Nicotinamide adenine dinucleotide: Biosynthesis, consumption and therapeutic role in cardiac diseases

DNA damage-induced PARP1 activation confers cardiomyocyte dysfunction through NAD+ depletion in experimental atrial fibrillation

(2019) Deli Zhang et al.   Nature Communications

Poly(ADP-ribosyl)ation by PARP1: reaction mechanism and regulatory proteins

(2019) Elizaveta E Alemasova et al.   NUCLEIC ACIDS RESEARCH

Cardioprotective Effect of the Mitochondrial Unfolded Protein Response During Chronic Pressure Overload

(2019) Ioannis Smyrnias et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Premature Myocardial Infarction: Genetic Variations in SIRT1 Affect Disease Susceptibility

(2019) Aylin Hatice Yamac et al.   Cardiology Research and Practice

Both gain and loss of Nampt function promote pressure-overload-induced heart failure

(2019) Jaemin Byun et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The nuclear and mitochondrial sirtuins, Sirt6 and Sirt3, regulate each other’s activity and protect the heart from developing obesity-mediated diabetic cardiomyopathy

(2019) Abhinav Kanwal et al.   FASEB JOURNAL

Boosting NAD+ with a small molecule that activates NAMPT

(2019) Stephen J. Gardell et al.   Nature Communications

Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults

(2019) Dietrich Conze et al.   Scientific Reports

Sirt3 Deficiency Shortens Life Span and Impairs Cardiac Mitochondrial Function Rescued by Opa1 Gene Transfer

(2019) Ariela Benigni et al.   ANTIOXIDANTS & REDOX SIGNALING

Low Cellular NAD+ Compromises Lipopolysaccharide-Induced Inflammatory Responses via Inhibiting TLR4 Signal Transduction in Human Monocytes

(2019) Kuan Yang et al.   JOURNAL OF IMMUNOLOGY

Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures

(2019) Yasir S. Elhassan et al.   Cell Reports

Cardiac Rehabilitation Increases SIRT1 Activity and β-Hydroxybutyrate Levels and Decreases Oxidative Stress in Patients with HF with Preserved Ejection Fraction

(2019) Graziamaria Corbi et al.   Oxidative Medicine and Cellular Longevity

Cardiomyocyte Sirt (Sirtuin) 7 Ameliorates Stress-Induced Cardiac Hypertrophy by Interacting With and Deacetylating GATA4

(2019) Satoru Yamamura et al.   HYPERTENSION

Amelioration of myocardial ischemia-reperfusion injury by SIRT4 involves mitochondrial protection and reduced apoptosis

(2018) Guangwei Zeng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PARP-1 inhibition attenuates cardiac fibrosis induced by myocardial infarction through regulating autophagy

(2018) Haibing Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence

(2018) Luis Rajman et al.   Cell Metabolism

A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD + Decline

(2018) Mariana G. Tarragó et al.   Cell Metabolism

Quantitative Analysis of NAD Synthesis-Breakdown Fluxes

(2018) Ling Liu et al.   Cell Metabolism

Cardioprotection by nicotinamide mononucleotide (NMN): Involvement of glycolysis and acidic pH

(2018) Sergiy M. Nadtochiy et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Genetic deletion of CD38 confers post-ischemic myocardial protection through preserved pyridine nucleotides

(2018) James Boslett et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults

(2018) Christopher R. Martens et al.   Nature Communications

CD38 Deficiency Protects Heart from High Fat Diet-Induced Oxidative Stress Via Activating Sirt3/FOXO3 Pathway

(2018) Ling-Fang Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Rescue of biosynthesis of nicotinamide adenine dinucleotide protects the heart in cardiomyopathy caused by lamin A/C gene mutation

(2018) Nicolas Vignier et al.   HUMAN MOLECULAR GENETICS

Nicotinamide Phosphate Transferase (NAMPT) Increases in Plasma in Patients with Acute Coronary Syndromes, and Promotes Macrophages to M2 Polarization

(2018) Chengxin Zhang et al.   International Heart Journal

Pterostilbene raises low density lipoprotein cholesterol in people

(2018) Charles Brenner et al.   CLINICAL NUTRITION

PARP1 Trapping by PARP Inhibitors Drives Cytotoxicity in Both Cancer Cells and Healthy Bone Marrow

(2018) Todd A. Hopkins et al.   MOLECULAR CANCER RESEARCH

PARP1 promote autophagy in cardiomyocytes via modulating FoxO3a transcription

(2018) Cheng Wang et al.   Cell Death & Disease

Nicotinamide riboside, a form of vitamin B3, protects against excitotoxicity-induced axonal degeneration

(2017) Pauline Vaur et al.   FASEB JOURNAL

A sirtuin 1/MMP2 prognostic index for myocardial infarction in patients with advanced coronary artery disease

(2017) Ilias P. Doulamis et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Synthesis of the Ca 2+ -mobilizing messengers NAADP and cADPR by intracellular CD38 enzyme in the mouse heart: Role in β-adrenoceptor signaling

(2017) Wee K. Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sirtuin 5 is required for mouse survival in response to cardiac pressure overload

(2017) Kathleen A. Hershberger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PARP1 induces cardiac fibrosis by mediating mTOR activity

(2017) Shuya Sun et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Mitochondrial energetics and calcium coupling in the heart

(2017) Michael Kohlhaas et al.   JOURNAL OF PHYSIOLOGY-LONDON

The sirtuin 6 prevents angiotensin II-mediated myocardial fibrosis and injury by targeting AMPK-ACE2 signaling

(2017) Zhen-Zhou Zhang et al.   Oncotarget

Cardioprotective Effects of SIRT6 in a Mouse Model of Transverse Aortic Constriction-Induced Heart Failure

(2017) Yongming Li et al.   Frontiers in Physiology

Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells

(2017) Rachel S. Fletcher et al.   Molecular Metabolism

Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy

(2017) Nicolas Diguet et al.   CIRCULATION

An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers

(2017) Sophia E. Airhart et al.   PLoS One

Receptor-interacting Protein 140 represses Sirtuin 3 to facilitate hypertrophy, mitochondrial dysfunction and energy metabolic dysfunction in cardiomyocytes

(2016) J. You et al.   Acta Physiologica

Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice

(2016) Natalie E. de Picciotto et al.   AGING CELL

Sirt3 protects mitochondrial DNA damage and blocks the development of doxorubicin-induced cardiomyopathy in mice

(2016) Vinodkumar B. Pillai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Age-Dependent Susceptibility to Pulmonary Fibrosis Is Associated with NLRP3 Inflammasome Activation

(2016) Heather W. Stout-Delgado et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Nicotinamide adenine dinucleotide homeostasis and signalling in heart disease: Pathophysiological implications and therapeutic potential

(2016) Mathias Mericskay   Archives of Cardiovascular Diseases

CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism

(2016) Juliana Camacho-Pereira et al.   Cell Metabolism

Nicotinamide Riboside Is a Major NAD+ Precursor Vitamin in Cow Milk

(2016) S. A. Trammell et al.   JOURNAL OF NUTRITION

SIRT6 suppresses phenylephrine-induced cardiomyocyte hypertrophy though inhibiting p300

(2016) Peiye Shen et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation

(2016) D. Ryu et al.   Science Translational Medicine

NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells

(2016) Joanna Ratajczak et al.   Nature Communications

Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

(2016) Samuel A. J. Trammell et al.   Nature Communications

Structural Insights into the Quaternary Catalytic Mechanism of Hexameric Human Quinolinate Phosphoribosyltransferase, a Key Enzyme in de novo NAD Biosynthesis

(2016) Hyung-Seop Youn et al.   Scientific Reports

Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy

(2016) Angela V. Hafner et al.   Aging-US

MicroRNA-497 Inhibits Cardiac Hypertrophy by Targeting Sirt4

(2016) Yimin Xiao et al.   PLoS One

SIRT3 deficiency impairs mitochondrial and contractile function in the heart

(2015) Christoph Koentges et al.   BASIC RESEARCH IN CARDIOLOGY

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

(2015) Carles Cantó et al.   Cell Metabolism

Sirt7 Contributes to Myocardial Tissue Repair by Maintaining Transforming Growth Factor-β Signaling PathwayCLINICAL PERSPECTIVE

(2015) Satoshi Araki et al.   CIRCULATION

Sirtuin function in aging heart and vessels

(2015) Chiara Cencioni et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Losartan Protects the Heart Against Ischemia Reperfusion Injury: Sirtuin3 Involvement

(2015) Mohsen Sharifi Klishadi et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

Depletion of NADP(H) due to CD38 activation triggers endothelial dysfunction in the postischemic heart

(2015) Levy A. Reyes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging Role of Sirtuin 2 in the Regulation of Mammalian Metabolism

(2015) Pedro Gomes et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

NAD+-dependent SIRT1 deactivation has a key role on ischemia–reperfusion-induced apoptosis

(2015) Arianna Cattelan et al.   VASCULAR PHARMACOLOGY

Monocyte-derived extracellular Nampt-dependent biosynthesis of NAD+ protects the heart against pressure overload

(2015) Masamichi Yano et al.   Scientific Reports

Lethal Cardiomyopathy in Mice Lacking Transferrin Receptor in the Heart

(2015) Wenjing Xu et al.   Cell Reports

Mouse SIRT3 Attenuates Hypertrophy-Related Lipid Accumulation in the Heart through the Deacetylation of LCAD

(2015) Tongshuai Chen et al.   PLoS One

SIRT3 deficiency exacerbates ischemia-reperfusion injury: implication for aged hearts

(2014) George A. Porter et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Evidence for a Direct Effect of the NAD+Precursor Acipimox on Muscle Mitochondrial Function in Humans

(2014) Tineke van de Weijer et al.   DIABETES

D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice

(2014) E. A. Akbay et al.   GENES & DEVELOPMENT

Nonenzymatic Protein Acylation as a Carbon Stress Regulated by Sirtuin Deacylases

(2014) Gregory R. Wagner et al.   MOLECULAR CELL

Inhibition of poly (ADP-ribose) polymerase and inducible nitric oxide synthase protects against ischemic myocardial damage by reduction of apoptosis

(2014) JUAN WANG et al.   Molecular Medicine Reports

Nicotinamide Mononucleotide, an Intermediate of NAD+ Synthesis, Protects the Heart from Ischemia and Reperfusion

(2014) Takanobu Yamamoto et al.   PLoS One

Mitochondrial Complex I Deficiency Increases Protein Acetylation and Accelerates Heart Failure

(2013) Georgios Karamanlidis et al.   Cell Metabolism

SIRT4 Prevents Hypoxia-Induced Apoptosis in H9c2 Cardiomyoblast Cells

(2013) Ban Liu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

A Role for Peroxisome Proliferator-Activated Receptor γ Coactivator-1 in the Control of Mitochondrial Dynamics During Postnatal Cardiac Growth

(2013) Ola J. Martin et al.   CIRCULATION RESEARCH

Sirt2 functions in spindle organization and chromosome alignment in mouse oocyte meiosis

(2013) Liang Zhang et al.   FASEB JOURNAL

Intracellular distribution of human SIRT7 and mapping of the nuclear/nucleolar localization signal

(2013) Shashi Kiran et al.   FEBS Journal

SIRT3 Deacetylates and Activates OPA1 To Regulate Mitochondrial Dynamics during Stress

(2013) Sadhana A. Samant et al.   MOLECULAR AND CELLULAR BIOLOGY

Nampt secreted from cardiomyocytes promotes development of cardiac hypertrophy and adverse ventricular remodeling

(2012) Vinodkumar B. Pillai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

PARP-2 knockdown protects cardiomyocytes from hypertrophy via activation of SIRT1

(2012) Biao Geng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sirtuin 6 protects cardiomyocytes from hypertrophyin vitrovia inhibition of NF-κB-dependent transcriptional activity

(2012) Shan-Shan Yu et al.   BRITISH JOURNAL OF PHARMACOLOGY

The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

(2012) Carles Cantó et al.   Cell Metabolism

The Role of PARP-1 and PARP-2 Enzymes in Metabolic Regulation and Disease

(2012) Péter Bai et al.   Cell Metabolism

Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38: Implications for Cellular NAD+ Metabolism, Protein Acetylation, and Treatment of Metabolic Syndrome

(2012) C. Escande et al.   DIABETES

Nmnat2 protects cardiomyocytes from hypertrophy via activation of SIRT6

(2012) Yi Cai et al.   FEBS LETTERS

Exogenous NAD+supplementation protects H9c2 cardiac myoblasts against hypoxia/reoxygenation injury via Sirt1-p53 pathway

(2012) Ling Liu et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Calorie Restriction and SIRT3 Trigger Global Reprogramming of the Mitochondrial Protein Acetylome

(2012) Alexander S. Hebert et al.   MOLECULAR CELL

The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun

(2012) Nagalingam R Sundaresan et al.   NATURE MEDICINE

The Membrane-Bound Enzyme CD38 Exists in Two Opposing Orientations

(2012) Y. J. Zhao et al.   Science Signaling

Deacetylation of PGC-1α by SIRT1: importance for skeletal muscle function and exercise-induced mitochondrial biogenesis

(2011) Brendon J. Gurd   Applied Physiology Nutrition and Metabolism

Suppression of leukocyte infiltration and cartilage degradation by selective inhibition of pre-B cell colony-enhancing factor/visfatin/nicotinamide phosphoribosyltransferase: Apo866-mediated therapy in human fibroblasts and murine collagen-induced arthrit

(2011) Laura Evans et al.   ARTHRITIS AND RHEUMATISM

PPARα-Sirt1 Complex Mediates Cardiac Hypertrophy and Failure through Suppression of the ERR Transcriptional Pathway

(2011) Shinichi Oka et al.   Cell Metabolism

Interpretation of elevated plasma visfatin concentrations in patients with ST-elevation myocardial infarction

(2011) Li-Fen Lu et al.   CYTOKINE

Pathways and Subcellular Compartmentation of NAD Biosynthesis in Human Cells

(2011) Andrey Nikiforov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT6 Promotes DNA Repair Under Stress by Activating PARP1

(2011) Z. Mao et al.   SCIENCE

Sirt1 acts in association with PPAR  to protect the heart from hypertrophy, metabolic dysregulation, and inflammation

(2010) A. Planavila et al.   CARDIOVASCULAR RESEARCH

The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

(2010) Lei Zhong et al.   CELL

Metabolic Networks of Longevity

(2010) Riekelt H. Houtkooper et al.   CELL

Silent Information Regulator 1 Protects the Heart From Ischemia/Reperfusion

(2010) Chiao-Po Hsu et al.   CIRCULATION

The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways

(2010) Riekelt H. Houtkooper et al.   ENDOCRINE REVIEWS

SIRT2 regulates NF- B-dependent gene expression through deacetylation of p65 Lys310

(2010) K. M. Rothgiesser et al.   JOURNAL OF CELL SCIENCE

NAD+ Depletion Is Necessary and Sufficient forPoly(ADP-Ribose) Polymerase-1-Mediated Neuronal Death

(2010) C. C. Alano et al.   JOURNAL OF NEUROSCIENCE

Synthesizing and Salvaging NAD+: Lessons Learned from Chlamydomonas reinhardtii

(2010) Huawen Lin et al.   PLoS Genetics

Fluorescence in situ hybridization and chromosomal organization of the sirtuin 4 gene (Sirt4) in the mouse

(2009) Ulrich Mahlknecht et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The NAD World: A New Systemic Regulatory Network for Metabolism and Aging—Sirt1, Systemic NAD Biosynthesis, and Their Importance

(2009) Shin-ichiro Imai   CELL BIOCHEMISTRY AND BIOPHYSICS

Association of plasma visfatin levels with inflammation, atherosclerosis and acute coronary syndromes (ACS) in humans

(2009) Sheng Wen Liu et al.   CLINICAL ENDOCRINOLOGY

The mechanism and mitigation of niacin-induced flushing

(2009) V. S. Kamanna et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Exogenous NAD Blocks Cardiac Hypertrophic Response via Activation of the SIRT3-LKB1-AMP-activated Kinase Pathway

(2009) Vinodkumar B. Pillai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recent progress in the biology and physiology of sirtuins

(2009) Toren Finkel et al.   NATURE

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

(2009) Shih-Min A. Huang et al.   NATURE

Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner

(2009) Frédéric Van Gool et al.   NATURE MEDICINE

Nicotinic Acid, Nicotinamide, and Nicotinamide Riboside: A Molecular Evaluation of NAD+ Precursor Vitamins in Human Nutrition

(2008) Katrina L Bogan et al.   Annual Review of Nutrition

Sirt7 Increases Stress Resistance of Cardiomyocytes and Prevents Apoptosis and Inflammatory Cardiomyopathy in Mice

(2008) Olesya Vakhrusheva et al.   CIRCULATION RESEARCH

SIRT3 Is a Stress-Responsive Deacetylase in Cardiomyocytes That Protects Cells from Stress-Mediated Cell Death by Deacetylation of Ku70

(2008) N. R. Sundaresan et al.   MOLECULAR AND CELLULAR BIOLOGY

SirT1 Regulates Energy Metabolism and Response to Caloric Restriction in Mice

(2008) Gino Boily et al.   PLoS One

Pharmacological Inhibition of Nicotinamide Phosphoribosyltransferase/Visfatin Enzymatic Activity Identifies a New Inflammatory Pathway Linked to NAD

(2008) Nathalie Busso et al.   PLoS One

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

(2008) B.-H. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA