TMPRSS2 Is a Host Factor That Is Essential for Pneumotropism and Pathogenicity of H7N9 Influenza A Virus in Mice

Novel Avian-Origin Influenza A (H7N9) Virus Attaches to Epithelium in Both Upper and Lower Respiratory Tract of Humans

(2013) Debby van Riel et al.   AMERICAN JOURNAL OF PATHOLOGY

Proteolytic activation of the SARS-coronavirus spike protein: Cutting enzymes at the cutting edge of antiviral research

(2013) Graham Simmons et al.   ANTIVIRAL RESEARCH

Identification of the first synthetic inhibitors of the type II transmembrane serine protease TMPRSS2 suitable for inhibition of influenza virus activation

(2013) Daniela Meyer et al.   BIOCHEMICAL JOURNAL

Cleavage Activation of Human-adapted Influenza Virus Subtypes by Kallikrein-related Peptidases 5 and 12

(2013) Brian S. Hamilton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TMPRSS2 Is an Activating Protease for Respiratory Parainfluenza Viruses

(2013) M. Abe et al.   JOURNAL OF VIROLOGY

Origin and diversity of novel avian influenza A H7N9 viruses causing human infection: phylogenetic, structural, and coalescent analyses

(2013) Di Liu et al.   LANCET

Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome

(2013) Yu Chen et al.   LANCET

Pathogenesis and transmission of avian influenza A (H7N9) virus in ferrets and mice

(2013) Jessica A. Belser et al.   NATURE

Limited airborne transmission of H7N9 influenza A virus between ferrets

(2013) Mathilde Richard et al.   NATURE

Receptor binding by an H7N9 influenza virus from humans

(2013) Xiaoli Xiong et al.   NATURE

Biological features of novel avian influenza A (H7N9) virus

(2013) Jianfang Zhou et al.   NATURE

Characterization of H7N9 influenza A viruses isolated from humans

(2013) Tokiko Watanabe et al.   NATURE

Human Infection with a Novel Avian-Origin Influenza A (H7N9) Virus

(2013) Rongbao Gao et al.   NEW ENGLAND JOURNAL OF MEDICINE

Infectivity, Transmission, and Pathology of Human-Isolated H7N9 Influenza Virus in Ferrets and Pigs

(2013) H. Zhu et al.   SCIENCE

H7N9 Influenza Viruses Are Transmissible in Ferrets by Respiratory Droplet

(2013) Q. Zhang et al.   SCIENCE

The Novel Human Influenza A(H7N9) Virus Is Naturally Adapted to Efficient Growth in Human Lung Tissue

(2013) J. Knepper et al.   mBio

Tmprss2 Is Essential for Influenza H1N1 Virus Pathogenesis in Mice

(2013) Bastian Hatesuer et al.   PLoS Pathogens

Influenza HA Subtypes Demonstrate Divergent Phenotypes for Cleavage Activation and pH of Fusion: Implications for Host Range and Adaptation

(2013) Summer E. Galloway et al.   PLoS Pathogens

Matriptase, HAT, and TMPRSS2 Activate the Hemagglutinin of H9N2 Influenza A Viruses

(2012) Joanna Baron et al.   JOURNAL OF VIROLOGY

Hemagglutinin activating host cell proteases provide promising drug targets for the treatment of influenza A and B virus infections

(2012) Eva Böttcher-Friebertshäuser et al.   VACCINE

Differential Host Determinants Contribute to the Pathogenesis of 2009 Pandemic H1N1 and Human H5N1 Influenza A Viruses in Experimental Mouse Models

(2011) Anna Otte et al.   AMERICAN JOURNAL OF PATHOLOGY

Aprotinin and similar protease inhibitors as drugs against influenza

(2011) O.P. Zhirnov et al.   ANTIVIRAL RESEARCH

H9 avian influenza reassortant with engineered polybasic cleavage site displays a highly pathogenic phenotype in chicken

(2011) S. Gohrbandt et al.   JOURNAL OF GENERAL VIROLOGY

Expression and Genetic Loss of Function Analysis of the HAT/DESC Cluster Proteases TMPRSS11A and HAT

(2011) Katiuchia Uzzun Sales et al.   PLoS One

H9N2 influenza virus acquires intravenous pathogenicity on the introduction of a pair of di-basic amino acid residues at the cleavage site of the hemagglutinin and consecutive passages in chickens

(2011) Kosuke Soda et al.   Virology Journal

TMPRSS2 and TMPRSS4 Facilitate Trypsin-Independent Spread of Influenza Virus in Caco-2 Cells

(2010) S. Bertram et al.   JOURNAL OF VIROLOGY

Modifications to the Hemagglutinin Cleavage Site Control the Virulence of a Neurotropic H1N1 Influenza Virus

(2010) X. Sun et al.   JOURNAL OF VIROLOGY

Inhibition of Influenza Virus Infection in Human Airway Cell Cultures by an Antisense Peptide-Conjugated Morpholino Oligomer Targeting the Hemagglutinin-Activating Protease TMPRSS2

(2010) E. Bottcher-Friebertshauser et al.   JOURNAL OF VIROLOGY

ETS Gene Fusions in Prostate Cancer: From Discovery to Daily Clinical Practice

(2009) Scott A. Tomlins et al.   EUROPEAN UROLOGY

Proteolytic Activation of the 1918 Influenza Virus Hemagglutinin

(2009) C. Chaipan et al.   JOURNAL OF VIROLOGY

MDCK cells that express proteases TMPRSS2 and HAT provide a cell system to propagate influenza viruses in the absence of trypsin and to study cleavage of HA and its inhibition

(2009) Eva Böttcher et al.   VACCINE

The androgen-regulated type II serine protease TMPRSS2 is differentially expressed and mislocalized in prostate adenocarcinoma

(2008) JM Lucas et al.   JOURNAL OF PATHOLOGY

Efficient Multiplication of Human Metapneumovirus in Vero Cells Expressing the Transmembrane Serine Protease TMPRSS2

(2008) Y. Shirogane et al.   JOURNAL OF VIROLOGY