Cellular senescence as a potential mediator of COVID‐19 severity in the elderly

Distinct Airway Epithelial Stem Cells Hide among Club Cells but Mobilize to Promote Alveolar Regeneration

(2020) Jaymin J. Kathiriya et al.   Cell Stem Cell

Abnormal Coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia

(2020) Ning Tang et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

(2020) Nanshan Chen et al.   LANCET

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China

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A pneumonia outbreak associated with a new coronavirus of probable bat origin

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Single-cell reconstruction of the adult human heart during heart failure and recovery reveals the cellular landscape underlying cardiac function

(2020) Li Wang et al.   NATURE CELL BIOLOGY

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

(2020) Zhe Xu et al.   Lancet Respiratory Medicine

COVID-19 and its implications for thrombosis and anticoagulation

(2020) Jean Marie Connors et al.   BLOOD

Nervous system involvement after infection with COVID-19 and other coronaviruses

(2020) Yeshun Wu et al.   BRAIN BEHAVIOR AND IMMUNITY

Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China

(2020) Chuan Qin et al.   CLINICAL INFECTIOUS DISEASES

Self DNA perpetuates IPF lung fibroblast senescence in a cGAS-dependent manner

(2020) Michael Schuliga et al.   CLINICAL SCIENCE

Pathogenesis of COVID-19 from a cell biology perspective

(2020) Robert J. Mason   EUROPEAN RESPIRATORY JOURNAL

Effect of renin–angiotensin system on senescence

(2020) Masaki Mogi   Geriatrics & Gerontology International

COVID-19: Abnormal liver function tests

(2020) Qingxian Cai et al.   JOURNAL OF HEPATOLOGY

Endothelial cell infection and endotheliitis in COVID-19

(2020) Zsuzsanna Varga et al.   LANCET

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

SARS-CoV-2 and viral sepsis: observations and hypotheses

(2020) Hui Li et al.   LANCET

Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study

(2020) Kelvin Kai-Wang To et al.   LANCET INFECTIOUS DISEASES

Sestrins induce natural killer function in senescent-like CD8+ T cells

(2020) Branca I. Pereira et al.   NATURE IMMUNOLOGY

Controversies of renin–angiotensin system inhibition during the COVID-19 pandemic

(2020) Andrew M. South et al.   Nature Reviews Nephrology

T cells with dysfunctional mitochondria induce multimorbidity and premature senescence

(2020) Gabriela Desdín-Micó et al.   SCIENCE

Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study

(2020) Annemarie B Docherty et al.   BMJ-British Medical Journal

Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China

(2020) Ling Mao et al.   JAMA Neurology

Pulmonary and cardiac pathology in African American patients with COVID-19: an autopsy series from New Orleans

(2020) Sharon E Fox et al.   Lancet Respiratory Medicine

Hospitalization Rates and Characteristics of Patients Hospitalized with Laboratory-Confirmed Coronavirus Disease 2019 — COVID-NET, 14 States, March 1–30, 2020

(2020) Shikha Garg et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Plasma Metabolomic and Lipidomic Alterations Associated with COVID-19

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Cardiac Involvement in a Patient With Coronavirus Disease 2019 (COVID-19)

(2020) Riccardo M. Inciardi et al.   JAMA Cardiology

Cardiovascular Implications of Fatal Outcomes of Patients With Coronavirus Disease 2019 (COVID-19)

(2020) Tao Guo et al.   JAMA Cardiology

Lymph node stromal CCL2 limits antibody responses

(2020) Dragos C. Dasoveanu et al.   Science Immunology

Single-cell RNA Expression Profiling of ACE2, The Receptor of SARS-CoV-2

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Targeting T-cell senescence and cytokine storm with rapamycin to prevent severe progression in COVID-19

(2020) Loukman Omarjee et al.   CLINICAL IMMUNOLOGY

Viral dynamics in mild and severe cases of COVID-19

(2020) Yang Liu et al.   LANCET INFECTIOUS DISEASES

Interleukin-6 as a potential biomarker of COVID-19 progression

(2020) Zulvikar Syambani Ulhaq et al.   MEDECINE ET MALADIES INFECTIEUSES

Severe COVID-19 infection associated with endothelial activation

(2020) Robert Escher et al.   THROMBOSIS RESEARCH

Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia

(2020) Sara De Biasi et al.   Nature Communications

Association of chemosensory dysfunction and COVID‐19 in patients presenting with influenza‐like symptoms

(2020) Carol H. Yan et al.   International Forum of Allergy & Rhinology

Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome

(2019) I-Yin Chen et al.   Frontiers in Microbiology

Assessment of Lymph Node Stromal Cells as an Underlying Factor in Age-Related Immune Impairment

(2019) April R Masters et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Converging Paths of Pulmonary Arterial Hypertension and Cellular Senescence.

(2019) Diederik E van der Feen et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Cellular Senescence in the Lung Across the Age Spectrum

(2019) Pavan Parikh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Cellular Senescence: The Trojan Horse in Chronic Lung Diseases

(2019) Shruthi Hamsanathan et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The molecular machinery of regulated cell death

(2019) Daolin Tang et al.   CELL RESEARCH

Senescent cell clearance by the immune system: Emerging therapeutic opportunities

(2019) Larissa G.P. Langhi Prata et al.   SEMINARS IN IMMUNOLOGY

Restored immune cell functions upon clearance of senescence in the irradiated splenic environment

(2019) Lina Palacio et al.   AGING CELL

Cellular senescence in cardiac diseases

(2019) Ippei Shimizu et al.   Journal of Cardiology

Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition

(2019) Branca I. Pereira et al.   Nature Communications

The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype

(2019) Priya Hari et al.   Science Advances

SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent Cells

(2019) Christopher D. Wiley et al.   Cell Reports

Mechanisms of aging and potential role of selected polyphenols in extending healthspan

(2019) Gian Luigi Russo et al.   BIOCHEMICAL PHARMACOLOGY

Cellular Senescence: Defining a Path Forward

(2019) Vassilis Gorgoulis et al.   CELL

Diminished immune responses with aging predispose older adults to common and uncommon influenza complications

(2019) Spencer R. Keilich et al.   CELLULAR IMMUNOLOGY

Targeting senescent cells in translational medicine

(2019) Marta Paez‐Ribes et al.   EMBO Molecular Medicine

Senescent cells: a therapeutic target for cardiovascular disease

(2018) Bennett G. Childs et al.   JOURNAL OF CLINICAL INVESTIGATION

In situ evidence of cellular senescence in Thymic Epithelial Cells (TECs) during human thymic involution

(2018) Alexandra Barbouti et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Endothelial dysfunction and angiogenesis impairment in the ageing vasculature

(2018) Zoltan Ungvari et al.   Nature Reviews Cardiology

Thymic involution and rising disease incidence with age

(2018) Sam Palmer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hallmarks of Cellular Senescence

(2018) Alejandra Hernandez-Segura et al.   TRENDS IN CELL BIOLOGY

Paracrine cellular senescence exacerbates biliary injury and impairs regeneration

(2018) Sofia Ferreira-Gonzalez et al.   Nature Communications

TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence

(2018) Thomas G. Bird et al.   Science Translational Medicine

Lymph nodes as barriers to T-cell rejuvenation in aging mice and nonhuman primates

(2018) Heather L. Thompson et al.   AGING CELL

Rapamycin, proliferation and geroconversion to senescence

(2018) Mikhail V. Blagosklonny   CELL CYCLE

Human peripheral late/exhausted memory B cells express a senescent-associated secretory phenotype and preferentially utilize metabolic signaling pathways

(2017) Daniela Frasca et al.   EXPERIMENTAL GERONTOLOGY

Cytoplasmic chromatin triggers inflammation in senescence and cancer

(2017) Zhixun Dou et al.   NATURE

Cellular senescence mediates fibrotic pulmonary disease

(2017) Marissa J. Schafer et al.   Nature Communications

NKG2D ligands mediate immunosurveillance of senescent cells

(2016) Adi Sagiv et al.   Aging-US

Senescence in chronic liver disease: Is the future in aging?

(2016) Aloysious D. Aravinthan et al.   JOURNAL OF HEPATOLOGY

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

What's Next After ARDS: Long-Term Outcomes

(2016) D. Chiumello et al.   Respiratory Care

The host immune response in respiratory virus infection: balancing virus clearance and immunopathology

(2016) Amy H. Newton et al.   Seminars in Immunopathology

Vascular Cell Senescence Contributes to Blood–Brain Barrier Breakdown

(2016) Yu Yamazaki et al.   STROKE

Endothelial cell senescence and thrombosis: Ageing clots

(2016) Magdalena L. Bochenek et al.   THROMBOSIS RESEARCH

Induction of DNA double-strand breaks and cellular senescence by human respiratory syncytial virus

(2016) Isidoro Martínez et al.   Virulence

IL1- and TGFβ-Nox4 signaling, oxidative stress and DNA damage response are shared features of replicative, oncogene-induced, and drug-induced paracrine ‘Bystander senescence’

(2016) Sona Hubackova et al.   Aging-US

The aged lymphoid tissue environment fails to support naïve T cell homeostasis

(2016) Bryan R. Becklund et al.   Scientific Reports

Cell senescence is an antiviral defense mechanism

(2016) Maite Baz-Martínez et al.   Scientific Reports

Mitochondrial Respiration Controls Lysosomal Function during Inflammatory T Cell Responses

(2015) Francesc Baixauli et al.   Cell Metabolism

Hallmarks of the ageing lung

(2015) Silke Meiners et al.   EUROPEAN RESPIRATORY JOURNAL

A CD153+CD4+T Follicular Cell Population with Cell-Senescence Features Plays a Crucial Role in Lupus Pathogenesis via Osteopontin Production

(2015) Suhail Tahir et al.   JOURNAL OF IMMUNOLOGY

Fibroblastic Reticular Cells: Organization and Regulation of the T Lymphocyte Life Cycle

(2015) Flavian D. Brown et al.   JOURNAL OF IMMUNOLOGY

A cGAS-Independent STING/IRF7 Pathway Mediates the Immunogenicity of DNA Vaccines

(2015) John J. Suschak et al.   JOURNAL OF IMMUNOLOGY

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

(2015) Remi-Martin Laberge et al.   NATURE CELL BIOLOGY

Stromal infrastructure of the lymph node and coordination of immunity

(2015) Jonathan E. Chang et al.   TRENDS IN IMMUNOLOGY

Age-Dependent Cell Trafficking Defects in Draining Lymph Nodes Impair Adaptive Immunity and Control of West Nile Virus Infection

(2015) Justin M. Richner et al.   PLoS Pathogens

NKG2D Receptor and Its Ligands in Host Defense

(2015) L. L. Lanier   Cancer Immunology Research

Senescence-Associated Secretory Phenotype and Its Possible Role in Chronic Obstructive Pulmonary Disease

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Senescence and apoptosis: dueling or complementary cell fates?

(2014) B. G. Childs et al.   EMBO REPORTS

High TNF-α levels in resting B cells negatively correlate with their response

(2014) Daniela Frasca et al.   EXPERIMENTAL GERONTOLOGY

The Role of the Liver in Sepsis

(2014) Jun Yan et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Splenic Stromal Cells from Aged Mice Produce Higher Levels of IL-6 Compared to Young Mice

(2014) Jihyun Park et al.   MEDIATORS OF INFLAMMATION

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation

(2013) Olga Moiseeva et al.   AGING CELL

Does senescence affect lymph node number and morphology? A systematic review

(2013) Omid Ahmadi et al.   ANZ JOURNAL OF SURGERY

Cellular senescence or EGFR signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR)

(2013) Christoph Garbers et al.   CELL CYCLE

Cell fusion induced by ERVWE1 or measles virus causes cellular senescence

(2013) A. Chuprin et al.   GENES & DEVELOPMENT

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

Senescent Cardiac Fibroblast Is Critical for Cardiac Fibrosis after Myocardial Infarction

(2013) Fuli Zhu et al.   PLoS One

Risk factors for community-acquired pneumonia in adults in Europe: a literature review

(2013) Antoni Torres et al.   THORAX

Role of the p63-FoxN1 regulatory axis in thymic epithelial cell homeostasis during aging

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The number of p16INK4a positive cells in human skin reflects biological age

(2012) Mariëtte E.C. Waaijer et al.   AGING CELL

An Official ATS/ERS/JRS/ALAT Statement: Idiopathic Pulmonary Fibrosis: Evidence-based Guidelines for Diagnosis and Management

(2011) Ganesh Raghu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Molecular mechanisms of cardiomyocyte aging

(2011) Anna Sheydina et al.   CLINICAL SCIENCE

Age-related increases in PGD2 expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice

(2011) Jincun Zhao et al.   JOURNAL OF CLINICAL INVESTIGATION

A Molecular Mechanism for TNF- -Mediated Downregulation of B Cell Responses

(2011) D. Frasca et al.   JOURNAL OF IMMUNOLOGY

Lung dendritic cells at the innate-adaptive immune interface

(2011) Tracy Voss Condon et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Plasmid Vector-Linked Maturation of Natural Killer (NK) Cells Is Coupled to Antigen-Dependent NK Cell Activation during DNA-Based Immunization in Mice

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Age-dependent histoarchitectural changes in human lymph nodes: an underestimated process with clinical relevance?

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Structural and Physiological Age-Associated Changes in Aging Lungs

(2010) Martin Miller   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

Expression ofp16INK4ain peripheral blood T-cells is a biomarker of human aging

(2009) Yan Liu et al.   AGING CELL

DNA damage response and cellular senescence in tissues of aging mice

(2009) Chunfang Wang et al.   AGING CELL

Senescence: an antiviral defense that is tumor suppressive?

(2009) R. R. Reddel   CARCINOGENESIS

SARS-coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS

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Modulation of T Lymphocyte Replicative Senescence via TNF-  Inhibition: Role of Caspase-3

(2009) S. T. Parish et al.   JOURNAL OF IMMUNOLOGY

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

Cell surface-bound IL-1  is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network

(2009) A. V. Orjalo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alveolar Cell Senescence Exacerbates Pulmonary Inflammation in Patients with Chronic Obstructive Pulmonary Disease

(2009) Takao Tsuji et al.   RESPIRATION

An evolutionary perspective on the mechanisms of immunosenescence

(2009) Daryl P. Shanley et al.   TRENDS IN IMMUNOLOGY

Architectural changes in the thymus of aging mice

(2008) Danielle Aw et al.   AGING CELL

Aging and cancer resistance in lymphoid progenitors are linked processes conferred by p16Ink4a and Arf

(2008) R. A.J. Signer et al.   GENES & DEVELOPMENT

Interferon-γ induces cellular senescence through p53-dependent DNA damage signaling in human endothelial cells

(2008) Kwang Seok Kim et al.   MECHANISMS OF AGEING AND DEVELOPMENT