The antifungal pipeline: a reality check

JNK1 negatively controls antifungal innate immunity by suppressing CD23 expression

(2017) Xueqiang Zhao et al.   NATURE MEDICINE

Preclinical Evaluation of the Stability, Safety, and Efficacy of CD101, a Novel Echinocandin

(2016) Voon Ong et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Investigational Fungal Cyp51 Inhibitor VT-1129 Demonstrates PotentIn VitroActivity against Cryptococcus neoformans and Cryptococcus gattii

(2016) Shawn R. Lockhart et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cryptococcal therapies and drug targets: the old, the new and the promising

(2016) Carolina Coelho et al.   CELLULAR MICROBIOLOGY

2016 Infectious Diseases Society of America (IDSA) Clinical Practice Guideline for the Treatment of Coccidioidomycosis

(2016) John N. Galgiani et al.   CLINICAL INFECTIOUS DISEASES

Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America

(2016) Thomas F. Patterson et al.   CLINICAL INFECTIOUS DISEASES

Executive Summary: Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America

(2016) Peter G. Pappas et al.   CLINICAL INFECTIOUS DISEASES

Novel investigational therapies for onychomycosis: an update

(2016) Aditya K. Gupta et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Strategies in the discovery of novel antifungal scaffolds

(2016) Na Liu et al.   Future Medicinal Chemistry

Sphingolipids as targets for treatment of fungal infections

(2016) Rodrigo Rollin-Pinheiro et al.   Future Medicinal Chemistry

Antifungal Agents

(2016) Jeniel E. Nett et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

In vitro antifungal and antibiofilm activities of halogenated quinoline analogues against Candida albicans and Cryptococcus neoformans

(2016) Ran Zuo et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

ASP2397: a novel antifungal agent produced by Acremonium persicinum MF-347833

(2016) Ikuko Nakamura et al.   JOURNAL OF ANTIBIOTICS

Discovery of a new antifungal agent ASP2397 using a silkworm model of Aspergillus fumigatus infection

(2016) Ikuko Nakamura et al.   JOURNAL OF ANTIBIOTICS

T-2307, a novel arylamidine, is transported intoCandida albicansby a high-affinity spermine and spermidine carrier regulated by Agp2

(2016) Hiroshi Nishikawa et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Activity of a long-acting echinocandin, CD101, determined using CLSI and EUCAST reference methods, againstCandidaandAspergillusspp., including echinocandin- and azole-resistant isolates

(2016) Michael A. Pfaller et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Cryptococcus neoformans population diversity and clinical outcomes of HIV-associated cryptococcal meningitis patients in Zimbabwe

(2016) Tinashe K. Nyazika et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Novel Water-Soluble Amphotericin B-PEG Conjugates with Low Toxicity and Potent in Vivo Efficacy

(2016) Assaf Halperin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Repurposing the Clinically Efficacious Antifungal Agent Itraconazole as an Anticancer Chemotherapeutic

(2016) Jennifer R. Pace et al.   JOURNAL OF MEDICINAL CHEMISTRY

Searching new antifungals: The use of in vitro and in vivo methods for evaluation of natural compounds

(2016) Liliana Scorzoni et al.   JOURNAL OF MICROBIOLOGICAL METHODS

Efficacy of adjunctive sertraline for the treatment of HIV-associated cryptococcal meningitis: an open-label dose-ranging study

(2016) Joshua Rhein et al.   LANCET INFECTIOUS DISEASES

Aspergillusvaccines: Hardly worth studying or worthy of hard study?: Table 1.

(2016) Stuart M. Levitz   MEDICAL MYCOLOGY

The anti-Aspergillusdrug pipeline: Is the glass half full or empty?: Table 1.

(2016) Nir Osherov et al.   MEDICAL MYCOLOGY

Carbon extension in peptidylnucleoside biosynthesis by radical SAM enzymes

(2016) Edward A Lilla et al.   Nature Chemical Biology

Investigation of the antifungal activity of carvacrol against strains ofCryptococcus neoformans

(2016) Rafaela de Oliveira Nóbrega et al.   PHARMACEUTICAL BIOLOGY

Glucosylceramide Administration as a Vaccination Strategy in Mouse Models of Cryptococcosis

(2016) Visesato Mor et al.   PLoS One

Synergistic Effect of Fluconazole and Calcium Channel Blockers against Resistant Candida albicans

(2016) Shuyuan Liu et al.   PLoS One

F901318 represents a novel class of antifungal drug that inhibits dihydroorotate dehydrogenase

(2016) Jason D. Oliver et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of trehalose-6-phosphate phosphatase from pathogenic fungi reveal the mechanisms of substrate recognition and catalysis

(2016) Yi Miao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of Protective Immunity to Cryptococcal Infection in Mice by a Heat-Killed, Chitosan-Deficient Strain of Cryptococcus neoformans

(2016) Rajendra Upadhya et al.   mBio

Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance

(2016) Kelley R. Healey et al.   Nature Communications

Trehalose pathway as an antifungal target

(2016) John R. Perfect et al.   Virulence

Calcineurin in fungal virulence and drug resistance: Prospects for harnessing targeted inhibition of calcineurin for an antifungal therapeutic approach

(2016) Praveen R. Juvvadi et al.   Virulence

Antitumor/Antifungal Celecoxib Derivative AR-12 is a Non-Nucleoside Inhibitor of the ANL-Family Adenylating Enzyme Acetyl CoA Synthetase

(2016) Kristy Koselny et al.   ACS Infectious Diseases

Combination Antifungal Therapy for Invasive Aspergillosis

(2015) Kieren A. Marr et al.   ANNALS OF INTERNAL MEDICINE

Hitting the Caspofungin Salvage Pathway of Human-Pathogenic Fungi with the Novel Lasso Peptide Humidimycin (MDN-0010)

(2015) Vito Valiante et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

VT-1161 Protects Immunosuppressed Mice from Rhizopus arrhizus var. arrhizus Infection

(2015) Teclegiorgis Gebremariam et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Population Pharmacokinetic Modeling of Itraconazole and Hydroxyitraconazole for Oral SUBA-Itraconazole and Sporanox Capsule Formulations in Healthy Subjects in Fed and Fasted States

(2015) Ahmad Y. Abuhelwa et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Increased Antifungal Drug Resistance in Clinical Isolates of Cryptococcus neoformans in Uganda

(2015) Kyle D. Smith et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Taming Amphotericin B

(2015) Vaclav Janout et al.   BIOCONJUGATE CHEMISTRY

Azole Resistance inAspergillus fumigatus: Can We Retain the Clinical Use of Mold-Active Antifungal Azoles?

(2015) Paul E. Verweij et al.   CLINICAL INFECTIOUS DISEASES

In vitro activity of a Hos2 deacetylase inhibitor, MGCD290, in combination with echinocandins against echinocandin-resistant Candida species

(2015) M.A. Pfaller et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Azole antifungals: 35 years of invasive fungal infection management

(2015) David Allen et al.   Expert Review of Anti-Infective Therapy

NanoCluster Itraconazole Formulations Provide a Potential Engineered Drug Particle Approach to Generate Effective Dry Powder Aerosols

(2015) Warangkana Pornputtapitak et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Antifungal activity of compounds targeting the Hsp90-calcineurin pathway against various mould species: Table 1.

(2015) Frédéric Lamoth et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Pan Assay Interference Compounds (PAINS) and Other Promiscuous Compounds in Antifungal Research

(2015) Martin Pouliot et al.   JOURNAL OF MEDICINAL CHEMISTRY

Disulphide-reduced psoriasin is a human apoptosis-inducing broad-spectrum fungicide

(2015) Kyaw Zaw Hein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How to bolster the antifungal pipeline

(2015) D. W. Denning et al.   SCIENCE

Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids

(2015) Visesato Mor et al.   mBio

The Clinical Candidate VT-1161 Is a Highly Potent Inhibitor of Candida albicans CYP51 but Fails To Bind the Human Enzyme

(2014) A. G. S. Warrilow et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Investigational Agent E1210 Is Effective in Treatment of Experimental Invasive Candidiasis Caused by Resistant Candida albicans

(2014) Nathan P. Wiederhold et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Molecular Umbrella–Amphotericin B Conjugates

(2014) Vaclav Janout et al.   BIOCONJUGATE CHEMISTRY

Activity, Reduced Toxicity, and Scale-Up Synthesis of Amphotericin B-Conjugated Polysaccharide

(2014) Diana E. Ickowicz et al.   BIOMACROMOLECULES

Development and Characterization of Amphotericin B Nanosuspensions for Oral Administration Through a Simple Top-Down Method

(2014) Zhiwen Yang et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Modeling Nikkomycin Z Dosing and Pharmacology in Murine Pulmonary Coccidioidomycosis Preparatory to Phase 2 Clinical Trials

(2014) L. F. Shubitz et al.   JOURNAL OF INFECTIOUS DISEASES

Inhibitors of the Glyoxylate Cycle Enzyme ICL1 in Candida albicans for Potential Use as Antifungal Agents

(2014) Hong-Leong Cheah et al.   PLoS One

Bioengineering T cells to target carbohydrate to treat opportunistic fungal infection

(2014) P. R. Kumaresan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Estrogen Receptor Antagonists Are Anti-Cryptococcal Agents That Directly Bind EF Hand Proteins and Synergize with Fluconazole In Vivo

(2014) A. Butts et al.   mBio

Novel Antifungal Drug Discovery Based on Targeting Pathways Regulating the Fungus-Conserved Upc2 Transcription Factor

(2013) Christina Gallo-Ebert et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Human Monoclonal Antibody-Based Therapy in the Treatment of Invasive Candidiasis

(2013) Francesca Bugli et al.   Clinical & Developmental Immunology

Increasing Echinocandin Resistance in Candida glabrata: Clinical Failure Correlates With Presence of FKS Mutations and Elevated Minimum Inhibitory Concentrations

(2013) Barbara D. Alexander et al.   CLINICAL INFECTIOUS DISEASES

Antifungal drug resistance mechanisms in pathogenic fungi: from bench to bedside

(2013) M. Cuenca-Estrella   CLINICAL MICROBIOLOGY AND INFECTION

The fungal Achilles’ heel: targeting Hsp90 to cripple fungal pathogens

(2013) Leah E Cowen   CURRENT OPINION IN MICROBIOLOGY

Clinical-scale generation of multi-specific anti-fungal T cells targeting Candida, Aspergillus and mucormycetes

(2013) Lars Tramsen et al.   CYTOTHERAPY

Amphotericin B Formulations: A Comparative Review of Efficacy and Toxicity

(2013) Richard J. Hamill   DRUGS

The Calcineurin Pathway Inhibitor Tacrolimus Enhances the In Vitro Activity of Azoles against Mucorales via Apoptosis

(2013) F. Shirazi et al.   EUKARYOTIC CELL

A phase II, randomized, double-blind, placebo-controlled, parallel group, dose-ranging study to investigate the efficacy and safety of 4 dose regimens of oral albaconazole in patients with distal subungual onychomycosis

(2013) Bárður Sigurgeirsson et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Fingolimod (FTY720) Stimulates Ca2+/Calcineurin Signaling in Fission Yeast

(2013) Kanako Hagihara et al.   PLoS One

Inhibiting GPI Anchor Biosynthesis in Fungi Stresses the Endoplasmic Reticulum and Enhances Immunogenicity

(2012) Catherine A. McLellan et al.   ACS Chemical Biology

Adjunctive interferon-γ immunotherapy for the treatment of HIV-associated cryptococcal meningitis

(2012) Joseph N. Jarvis et al.   AIDS

Limited Activity of Miltefosine in Murine Models of Cryptococcal Meningoencephalitis and Disseminated Cryptococcosis

(2012) N. P. Wiederhold et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

T-2307 Causes Collapse of Mitochondrial Membrane Potential in Yeast

(2012) Tatsuya Shibata et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Antidepressant Sertraline Provides a Promising Therapeutic Option for Neurotropic Cryptococcal Infections

(2012) Bing Zhai et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antifungal Lock Therapy

(2012) Carla J. Walraven et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Impact of Treatment Strategy on Outcomes in Patients with Candidemia and Other Forms of Invasive Candidiasis: A Patient-Level Quantitative Review of Randomized Trials

(2012) D. R. Andes et al.   CLINICAL INFECTIOUS DISEASES

Fungal cell wall vaccines: an update

(2012) J. E. Edwards   JOURNAL OF MEDICAL MICROBIOLOGY

Identification and Characterization of Antifungal Compounds Using a Saccharomyces cerevisiae Reporter Bioassay

(2012) Brad Tebbets et al.   PLoS One

Comparison and Temporal Trends of Three Groups with Cryptococcosis: HIV-Infected, Solid Organ Transplant, and HIV-Negative/Non-Transplant

(2012) Emily W. Bratton et al.   PLoS One

Tackling Human Fungal Infections

(2012) G. D. Brown et al.   SCIENCE

Antifungal Drug Discovery: Something Old and Something New

(2012) Arielle Butts et al.   PLoS Pathogens

Identification,in VitroActivity and Mode of Action of Phosphoinositide-Dependent-1 Kinase Inhibitors as Antifungal Molecules

(2011) Bonnie K. Baxter et al.   ACS Chemical Biology

Echinocandins: Addressing outstanding questions surrounding treatment of invasive fungal infections

(2011) S. L. Holt et al.   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

Dose Range Evaluation of Mycograb C28Y Variant, a Human Recombinant Antibody Fragment to Heat Shock Protein 90, in Combination with Amphotericin B-Desoxycholate for Treatment of Murine Systemic Candidiasis

(2011) Arnold Louie et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Discovery of a Novel Class of Orally Active Antifungal β-1,3-d-Glucan Synthase Inhibitors

(2011) Scott S. Walker et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Efficacy of Oral E1210, a New Broad-Spectrum Antifungal with a Novel Mechanism of Action, in Murine Models of Candidiasis, Aspergillosis, and Fusariosis

(2011) Katsura Hata et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In VitroActivity of E1210, a Novel Antifungal, against Clinically Important Yeasts and Molds

(2011) Mamiko Miyazaki et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

E1210, a New Broad-Spectrum Antifungal, Suppresses Candida albicans Hyphal Growth through Inhibition of Glycosylphosphatidylinositol Biosynthesis

(2011) Nao-aki Watanabe et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Confronting the Challenges of Natural Product-Based Antifungal Discovery

(2011) Terry Roemer et al.   CHEMISTRY & BIOLOGY

Addressing current medical needs in invasive fungal infection prevention and treatment with new antifungal agents, strategies and formulations

(2011) Stuart K Pitman et al.   EXPERT OPINION ON EMERGING DRUGS

Structures ofCryptococcus neoformansProtein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal Pathogens

(2011) Michael A. Hast et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cross-species discovery of syncretic drug combinations that potentiate the antifungal fluconazole

(2011) M. Spitzer et al.   Molecular Systems Biology

Toward Developing a Universal Treatment for Fungal Disease Using Radioimmunotherapy Targeting Common Fungal Antigens

(2011) R. A. Bryan et al.   MYCOPATHOLOGIA

Mutational Analysis of Flucytosine Resistance in Candida glabrata

(2010) T. D. Edlind et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

T-2307 Shows Efficacy in a Murine Model of Candida glabrata Infection despite In Vitro Trailing Growth Phenomena

(2010) E. Yamada et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Clinical Practice Guidelines for the Management of Cryptococcal Disease: 2010 Update by the Infectious Diseases Society of America

(2010) John R. Perfect et al.   CLINICAL INFECTIOUS DISEASES

An insight into the antifungal pipeline: selected new molecules and beyond

(2010) Luis Ostrosky-Zeichner et al.   NATURE REVIEWS DRUG DISCOVERY

Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS

(2009) Benjamin J Park et al.   AIDS

Antifungal Activity of Tamoxifen: In Vitro and In Vivo Activities and Mechanistic Characterization

(2009) K. Dolan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

FR290581, a novel sordarin derivative: Synthesis and antifungal activity

(2009) Tadaatsu Hanadate et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Amphotericin B-entrapping lipid nanoparticles and their in vitro and in vivo characteristics

(2009) Suk Hyun Jung et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

The Trehalose Synthesis Pathway Is an Integral Part of the Virulence Composite for Cryptococcus gattii

(2009) P. Ngamskulrungroj et al.   INFECTION AND IMMUNITY

Activity of aminocandin (IP960; HMR3270) compared with amphotericin B, itraconazole, caspofungin and micafungin in neutropenic murine models of disseminated infection caused by itraconazole-susceptible and -resistant strains of Aspergillus fumigatus

(2009) Peter A. Warn et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Activity of MGCD290, a Hos2 Histone Deacetylase Inhibitor, in Combination with Azole Antifungals against Opportunistic Fungal Pathogens

(2009) M. A. Pfaller et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease

(2009) Leah E. Cowen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Inositol Phosphorylceramide Synthase by the Cyclic Peptide Aureobasidin A

(2008) P. A. Aeed et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Discovery of a Small-Molecule Inhibitor of  -1,6-Glucan Synthesis

(2008) A. Kitamura et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Differential Effects of Inhibiting Chitin and 1,3- -D-Glucan Synthesis in Ras and Calcineurin Mutants of Aspergillus fumigatus

(2008) J. R. Fortwendel et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In Vitro and In Vivo Antifungal Activities of T-2307, a Novel Arylamidine

(2008) J. Mitsuyama et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Vaccines to Prevent Systemic Mycoses: Holy Grails Meet Translational Realities

(2008) John N. Galgiani   JOURNAL OF INFECTIOUS DISEASES