Targeting Candida albicans filamentation for antifungal drug development

Invasive Candidiasis

(2016) Todd P. McCarty et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

Innate Immunity and Saliva in Candida albicans–mediated Oral Diseases

(2016) O. Salvatori et al.   JOURNAL OF DENTAL RESEARCH

Invasive Candidiasis

(2015) Bart Jan Kullberg et al.   NEW ENGLAND JOURNAL OF MEDICINE

How to bolster the antifungal pipeline

(2015) D. W. Denning et al.   SCIENCE

A novel small molecule inhibitor of Candida albicans biofilm formation, filamentation and virulence with low potential for the development of resistance

(2015) Christopher G Pierce et al.   npj Biofilms and Microbiomes

Echinocandin resistance

(2014) Maiken C. Arendrup et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Effect of progesterone on Candida albicans vaginal pathogenicity

(2014) Carlos Tiago Alves et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Amphotericin forms an extramembranous and fungicidal sterol sponge

(2014) Thomas M Anderson et al.   Nature Chemical Biology

High-content phenotypic screenings to identify inhibitors ofCandida albicansbiofilm formation and filamentation

(2014) Christopher G. Pierce et al.   Pathogens and Disease

Candida albicans: Adapting to Succeed

(2013) David Kadosh et al.   Cell Host & Microbe

Antifungal therapy with an emphasis on biofilms

(2013) Christopher G Pierce et al.   CURRENT OPINION IN PHARMACOLOGY

A Core Filamentation Response Network in Candida albicans Is Restricted to Eight Genes

(2013) Ronny Martin et al.   PLoS One

Chemical screening identifies filastatin, a small molecule inhibitor of Candida albicans adhesion, morphogenesis, and pathogenesis

(2013) A. Fazly et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Candida albicanspathogenicity mechanisms

(2013) François L. Mayer et al.   Virulence

Shaping Up for Battle: Morphological Control Mechanisms in Human Fungal Pathogens

(2013) David Kadosh   PLoS Pathogens

BRG1 and NRG1 form a novel feedback circuit regulating Candida albicans hypha formation and virulence

(2012) Ian A. Cleary et al.   MOLECULAR MICROBIOLOGY

Mouse model of oropharyngeal candidiasis

(2012) Norma V Solis et al.   Nature Protocols

Polyene antibiotic that inhibits membrane transport proteins

(2012) Y. M. te Welscher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amphotericin primarily kills yeast by simply binding ergosterol

(2012) K. C. Gray et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hidden Killers: Human Fungal Infections

(2012) G. D. Brown et al.   Science Translational Medicine

Growth of Candida albicans hyphae

(2011) Peter E. Sudbery   NATURE REVIEWS MICROBIOLOGY

Small Molecule Inhibitors of the Candida albicans Budded-to-Hyphal Transition Act through Multiple Signaling Pathways

(2011) John Midkiff et al.   PLoS One

A Biphasic Innate Immune MAPK Response Discriminates between the Yeast and Hyphal Forms of Candida albicans in Epithelial Cells

(2010) David L. Moyes et al.   Cell Host & Microbe

Candidosis, a new challenge

(2010) Rubén López-Martínez   CLINICS IN DERMATOLOGY

Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity

(2010) Suzanne M Noble et al.   NATURE GENETICS

An insight into the antifungal pipeline: selected new molecules and beyond

(2010) Luis Ostrosky-Zeichner et al.   NATURE REVIEWS DRUG DISCOVERY

Oropharyngeal candidiasis in the era of antiretroviral therapy

(2010) George R. Thompson et al.   ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS

Inhibitors of cellular signalling are cytotoxic or block the budded-to-hyphal transition in the pathogenic yeast Candida albicans

(2009) K. A. Toenjes et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Hyphal Chain Formation in Candida albicans: Cdc28-Hgc1 Phosphorylation of Efg1 Represses Cell Separation Genes

(2009) A. Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

Pyrosequencing To Detect Mutations in FKS1 That Confer Reduced Echinocandin Susceptibility in Candida albicans

(2008) N. P. Wiederhold et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Candida albicans-Endothelial Cell Interactions: a Key Step in the Pathogenesis of Systemic Candidiasis

(2008) S. E. W. Grubb et al.   INFECTION AND IMMUNITY

Expression levels of a filament-specific transcriptional regulator are sufficient to determine Candida albicans morphology and virulence

(2008) P. L. Carlisle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The biology and future prospects of antivirulence therapies

(2007) Lynette Cegelski et al.   NATURE REVIEWS MICROBIOLOGY