Potential Interplay between Dietary Saturated Fats and Genetic Variants of the NLRP3 Inflammasome to Modulate Insulin Resistance and Diabetes Risk: Insights from a Meta‐Analysis of 19 005 Individuals

Human Tongue Electrophysiological Response to Oleic Acid and Its Associations with PROP Taster Status and the CD36 Polymorphism (rs1761667)

(2019) Giorgia Sollai et al.   Nutrients

Orosensory Detection of Dietary Fatty Acids Is Altered in CB1R−/− Mice

(2018) Léa Brissard et al.   Nutrients

Dietary PUFAs attenuate NLRP3 inflammasome activation via enhancing macrophage autophagy

(2017) Lulu Shen et al.   JOURNAL OF LIPID RESEARCH

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease

(2017) Pim van der Harst et al.   CIRCULATION RESEARCH

Saturated fatty acids trigger TLR4-mediated inflammatory response

(2016) D.M. Rocha et al.   ATHEROSCLEROSIS

Type 2 diabetes: A 21st century epidemic

(2016) Lindsay M. Jaacks et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

What Does Diabetes “Taste” Like?

(2016) Fabrice Neiers et al.   Current Diabetes Reports

The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux

(2016) Varman T. Samuel et al.   JOURNAL OF CLINICAL INVESTIGATION

TRPV1 Gene Polymorphisms Are Associated with Type 2 Diabetes by Their Interaction with Fat Consumption in the Korean Genome Epidemiology Study

(2016) Sunmin Park et al.   Journal of Nutrigenetics and Nutrigenomics

Taste of Fat: A Sixth Taste Modality?

(2016) Philippe Besnard et al.   PHYSIOLOGICAL REVIEWS

The Toll-Like Receptor 4 (TLR4) Variant rs2149356 and Risk of Gout in European and Polynesian Sample Sets

(2016) Humaira Rasheed et al.   PLoS One

Monounsaturated Fatty Acid–Enriched High-Fat Diets Impede Adipose NLRP3 Inflammasome–Mediated IL-1β Secretion and Insulin Resistance Despite Obesity

(2015) Orla M. Finucane et al.   DIABETES

The Rotterdam Study: 2016 objectives and design update

(2015) Albert Hofman et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

SIFT missense predictions for genomes

(2015) Robert Vaser et al.   Nature Protocols

Oral and intestinal sweet and fat tasting: impact of receptor polymorphisms and dietary modulation for metabolic disease

(2015) N. Cvijanovic et al.   NUTRITION REVIEWS

Exclusive olive oil consumption has a protective effect on coronary artery disease; overview of the THISEAS study

(2015) Maria Dimitriou et al.   PUBLIC HEALTH NUTRITION

Role of the Sweet Taste Receptor in Glucose Metabolism: No Sweets for Diabetes?

(2015) Masatoshi Nomura et al.   YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN

NLR family pyrin domain containing 3 (NLRP3) inflammasome gene polymorphism rs7512998 (C>T) predicts aging-related increase of blood pressure, the TAMRISK study

(2015) Tarja Kunnas et al.   Immunity & Ageing

Genetic Polymorphisms in Inflammasome-Dependent Innate Immunity among Pediatric Patients with Severe Renal Parenchymal Infections

(2015) Chi-Hui Cheng et al.   PLoS One

Macrophages, Immunity, and Metabolic Disease

(2014) Joanne C. McNelis et al.   IMMUNITY

Targeting inflammation in the treatment of type 2 diabetes: time to start

(2014) Marc Y. Donath   NATURE REVIEWS DRUG DISCOVERY

Saturated Fat Intake Modulates the Association between an Obesity Genetic Risk Score and Body Mass Index in Two US Populations

(2014) Patricia Casas-Agustench et al.   Journal of the Academy of Nutrition and Dietetics

Saturated fatty acids and type 2 diabetes: more evidence to re-invent dietary guidelines

(2014) Dariush Mozaffarian   Lancet Diabetes & Endocrinology

Differences in the prospective association between individual plasma phospholipid saturated fatty acids and incident type 2 diabetes: the EPIC-InterAct case-cohort study

(2014) Nita G Forouhi et al.   Lancet Diabetes & Endocrinology

Beyond GWASs: Illuminating the Dark Road from Association to Function

(2013) Stacey L. Edwards et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Netherlands Epidemiology of Obesity (NEO) study: study design and data collection

(2013) Renée de Mutsert et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Variants of NLRP3 gene are associated with insulin resistance in Chinese Han population with type-2 diabetes

(2013) Yingying Zheng et al.   GENE

Does Inflammation Determine Metabolic Health Status in Obese and Nonobese Adults?

(2013) Catherine M. Phillips et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

NLRP3 polymorphisms are associated with late-onset Alzheimer's disease in Han Chinese

(2013) Meng-Shan Tan et al.   JOURNAL OF NEUROIMMUNOLOGY

Association ofNLRP3andCARD8genetic polymorphisms with juvenile idiopathic arthritis in a Taiwanese population

(2013) C-A Yang et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Mechanisms for Insulin Resistance: Common Threads and Missing Links

(2012) Varman T. Samuel et al.   CELL

The Inflammasome Puts Obesity in the Danger Zone

(2012) Rinke Stienstra et al.   Cell Metabolism

A Ceramide-Centric View of Insulin Resistance

(2012) Jose A. Chavez et al.   Cell Metabolism

Saturated Fatty Acid and TLR Signaling Link β Cell Dysfunction and Islet Inflammation

(2012) Kosei Eguchi et al.   Cell Metabolism

Olfaction Under Metabolic Influences

(2012) B. Palouzier-Paulignan et al.   CHEMICAL SENSES

Upregulated NLRP3 Inflammasome Activation in Patients With Type 2 Diabetes

(2012) Hye-Mi Lee et al.   DIABETES

Dietary fat modifies the postprandial inflammatory state in subjects with metabolic syndrome: the LIPGENE study

(2012) Cristina Cruz-Teno et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Dietary saturated fatty acids prime the NLRP3 inflammasome via TLR4 in dendritic cells-implications for diet-induced insulin resistance

(2012) Clare M. Reynolds et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The cellular and signaling networks linking the immune system and metabolism in disease

(2012) Olivia Osborn et al.   NATURE MEDICINE

Dietary fat, abdominal obesity and smoking modulate the relationship between plasma complement component 3 concentrations and metabolic syndrome risk

(2011) Catherine M. Phillips et al.   ATHEROSCLEROSIS

Lack of Interleukin-1 Receptor I (IL-1RI) Protects Mice From High-Fat Diet-Induced Adipose Tissue Inflammation Coincident With Improved Glucose Homeostasis

(2011) F. C. McGillicuddy et al.   DIABETES

Association study of CARD8 (p.C10X) and NLRP3 (p.Q705K) variants with rheumatoid arthritis in French and Tunisian populations

(2011) M. Ben Hamad et al.   International Journal of Immunogenetics

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants

(2011) L. D. Ward et al.   NUCLEIC ACIDS RESEARCH

Inflammasome is a central player in the induction of obesity and insulin resistance

(2011) R. Stienstra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophages, Inflammation, and Insulin Resistance

(2010) Jerrold M. Olefsky et al.   Annual Review of Physiology

Fibrinogen beta variants confer protection against coronary artery disease in a Greek case-control study

(2010) Eirini V Theodoraki et al.   BMC Medical Genetics

The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity

(2010) Rinke Stienstra et al.   Cell Metabolism

Effects of dietary fat modification on insulin sensitivity and on other risk factors of the metabolic syndrome—LIPGENE: a European randomized dietary intervention study

(2010) A C Tierney et al.   INTERNATIONAL JOURNAL OF OBESITY

Additive Effect of Polymorphisms in theIL-6,LTA, andTNF-α Genes and Plasma Fatty Acid Level Modulate Risk for the Metabolic Syndrome and Its Components

(2010) Catherine M. Phillips et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Saturated Fat and Cardiometabolic Risk Factors, Coronary Heart Disease, Stroke, and Diabetes: a Fresh Look at the Evidence

(2010) Renata Micha et al.   LIPIDS

Complement component 3 polymorphisms interact with polyunsaturated fatty acids to modulate risk of metabolic syndrome

(2009) Catherine M Phillips et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

A saturated fatty acid–rich diet induces an obesity-linked proinflammatory gene expression profile in adipose tissue of subjects at risk of metabolic syndrome

(2009) Susan J van Dijk et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

ROS1 Asp2213Asn polymorphism is not associated with coronary artery disease in a Greek case-control study

(2009) Eirini V. Theodoraki et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Cohort Profile: The Cardiovascular Risk in Young Finns Study

(2008) O. T Raitakari et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Common variants in the NLRP3 region contribute to Crohn's disease susceptibility

(2008) Alexandra-Chloé Villani et al.   NATURE GENETICS

Bitter Taste Receptors Influence Glucose Homeostasis

(2008) Cedrick D. Dotson et al.   PLoS One