Echinocandins: production and applications

Efficacy of a Single 6 mg/kg versus Two 3 mg/Kg Caspofungin Doses for Treatment of Disseminated Candidiasis Caused byCandida albicansin a Neutropenic Mouse Model

(2014) S. Bayegan et al.   JOURNAL OF CHEMOTHERAPY

Echinocandins: Are They All The Same?

(2014) PK Mukherjee et al.   JOURNAL OF CHEMOTHERAPY

Caspofungin Kills Candida albicans by Causing both Cellular Apoptosis and Necrosis

(2012) Binghua Hao et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In Vitro Activity of Calcineurin and Heat Shock Protein 90 Inhibitors against Aspergillus fumigatus Azole- and Echinocandin-Resistant Strains

(2012) F. Lamoth et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Fks1 and Fks2 Are Functionally Redundant but Differentially Regulated in Candida glabrata: Implications for Echinocandin Resistance

(2012) Santosh K. Katiyar et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Elevated Chitin Content Reduces the Susceptibility of Candida Species to Caspofungin

(2012) Louise A. Walker et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The echinocandin B producer fungus Aspergillus nidulans var. roseus ATCC 58397 does not possess innate resistance against its lipopeptide antimycotic

(2012) Viktória Tóth et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Effect of 50% human serum on the killing activity of micafungin against eight Candida species using time–kill methodology

(2012) Richárd Földi et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Micafungin

(2012) Lesley J. Scott   DRUGS

Genome Sequence of the Fungus Glarea lozoyensis: the First Genome Sequence of a Species from the Helotiaceae Family

(2012) Loubna Youssar et al.   EUKARYOTIC CELL

Total synthesis and structure–activity relationships of new echinocandin-like antifungal cyclolipohexapeptides

(2012) Jianzhong Yao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Effect of nikkomycin Z and 50% human serum on the killing activity of high-concentration caspofungin againstCandida speciesusing time-kill methodology

(2012) Judit Szilágyi et al.   JOURNAL OF CHEMOTHERAPY

Frequency of Decreased Susceptibility and Resistance to Echinocandins among Fluconazole-Resistant Bloodstream Isolates of Candida glabrata

(2012) M. A. Pfaller et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Echinocandin resistance due to simultaneous FKS mutation and increased cell wall chitin in a Candida albicans bloodstream isolate following brief exposure to caspofungin

(2012) T. Imtiaz et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Identification and Characterization of the Echinocandin B Biosynthetic Gene Cluster from Emericella rugulosa NRRL 11440

(2012) Ralph A. Cacho et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Deciphering cell wall integrity signalling in Aspergillus fumigatus: identification and functional characterization of cell wall stress sensors and relevant Rho GTPases

(2012) Karl Dichtl et al.   MOLECULAR MICROBIOLOGY

Cyclization of fungal nonribosomal peptides by a terminal condensation-like domain

(2012) Xue Gao et al.   Nature Chemical Biology

Global Analysis of the Evolution and Mechanism of Echinocandin Resistance in Candida glabrata

(2012) Sheena D. Singh-Babak et al.   PLoS Pathogens

Antifungal Drug Resistance: Mechanisms, Epidemiology, and Consequences for Treatment

(2011) Michael A. Pfaller   AMERICAN JOURNAL OF MEDICINE

Susceptibility of Pneumocystis to Echinocandins in Suspension and Biofilm Cultures

(2011) Melanie T. Cushion et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Five-Minute Exposure to Caspofungin Results in Prolonged Postantifungal Effects and Eliminates the Paradoxical Growth of Candida albicans

(2011) Ryan K. Shields et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Improved Detection of Candida sp.fksHot Spot Mutants by Using the Method of the CLSI M27-A3 Document with the Addition of Bovine Serum Albumin

(2011) Guillermo Garcia-Effron et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Paradoxical Effect of Caspofungin against Candida Bloodstream Isolates Is Mediated by Multiple Pathways but Eliminated in Human Serum

(2011) Ryan K. Shields et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Reshuffling of Aspergillus fumigatus Cell Wall Components Chitin and β-Glucan under the Influence of Caspofungin or Nikkomycin Z Alone or in Combination

(2011) Patricia E. B. Verwer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

New Fks Hot Spot for Acquired Echinocandin Resistance inSaccharomyces cerevisiaeand Its Contribution to Intrinsic Resistance ofScedosporiumSpecies

(2011) Michael E. Johnson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Elevated Cell Wall Chitin in Candida albicans Confers Echinocandin ResistanceIn Vivo

(2011) Keunsook K. Lee et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Clinical breakpoints for the echinocandins and Candida revisited: Integration of molecular, clinical, and microbiological data to arrive at species-specific interpretive criteria

(2011) M.A. Pfaller et al.   DRUG RESISTANCE UPDATES

Polyphasic characterization of “Aspergillus nidulans var. roseus” ATCC 58397

(2011) Viktória Tóth et al.   FOLIA MICROBIOLOGICA

Distribution of sterigmatocystin in filamentous fungi

(2011) Christian Rank et al.   Fungal Biology

Current perspectives on echinocandin class drugs

(2011) David S Perlin   Future Microbiology

Efficacy of anidulafungin against Aspergillus niger in vitro and in vivo

(2011) Enrique Calvo et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Strain selection and scale-up fermentation for FR901379 acylase production by Streptomyces sp. no. 6907

(2011) Satoshi Ueda et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Fitness and Virulence Costs of Candida albicans FKS1 Hot Spot Mutations Associated With Echinocandin Resistance

(2011) Ronen Ben-Ami et al.   JOURNAL OF INFECTIOUS DISEASES

Combined Therapy of Voriconazole and Anidulafungin in Murine Infections by Aspergillus flavus

(2011) Enrique Calvo et al.   MYCOPATHOLOGIA

A novel assay of biofilm antifungal activity reveals that amphotericin B and caspofungin lyse Candida albicans cells in biofilms

(2011) Louis DiDone et al.   YEAST

Transcriptional Regulation of Chitin Synthases by Calcineurin Controls Paradoxical Growth of Aspergillus fumigatus in Response to Caspofungin

(2010) J. R. Fortwendel et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Madurella mycetomatis Is Not Susceptible to the Echinocandin Class of Antifungal Agents

(2010) W. W. J. van de Sande et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Immobilized aculeacin A acylase from Actinoplanes utahensis: Characterization of a novel biocatalyst

(2010) Daniel Hormigo et al.   BIORESOURCE TECHNOLOGY

Functional Dissection of Surfactin Synthetase Initiation Module Reveals Insights into the Mechanism of Lipoinitiation

(2010) Femke I. Kraas et al.   CHEMISTRY & BIOLOGY

Echinocandin and triazole antifungal susceptibility profiles for Candida spp., Cryptococcus neoformans, and Aspergillus fumigatus: application of new CLSI clinical breakpoints and epidemiologic cutoff values to characterize resistance in the SENTRY Antimicrobial Surveillance Program (2009)

(2010) Michael A. Pfaller et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Echinocandin Antifungal Drugs in Fungal Infections

(2010) Sharon C.-A. Chen et al.   DRUGS

Cloning and expression of the FR901379 acylase gene from Streptomyces sp. no. 6907

(2010) Satoshi Ueda et al.   JOURNAL OF ANTIBIOTICS

Evaluation of the Etest method for susceptibility testing ofAspergillusspp. andFusariumspp. to three echinocandins

(2010) A. I. Martos et al.   MEDICAL MYCOLOGY

Acquired antifungal drug resistance inAspergillus fumigatus:epidemiology and detection

(2010) Susan Julie Howard et al.   MEDICAL MYCOLOGY

Role for Fks1 in the Intrinsic Echinocandin Resistance of Fusarium solani as Evidenced by Hybrid Expression in Saccharomyces cerevisiae

(2009) S. K. Katiyar et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Effect of Candida glabrata FKS1 and FKS2 Mutations on Echinocandin Sensitivity and Kinetics of 1,3- -D-Glucan Synthase: Implication for the Existing Susceptibility Breakpoint

(2009) G. Garcia-Effron et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Multicenter, Double‐Blind Trial of a High‐Dose Caspofungin Treatment Regimen versus a Standard Caspofungin Treatment Regimen for Adult Patients with Invasive Candidiasis

(2009) Robert F. Betts et al.   CLINICAL INFECTIOUS DISEASES

Clinical Practice Guidelines for the Management of Candidiasis: 2009 Update by the Infectious Diseases Society of America

(2009) Peter G. Pappas et al.   CLINICAL INFECTIOUS DISEASES

Fungal echinocandin resistance

(2009) Louise A. Walker et al.   FUNGAL GENETICS AND BIOLOGY

The echinocandins: three useful choices or three too many?

(2009) A.M. Bal   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Screening and characterization of microorganisms with FR901379 acylase activity

(2009) Satoshi Ueda et al.   JOURNAL OF ANTIBIOTICS

Improvement of FR901379 production by mutant selection and medium optimization

(2009) Munekazu Kanda et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Scale-up fermentation of echinocandin type antibiotic FR901379

(2009) Munekazu Kanda et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Hsp90 Governs Echinocandin Resistance in the Pathogenic Yeast Candida albicans via Calcineurin

(2009) Sheena D. Singh et al.   PLoS Pathogens

Establishing In Vitro-In Vivo Correlations for Aspergillus fumigatus: the Challenge of Azoles versus Echinocandins

(2008) M. C. Arendrup et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Naturally Occurring Proline-to-Alanine Amino Acid Change in Fks1p in Candida parapsilosis, Candida orthopsilosis, and Candida metapsilosis Accounts for Reduced Echinocandin Susceptibility

(2008) G. Garcia-Effron et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Correlating Echinocandin MIC and Kinetic Inhibition of fks1 Mutant Glucan Synthases for Candida albicans: Implications for Interpretive Breakpoints

(2008) G. Garcia-Effron et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Patients at High Risk of Invasive Fungal Infections

(2008) Maria J G T Rüping et al.   DRUGS

Role of DptE and DptF in the lipidation reaction of daptomycin

(2008) Melanie Wittmann et al.   FEBS Journal

Functional analysis of Candida albicans GPI-anchored proteins: Roles in cell wall integrity and caspofungin sensitivity

(2008) Armêl Plaine et al.   FUNGAL GENETICS AND BIOLOGY

Phylogenetic analysis of Aspergillus species using DNA sequences from four loci

(2008) S. W. Peterson   MYCOLOGIA

Stimulation of Chitin Synthesis Rescues Candida albicans from Echinocandins

(2008) Louise A. Walker et al.   PLoS Pathogens

Resistance to Antifungal Agents: Mechanisms and Clinical Impact

(2007) Z. A. Kanafani et al.   CLINICAL INFECTIOUS DISEASES