Modified Vaccinia Virus Ankara Triggers Type I IFN Production in Murine Conventional Dendritic Cells via a cGAS/STING-Mediated Cytosolic DNA-Sensing Pathway
Published 2014 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Modified Vaccinia Virus Ankara Triggers Type I IFN Production in Murine Conventional Dendritic Cells via a cGAS/STING-Mediated Cytosolic DNA-Sensing Pathway
Authors
Keywords
Interferons, Enzyme-linked immunoassays, Dendritic cells, Polymerase chain reaction, Vaccinia virus, Phosphorylation, Transcription factors, Lysosomes
Journal
PLoS Pathogens
Volume 10, Issue 4, Pages e1003989
Publisher
Public Library of Science (PLoS)
Online
2014-04-18
DOI
10.1371/journal.ppat.1003989
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA
- (2013) Pu Gao et al. CELL
- Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase
- (2013) Pu Gao et al. CELL
- Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING
- (2013) Xu Zhang et al. MOLECULAR CELL
- cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING
- (2013) Andrea Ablasser et al. NATURE
- Structural mechanism of cytosolic DNA sensing by cGAS
- (2013) Filiz Civril et al. NATURE
- Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects
- (2013) X.-D. Li et al. SCIENCE
- Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity
- (2013) Philip J. Kranzusch et al. Cell Reports
- The Innate Immune DNA Sensor cGAS Produces a Noncanonical Cyclic Dinucleotide that Activates Human STING
- (2013) Elie J. Diner et al. Cell Reports
- The Amino Terminus of the Vaccinia Virus E3 Protein Is Necessary To Inhibit the Interferon Response
- (2012) S. D. White et al. JOURNAL OF VIROLOGY
- Re(de)fining the dendritic cell lineage
- (2012) Ansuman T Satpathy et al. NATURE IMMUNOLOGY
- Innate Immune Response of Human Plasmacytoid Dendritic Cells to Poxvirus Infection Is Subverted by Vaccinia E3 via Its Z-DNA/RNA Binding Domain
- (2012) Hua Cao et al. PLoS One
- Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA
- (2012) J. Wu et al. SCIENCE
- Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
- (2012) L. Sun et al. SCIENCE
- MVA and NYVAC as Vaccines against Emergent Infectious Diseases and Cancer
- (2011) Carmen E. Gomez et al. CURRENT GENE THERAPY
- Innate immune DNA sensing pathways: STING, AIMII and the regulation of interferon production and inflammatory responses
- (2011) Glen N Barber CURRENT OPINION IN IMMUNOLOGY
- DDX1, DDX21, and DHX36 Helicases Form a Complex with the Adaptor Molecule TRIF to Sense dsRNA in Dendritic Cells
- (2011) Zhiqiang Zhang et al. IMMUNITY
- Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity
- (2011) Taro Kawai et al. IMMUNITY
- Activation of Autophagy by α-Herpesviruses in Myeloid Cells Is Mediated by Cytoplasmic Viral DNA through a Mechanism Dependent on Stimulator of IFN Genes
- (2011) Simon B. Rasmussen et al. JOURNAL OF IMMUNOLOGY
- Phase 1 Safety and Immunogenicity Testing of DNA and Recombinant Modified Vaccinia Ankara Vaccines Expressing HIV-1 Virus-like Particles
- (2011) Paul A. Goepfert et al. JOURNAL OF INFECTIOUS DISEASES
- Myxoma Virus Induces Type I Interferon Production in Murine Plasmacytoid Dendritic Cells via a TLR9/MyD88-, IRF5/IRF7-, and IFNAR-Dependent Pathway
- (2011) P. Dai et al. JOURNAL OF VIROLOGY
- STING is a direct innate immune sensor of cyclic di-GMP
- (2011) Dara L. Burdette et al. NATURE
- The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells
- (2011) Zhiqiang Zhang et al. NATURE IMMUNOLOGY
- Safety and immunogenicity of a modified pox vector-based HIV/AIDS vaccine candidate expressing Env, Gag, Pol and Nef proteins of HIV-1 subtype B (MVA-B) in healthy HIV-1-uninfected volunteers: A phase I clinical trial (RISVAC02)
- (2011) Felipe García et al. VACCINE
- TheN-Ethyl-N-Nitrosourea-InducedGoldenticketMouse Mutant Reveals an Essential Function ofStingin theIn VivoInterferon Response toListeria monocytogenesand Cyclic Dinucleotides
- (2010) John-Demian Sauer et al. INFECTION AND IMMUNITY
- IFI16 is an innate immune sensor for intracellular DNA
- (2010) Leonie Unterholzner et al. NATURE IMMUNOLOGY
- STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
- (2009) Hiroki Ishikawa et al. NATURE
- ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization
- (2009) W. Sun et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Modified vaccinia virus Ankara can activate NF-κB transcription factors through a double-stranded RNA-activated protein kinase (PKR)-dependent pathway during the early phase of virus replication
- (2009) Heather E. Lynch et al. VIROLOGY
- The effect of the vaccinia K1 protein on the PKR-eIF2α pathway in RK13 and HeLa cells
- (2009) Kristen L. Willis et al. VIROLOGY
- Innate Immune Sensing of Modified Vaccinia Virus Ankara (MVA) Is Mediated by TLR2-TLR6, MDA-5 and the NALP3 Inflammasome
- (2009) Julie Delaloye et al. PLoS Pathogens
- Induction of IFN-β and the Innate Antiviral Response in Myeloid Cells Occurs through an IPS-1-Dependent Signal That Does Not Require IRF-3 and IRF-7
- (2009) Stephane Daffis et al. PLoS Pathogens
- The Poxvirus Vectors MVA and NYVAC as Gene Delivery Systems for Vaccination Against Infectious Diseases and Cancer
- (2008) Carmen Gomez et al. CURRENT GENE THERAPY
- The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation
- (2008) Bo Zhong et al. IMMUNITY
- Vaccinia Virus Subverts a Mitochondrial Antiviral Signaling Protein-Dependent Innate Immune Response in Keratinocytes through Its Double-Stranded RNA Binding Protein, E3
- (2008) L. Deng et al. JOURNAL OF VIROLOGY
- Vaccinia Virus-Mediated Inhibition of Type I Interferon Responses Is a Multifactorial Process Involving the Soluble Type I Interferon Receptor B18 and Intracellular Components
- (2008) Z. Waibler et al. JOURNAL OF VIROLOGY
- MPYS, a Novel Membrane Tetraspanner, Is Associated with Major Histocompatibility Complex Class II and Mediates Transduction of Apoptotic Signals
- (2008) L. Jin et al. MOLECULAR AND CELLULAR BIOLOGY
- STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
- (2008) Hiroki Ishikawa et al. NATURE
- Vaccinia Virus Proteins A52 and B14 Share a Bcl-2–Like Fold but Have Evolved to Inhibit NF-κB rather than Apoptosis
- (2008) Stephen C. Graham et al. PLoS Pathogens
- Vaccinia Virus E3 Protein Prevents the Antiviral Action of ISG15
- (2008) Susana Guerra et al. PLoS Pathogens
- Enhanced cell surface expression, immunogenicity and genetic stability resulting from a spontaneous truncation of HIV Env expressed by a recombinant MVA
- (2007) Linda S. Wyatt et al. VIROLOGY
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started