Genome-wide association studies (GWAS): impact on elucidating the aetiology of diabetes

Interpretation of Association Signals and Identification of Causal Variants from Genome-wide Association Studies

(2010) Kai Wang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion

(2010) N. Wijesekara et al.   DIABETOLOGIA

Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight

(2010) E. A. Andersson et al.   DIABETOLOGIA

In silico replication of the genome-wide association results of the Type 1 Diabetes Genetics Consortium

(2010) Hui-Qi Qu et al.   HUMAN MOLECULAR GENETICS

Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects

(2010) Kai Wang et al.   HUMAN MOLECULAR GENETICS

Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls

(2010)   NATURE

Hundreds of variants clustered in genomic loci and biological pathways affect human height

(2010) Hana Lango Allen et al.   NATURE

Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight

(2010) Rachel M Freathy et al.   NATURE GENETICS

A map of open chromatin in human pancreatic islets

(2010) Kyle J Gaulton et al.   NATURE GENETICS

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

(2010) Josée Dupuis et al.   NATURE GENETICS

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

(2010) Benjamin F Voight et al.   NATURE GENETICS

Rare Variants Create Synthetic Genome-Wide Associations

(2010) Samuel P. Dickson et al.   PLOS BIOLOGY

Two New Loci for Body-Weight Regulation Identified in a Joint Analysis of Genome-Wide Association Studies for Early-Onset Extreme Obesity in French and German Study Groups

(2010) André Scherag et al.   PLoS Genetics

Transcription factor 7-like 2-gene polymorphism is related to fasting C peptide in latent autoimmune diabetes in adults (LADA)

(2009) Barbara Szepietowska et al.   ACTA DIABETOLOGICA

Examination of All Type 2 Diabetes GWAS Loci Reveals HHEX-IDE as a Locus Influencing Pediatric BMI

(2009) J. Zhao et al.   DIABETES

Type 2 Diabetes Risk Alleles Are Associated With Reduced Size at Birth

(2009) R. M. Freathy et al.   DIABETES

Examination of Type 2 Diabetes Loci Implicates CDKAL1 as a Birth Weight Gene

(2009) J. Zhao et al.   DIABETES

No association of multiple type 2 diabetes loci with type 1 diabetes

(2009) S. M. Raj et al.   DIABETOLOGIA

Interaction between prenatal growth and high-risk genotypes in the development of type 2 diabetes

(2009) N. Pulizzi et al.   DIABETOLOGIA

Analysis of 55 autoimmune disease and type II diabetes loci: further confirmation of chromosomes 4q27, 12q13.2 and 12q24.13 as type I diabetes loci and support for a new locus, 12q13.3–q14.1

(2009) J D Cooper et al.   GENES AND IMMUNITY

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Common genetic variants on 5p14.1 associate with autism spectrum disorders

(2009) Kai Wang et al.   NATURE

Parental origin of sequence variants associated with complex diseases

(2009) Augustine Kong et al.   NATURE

Inactivation of the Fto gene protects from obesity

(2009) Julia Fischer et al.   NATURE

The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer

(2009) Mark M Pomerantz et al.   NATURE GENETICS

Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia

(2009) Johan Rung et al.   NATURE GENETICS

The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling

(2009) Sari Tuupanen et al.   NATURE GENETICS

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

(2009) Jeffrey C Barrett et al.   NATURE GENETICS

Variants ofDENND1BAssociated with Asthma in Children

(2009) Patrick M.A. Sleiman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rare Variants of IFIH1, a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes

(2009) S. Nejentsev et al.   SCIENCE

Prediction and Interaction in Complex Disease Genetics: Experience in Type 1 Diabetes

(2009) David G. Clayton   PLoS Genetics

A Human Type 1 Diabetes Susceptibility Locus Maps to Chromosome 21q22.3

(2008) P. Concannon et al.   DIABETES

Association Analysis of Type 2 Diabetes Loci in Type 1 Diabetes

(2008) H.-Q. Qu et al.   DIABETES

A Novel Susceptibility Locus for Type 1 Diabetes on Chr12q13 Identified by a Genome-Wide Association Study

(2008) H. Hakonarson et al.   DIABETES

Follow-Up Analysis of Genome-Wide Association Data Identifies Novel Loci for Type 1 Diabetes

(2008) S. F.A. Grant et al.   DIABETES

Genetic Similarities Between Latent Autoimmune Diabetes in Adults, Type 1 Diabetes, and Type 2 Diabetes

(2008) C. Cervin et al.   DIABETES

A genetic link between type 2 diabetes and prostate cancer

(2008) T. M. Frayling et al.   DIABETOLOGIA

Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus

(2008) E Y M G Fung et al.   GENES AND IMMUNITY

A HapMap harvest of insights into the genetics of common disease

(2008) Teri A. Manolio et al.   JOURNAL OF CLINICAL INVESTIGATION

Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci

(2008) Jason D Cooper et al.   NATURE GENETICS

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

(2008) Valeriya Lyssenko et al.   NATURE GENETICS

Common variants near MC4R are associated with fat mass, weight and risk of obesity

(2008) Ruth J F Loos et al.   NATURE GENETICS

Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus

(2008) Kazuki Yasuda et al.   NATURE GENETICS

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

(2008) Eleftheria Zeggini et al.   NATURE GENETICS

Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity

(2008) Gudmar Thorleifsson et al.   NATURE GENETICS

SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations

(2008) Hiroyuki Unoki et al.   NATURE GENETICS

Variants in MTNR1B influence fasting glucose levels

(2008) Inga Prokopenko et al.   NATURE GENETICS

A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk

(2008) Nabila Bouatia-Naji et al.   NATURE GENETICS

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

(2008) Cristen J Willer et al.   NATURE GENETICS

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS

Genome-wide association studies for complex traits: consensus, uncertainty and challenges

(2008) Mark I. McCarthy et al.   NATURE REVIEWS GENETICS

Shared and Distinct Genetic Variants in Type 1 Diabetes and Celiac Disease

(2008) Deborah J. Smyth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Association Analysis of the FTO Gene with Obesity in Children of Caucasian and African Ancestry Reveals a Common Tagging SNP

(2008) Struan F. A. Grant et al.   PLoS One

Nutrition interventions for the prevention of type 2 diabetes

(2008) Nelia P. Steyn et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Genetic Mapping in Human Disease

(2008) D. Altshuler et al.   SCIENCE