Sweet tea (Lithocarpus polystachyus rehd.) as a new natural source of bioactive dihydrochalcones with multiple health benefits

Phloretin Inhibits Zika Virus Infection by Interfering with the Cellular Glucose Utilization

(2019) Shih-Chao Lin et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Phloretin protects against cardiac damage and remodeling via restoring SIRT1 and anti-inflammatory effects in the streptozotocin-induced diabetic mouse model

(2019) Yin Ying et al.   Aging-US

Progress in the discovery of naturally occurring anti-diabetic drugs and in the identification of their molecular targets

(2019) Jian-Hua He et al.   FITOTERAPIA

Target Proteins of Phloretin for Its Anti-Inflammatory and Antibacterial Activities Against Propionibacterium acnes-Induced Skin Infection

(2019) Dasom Cheon et al.   MOLECULES

Phloretin and phloridzin improve insulin sensitivity and enhance glucose uptake by subverting PPARγ/Cdk5 interaction in differentiated adipocytes

(2019) Shiv Kumar et al.   EXPERIMENTAL CELL RESEARCH

Phloretin loaded chitosan nanoparticles augments the pH-dependent mitochondrial-mediated intrinsic apoptosis in human oral cancer cells

(2019) Arokia Vijaya Anand Mariadoss et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Bioactive Compounds and Biological Functions of Garlic (Allium sativum L.)

(2019) Shang et al.   Foods

Phloretin suppresses metastasis by targeting protease and inhibits cancer stemness and angiogenesis in human cervical cancer cells

(2019) Yi-Hsuan Hsiao et al.   PHYTOMEDICINE

Targeting Gut Microbiota for the Prevention and Management of Diabetes Mellitus by Dietary Natural Products

(2019) Li et al.   Foods

Phytochemical identification of Lithocarpus polystachyus extracts by ultra‐high‐performance liquid chromatography–quadrupole time‐of‐flight–MS and their protein tyrosine phosphatase 1B and α ‐glucosidase activities

(2019) Ying Meng et al.   BIOMEDICAL CHROMATOGRAPHY

Phloretin attenuates STAT-3 activity and overcomes sorafenib resistance targeting SHP-1–mediated inhibition of STAT3 and Akt/VEGFR2 pathway in hepatocellular carcinoma

(2019) Sarita Saraswati et al.   Cell Communication and Signaling

Impact of Citral and Phloretin, Alone and in Combination, on Major Virulence Traits of Streptococcus pyogenes

(2019) Mohd Adil et al.   MOLECULES

Comprehensive Transcriptome Analysis Revealed the Effects of the Light Quality, Light Intensity, and Photoperiod on Phlorizin Accumulation in Lithocarpus polystachyus Rehd.

(2019) Yantong Zhang et al.   Forests

Low-dose phloretin alleviates diabetic atherosclerosis through endothelial KLF2 restoration

(2019) Yong Xia et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Phloretin either alone or in combination with duloxetine alleviates the STZ-induced diabetic neuropathy in rats

(2018) Mohamed Balaha et al.   BIOMEDICINE & PHARMACOTHERAPY

Phloretin attenuates mucus hypersecretion and airway inflammation induced by cigarette smoke

(2018) Hao Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Antioxidant Structure–Activity Relationship Analysis of Five Dihydrochalcones

(2018) Xican Li et al.   MOLECULES

Green Extraction of Natural Antioxidants from the Sterculia nobilis Fruit Waste and Analysis of Phenolic Profile

(2018) Jiao-Jiao Zhang et al.   MOLECULES

Phloretin as a Potent Natural TLR2/1 Inhibitor Suppresses TLR2-Induced Inflammation

(2018) Jieun Kim et al.   Nutrients

Increased phloridzin content associated with russeting in apple (Malus domestica (Suckow) Borkh.) fruit

(2018) Benjamin L. Gutierrez et al.   GENETIC RESOURCES AND CROP EVOLUTION

Phlorizin administration ameliorates cognitive deficits by reducing oxidative stress, tau hyper-phosphorylation, and neuroinflammation in a rat model of Alzheimer’s disease

(2018) Yuan Tian et al.   JOURNAL OF FOOD BIOCHEMISTRY

Anticancer Activity of Phloretin Against Human Gastric Cancer Cell Lines Involves Apoptosis, Cell Cycle Arrest, and Inhibition of Cell Invasion and JNK Signalling Pathway

(2018) Min Xu et al.   MEDICAL SCIENCE MONITOR

Trilobatin Protects Against Oxidative Injury in Neuronal PC12 Cells Through Regulating Mitochondrial ROS Homeostasis Mediated by AMPK/Nrf2/Sirt3 Signaling Pathway

(2018) Jianmei Gao et al.   Frontiers in Molecular Neuroscience

Lithocarpus�polystachyus Rehd. leaves aqueous extract protects against hydrogen peroxide‑induced SH-SY5Y cells injury through activation of Sirt3 signaling pathway

(2018) Jianmei Gao et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Activation of Nrf2 by Phloretin Attenuates Palmitic Acid-Induced Endothelial Cell Oxidative Stress via AMPK-Dependent Signaling

(2018) Qing Yang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Phloretin Prevents Diabetic Cardiomyopathy by Dissociating Keap1/Nrf2 Complex and Inhibiting Oxidative Stress

(2018) Yin Ying et al.   Frontiers in Endocrinology

Decrease of microbial community diversity, biogenic amines formation, and lipid oxidation by phloretin in Atlantic salmon fillets

(2018) Jing Wang et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Extraction, identification, and antioxidant and anticancer tests of seven dihydrochalcones from Malus ‘Red Splendor’ fruit

(2017) Zhengcao Xiao et al.   FOOD CHEMISTRY

Inhibitory effect of phloretin on α-glucosidase: Kinetics, interaction mechanism and molecular docking

(2017) Lin Han et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Phloretin attenuates hyperuricemia-induced endothelial dysfunction through co-inhibiting inflammation and GLUT9-mediated uric acid uptake

(2017) Shuyun Liu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Short-term phlorizin treatment attenuates adipose tissue inflammation without alerting obesity in high-fat diet fed mice

(2017) Yuan Tian et al.   JOURNAL OF FOOD BIOCHEMISTRY

Microwave-Assisted Extraction of Natural Antioxidants from the Exotic Gordonia axillaris Fruit: Optimization and Identification of Phenolic Compounds

(2017) Ya Li et al.   MOLECULES

Evaluation of toxicity studies of flavonoid fraction of Lithocarpus polystachyus Rehd in rodents

(2017) Jian Liang et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Synergistic inhibition of colon cancer cell growth by a combination of atorvastatin and phloretin

(2017) Mo Zhou et al.   Oncology Letters

Phloretin induces apoptosis of human esophageal cancer via a mitochondria‑dependent pathway

(2017) Hongtao Duan et al.   Oncology Letters

Phloretin exerts hypoglycemic effect in streptozotocin-induced diabetic rats and improves insulin resistance in vitro

(2017) Xin Shen et al.   Drug Design Development and Therapy

Fruits for Prevention and Treatment of Cardiovascular Diseases

(2017) Cai-Ning Zhao et al.   Nutrients

Effects of Vegetables on Cardiovascular Diseases and Related Mechanisms

(2017) Guo-Yi Tang et al.   Nutrients

Phloretin Attenuates Listeria monocytogenes Virulence Both In vitro and In vivo by Simultaneously Targeting Listeriolysin O and Sortase A

(2017) Jianfeng Wang et al.   Frontiers in Cellular and Infection Microbiology

Subinhibitory concentrations of phloretin repress the virulence of Salmonella typhimurium and protect against Salmonella typhimurium infection

(2016) Wu Shuai-Cheng et al.   ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY

In vitro and in vivo inhibition of aldose reductase and advanced glycation end products by phloretin, epigallocatechin 3-gallate and [6]-gingerol

(2016) Chethan Sampath et al.   BIOMEDICINE & PHARMACOTHERAPY

Potent Antiarthritic Properties of Phloretin in Murine Collagen-Induced Arthritis

(2016) Shun-Ping Wang et al.   Evidence-based Complementary and Alternative Medicine

Hepatotoxicity and endothelial dysfunction induced by high choline diet and the protective effects of phloretin in mice

(2016) Daoyuan Ren et al.   FOOD AND CHEMICAL TOXICOLOGY

Insulin Sensitivity-Enhancing Activity of Phlorizin Is Associated with Lipopolysaccharide Decrease and Gut Microbiota Changes in Obese and Type 2 Diabetes (db/db) Mice

(2016) Xueran Mei et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Phloretin induces cell cycle arrest and apoptosis of human glioblastoma cells through the generation of reactive oxygen species

(2016) Yuanyuan Liu et al.   JOURNAL OF NEURO-ONCOLOGY

Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies

(2016) Vibha Rani et al.   LIFE SCIENCES

Pharmacological research on natural substances in Latvia: Focus on lunasin, betulin, polyprenol and phlorizin

(2016) Ruta Muceniece et al.   PHARMACOLOGICAL RESEARCH

Phlorizin treatment attenuates obesity and related disorders through improving BAT thermogenesis

(2016) Xin Yuan et al.   Journal of Functional Foods

Phlorizin Supplementation Attenuates Obesity, Inflammation, and Hyperglycemia in Diet-Induced Obese Mice Fed a High-Fat Diet

(2016) Su-Kyung Shin et al.   Nutrients

Effects of phloretin on oxidative and inflammatory reaction in rat model of cecal ligation and puncture induced sepsis

(2016) Mehdi Aliomrani et al.   DARU-Journal of Pharmaceutical Sciences

Leaf Extract from Lithocarpus polystachyus Rehd. Promote Glycogen Synthesis in T2DM Mice

(2016) Jinfei Wang et al.   PLoS One

Phloretin increases the anti-tumor efficacy of intratumorally delivered heat-shock protein 70 kDa (HSP70) in a murine model of melanoma

(2015) Sergey V. Abkin et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Contribution of hyperglycemia on diabetic complications in obese type 2 diabetic SDT fatty rats: effects of SGLT inhibitor phlorizin

(2015) Yoshiaki KATSUDA et al.   EXPERIMENTAL ANIMALS

Trilobatin attenuates the LPS-mediated inflammatory response by suppressing the NF-κB signaling pathway

(2015) Xiaolong Fan et al.   FOOD CHEMISTRY

Phloretin ameliorates chemokines and ICAM-1 expression via blocking of the NF-κB pathway in the TNF-α-induced HaCaT human keratinocytes

(2015) Wen-Chung Huang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Phloretin exhibits an anticancer effect and enhances the anticancer ability of cisplatin on non-small cell lung cancer cell lines by regulating expression of apoptotic pathways and matrix metalloproteinases

(2015) LIJIE MA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Phloretin Inhibits Platelet-derived Growth Factor-BB–induced Rat Aortic Smooth Muscle Cell Proliferation, Migration, and Neointimal Formation After Carotid Injury

(2015) Dong Wang et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Preparative isolation, quantification and antioxidant activity of dihydrochalcones from Sweet Tea (Lithocarpus polystachyus Rehd.)

(2015) Yinshi Sun et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Mediators of Inflammation: Inflammation in Cancer, Chronic Diseases, and Wound Healing

(2015) Caigan Du et al.   MEDIATORS OF INFLAMMATION

Phloretin induces apoptosis of non-small cell lung carcinoma A549 cells via JNK1/2 and p38 MAPK pathways

(2015) JIE MIN et al.   ONCOLOGY REPORTS

Evaluation of Apoptotic and Growth Inhibitory Activity of Phloretin in BGC823 Gastric Cancer Cell

(2015) M Lu et al.   TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH

Phloretin inhibits interleukin-1β-induced COX-2 and ICAM-1 expression through inhibition of MAPK, Akt, and NF-κB signaling in human lung epithelial cells

(2015) Wen-Chung Huang et al.   Food & Function

Hyperuricemia, Gout, and Cardiovascular Disease: An Update

(2015) Aryeh M. Abeles   Current Rheumatology Reports

Antioxidant Capacity of Caffeic Acid, Phloretin and Glutathione Mixtures and Formula Optimization

(2014)   ASIAN JOURNAL OF CHEMISTRY

Phlorizin Prevents Electrically-Induced Ventricular Tachyarrhythmia during Ischemia in Langendorff-Perfused Guinea-Pig Hearts

(2014) Masamichi Hirose et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Stress and Atherosclerotic Cardiovascular Disease

(2014) Nobutaka Inoue   Journal of Atherosclerosis and Thrombosis

Beneficial effects of phlorizin on diabetic nephropathy in diabetic db/db mice

(2014) Fei Pei et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Hepatoprotective effects and antioxidant, antityrosinase activities of phloretin and phloretin isonicotinyl hydrazone

(2014) Ai-Ren Zuo et al.   Journal of the Chinese Medical Association

Lithocarpus Polystachyus Rehd Leaf Aqueous Extract Inhibits Human Breast Cancer Growth In Vitro and In Vivo

(2014) Caiyu Lin et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Characterization of phenolic constituents in Lithocarpus polystachyus

(2013) Ya Zhao et al.   Analytical Methods

Immunity, atherosclerosis and cardiovascular disease

(2013) Johan Frostegård   BMC Medicine

Phlorizin Pretreatment Reduces Acute Renal Toxicity in a Mouse Model for Diabetic Nephropathy

(2013) Bas Brouwers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibitory effect of phloretin and biochanin A on IgE-mediated allergic responses in rat basophilic leukemia RBL-2H3 cells

(2013) Mi Ja Chung et al.   LIFE SCIENCES

Phloretin suppresses thrombin-mediated leukocyte-platelet-endothelial interactions

(2013) Min Soo Kim et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Phloretin and phlorizin promote lipolysis and inhibit inflammation in mouse 3T3-L1 cells and in macrophage-adipocyte co-cultures

(2013) Wen-Chung Huang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Investigation of the Protective Effects of Phlorizin on Diabetic Cardiomyopathy indb/dbMice by Quantitative Proteomics

(2013) Qian Cai et al.   Journal of Diabetes Research

Phloretin induced apoptosis of human hepatoma cells SMMC-7721 and its correlative biological mechanisms

(2012) Hui Wang   African Journal of Pharmacy and Pharmacology

The inhibitory effect of phloretin on the formation of Escherichia coli O157:H7 biofilm in a microfluidic system

(2012) Aeri Park et al.   BioChip Journal

Hepatoprotective Effects of Phloridzin on Hepatic Fibrosis Induced by Carbon Tetrachloride against Oxidative Stress-Triggered Damage and Fibrosis in Rats

(2012) Gaigai Deng et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Evaluation of the anti-inflammatory effects of phloretin and phlorizin in lipopolysaccharide-stimulated mouse macrophages

(2012) Wei-Tien Chang et al.   FOOD CHEMISTRY

The effect of Phloretin on human γδ T cells killing colon cancer SW-1116 cells

(2012) Sheng-Ping Zhu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The relationships among hyperuricemia, endothelial dysfunction, and cardiovascular diseases: Molecular mechanisms and clinical implications

(2012) Paolo Puddu et al.   Journal of Cardiology

Effect of the flavonoid fraction of Lithocarpus polystachyus Rehd. on spontaneously hypertensive and normotensive rats

(2012) Shao-zhen Hou et al.   JOURNAL OF ETHNOPHARMACOLOGY

Sweet tea leaves extract improves leptin resistance in diet-induced obese rats

(2012) Cai-Jie Zhou et al.   JOURNAL OF ETHNOPHARMACOLOGY

Quantitative proteomics study on the protective mechanism of phlorizin on hepatic damage in diabetic db/db mice

(2012) Hai-Qing Gao   Molecular Medicine Reports

Biotransformation of phlorizin by human intestinal flora and inhibition of biotransformation products on tyrosinase activity

(2011) Li-Qin Zhang et al.   FOOD CHEMISTRY

Inhibitory potential of trilobatin from Lithocarpus polystachyus Rehd against α-glucosidase and α-amylase linked to type 2 diabetes

(2011) Hua-Qiang Dong et al.   FOOD CHEMISTRY

Induction of glutathione synthesis and heme oxygenase 1 by the flavonoids butein and phloretin is mediated through the ERK/Nrf2 pathway and protects against oxidative stress

(2011) Ya-Chen Yang et al.   FREE RADICAL BIOLOGY AND MEDICINE

The hypoglycemic activity of Lithocarpus polystachyus Rehd. leaves in the experimental hyperglycemic rats

(2011) Shao-zhen Hou et al.   JOURNAL OF ETHNOPHARMACOLOGY

Phloretin Inhibits Phorbol Ester–Induced Tumor Promotion and Expression of Cyclooxygenase-2 in Mouse Skin: Extracellular Signal-Regulated Kinase and Nuclear Factor-κB as Potential Targets

(2011) Jun-Wan Shin et al.   JOURNAL OF MEDICINAL FOOD

Phloridzin reduces blood glucose levels and improves lipids metabolism in streptozotocin-induced diabetic rats

(2011) Mahmood Najafian et al.   MOLECULAR BIOLOGY REPORTS

Phlorizin Prevents Glomerular Hyperfiltration but not Hypertrophy in Diabetic Rats

(2008) Slava Malatiali et al.   Experimental Diabetes Research

In vitroandin vivostudy of phloretin-induced apoptosis in human liver cancer cells involving inhibition of type II glucose transporter

(2008) Chih-Hsiung Wu et al.   INTERNATIONAL JOURNAL OF CANCER