The Genetic Architecture of Type 1 Diabetes

Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells

(2017) Joshua D. Ooi et al.   NATURE

Type 1 Diabetes Candidate Genes Linked to Pancreatic Islet Cell Inflammation and Beta-Cell Apoptosis

(2017) Joachim Størling et al.   Genes

Effects of Type 1 Diabetes Risk Alleles on Immune Cell Gene Expression

(2017) Ramesh Ram et al.   Genes

Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans

(2016) Tommi Vatanen et al.   CELL

Type 1 Diabetes Prevention: A Goal Dependent on Accepting a Diagnosis of an Asymptomatic Disease

(2016) Anette-G. Ziegler et al.   DIABETES

Type 1 Diabetes Genetic Risk Score: A Novel Tool to Discriminate Monogenic and Type 1 Diabetes

(2016) Kashyap A. Patel et al.   DIABETES

HLA-DRB1*15:01-DQA1*01:02-DQB1*06:02 Haplotype Protects Autoantibody-Positive Relatives From Type 1 Diabetes Throughout the Stages of Disease Progression

(2016) Alberto Pugliese et al.   DIABETES

Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes

(2016) Sarah J. Richardson et al.   DIABETOLOGIA

Infections in Early Life and Development of Type 1 Diabetes

(2016) Andreas Beyerlein et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Genetic variation in MHC proteins is associated with T cell receptor expression biases

(2016) Eilon Sharon et al.   NATURE GENETICS

Increased DNA methylation variability in type 1 diabetes across three immune effector cell types

(2016) Dirk S. Paul et al.   Nature Communications

Association of Early Exposure of Probiotics and Islet Autoimmunity in the TEDDY Study

(2016) Ulla Uusitalo et al.   JAMA Pediatrics

The Dynamics of the Human Infant Gut Microbiome in Development and in Progression toward Type 1 Diabetes

(2015) Aleksandar D. Kostic et al.   Cell Host & Microbe

Alterations in Intestinal Microbiota Correlate With Susceptibility to Type 1 Diabetes

(2015) Aimon K. Alkanani et al.   DIABETES

Shared Genetic Basis for Type 1 Diabetes, Islet Autoantibodies, and Autoantibodies Associated With Other Immune-Mediated Diseases in Families With Type 1 Diabetes

(2015) Caroline A. Brorsson et al.   DIABETES CARE

A Type 1 Diabetes Genetic Risk Score Can Aid Discrimination Between Type 1 and Type 2 Diabetes in Young Adults

(2015) Richard A. Oram et al.   DIABETES CARE

Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers

(2015) Suna Onengut-Gumuscu et al.   NATURE GENETICS

Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases

(2015) Tobias L Lenz et al.   NATURE GENETICS

Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls

(2015) Mary D Fortune et al.   NATURE GENETICS

Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases

(2015) Yun R Li et al.   NATURE MEDICINE

Heterogeneity of autoimmune diseases: pathophysiologic insights from genetics and implications for new therapies

(2015) Judy H Cho et al.   NATURE MEDICINE

Widespread seasonal gene expression reveals annual differences in human immunity and physiology

(2015) Xaquin Castro Dopico et al.   Nature Communications

Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping

(2015) Chris Wallace et al.   PLoS Genetics

Genetics of Type 2 Diabetes and Clinical Utility

(2015) Rajkumar Dorajoo et al.   Genes

Genetics of Type 2 Diabetes—Pitfalls and Possibilities

(2015) Rashmi Prasad et al.   Genes

Blood and Islet Phenotypes Indicate Immunological Heterogeneity in Type 1 Diabetes

(2014) Sefina Arif et al.   DIABETES

Type 2 diabetes susceptibility gene variants predispose to adult-onset autoimmune diabetes

(2014) Mette K. Andersen et al.   DIABETOLOGIA

Genetic and epigenetic fine mapping of causal autoimmune disease variants

(2014) Kyle Kai-How Farh et al.   NATURE

Genome-Wide Associations between Genetic and Epigenetic Variation Influence mRNA Expression and Insulin Secretion in Human Pancreatic Islets

(2014) Anders H. Olsson et al.   PLoS Genetics

Characteristics of rapid vs slow progression to type 1 diabetes in multiple islet autoantibody-positive children

(2013) P. Achenbach et al.   DIABETOLOGIA

Seroconversion to Multiple Islet Autoantibodies and Risk of Progression to Diabetes in Children

(2013) Anette G. Ziegler et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Negligible impact of rare autoimmune-locus coding-region variants on missing heritability

(2013) Karen A. Hunt et al.   NATURE

Impact of the CTLA-4/CD28 axis on the processes of joint inflammation in rheumatoid arthritis

(2012) Dezsö Körmendy et al.   ARTHRITIS AND RHEUMATISM

Guts, Germs, and Meals: The Origin of Type 1 Diabetes

(2012) H. Beyan et al.   Current Diabetes Reports

Rising Incidence of Type 1 Diabetes Is Associated With Altered Immunophenotype at Diagnosis

(2012) A. E. Long et al.   DIABETES

Effect of the PTPN22 and INS Risk Genotypes on the Progression to Clinical Type 1 Diabetes After the Initiation of  -Cell Autoimmunity

(2012) J. Lempainen et al.   DIABETES

Evidence of Gene-Gene Interaction and Age-at-Diagnosis Effects in Type 1 Diabetes

(2012) J. M. M. Howson et al.   DIABETES

Frequency, Immunogenetics, and Clinical Characteristics of Latent Autoimmune Diabetes in China (LADA China Study): A Nationwide, Multicenter, Clinic-Based Cross-Sectional Study

(2012) Z. Zhou et al.   DIABETES

Identification of Novel Type 1 Diabetes Candidate Genes by Integrating Genome-Wide Association Data, Protein-Protein Interactions, and Human Pancreatic Islet Gene Expression

(2012) R. Bergholdt et al.   DIABETES

Association between cytotoxic T lymphocyte antigen-4 polymorphism and type 1 diabetes: A meta-analysis

(2012) Zixian Chen et al.   GENE

Pancreas Organ Weight in Individuals With Disease-Associated Autoantibodies at Risk for Type 1 Diabetes

(2012) Martha Campbell-Thompson et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Formation of a Human β-Cell Population within Pancreatic Islets Is Set Early in Life

(2012) Brigid E. Gregg et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Evolution and Functional Impact of Rare Coding Variation from Deep Sequencing of Human Exomes

(2012) J. A. Tennessen et al.   SCIENCE

An Interferon-Induced Helicase (IFIH1) Gene Polymorphism Associates With Different Rates of Progression From Autoimmunity to Type 1 Diabetes

(2011) C. Winkler et al.   DIABETES

Genetic Analysis of Adult-Onset Autoimmune Diabetes

(2011) J. M. M. Howson et al.   DIABETES

Cesarean Section and Interferon-Induced Helicase Gene Polymorphisms Combine to Increase Childhood Type 1 Diabetes Risk

(2011) E. Bonifacio et al.   DIABETES

An important minority of prediabetic first-degree relatives of type 1 diabetic patients derives from seroconversion to persistent autoantibody positivity after 10 years of age

(2011) I. Vermeulen et al.   DIABETOLOGIA

The threshold hypothesis: solving the equation of nurture vs nature in type 1 diabetes

(2011) C. Wasserfall et al.   DIABETOLOGIA

Unraveling the Genetics of Autoimmunity

(2010) Lauren A. Zenewicz et al.   CELL

Genetics of Type 1 Diabetes: What's Next?

(2010) F. Pociot et al.   DIABETES

A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk

(2010) Matthias Heinig et al.   NATURE

Epidemiology of type 1 diabetes and what animal models teach us about the role of viruses in disease mechanisms

(2009) Danny Zipris   CLINICAL IMMUNOLOGY

The genetics of autoimmune diseases: a networked perspective

(2009) Sergio E Baranzini   CURRENT OPINION IN IMMUNOLOGY

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

(2009) Jeffrey C Barrett et al.   NATURE GENETICS

Rare Variants of IFIH1, a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes

(2009) S. Nejentsev et al.   SCIENCE

Genetic Similarities Between Latent Autoimmune Diabetes in Adults, Type 1 Diabetes, and Type 2 Diabetes

(2008) C. Cervin et al.   DIABETES

Autoimmune diseases: insights from genome-wide association studies

(2008) G. Lettre et al.   HUMAN MOLECULAR GENETICS

Concordance for Islet Autoimmunity among Monozygotic Twins

(2008) Maria J. Redondo et al.   NEW ENGLAND JOURNAL OF MEDICINE