Current Antimycotics, New Prospects, and Future Approaches to Antifungal Therapy

Identification of repositionable drugs with novel antimycotic activity by screening Prestwick Chemical Library against emerging invasive molds

(2020) Hanane Yousfi et al.   Journal of Global Antimicrobial Resistance

Screening Repurposing Libraries for the Identification of Drugs with Novel Antifungal Activity

(2020) Gina Wall et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Identification of Off-Patent Compounds That Present Antifungal Activity Against the Emerging Fungal Pathogen Candida auris

(2019) Haroldo Cesar de Oliveira et al.   Frontiers in Cellular and Infection Microbiology

Impact of triazole therapeutic drug monitoring availability and timing

(2019) Erin K. McCreary et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Novel Arylamidine T-2307 Selectively Disrupts Yeast Mitochondrial Function by Inhibiting Respiratory Chain Complexes

(2019) Kohei Yamashita et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Siderophore Transporter Sit1 Determines Susceptibility to the Antifungal VL-2397

(2019) Anna-Maria Dietl et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Nanoparticles in the Treatment of Infections Caused by Multidrug-Resistant Organisms

(2019) Nan-Yao Lee et al.   Frontiers in Pharmacology

The novel fungal CYP51 inhibitor VT-1598 is efficacious alone and in combination with liposomal amphotericin B in a murine model of cryptococcal meningitis

(2018) E P Garvey et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Screening a Repurposing Library for Inhibitors of Multidrug-Resistant Candida auris Identifies Ebselen as a Repositionable Candidate for Antifungal Drug Development

(2018) Gina Wall et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Activity of novel antifungal compound APX001A against a large collection of Candida auris

(2018) Elizabeth L Berkow et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Echinocandins in antifungal pharmacotherapy

(2017) Akash Patil et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Antifungal Resistance, Metabolic Routes as Drug Targets, and New Antifungal Agents: An Overview about Endemic Dimorphic Fungi

(2017) Juliana Alves Parente-Rocha et al.   MEDIATORS OF INFLAMMATION

The antifungal pipeline: a reality check

(2017) John R. Perfect   NATURE REVIEWS DRUG DISCOVERY

Development of Anti-Virulence Approaches for Candidiasis via a Novel Series of Small-Molecule Inhibitors of Candida albicans Filamentation

(2017) Jesus A. Romo et al.   mBio

Azole Antifungal Resistance in Candida albicans and Emerging Non-albicans Candida Species

(2017) Sarah G. Whaley et al.   Frontiers in Microbiology

Stop neglecting fungi

(2017)   Nature Microbiology

The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme

(2016) Andrew G. S. Warrilow et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The celecoxib derivative AR-12 has broad spectrum antifungal activity in vitro and improves the activity of fluconazole in a murine model of cryptococcosis

(2016) Kristy Koselny et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

CD101: a novel long-acting echinocandin

(2016) Yanan Zhao et al.   CELLULAR MICROBIOLOGY

Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America

(2016) Thomas F. Patterson et al.   CLINICAL INFECTIOUS DISEASES

F901318 represents a novel class of antifungal drug that inhibits dihydroorotate dehydrogenase

(2016) Jason D. Oliver et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Candida albicans filamentation for antifungal drug development

(2016) Taissa Vila et al.   Virulence

New facets of antifungal therapy

(2016) Ya-Lin Chang et al.   Virulence

Repurposing auranofin as an antifungal: In vitro activity against a variety of medically important fungi

(2016) Nathan P. Wiederhold et al.   Virulence

Echinocandins: The Expanding Antifungal Armamentarium

(2015) Daniel Aguilar-Zapata et al.   CLINICAL INFECTIOUS DISEASES

Alternative Antimicrobial Approach: Nano-Antimicrobial Materials

(2015) Nurit Beyth et al.   Evidence-based Complementary and Alternative Medicine

Treatment of drug-resistantAspergillusinfection

(2015) Maria Aigner et al.   EXPERT OPINION ON PHARMACOTHERAPY

Repurposing FDA approved drugs against the human fungal pathogen, Candida albicans

(2015) Kevin Kim et al.   Annals of Clinical Microbiology and Antimicrobials

Screening of Pharmacologically Active Small Molecule Compounds Identifies Antifungal Agents Against Candida Biofilms

(2015) Takao Watamoto et al.   Frontiers in Microbiology

Effect of silver nanoparticles on Candida albicans biofilms: an ultrastructural study

(2015) Humberto H. Lara et al.   JOURNAL OF NANOBIOTECHNOLOGY

Susceptibility of Candida albicans and Candida glabrata biofilms to silver nanoparticles in intermediate and mature development phases

(2015) Douglas Roberto Monteiro et al.   Journal of Prosthodontic Research

A novel small molecule inhibitor of Candida albicans biofilm formation, filamentation and virulence with low potential for the development of resistance

(2015) Christopher G Pierce et al.   npj Biofilms and Microbiomes

Pharmacodynamic Target Evaluation of a Novel Oral Glucan Synthase Inhibitor, SCY-078 (MK-3118), Using anIn VivoMurine Invasive Candidiasis Model

(2014) Alexander J. Lepak et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Clinical Candidate VT-1161 Is a Highly Potent Inhibitor of Candida albicans CYP51 but Fails To Bind the Human Enzyme

(2014) A. G. S. Warrilow et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Amphotericin forms an extramembranous and fungicidal sterol sponge

(2014) Thomas M Anderson et al.   Nature Chemical Biology

Ultrastructural Analysis of Candida albicans When Exposed to Silver Nanoparticles

(2014) Roberto Vazquez-Muñoz et al.   PLoS One

A neglected epidemic: fungal infections in HIV/AIDS

(2014) Darius Armstrong-James et al.   TRENDS IN MICROBIOLOGY

Antifungal Pharmacokinetics and Pharmacodynamics

(2014) A. J. Lepak et al.   Cold Spring Harbor Perspectives in Medicine

Mechanisms of Antifungal Drug Resistance

(2014) Leah E. Cowen et al.   Cold Spring Harbor Perspectives in Medicine

High-Throughput Screening of a Collection of Known Pharmacologically Active Small Compounds for Identification of Candida albicans Biofilm Inhibitors

(2013) Samuel A. Siles et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Echinocandins: production and applications

(2013) Tamás Emri et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Antifungal therapy with an emphasis on biofilms

(2013) Christopher G Pierce et al.   CURRENT OPINION IN PHARMACOLOGY

Candidiasis drug discovery and development: new approaches targeting virulence for discovering and identifying new drugs

(2013) Christopher G Pierce et al.   Expert Opinion on Drug Discovery

Antifungal Activity of Geldanamycin Alone or in Combination with Fluconazole Against Candida species

(2013) Jinqing Zhang et al.   MYCOPATHOLOGIA

The Antidepressant Sertraline Provides a Promising Therapeutic Option for Neurotropic Cryptococcal Infections

(2012) Bing Zhai et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Repurposing Approach Identifies Off-Patent Drugs with Fungicidal Cryptococcal Activity, a Common Structural Chemotype, and Pharmacological Properties Relevant to the Treatment of Cryptococcosis

(2012) Arielle Butts et al.   EUKARYOTIC CELL

Emerging fungal threats to animal, plant and ecosystem health

(2012) Matthew C. Fisher et al.   NATURE

Polyene antibiotic that inhibits membrane transport proteins

(2012) Y. M. te Welscher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amphotericin primarily kills yeast by simply binding ergosterol

(2012) K. C. Gray et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hidden Killers: Human Fungal Infections

(2012) G. D. Brown et al.   Science Translational Medicine

Rapamycin Exerts Antifungal Activity In Vitro and In Vivo against Mucor circinelloides via FKBP12-Dependent Inhibition of Tor

(2011) Robert J. Bastidas et al.   EUKARYOTIC CELL

Current perspectives on echinocandin class drugs

(2011) David S Perlin   Future Microbiology

Echinocandin Antifungal Drugs in Fungal Infections

(2010) Sharon C.-A. Chen et al.   DRUGS

An insight into the antifungal pipeline: selected new molecules and beyond

(2010) Luis Ostrosky-Zeichner et al.   NATURE REVIEWS DRUG DISCOVERY

Echinocandins: The Newest Class of Antifungals

(2009) Allana J Sucher et al.   ANNALS OF PHARMACOTHERAPY

Antifungal Activity of Tamoxifen: In Vitro and In Vivo Activities and Mechanistic Characterization

(2009) K. Dolan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antifungal activity of silver nanoparticles against Candida spp.

(2009) Aleš Panáček et al.   BIOMATERIALS

Fungal echinocandin resistance

(2009) Louise A. Walker et al.   FUNGAL GENETICS AND BIOLOGY