Effects of metformin on colorectal cancer stem cells depend on alterations in glutamine metabolism

Glutamine and alanyl-glutamine promote crypt expansion and mTOR signaling in murine enteroids

(2015) Sean R. Moore et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Lactate dehydrogenase 5: An old friend and a new hope in the war on cancer

(2015) Katarzyna Augoff et al.   CANCER LETTERS

FOXM1-Induced PRX3 Regulates Stemness and Survival of Colon Cancer Cells via Maintenance of Mitochondrial Function

(2015) In-Sung Song et al.   GASTROENTEROLOGY

ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer

(2015) M van Geldermalsen et al.   ONCOGENE

Discovery of selective inhibitors of Glutaminase-2, which inhibit mTORC1, activate autophagy and inhibit proliferation in cancer cells

(2015) Yue-Zhi Lee et al.   Oncotarget

Inhibition of lactate dehydrogenase activity as an approach to cancer therapy

(2014) Luigi Fiume et al.   Future Medicinal Chemistry

CpG Island Methylator Phenotype Is Associated With Response to Adjuvant Irinotecan-Based Therapy for Stage III Colon Cancer

(2014) Stacey Shiovitz et al.   GASTROENTEROLOGY

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

(2014) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides

(2014) Kıvanç Birsoy et al.   NATURE

Initial Therapy with FOLFOXIRI and Bevacizumab for Metastatic Colorectal Cancer

(2014) Fotios Loupakis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Metformin: A Potential Therapeutic Agent for Recurrent Colon Cancer

(2014) Pratima Nangia-Makker et al.   PLoS One

Chemopreventive drugs: Mechanismsviainhibition of cancer stem cells in colorectal cancer

(2014) Tae Il Kim   WORLD JOURNAL OF GASTROENTEROLOGY

Metformin Decreases Glucose Oxidation and Increases the Dependency of Prostate Cancer Cells on Reductive Glutamine Metabolism

(2013) S.-M. Fendt et al.   CANCER RESEARCH

Tumour heterogeneity and cancer cell plasticity

(2013) Corbin E. Meacham et al.   NATURE

Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth

(2013) H. A. Hirsch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutamine fuels a vicious cycle of autophagy in the tumor stroma and oxidative mitochondrial metabolism in epithelial cancer cells

(2012) Ying-Hui Ko et al.   CANCER BIOLOGY & THERAPY

The Metabolic Profile of Tumors Depends on Both the Responsible Genetic Lesion and Tissue Type

(2012) Mariia O. Yuneva et al.   Cell Metabolism

Metformin use is associated with a decreased incidence of colorectal adenomas in diabetic patients with previous colorectal cancer

(2012) Jin Ha Lee et al.   DIGESTIVE AND LIVER DISEASE

Addition of cetuximab to chemotherapy as first-line treatment for KRAS wild-type metastatic colorectal cancer: Pooled analysis of the CRYSTAL and OPUS randomised clinical trials

(2012) Carsten Bokemeyer et al.   EUROPEAN JOURNAL OF CANCER

Knockdown of lactate dehydrogenase A suppresses tumor growth and metastasis of human hepatocellular carcinoma

(2012) Shi L. Sheng et al.   FEBS Journal

Metformin and cancer: from the old medicine cabinet to pharmacological pitfalls and prospects

(2012) Arian Emami Riedmaier et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Energy metabolism of cancer: Glycolysis versus oxidative phosphorylation (Review)

(2012) JIE ZHENG   Oncology Letters

Metformin Decreases the Dose of Chemotherapy for Prolonging Tumor Remission in Mouse Xenografts Involving Multiple Cancer Cell Types

(2011) D. Iliopoulos et al.   CANCER RESEARCH

Reduced Risk of Colorectal Cancer With Metformin Therapy in Patients With Type 2 Diabetes: A meta-analysis

(2011) Z.-J. Zhang et al.   DIABETES CARE

The effects of metformin on the survival of colorectal cancer patients with diabetes mellitus

(2011) Jin Ha Lee et al.   INTERNATIONAL JOURNAL OF CANCER

The axis of mTOR-mitochondria-ROS and stemness of the hematopoietic stem cells

(2010) Chong Chen et al.   CELL CYCLE

Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase

(2010) Carolyn Algire et al.   ENDOCRINE-RELATED CANCER

Empowering self-renewal and differentiation: the role of mitochondria in stem cells

(2010) Jalees Rehman   JOURNAL OF MOLECULAR MEDICINE-JMM

Metformin suppresses azoxymethane-induced colorectal aberrant crypt foci by activating AMP-activated protein kinase

(2010) Kunihiro Hosono et al.   MOLECULAR CARCINOGENESIS

Annual report to the nation on the status of cancer, 1975-2006, featuring colorectal cancer trends and impact of interventions (risk factors, screening, and treatment) to reduce future rates

(2009) Brenda K. Edwards et al.   CANCER

Glioblastoma Cells Require Glutamate Dehydrogenase to Survive Impairments of Glucose Metabolism or Akt Signaling

(2009) C. Yang et al.   CANCER RESEARCH

Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth and Prolong Remission

(2009) H. A. Hirsch et al.   CANCER RESEARCH