Article
Endocrinology & Metabolism
Jan Willem van Dalen, Henri J. M. M. Mutsaerts, Jan Petr, Matthan Wa Caan, Eric P. Moll van Charante, Bradley J. MacIntosh, Willem A. van Gool, Aart J. Nederveen, Edo Richard
Summary: This study found no associations between blood pressure measures and cerebral blood flow, but antihypertensive medication use was associated with lower cerebral blood flow and increased ASL signal heterogeneity.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Clinical Neurology
Zhen-Gui Xu, Jin-Jing Xu, Jinghua Hu, Yuanqing Wu, Dan Wang
Summary: This study investigated abnormal cerebral blood flow in tinnitus patients and the effects of headache on cerebral blood flow, finding decreased CBF in the auditory and prefrontal cortex of chronic tinnitus patients. Headache may accelerate CBF reductions in tinnitus, forming the neurological mechanism in chronic tinnitus with tension-type headache.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Fang Ye, Lei Du, Bing Liu, Xinying Gao, Aocai Yang, Die Liu, Yue Chen, Kuan Lv, Pengfei Xu, Yuanmei Chen, Jing Liu, Lipeng Zhang, Shijun Li, Amir Shmuel, Qi Zhang, Guolin Ma
Summary: This study compared cerebral blood flow using pCASL perfusion imaging in individuals with autism spectrum disorders (ASD) and typically developing children. The results showed that individuals with ASD had reduced cerebral blood flow in certain brain regions, and there were correlations between cerebral blood flow and clinical characteristics/developmental profile.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ezgi Yetim, John Jacoby, Nikou L. Damestani, Allison E. Lovely, David H. Salat, Meher R. Juttukonda
Summary: In this study, the relationship between mean arterial pressure (MAP) and cerebral hemodynamics was examined in a large sample of participants across different age groups. The findings revealed a negative association between MAP and cerebral blood flow (CBF) globally, with the strongest correlation observed in the younger-old group. Furthermore, the spatial pattern of this relationship differed with aging.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Review
Psychology, Developmental
Laust Knudsen, Abigail J. Sheldrick, Manouchehr S. Vafaee, Tanja Maria Michel
Summary: Cognition and brain homeostasis rely on cerebral blood flow for adequate oxygen and nutrient supply to the brain tissue. Altered cerebral blood flow has been observed in individuals with autism spectrum condition, suggesting it as a potential biomarker for autism. Technological advancements have made it possible to non-invasively measure cerebral blood flow using arterial spin labeling magnetic resonance imaging. However, most neuroimaging studies still rely on indirect measures from functional magnetic resonance imaging. This review explores the use of arterial spin labeling in studying the neurobiology of autism, comparing the results with molecular imaging and discussing its potential applications. We found consistent results between arterial spin labeling and molecular imaging, especially when considering age and sex. Arterial spin labeling also has other applications beyond measuring cerebral blood flow, such as evaluating functional connectivity. Researchers are encouraged to consider the application of arterial spin labeling in future studies to better understand the neurobiology of autism.
Article
Medicine, General & Internal
Tingting Zhang, Haijun Niu, Yawen Liu, Linkun Cai, Dong Liu, Erwei Zhao, Min Li, Wenjuan Liu, Jing Li, PengGang Qiao, Wei Zheng, Pengling Ren, Zhenchang Wang
Summary: This study investigated the effects of dobutamine on cerebral hemodynamics and found that dobutamine stress significantly decreased cerebral blood flow in the frontal lobe anterior circulation. Additionally, body mass index, resting systolic blood pressure, and basilar artery diameter were significantly associated with changes in frontal lobe cerebral blood flow.
Article
Cell Biology
Joseph S. R. Alisch, Nikkita Khattar, Richard W. Kim, Luis E. Cortina, Abinand C. Rejimon, Wenshu Qian, Luigi Ferrucci, Susan M. Resnick, Richard G. Spencer, Mustapha Bouhrara
Summary: Cerebral blood flow varies with age in different brain regions, with white matter regions showing increased blood flow with age and women having higher blood flow than men. The study results provide a foundation for further investigation of CNS perfusion in various scenarios.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ying Hu, Rongbo Liu, Fabao Gao
Summary: The study on 90 healthy adults found that the age-related perfusion patterns in most brain regions were best fitted by cubic models, and age-dependent CBF changes showed a nonlinear decreasing trend, with the rate of reduction slowing down with age.
KOREAN JOURNAL OF RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shiori Amemiya, Yusuke Watanabe, Naoyuki Takei, Tsuyoshi Ueyama, Satoru Miyawaki, Satoshi Koizumi, Seiji Kato, Hidemasa Takao, Osamu Abe, Nobuhito Saito
Summary: The study found that in severe steno-occlusive diseases, the Combo strategy using ATT correction can improve CBF measurement accuracy, and VS significantly enhances CBF measurement accuracy in standard protocol and in moyamoya patients for the Combo.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Neurosciences
Xiaonan Wang, Di Wang, Xinyang Li, Wenqi Wang, Ping Gao, Baohui Lou, Josef Pfeuffer, Xianchang Zhang, Jinxia Zhu, Chunmei Li, Min Chen
Summary: This study demonstrates that the combined use of cerebral blood flow and T1-mapping techniques improves the diagnostic accuracy in discriminating patients with Alzheimer's disease from cognitively normal control subjects. T1-mapping has the potential to become a competitive technique for quantitatively measuring pathologic changes in the brain.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Yuki Kitazaki, Masamichi Ikawa, Tadanori Hamano, Hirohito Sasaki, Tomohisa Yamaguchi, Soichi Enomoto, Norimichi Shirafuji, Kouji Hayashi, Osamu Yamamura, Tetsuya Tsujikawa, Hidehiko Okazawa, Hirohiko Kimura, Yasunari Nakamoto
Summary: This study aimed to evaluate the clinical utility of ASL perfusion imaging in the diagnosis of CJD. The results showed that CJD patients exhibited ASL hypoperfusion in lesions with DWI hyperintensity, suggesting the potential diagnostic aid of ASL-CBF in CJD.
FRONTIERS IN NEUROLOGY
(2023)
Article
Physiology
Sergio M. Solis-Barquero, Rebeca Echeverria-Chasco, Marta Calvo-Imirizaldu, Elena Cacho-Asenjo, Antonio Martinez-Simon, Marta Vidorreta, Pablo D. Dominguez, Reyes Garcia de Eulate, Miguel Fernandez-Martinez, Maria A. Fernandez-Seara
Summary: A PCASL sequence combined with background suppression and accelerated 3D RARE stack-of-spirals was used to evaluate cerebrovascular reactivity induced by breath-holding in healthy volunteers. The study found that elevated cerebral blood flow was observed in most regions under hypercapnia, with significantly higher values in gray matter compared to white matter.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xinyu Wang, Weiqiang Dou, Dong Dong, Xinyi Wang, Xueyu Chen, Kunjian Chen, Huimin Mao, Yu Guo, Chao Zhang
Summary: This study aimed to explore the feasibility of three-dimensional pseudo-continuous arterial-spin-labeling (tASL) in evaluating MCA recanalization. After recanalization, tASL provided good prognosis and was found to be an independent predictor of good clinical outcome.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Joseph G. Woods, Eric C. Wong, Emma C. Boyd, Divya S. Bolar
Summary: In this study, a novel pulse sequence called VESPA ASL is introduced that combines velocity-selective and pseudo-continuous ASL to simultaneously label different pools of arterial blood for robust cerebral blood flow (CBF) and arterial transit time (ATT) measurement. The results show that VESPA ASL accurately measures CBF in the presence of long ATTs, and ATTs < TI can also be measured. VESPA ASL offers important advantages over existing methods for noninvasive perfusion and transit time imaging in vascular diseases with delayed arterial transit.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Endocrinology & Metabolism
Diana Kindler, Cinzia Maschio, Ruiqing Ni, Valerio Zerbi, Daniel Razansky, Jan Klohs
Summary: The study found no significant differences in regional cerebral blood flow between P301L mice and non-transgenic littermates at different disease stages, indicating that hypoperfusion and neurodegeneration are not phenotypes of P301L mice. Additional research is needed to further understand the relationship between tau, neurodegeneration, vascular dysfunction, and modulators in Alzheimer's disease and primary tauopathies.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Medicine, General & Internal
Karim Ali, Tanweer Azher, Mahin Baqi, Alexandra Binnie, Sergio Borgia, Francois M. Carrier, Yiorgos Alexandros Cavayas, Nicolas Chagnon, Matthew P. Cheng, John Conly, Cecilia Costiniuk, Peter Daley, Nick Daneman, Josh Douglas, Catarina Downey, Erick Duan, Emmanuelle Duceppe, Madeleine Durand, Shane English, George Farjou, Evradiki Fera, Patricia Fontela, Rob Fowler, Michael Fralick, Anna Geagea, Jennifer Grant, Luke B. Harrison, Thomas Havey, Holly Hoang, Lauren E. Kelly, Yoav Keynan, Kosar Khwaja, Gail Klein, Marina Klein, Christophe Kolan, Nadine Kronfli, Francois Lamontagne, Michael Lau, Todd C. Lee, Nelson Lee, Rachel Lim, Sarah Longo, Alexandra Lostun, Erika MacIntyre, Isabelle Malhame, Kathryn Mangoff, Marlee McGuinty, Sonya Mergler, Matthew Munan, Srinivas Murthy, Conar O'Neil, Daniel Ovakim, Jesse Papenburg, Ken Kuljit S. Parhar, Seema Nair Parvathy, Chandni Patel, Santiago Perez-Patrigeon, Ruxandra Pinto, Subitha Rajakumaran, Asgar Rishu, Malaika Roba-Oshin, Moira Rushton, Mariam Saleem, Marina Salvadori, Kim Scherr, Kevin Schwartz, Makeda Semret, Michael Silverman, Ameeta Singh, Wendy Sligl, Stephanie Smith, Ranjani Somayaji, Darrell H. S. Tan, Siobhan Tobin, Meaghan Todd, Tuong-Vi Tran, Alain Tremblay, Jennifer Tsang, Alexis Turgeon, Erik Vakil, Jason Weatherald, Cedric Yansouni, Ryan Zarychanski
Summary: This Canadian study explores the effectiveness of remdesivir as a treatment for COVID-19. The results show that remdesivir has a modest but significant impact on important outcomes for patients and healthcare systems, such as the need for mechanical ventilation.
CANADIAN MEDICAL ASSOCIATION JOURNAL
(2022)
Letter
Medicine, General & Internal
Arnav Agarwal, Francois Lamontagne, Neill K. J. Adhikari
IRISH JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Biochemical Research Methods
Yassene Mohammed, David R. Goodlett, Matthew P. Cheng, Donald C. Vinh, Todd C. Lee, Allison Mcgeer, David Sweet, Karen Tran, Terry Lee, Srinivas Murthy, John H. Boyd, Joel Singer, Keith R. Walley, David M. Patrick, Curtis Quan, Sara Ismail, Laetitia Amar, Aditya Pal, Rayhaan Bassawon, Lara Fesdekjian, Karine Gou, Francois Lamontagne, John Marshall, Greg Haljan, Robert Fowler, Brent W. Winston, James A. Russell
Summary: This study conducted longitudinal proteomic analysis of acute-phase COVID-19 patients, revealing changes in lipid-associated functions, complement activation, humoral immune response, and acute inflammatory response-related proteins. The study also identified differentiated proteins between survivors and nonsurvivors.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Anesthesiology
Marie-Helene Masse, Neill K. J. Adhikari, Xavier Theroux, Marie-Claude Battista, Frederick D'Aragon, Ruxandra Pinto, Alan Cohen, Michael Mayette, Charles St-Arnaud, Michelle Kho, Michael Chasse, Martine Lebrasseur, Irene Watpool, Rebecca Porteous, M. Elizabeth Wilcox, Francois Lamontagne
Summary: In this study, we found that a lower mean arterial pressure target in an unblinded trial was not associated with a change in mean arterial pressure, indicating stability in the net effect of usual clinician practices over time.
BMC ANESTHESIOLOGY
(2022)
Review
Health Care Sciences & Services
Arnav Agarwal, John Basmaji, Shannon M. Fernando, Fang Zhou Ge, Yingqi Xiao, Haseeb Faisal, Kimia Honarmand, Mathieu Hylands, Vincent Lau, Kimberley Lewis, Rachel Couban, Francois Lamontagne, Neill K. J. Adhikari
Summary: This study describes a protocol for a living systematic review that aims to evaluate the effectiveness and safety of parenteral vitamin C administration in adults with severe infections, including COVID-19 patients. The review will provide important insights for critical care physicians and hospitalists and may inform international clinical guidance. The review will be updated iteratively as new trial evidence becomes available.
JMIR RESEARCH PROTOCOLS
(2022)
Article
Emergency Medicine
Godwill Abiala, Melanie Berube, Eric Mercier, Natalie Yanchar, H. Thomas Stelfox, Patrick Archambault, Gilles Bourgeois, Amina Belcaid, Xavier Neveu, Chartelin J. Isaac, Julien Clement, Francois Lamontagne, Lynne Moore
Summary: The study results indicate that pretransfer CT and repeat posttransfer CT are frequent and subject to significant practice variation in trauma transfers. Additionally, pretransfer CT is associated with increased time to transfer. These findings suggest potential opportunities to reduce low-value imaging for trauma transfers.
ACADEMIC EMERGENCY MEDICINE
(2022)
Letter
Critical Care Medicine
John R. Best, Meng Wang, Terry Lee, James A. Russell, Mari L. DeMarco
INTENSIVE CARE MEDICINE
(2022)
Article
Medicine, General & Internal
Charlotte A. Bradbury, Patrick R. Lawler, Simon J. Stanworth, Bryan J. McVerry, Zoe McQuilten, Alisa M. Higgins, Paul R. Mouncey, Farah Al-Beidh, Kathryn M. Rowan, Lindsay R. Berry, Elizabeth Lorenzi, Ryan Zarychanski, Yaseen M. Arabi, Djillali Annane, Abi Beane, Wilma Van Bentum-Puijk, Zahra Bhimani, Shailesh Bihari, Marc J. M. Bonten, Frank M. Brunkhorst, Adrian Buzgau, Meredith Buxton, Marc Carrier, Allen C. Cheng, Matthew Cove, Michelle A. Detry, Lise J. Estcourt, Mark Fitzgerald, Timothy D. Girard, Ewan C. Goligher, Herman Goossens, Rashan Haniffa, Thomas Hills, David T. Huang, Christopher M. Horvat, Beverley J. Hunt, Nao Ichihara, Francois Lamontagne, Helen L. Leavis, Kelsey M. Linstrum, Edward Litton, John C. Marshall, Daniel F. McAuley, Anna McGlothlin, Shay P. McGuinness, Saskia Middeldorp, Stephanie K. Montgomery, Susan C. Morpeth, Srinivas Murthy, Matthew D. Neal, Alistair D. Nichol, Rachael L. Parke, Jane C. Parker, Luis Reyes, Hiroki Saito, Marlene S. Santos, Christina T. Saunders, Ary Serpa-Neto, Christopher W. Seymour, Manu Shankar-Hari, Vanessa Singh, Timo Tolppa, Alexis F. Turgeon, Anne M. Turner, Frank L. van de Veerdonk, Cameron Green, Roger J. Lewis, Derek C. Angus, Colin J. McArthur, Scott Berry, Lennie P. G. Derde, Steve A. Webb, Anthony C. Gordon
Summary: The study results showed that among critically ill patients with COVID-19, treatment with an antiplatelet agent compared with no antiplatelet agent did not significantly improve the number of organ support-free days within 21 days. The use of antiplatelet therapy in critically ill patients with COVID-19 did not show significant benefits.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Health Care Sciences & Services
Zia Sadique, Richard Grieve, Karla Diaz-Ordaz, Paul Mouncey, Francois Lamontagne, Stephen O'Neill
Summary: Personalizing treatment recommendations requires understanding the heterogeneity of treatment effects. Machine-learning approaches, such as causal forests, can explore this heterogeneity by considering multiple covariates. This study compares the causal forest method with parametric approaches and finds similar estimates of treatment effectiveness. The results suggest that the permissive hypotension strategy is expected to reduce mortality for most patients, but there is variability in the estimated effects.
MEDICAL DECISION MAKING
(2022)
Article
Surgery
Lynne Moore, Melanie Berube, Pier-Alexandre Tardif, Francois Lauzier, Alexis Turgeon, Peter Cameron, Howard Champion, Natalie Yanchar, Fiona Lecky, John Kortbeek, David Evans, Eric Mercier, Patrick Archambault, Francois Lamontagne, Belinda Gabbe, Jerome Paquet, Tarek Razek, Henry Thomas Stelfox
Summary: A set of evidence-based and patient-informed quality indicators targeting reductions in low-value clinical practices in acute, in-hospital trauma care was developed through a consensus study. These indicators can be used in trauma quality programs to measure and reduce low-value care in high-income countries.
Article
Health Care Sciences & Services
Neill K. J. Adhikari, Ruxandra Pinto, Andrew G. Day, Marie-Helene Masse, Julie Menard, Sheila Sprague, Djillali Annane, Yaseen M. Arabi, Marie-Claude Battista, Dian Cohen, Deborah J. Cook, Gordon H. Guyatt, Daren K. Heyland, Salmaan Kanji, Shay P. McGuinness, Rachael L. Parke, Bharath Kumar Tirupakuzhi Vijayaraghavan, Emmanuel Charbonney, Michael Chasse, Lorenzo Del Sorbo, Demetrios James Kutsogiannis, Francois Lauzier, Remi Leblanc, David M. Maslove, Sangeeta Mehta, Armand Mekontso Dessap, Tina S. Mele, Bram Rochwerg, Oleksa G. Rewa, Jason Shahin, Pawel Twardowski, Paul Jeffrey Young, Francois Lamontagne
Summary: This study aims to describe a prespecified statistical analysis plan (SAP) for the LOVIT trial, which includes the primary and secondary outcomes and planned analysis methods. The primary outcome is a combination of mortality and persistent organ dysfunction at 28 days. The study will use a frequentist statistical framework and consider the impacts of different subgroups.
JMIR RESEARCH PROTOCOLS
(2022)
Article
Medicine, General & Internal
Francois Lamontagne, Marie-Helene Masse, Julie Menard, Sheila Sprague, Ruxandra Pinto, Daren K. Heyland, Deborah J. Cook, Marie-Claude Battista, Andrew G. Day, Gordon H. Guyatt, Salmaan Kanji, Rachael Parke, Shay P. McGuinness, Bharath-Kumar Tirupakuzhi Vijayaraghavan, Djillali Annane, Dian Cohen, Yaseen M. Arabi, Brigitte Bolduc, Nicole Marinoff, Bram Rochwerg, Tina Millen, Maureen O. Meade, Lori Hand, Irene Watpool, Rebecca Porteous, Paul J. Young, Frederick D'Aragon, Emilie P. Belley-Cote, Elaine Carbonneau, France Clarke, David M. Maslove, Miranda Hunt, Michael Chasse, Martine Lebrasseur, Francois Lauzier, Sangeeta Mehta, Hector Quiroz-Martinez, Oleksa G. Rewa, Emmanuel Charbonney, Andrew J. E. Seely, Demetrios J. Kutsogiannis, Remi LeBlanc, Armand Mekontso-Dessap, Tina S. Mele, Alexis F. Turgeon, Gordon Wood, Sandeep S. Kohli, Jason Shahin, Pawel Twardowski, Neill K. J. Adhikari
Summary: A study on the use of intravenous vitamin C in adult sepsis patients receiving vasopressor therapy in the ICU showed that there is a higher risk of death or persistent organ dysfunction compared to placebo.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Critical Care Medicine
Alyson Takaoka, Nicole Zytaruk, Megan Davis, Andrea Matte, Jennie Johnstone, Francois Lauzier, John Marshall, Neill Adhikari, France J. Clarke, Bram Rochwerg, Francois Lamontagne, Lori Hand, Irene Watpool, Rebecca K. Porteous, Marie-Helene Masse, Frederick D'Aragon, Daniel Niven, Diane Heels-Ansdell, Erick Duan, Joanna Dionne, Shane English, Charles St-Arnaud, Tina Millen, Deborah J. Cook, PROSPECT Investigator, Canadian Critical Care Trials Grp
Summary: The purpose of this study was to categorize, quantify, and interpret findings documented in feedback letters from monitoring or auditing visits for a multicenter randomized trial. The results showed that most observations were related to training documentation and the informed consent process. There were minimal threats to data integrity, patient privacy, or safety.
JOURNAL OF CRITICAL CARE
(2022)
Article
Medicine, Research & Experimental
Julie C. Reid, Alex Molloy, Geoff Strong, Laurel Kelly, Heather O'Grady, Deborah Cook, Patrick M. Archambault, Ian Ball, Sue Berney, Karen E. A. Burns, Frederick D'Aragon, Erick Duan, Shane W. English, Francois Lamontagne, Amy M. Pastva, Bram Rochwerg, Andrew J. E. Seely, Karim Serri, Jennifer L. Y. Tsang, Avelino C. Verceles, Brenda Reeve, Alison Fox-Robichaud, John Muscedere, Margaret Herridge, Lehana Thabane, Michelle E. Kho
Summary: The COVID-19 pandemic has disrupted non-COVID critical care trials. This study uses the CONSERVE statement to report the impact of the pandemic on the CYCLE trial and describes the mitigation approaches.
Article
Respiratory System
Luis Felipe Reyes, Srinivas Murthy, Esteban Garcia-Gallo, Mike Irvine, Laura Merson, Ignacio Martin-Loeches, Jordi Rello, Fabio S. Taccone, Robert A. Fowler, Annemarie B. Docherty, Christiana Kartsonaki, Irene Aragao, Peter W. Barrett, Abigail Beane, Aidan Burrell, Matthew Pellan Cheng, Michael D. Christian, Jose Pedro Cidade, Barbara Wanjiru Citarella, Christl A. Donnelly, Susana M. Fernandes, Craig French, Rashan Haniffa, Ewen M. Harrison, Antonia Ying Wai Ho, Mark Joseph, Irfan Khan, Michelle E. Kho, Anders Benjamin Kildal, Demetrios Kutsogiannis, Francois Lamontagne, Todd C. Lee, Gianluigi Li Bassi, Jose Wagner Lopez Revilla, Catherine Marquis, Jonathan Millar, Raul Neto, Alistair Nichol, Rachael Parke, Rui Pereira, Sergio Poli, Pedro Povoa, Kollengode Ramanathan, Oleksa Rewa, Jordi Riera, Sally Shrapnel, Maria Joao Silva, Andrew Udy, Timothy Uyeki, Steve A. Webb, Evert-Jan Wils, Amanda Rojek, Piero L. Olliaro
Summary: This study investigated the clinical outcomes of severe COVID-19 patients treated outside the ICU, compared to those treated in the ICU. It found that patients admitted to an ICU had a longer hospital stay and a lower 28-day fatality ratio.