Lifelong CMV infection improves immune defense in old mice by broadening the mobilized TCR repertoire against third-party infection

Cytomegalovirus (CMV) research in immune senescence comes of age: overview of the 6th International Workshop on CMV and Immunosenescence

(2017) Janko Nikolich-Žugich et al.   GeroScience

A constant companion: immune recognition and response to cytomegalovirus with aging and implications for immune fitness

(2017) Aisha Souquette et al.   GeroScience

CMV immune evasion and manipulation of the immune system with aging

(2017) Sarah E. Jackson et al.   GeroScience

Sequential Infection with Common Pathogens Promotes Human-like Immune Gene Expression and Altered Vaccine Response

(2016) Tiffany A. Reese et al.   Cell Host & Microbe

Heightened self-reactivity associated with selective survival, but not expansion, of naïve virus-specific CD8+T cells in aged mice

(2016) Kylie M. Quinn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune Protection against Virus Challenge in Aging Mice Is Not Affected by Latent Herpesviral Infections

(2015) Thomas F. Marandu et al.   JOURNAL OF VIROLOGY

Cytomegalovirus infection enhances the immune response to influenza

(2015) David Furman et al.   Science Translational Medicine

MT-Toolbox: improved amplicon sequencing using molecule tags

(2014) Scott M Yourstone et al.   BMC BIOINFORMATICS

TLR5-Mediated Sensing of Gut Microbiota Is Necessary for Antibody Responses to Seasonal Influenza Vaccination

(2014) Jason Z. Oh et al.   IMMUNITY

Aging and Cytomegalovirus Infection Differentially and Jointly Affect Distinct Circulating T Cell Subsets in Humans

(2014) A. M. Wertheimer et al.   JOURNAL OF IMMUNOLOGY

Gammaherpesvirus Latency Differentially Impacts the Generation of Primary versus Secondary Memory CD8+ T Cells during Subsequent Infection

(2014) E. S. Barton et al.   JOURNAL OF VIROLOGY

Diversity and clonal selection in the human T-cell repertoire

(2014) Q. Qi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Naïve and memory CD8 T cell pool homeostasis in advanced aging: impact of age and of antigen-specific responses to cytomegalovirus

(2013) Rosanna Vescovini et al.   AGE

Immunosenenescence: Role of cytomegalovirus

(2013) Graham Pawelec   EXPERIMENTAL GERONTOLOGY

CD27-CD70 Costimulation Controls T Cell Immunity during Acute and Persistent Cytomegalovirus Infection

(2013) S. P. M. Welten et al.   JOURNAL OF VIROLOGY

IgBLAST: an immunoglobulin variable domain sequence analysis tool

(2013) Jian Ye et al.   NUCLEIC ACIDS RESEARCH

Dual Analysis of the Murine Cytomegalovirus and Host Cell Transcriptomes Reveal New Aspects of the Virus-Host Cell Interface

(2013) Vanda Juranic Lisnic et al.   PLoS Pathogens

Age-associated alterations in CD8α+ dendritic cells impair CD8 T-cell expansion in response to an intracellular bacterium

(2012) Gang Li et al.   AGING CELL

Lifelong Persistent Viral Infection Alters the Naive T Cell Pool, Impairing CD8 T Cell Immunity in Late Life

(2012) M. J. Smithey et al.   JOURNAL OF IMMUNOLOGY

Autoreactive Effector/Memory CD4+ and CD8+ T Cells Infiltrating Grafted and Endogenous Islets in Diabetic NOD Mice Exhibit Similar T Cell Receptor Usage

(2012) Ramiro Diz et al.   PLoS One

Early Priming Minimizes the Age-Related Immune Compromise of CD8+ T Cell Diversity and Function

(2012) Sophie A. Valkenburg et al.   PLoS Pathogens

Cytomegalovirus Infection Impairs Immune Responses and Accentuates T-cell Pool Changes Observed in Mice with Aging

(2012) Luka Cicin-Sain et al.   PLoS Pathogens

Immune Senescence: Relative Contributions of Age and Cytomegalovirus Infection

(2012) Andrea Mekker et al.   PLoS Pathogens

The LCMV gp33-specific memory T cell repertoire narrows with age

(2012) Adam Bunztman et al.   Immunity & Ageing

Increased apoptosis, curtailed expansion and incomplete differentiation of CD8+ T cells combine to decrease clearance of L. monocytogenes in old mice

(2011) Megan J. Smithey et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Splenic CD8α+ dendritic cells undergo rapid programming by cytosolic bacteria and inflammation to induce protective CD8+ T-cell memory

(2011) Laura Campisi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Evolution of the Antigen-Specific CD8+ TCR Repertoire across the Life Span: Evidence for Clonal Homogenization of the Old TCR Repertoire

(2011) B. D. Rudd et al.   JOURNAL OF IMMUNOLOGY

Plasmacytoid DC from Aged Mice Down-Regulate CD8 T Cell Responses by Inhibiting cDC Maturation after Encephalitozoon cuniculi Infection

(2011) Jason P. Gigley et al.   PLoS One

Nonrandom attrition of the naive CD8+ T-cell pool with aging governed by T-cell receptor:pMHC interactions

(2011) B. D. Rudd et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytomegalovirus Seroprevalence in the United States: The National Health and Nutrition Examination Surveys, 1988–2004

(2010) Sheri Lewis Bate et al.   CLINICAL INFECTIOUS DISEASES

Key role of T cell defects in age-related vulnerability to West Nile virus

(2009) James D. Brien et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Limited expansion of virus-specific CD8 T cells in the aged environment

(2009) Jiu Jiang et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Complete but curtailed T-cell response to very low-affinity antigen

(2009) Dietmar Zehn et al.   NATURE

Recruitment of Antigen-Specific CD8+ T Cells in Response to Infection Is Markedly Efficient

(2009) J. W. J. van Heijst et al.   SCIENCE

Endogenous Naive CD8+ T Cell Precursor Frequency Regulates Primary and Memory Responses to Infection

(2008) Joshua J. Obar et al.   IMMUNITY

Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus

(2008) Eric J. Yager et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Method for assessing the similarity between subsets of the T cell receptor repertoire

(2007) Vanessa Venturi et al.   JOURNAL OF IMMUNOLOGICAL METHODS