Obesity, COVID-19 and innate immunometabolism

Dietary substitution of saturated with monounsaturated fatty acids within high-fat diets attenuates hyperinsulinemia and pancreatic islet dysfunction

(2020) Jessica C. Ralston et al.   BRITISH JOURNAL OF NUTRITION

Is global BCG vaccination‐induced trained immunity relevant to the progression of SARS‐CoV‐2 pandemic?

(2020) Mayda Gursel et al.   ALLERGY

Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes

(2020) Lihua Zhu et al.   Cell Metabolism

Obesity a Risk Factor for Severe COVID-19 Infection: Multiple Potential Mechanisms

(2020) Naveed Sattar et al.   CIRCULATION

Obesity in Patients Younger Than 60 Years Is a Risk Factor for COVID-19 Hospital Admission

(2020) Jennifer Lighter et al.   CLINICAL INFECTIOUS DISEASES

COVID-19 and the role of chronic inflammation in patients with obesity

(2020) Sonja Chiappetta et al.   INTERNATIONAL JOURNAL OF OBESITY

Insight into the relationship between obesity-induced low-level chronic inflammation and COVID-19 infection

(2020) Jihye Kim et al.   INTERNATIONAL JOURNAL OF OBESITY

Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area

(2020) Safiya Richardson et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

High prevalence of obesity in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) requiring invasive mechanical ventilation

(2020) Arthur Simonnet et al.   Obesity

Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China

(2020) Chaomin Wu et al.   JAMA Internal Medicine

The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation

(2019) Freya R. Svedberg et al.   NATURE IMMUNOLOGY

Impact of Obesity on Influenza A Virus Pathogenesis, Immune Response, and Evolution

(2019) Rebekah Honce et al.   Frontiers in Immunology

Tissue Resident Alveolar Macrophages Do Not Rely on Glycolysis for LPS-induced Inflammation

(2019) Parker S Woods et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Potential Interplay between Dietary Saturated Fats and Genetic Variants of the NLRP3 Inflammasome to Modulate Insulin Resistance and Diabetes Risk: Insights from a Meta‐Analysis of 19 005 Individuals

(2019) Aoife M. Murphy et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Alveolar Macrophage Immunometabolism and Lung Function Impairment in Smoking and Chronic Obstructive Pulmonary Disease

(2019) Sarah L O'Beirne et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cigarette Smoking Impairs the Bioenergetic Immune Response to Mycobacterium Tuberculosis Infection

(2018) Laura E Gleeson et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming

(2018) Anette Christ et al.   CELL

Host Immune Response to Influenza A Virus Infection

(2018) Xiaoyong Chen et al.   Frontiers in Immunology

Targeting of NLRP3 inflammasome with gene editing for the amelioration of inflammatory diseases

(2018) Congfei Xu et al.   Nature Communications

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

Cutting Edge:Mycobacterium tuberculosisInduces Aerobic Glycolysis in Human Alveolar Macrophages That Is Required for Control of Intracellular Bacillary Replication

(2016) Laura E. Gleeson et al.   JOURNAL OF IMMUNOLOGY

Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants

(2016)   LANCET

Trained immunity: A program of innate immune memory in health and disease

(2016) M. G. Netea et al.   SCIENCE

Metabolic reprogramming & inflammation: Fuelling the host response to pathogens

(2016) Laura E. Gleeson et al.   SEMINARS IN IMMUNOLOGY

Obesity Outweighs Protection Conferred by Adjuvanted Influenza Vaccination

(2016) Erik A. Karlsson et al.   mBio

Obesity and cancer: the role of adipose tissue and adipo-cytokines-induced chronic inflammation

(2016) Rosa Divella et al.   Journal of Cancer

Insulin resistance determines a differential response to changes in dietary fat modification on metabolic syndrome risk factors: the LIPGENE study

(2015) Elena M Yubero-Serrano et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Monounsaturated Fatty Acid–Enriched High-Fat Diets Impede Adipose NLRP3 Inflammasome–Mediated IL-1β Secretion and Insulin Resistance Despite Obesity

(2015) Orla M. Finucane et al.   DIABETES

The effect of lipopolysaccharide-induced obesity and its chronic inflammation on influenza virus-related pathology

(2015) Sun-Young Ahn et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Cigarette Smoking Impairs Human Pulmonary Immunity toMycobacterium tuberculosis

(2014) Seónadh M. O’Leary et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Metabolic Dysfunction Drives a Mechanistically Distinct Proinflammatory Phenotype in Adipose Tissue Macrophages

(2014) Mario Kratz et al.   Cell Metabolism

NLRP3 inflammasome activation is required for fibrosis development in NAFLD

(2014) Alexander Wree et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Diet-Induced Obese Mice Exhibit Altered Heterologous Immunity during a Secondary 2009 Pandemic H1N1 Infection

(2013) J. J. Milner et al.   JOURNAL OF IMMUNOLOGY

Obesity and the risk and outcome of infection

(2012) R Huttunen et al.   INTERNATIONAL JOURNAL OF OBESITY

Inflammatory Mechanisms in Obesity

(2011) Margaret F. Gregor et al.   Annual Review of Immunology

A Novel Risk Factor for a Novel Virus: Obesity and 2009 Pandemic Influenza A (H1N1)

(2011) J. K. Louie et al.   CLINICAL INFECTIOUS DISEASES

Obese mice have increased morbidity and mortality compared to non-obese mice during infection with the 2009 pandemic H1N1 influenza virus

(2011) Judith D. Easterbrook et al.   Influenza and Other Respiratory Viruses

Obesity is associated with impaired immune response to influenza vaccination in humans

(2011) P A Sheridan et al.   INTERNATIONAL JOURNAL OF OBESITY

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE