Synthesis of the Ca 2+ -mobilizing messengers NAADP and cADPR by intracellular CD38 enzyme in the mouse heart: Role in β-adrenoceptor signaling

High resolution structural evidence suggests the Sarcoplasmic Reticulum forms microdomains with Acidic Stores (lysosomes) in the heart

(2017) Daniel Aston et al.   Scientific Reports

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Cyclic ADP-Ribose (cADPR) Mediate Ca2+ Signaling in Cardiac Hypertrophy Induced by β-Adrenergic Stimulation

(2016) Rukhsana Gul et al.   PLoS One

Determinants of the membrane orientation of a calcium signaling enzyme CD38

(2015) Yong Juan Zhao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A primer of NAADP-mediated Ca2+ signalling: From sea urchin eggs to mammalian cells

(2015) Antony Galione   CELL CALCIUM

Two-pore Channels (TPC2s) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) at Lysosomal-Sarcoplasmic Reticular Junctions Contribute to Acute and Chronic β-Adrenoceptor Signaling in the Heart

(2015) Rebecca A. Capel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A new cytoplasmic interaction between junctin and ryanodine receptor Ca2+ release channels

(2015) L. Li et al.   JOURNAL OF CELL SCIENCE

The ADP-ribosyl cyclases - the current evolutionary state of the ARCs

(2014) Enza et al.   Frontiers in Bioscience-Landmark

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)-mediated Calcium Signaling and Arrhythmias in the Heart Evoked by β-Adrenergic Stimulation

(2013) Merle Nebel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ß-Adrenergic receptor signaling increases NAADP and cADPR levels in the heart

(2012) Alexander M. Lewis et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Beta-Adrenergic Receptors, from Their Discovery and Characterization through Their Manipulation to Beneficial Clinical Application

(2012) S. Blake Wachter et al.   CARDIOLOGY

Cyclic ADP-ribose and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) as Messengers for Calcium Mobilization

(2012) Hon Cheung Lee   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective inhibitors of cardiac ADPR cyclase as novel anti-arrhythmic compounds

(2012) Aimo Kannt et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

FKBP12 Activates the Cardiac Ryanodine Receptor Ca2+-Release Channel and Is Antagonised by FKBP12.6

(2012) Elena Galfré et al.   PLoS One

The Membrane-Bound Enzyme CD38 Exists in Two Opposing Orientations

(2012) Y. J. Zhao et al.   Science Signaling

Tetrameric Interaction of the Ectoenzyme CD38 on the Cell Surface Enables Its Catalytic and Raft-Association Activities

(2012) Miki Hara-Yokoyama et al.   STRUCTURE

NAADP influences excitation–contraction coupling by releasing calcium from lysosomes in atrial myocytes

(2011) Thomas P. Collins et al.   CELL CALCIUM

Cytosolic CD38 Protein Forms Intact Disulfides and Is Active in Elevating Intracellular Cyclic ADP-ribose

(2011) Yong Juan Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Improved Treatment of Ligands and Coupling Effects in Empirical Calculation and Rationalization of pKaValues

(2011) Chresten R. Søndergaard et al.   Journal of Chemical Theory and Computation

Fast docking using the CHARMM force field with EADock DSS

(2011) Aurélien Grosdidier et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

SwissDock, a protein-small molecule docking web service based on EADock DSS

(2011) A. Grosdidier et al.   NUCLEIC ACIDS RESEARCH

From Eggs to Hearts: What Is the Link between Cyclic ADP-Ribose and Ryanodine Receptors?

(2010) Elisa Venturi et al.   Cardiovascular Therapeutics

The Ecto-enzyme CD38 Is a Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Synthase That Couples Receptor Activation to Ca2+Mobilization from Lysosomes in Pancreatic Acinar Cells

(2010) François Cosker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD38 as a Regulator of Cellular NAD: A Novel Potential Pharmacological Target for Metabolic Conditions

(2009) Eduardo Chini   CURRENT PHARMACEUTICAL DESIGN

Identifying and Characterizing Binding Sites and Assessing Druggability

(2009) Thomas A. Halgren   Journal of Chemical Information and Modeling

Conformational Closure of the Catalytic Site of Human CD38 Induced by Calcium†‡

(2008) Qun Liu et al.   BIOCHEMISTRY

Ca2+ Signaling Occurs via Second Messenger Release from Intraorganelle Synthesis Sites

(2008) Lianne C. Davis et al.   CURRENT BIOLOGY