Article
Infectious Diseases
Manuel Ponce-Alonso, Borja M. Fernandez-Felix, Ana Halperin, Mario Rodriguez-Dominguez, Ana M. Sanchez-Diaz, Rafael Canton, Alfonso Muriel, Javier Zamora, Rosa del Campo
Summary: In this study, it was found that male patients admitted to the ICU with septic bacteremia were more likely to have sepsis and higher mortality rates. Although males presented with worse clinical characteristics upon ICU admission, gender did not have a significant influence on mortality.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Critical Care Medicine
Jeremy Cheuk Kin Sin, Kevin B. Laupland, Mahesh Ramanan, Alexis Tabah
Summary: This study investigated the impact of serum phosphate abnormalities at ICU admission on risk of death and length of stay in critically ill patients. The findings indicated that both hypophosphatemia and hyperphosphatemia were independently associated with an increased risk of death, highlighting the importance of monitoring phosphate levels in ICU patients.
JOURNAL OF CRITICAL CARE
(2021)
Article
Endocrinology & Metabolism
Aisha R. Saand, Monica Flores, Tariq Kewan, Sura Alqaisi, Mahmoud Alwakeel, Lori Griffiths, Xiaofeng Wang, Xiaozhen Han, Robert Burton, Mohammed J. Al-Jaghbeer, Francois Abi Fadel
Summary: The study shows that hyperglycemia in COVID-19 patients is significantly associated with prolonged ICU stay, higher need of mechanical ventilation, and increased risk of mortality. Old age and hyperglycemia are the main predictors of in-hospital mortality.
JOURNAL OF DIABETES
(2021)
Article
Critical Care Medicine
Koji Endo, Kayoko Mizuno, Tomotsugu Seki, Woo Jin Joo, Chikashi Takeda, Masato Takeuchi, Koji Kawakami
Summary: This study compared mortality data and resource use between ICU and HDU admissions for patients with septic shock and found an association between ICU admission and lower 30-day mortality. These findings provide essential insights for building a more appropriate treatment system.
JOURNAL OF INTENSIVE CARE
(2022)
Article
Cardiac & Cardiovascular Systems
Alessandro Brunelli, Housne Begum, Nilanjan Chaudhuri, John Agzarian, Richard Milton, Christian Finley, Peter Tcherveniakov, Laura Valuckiene, Konstantinos Gioutsos, Wael Hanna, Kostas Papagiannopoulos, Yaron Shargall
Summary: The aim of this study was to develop a risk-adjusting model to stratify the risk of unplanned admission to the ICU following lung resection. A retrospective analysis of patients undergoing anatomical lung resections was performed, and variables associated with ICU admission were identified. A risk score was developed based on these variables, and patients were classified into different risk classes.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Medicine, General & Internal
Mohammad Ryadh Pokeerbux, Cecile M. Yelnik, Emmanuel Faure, Elodie Drumez, Amelie Bruandet, Julien Labreuche, Ady Assaf, Anne Goffard, Charles Garabedian, Julien Poissy, Jacques Desbordes, Delphine Garrigue, Arnaud Scherpereel, Karine Faure, Marc Lambert
Summary: No risk stratification tool has been validated in hospitalised patients with COVID-19. The National Early Warning Score (NEWS) at admission was found to be an independent predictor of ICU transfer and in-hospital death in this study.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Medicine, General & Internal
Matheus Carvalho Alves Nogueira, Vandack Nobre, Magda Carvalho Pires, Lucas Emanuel Ferreira Ramos, Yara Cristina Neves Marques Barbosa Ribeiro, Rubia Laura Oliveira Aguiar, Flavia Maria Borges Vigil, Virginia Mara Reis Gomes, Camila de Oliveira Santos, Davi Mesquita Miranda, Pamela Andrea Alves Duraes, Josiane Moreira da Costa, Alexandre Vargas Schwarzbold, Angelica Gomides dos Reis Gomes, Bruno Porto Pessoa, Carolina Cunha Matos, Christiane Correa Rodrigues Cimini, Cintia Alcantara de Carvalho, Daniela Ponce, Euler Roberto Fernandes Manenti, Evelin Paola de Almeida Cenci, Fernando Anschau, Flavia Carvalho Cardoso Costa, Francine Janaina Magalhaes Nascimento, Frederico Bartolazzi, Genna Maira Santos Grizende, Heloisa Reniers Vianna, Jomar Cristeli Nepomuceno, Karen Brasil Ruschel, Liege Barella Zandona, Luis Cesar de Castro, Maira Dias Souza, Marcelo Carneiro, Maria Aparecida Camargos Bicalho, Mariana do Nascimento Vilaca, Naiara Patricia Fagundes Bonardi, Neimy Ramos de Oliveira, Raquel Lutkmeier, Saionara Cristina Francisco, Silvia Ferreira Araujo, Polianna Delfino-Pereira, Milena Soriano Marcolino
Summary: This study assessed the ability of the ABC(2)-SPH score to predict COVID-19 in-hospital mortality during ICU admission and compared its performance with other scores. The results showed that ABC(2)-SPH score was superior to other scores, but it still needs improvement in predicting mortality in critically ill COVID-19 patients.
FRONTIERS IN MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Fei Gao, Yun Zhang
Summary: The study revealed that inotropic administration in cardiogenic shock patients may increase mortality risk. Low-dose norepinephrine and milrinone were associated with lower hospital mortality in the inotrope group, while high-dose inotropes were linked to higher mortality risk.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Editorial Material
Clinical Neurology
Benjamin Rohaut
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Critical Care Medicine
Aude Sangare, Clemence Marois, Vincent Perlbarg, Nadya Pyatigorskaya, Melanie Valente, Julie Zyss, Alaina Borden, Virginie Lambrecq, Loic Le Guennec, Jacobo Sitt, Nicolas Weiss, Benjamin Rohaut, Sophie Demeret, Louis Puybasset, Alexandre Demoule, Lionel Naccache
Summary: This retrospective cohort study described the neurological assessment and outcomes of patients with hypoglycemic encephalopathy hospitalized in the intensive care unit. The study found that the overall prognosis of severe hypoglycemic encephalopathy patients was poor, with only a small fraction showing slow improvement after discharge. A multimodal neurological assessment approach using advanced brain imaging and electrophysiology techniques could potentially improve diagnostic and prognostic performance in severe hypoglycemic encephalopathy.
NEUROCRITICAL CARE
(2023)
Article
Health Care Sciences & Services
Dimitris Mavridis, Adriani Nikolakopoulou, Irini Moustaki, Anna Chaimani, Raphael Porcherd, Isabelle Boutron, Philippe Ravaud
Summary: This study presents graphical methods to group interventions and uses conjoint analysis to place weights on outcomes based on stakeholders' preferences. The results provide valuable information about the clustering of interventions. Grouping interventions helps decision makers identify optimal options in terms of benefit-risk balance and choose interventions from the best cluster based on other factors such as cost and implementation.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2023)
Review
Hematology
Jerome Lambert, Etienne Lengline, Raphael Porcher, Rodolphe Thiebaut, Sarah Zohar, Sylvie Chevret
Summary: In the past decade, it has become common practice to provide rapid answers and early patient access to innovative treatments in the absence of randomized clinical trials. This trend is particularly important in oncology when evaluating new targeted therapies. This article provides guidelines for the critical appraisal of comparisons or conducting single-arm trials, using the example of ciltacabtagene autoleucel for the treatment of relapsed or refractory multiple myeloma.
Article
Clinical Neurology
Amina Ben Salah, Clemence Marois, Aude Sangare, Melanie Valente, Jacobo Sitt, Benjamin Rohaut, Lionel Naccache
Summary: This study aimed to investigate covert language processing in patients with disorders of consciousness. An auditory paradigm was used to contrast words and pronounceable pseudowords, while recording EEG and analyzing N400 and LPC. The study included healthy volunteers and 19 patients, with 10 in a minimally conscious state and 9 in a vegetative state (also known as unresponsive wakefulness syndrome). N400 was observed in all groups, whereas LPC was only present in the healthy volunteers and minimally conscious state groups. The study achieved an unprecedented detection rate of N400 and LPC at the individual level, and LPC predicted significant cognitive improvement at 6 months.
ANNALS OF NEUROLOGY
(2023)
Article
Hematology
Florie Brion Bouvier, Raphael Porcher
Summary: The preferred approach to compare two treatments is a randomized controlled trial (RCT) which ensures similarity between groups and allows causal conclusions. When RCTs are not possible, observational data can be used to infer treatment effectiveness under certain assumptions, using regression modeling or propensity score methods. Target trial emulation principles are also discussed.
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY
(2023)
Letter
Clinical Neurology
Geoffroy Vellieux, Emmanuelle Apartis, Vincent Degos, Philippe Fossati, Vincent Navarro
Article
Critical Care Medicine
Romain Sonneville, Etienne de Montmollin, Damien Contou, Ricard Ferrer, Mohan Gurjar, Kada Klouche, Benjamine Sarton, Sophie Demeret, Pierre Bailly, Daniel da Silva, Etienne Escudier, Loic Le Guennec, Russel Chabanne, Laurent Argaud, Omar Ben Hadj Salem, Martial Thyrault, Aurelien Frerou, Guillaume Louis, Gennaro De Pascale, Janneke Horn, Raimund Helbok, Guillaume Geri, Fabrice Bruneel, Ignacio Martin-Loeches, Fabio Silvio Taccone, Jan De Waele, Stephane Ruckly, Quentin Staiquly, Giuseppe Citerio, Jean-Francois Timsit, EURECA Investigator Study Grp
Summary: This study aimed to characterize the outcomes of severe meningoencephalitis patients requiring intensive care. A multicenter international cohort study was conducted from 2017 to 2020 in 68 centers across 7 countries. Among the enrolled patients, 50.5% had a poor functional outcome at 3 months, and the independent factors associated with this outcome included age > 60 years, immunodepression, delayed ICU admission, low Glasgow Coma Scale score, motor deficits, respiratory and cardiovascular complications, while administration of certain medications on ICU admission was protective.
INTENSIVE CARE MEDICINE
(2023)
Editorial Material
Critical Care Medicine
Soojin Park, Chiara Robba, Romain Sonneville
INTENSIVE CARE MEDICINE
(2023)
Article
Critical Care Medicine
Lina Jeantin, Claire Dupuis, Geoffroy Vellieux, Pierre Jaquet, Etienne de Montmollin, Jean-Francois Timsit, Romain Sonneville
Summary: The presence of absence of EEG reactivity to auditory/noxious stimuli is an independent predictor of poor functional outcome in severe herpes simplex encephalitis.
ANNALS OF INTENSIVE CARE
(2023)
Article
Clinical Neurology
Cedric Dusanter, Marion Houot, Marie Mere, Marisa Denos, Severine Samson, Bastien Herlin, Vincent Navarro, Sophie Dupont
Summary: The aim of this study was to evaluate the specific effects of antiseizure medications (ASMs) on cognition in a group of refractory patients with epilepsy. The results showed that the type and number of ASMs had a significant impact on cognition, especially topiramate (TPM) and sodium valproate (VPA). Based on the findings, it is recommended to reduce the total number of drugs received and avoid medications with unfavorable cognitive profiles.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Letter
Critical Care Medicine
Romain Sonneville, Etienne de Montmollin, Augustin Gaudemer, Stephane Ruckly, Jean-Francois Timsit
INTENSIVE CARE MEDICINE
(2023)
Article
Clinical Neurology
Romain Sonneville, Mikael Mazighi, Magalie Collet, Etienne Gayat, Vincent Degos, Jacques Duranteau, Charles Gregoire, Tarek Sharshar, Giulia Naim, David Cortier, Paul-Henri Jost, Arnaud Foucrier, Francois Bagate, Etienne de Montmollin, Gregory Papin, Eric Magalhaes, Bertrand Guidet, Omar Ben Hadj Salem, Sarah Benghanem, Loic le Guennec, Eric Delpierre, Stephane Legriel, Bruno Megarbane, Karim Toumert, Marc Tran, Guillaume Geri, Mehran Monchi, Eric Bodiguel, Eric Mariotte, Alexandre Demoule, Jonathan Zarka, Jean-Luc Diehl, Damien Roux, Eric Barre, Sebastien Tanaka, David Osman, Pierre Pasquier, Fariza Lamara, Isabelle Crassard, Perrine Boursin, Stephane Ruckly, Quentin Staiquly, Jean-Francois Timsit, France Woimant
Summary: This study investigated the one-year outcomes of patients with stroke requiring mechanical ventilation in ICUs in France. The results showed that 66.5% of the included patients had a poor functional outcome. Age ≥70 years, Charlson comorbidity index ≥2, Glasgow Coma Scale <8 at ICU admission, and stroke subtype were independently associated with poor functional outcome.
Article
Critical Care Medicine
Mikhael Giabicani, Christophe Le Terrier, Antoine Poncet, Bertrand Guidet, Jean-Philippe Rigaud, Jean-Pierre Quenot, Marie-France Mamzer, Jerome Pugin, Emmanuel Weiss, Simon Bourcier
Summary: During the COVID-19 pandemic, limitations on life-sustaining therapies (LST) were frequently implemented in ICUs. This study aimed to investigate the prevalence, timing, and factors associated with LST decisions in critically ill COVID-19 patients. Data from 163 ICUs in France, Belgium, and Switzerland were analyzed, revealing an association between ICU load, age, frailty, and respiratory severity with LST limitations.
Article
Critical Care Medicine
Tarek Sharshar, Raphael Porcher, Pierre Asfar, Lamiae Grimaldi, Julien Jabot, Laurent Argaud, Christine Lebert, Pierre-Edouard Bollaert, Marie Line Harlay, Patrick Chillet, Eric Maury, Francois Santoli, Pascal Blanc, Romain Sonneville, Vu Dinh Chuyen, Benjamin Rohaut, Aurelien Mazeraud, Jean-Claude Alvarez, Vincent Navarro, Bernard Clair, Herve Outin
Summary: This multicentre, double-blind, randomised controlled trial in 244 adults with GCSE found that adding VPA as a complementary treatment to the recommended strategy did not increase the proportion of patients discharged from hospital by day 15.