Critical Roles of N6-Methyladenosine (m6A) in Cancer and Virus Infection

METTL3 Modulates Osteoclast Differentiation and Function by Controlling RNA Stability and Nuclear Export

(2020) Di Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

N6-methyladenosine modification enables viral RNA to escape recognition by RNA sensor RIG-I

(2020) Mijia Lu et al.   Nature Microbiology

Silencing METTL3 inhibits the proliferation and invasion of osteosarcoma by regulating ATAD2

(2020) Lei Zhou et al.   BIOMEDICINE & PHARMACOTHERAPY

m6A Modification in Coding and Non-coding RNAs: Roles and Therapeutic Implications in Cancer

(2020) Huilin Huang et al.   CANCER CELL

The Architecture of SARS-CoV-2 Transcriptome

(2020) Dongwan Kim et al.   CELL

Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms

(2020) Xi Jin et al.   GUT

Epitranscriptomics in liver disease: Basic concepts and therapeutic potential

(2020) Zhicong Zhao et al.   JOURNAL OF HEPATOLOGY

m6A-dependent glycolysis enhances colorectal cancer progression

(2020) Chaoqin Shen et al.   Molecular Cancer

The YTH Domain Family of N6-Methyladenosine “Readers” in the Diagnosis and Prognosis of Colonic Adenocarcinoma

(2020) Dian Xu et al.   Biomed Research International

The m6A methyltransferase METTL3 promotes bladder cancer progression via AFF4/NF-κB/MYC signaling network

(2019) Maosheng Cheng et al.   ONCOGENE

Discovery of Small Molecules that Activate RNA Methylation through Cooperative Binding to the METTL3-14-WTAP Complex Active Site

(2019) Simona Selberg et al.   Cell Reports

Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia

(2019) Jasmin Paris et al.   Cell Stem Cell

Charging the code — tRNA modification complexes

(2019) Rościsław Krutyhołowa et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation

(2019) Luca Pandolfini et al.   MOLECULAR CELL

RNA modifications regulating cell fate in cancer

(2019) Sylvain Delaunay et al.   NATURE CELL BIOLOGY

The m6A-suppressed P2RX6 activation promotes renal cancer cells migration and invasion through ATP-induced Ca2+ influx modulating ERK1/2 phosphorylation and MMP9 signaling pathway

(2019) Dongkui Gong et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221/222 maturation in m6A-dependent manner

(2019) Jie Han et al.   Molecular Cancer

METTL3 facilitates tumor progression via an m6A-IGF2BP2-dependent mechanism in colorectal carcinoma

(2019) Ting Li et al.   Molecular Cancer

Effect of methylation of adenine N6 on kink turn structure depends on location

(2019) Saira Ashraf et al.   RNA Biology

The m6A methyltransferase METTL3 promotes osteosarcoma progression by regulating the m6A level of LEF1

(2019) Wujun Miao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Upregulated METTL3 promotes metastasis of colorectal Cancer via miR-1246/SPRED2/MAPK signaling pathway

(2019) Wen Peng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1

(2019) Yunhao Chen et al.   Molecular Cancer

The RNA m6A methyltransferase METTL3 promotes pancreatic cancer cell proliferation and invasion

(2019) Tianfang Xia et al.   PATHOLOGY RESEARCH AND PRACTICE

N6-methyladenosine RNA modification–mediated cellular metabolism rewiring inhibits viral replication

(2019) Yang Liu et al.   SCIENCE

The Oncogene Metadherin Interacts with the Known Splicing Proteins YTHDC1, Sam68 and T-STAR and Plays a Novel Role in Alternative mRNA Splicing

(2019) Hayley J. Luxton et al.   Cancers

METTL3-mediated m6A modification of HDGF mRNA promotes gastric cancer progression and has prognostic significance

(2019) Qiang Wang et al.   GUT

METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer

(2019) Ben Yue et al.   Molecular Cancer

METTL14 Suppresses CRC Progression via Regulating N6-Methyladenosine-Dependent Primary miR-375 Processing

(2019) Xiaoxiang Chen et al.   MOLECULAR THERAPY

Chemical inhibitors make their RNA epigenetic mark

(2019) Megan Cully   NATURE REVIEWS DRUG DISCOVERY

Association of N6-methyladenosine with viruses and related diseases

(2019) Fang Wu et al.   Virology Journal

Accurate detection of m6A RNA modifications in native RNA sequences

(2019) Huanle Liu et al.   Nature Communications

m6A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC2

(2019) Yuanhui Mao et al.   Nature Communications

Deregulation of the Histone Lysine-Specific Demethylase 1 Is Involved in Human Hepatocellular Carcinoma

(2019) Sangchul Kim et al.   Biomolecules

IGF2BP2 regulates DANCR by serving as an N6-methyladenosine reader

(2019) Xiaoge Hu et al.   CELL DEATH AND DIFFERENTIATION

Altered m6A Modification of Specific Cellular Transcripts Affects Flaviviridae Infection

(2019) Nandan S. Gokhale et al.   MOLECULAR CELL

m 6 A demethylase FTO facilitates tumor progression in lung squamous cell carcinoma by regulating MZF1 expression

(2018) Jiqin Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m 6 A/MYC/CEBPA Signaling

(2018) Rui Su et al.   CELL

Modifications and functional genomics of human transfer RNA

(2018) Tao Pan   CELL RESEARCH

METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m 6 A Modification

(2018) Hengyou Weng et al.   Cell Stem Cell

ALKBH5 Inhibits Pancreatic Cancer Motility by Decreasing Long Non-Coding RNA KCNK15-AS1 Methylation

(2018) Yuan He et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Regulation of poly ADP-Ribose polymerase 1 functions by post-translational modifications

(2018) Ryuji Hamamoto   Frontiers in Bioscience-Landmark

Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d

(2018) Philip Knuckles et al.   GENES & DEVELOPMENT

RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2

(2018) Mengnuo Chen et al.   HEPATOLOGY

Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

(2018) Huilin Huang et al.   NATURE CELL BIOLOGY

Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development

(2018) Seth D. Kasowitz et al.   PLoS Genetics

N 6 -methyladenosine modification: a novel pharmacological target for anti-cancer drug development

(2018) Yi Niu et al.   Acta Pharmaceutica Sinica B

VIRMA mediates preferential m6A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation

(2018) Yanan Yue et al.   Cell Discovery

The SMAD2/3 interactome reveals that TGFβ controls m6A mRNA methylation in pluripotency

(2018) Alessandro Bertero et al.   NATURE

mRNA circularization by METTL3–eIF3h enhances translation and promotes oncogenesis

(2018) Junho Choe et al.   NATURE

m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer

(2018) Jun Liu et al.   NATURE CELL BIOLOGY

Acetate-dependent tRNA acetylation required for decoding fidelity in protein synthesis

(2018) Takaaki Taniguchi et al.   Nature Chemical Biology

Overexpression of KDM5B/JARID1B is associated with poor prognosis in hepatocellular carcinoma

(2018) Yoshinobu Shigekawa et al.   Oncotarget

Structural insights into the RNA methyltransferase domain of METTL16

(2018) Agnieszka Ruszkowska et al.   Scientific Reports

The m6A-methylase complex recruits TREX and regulates mRNA export

(2018) Simon Lesbirel et al.   Scientific Reports

The novel prognostic marker, EHMT2, is involved in cell proliferation via HSPD1 regulation in breast cancer

(2018) Seon‑Kyu Kim et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

IGF2BP1 promotes SRF-dependent transcription in cancer in a m6A- and miRNA-dependent manner

(2018) Simon Müller et al.   NUCLEIC ACIDS RESEARCH

YTHDF2 suppresses cell proliferation and growth via destabilizing the EGFR mRNA in hepatocellular carcinoma

(2018) Li Zhong et al.   CANCER LETTERS

The epitranscriptome m6A writer METTL3 promotes chemo- and radioresistance in pancreatic cancer cells

(2017) Kosuke Taketo et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Three distinct 3-methylcytidine (m 3 C) methyltransferases modify tRNA and mRNA in mice and humans

(2017) Luang Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of m 6 A Transcripts by the 3ʹ→5ʹ RNA Helicase YTHDC2 Is Essential for a Successful Meiotic Program in the Mammalian Germline

(2017) Magdalena Natalia Wojtas et al.   MOLECULAR CELL

m 6 A Facilitates eIF4F-Independent mRNA Translation

(2017) Ryan A. Coots et al.   MOLECULAR CELL

Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control

(2017) Isaia Barbieri et al.   NATURE

The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells

(2017) Ly P Vu et al.   NATURE MEDICINE

RNA fate determination through cotranscriptional adenosine methylation and microprocessor binding

(2017) Philip Knuckles et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Identification of factors required for m6 A mRNA methylation in Arabidopsis reveals a role for the conserved E3 ubiquitin ligase HAKAI

(2017) Kamil Růžička et al.   NEW PHYTOLOGIST

N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3′-end processing

(2017) Marek Bartosovic et al.   NUCLEIC ACIDS RESEARCH

Essential role of METTL3-mediated m6A modification in glioma stem-like cells maintenance and radioresistance

(2017) A Visvanathan et al.   ONCOGENE

Frameshift Mutations in Repeat Sequences of ANK3, HACD4, TCP10L, TP53BP1, MFN1, LCMT2, RNMT, TRMT6, METTL8 and METTL16 Genes in Colon Cancers

(2017) Su Yeon Yeon et al.   PATHOLOGY & ONCOLOGY RESEARCH

Transcriptome-Wide Mapping of RNA 5-Methylcytosine in Arabidopsis mRNAs and Noncoding RNAs

(2017) Rakesh David et al.   PLANT CELL

ALKBH5-dependent m6A demethylation controls splicing and stability of long 3′-UTR mRNAs in male germ cells

(2017) Chong Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The RNA modification landscape in human disease

(2017) Nicky Jonkhout et al.   RNA

RNA fate determination through cotranscriptional adenosine methylation and microprocessor binding

(2017) Philip Knuckles et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Novel prognostic marker PRMT1 regulates cell growth via downregulation of CDKN1A in HCC

(2017) Jea-Woon Ryu et al.   Oncotarget

Oncogene c-Myc promotes epitranscriptome m6A reader YTHDF1 expression in colorectal cancer

(2017) Yujiro Nishizawa et al.   Oncotarget

S -Adenosylmethionine Synthesis Is Regulated by Selective N 6 -Adenosine Methylation and mRNA Degradation Involving METTL16 and YTHDC1

(2017) Hiroki Shima et al.   Cell Reports

m 6 A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells

(2017) Qi Cui et al.   Cell Reports

60 years ago, Francis Crick changed the logic of biology

(2017) Matthew Cobb   PLOS BIOLOGY

YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs

(2017) Ian A Roundtree et al.   eLife

RNA helicase YTHDC2 promotes cancer metastasis via the enhancement of the efficiency by which HIF-1α mRNA is translated

(2016) Atsushi Tanabe et al.   CANCER LETTERS

Dysregulation of protein methyltransferases in human cancer: An emerging target class for anticancer therapy

(2016) Ryuji Hamamoto et al.   CANCER SCIENCE

Dynamics of Human and Viral RNA Methylation during Zika Virus Infection

(2016) Gianluigi Lichinchi et al.   Cell Host & Microbe

N6 -Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection

(2016) Nandan S. Gokhale et al.   Cell Host & Microbe

Posttranscriptional m 6 A Editing of HIV-1 mRNAs Enhances Viral Gene Expression

(2016) Edward M. Kennedy et al.   Cell Host & Microbe

METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulatingN6-methyladenosine-dependent primary MicroRNA processing

(2016) Jin-zhao Ma et al.   HEPATOLOGY

Nuclear m 6 A Reader YTHDC1 Regulates mRNA Splicing

(2016) Wen Xiao et al.   MOLECULAR CELL

The m 6 A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells

(2016) Shuibin Lin et al.   MOLECULAR CELL

m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination

(2016) Irmgard U. Haussmann et al.   NATURE

The dynamic N1-methyladenosine methylome in eukaryotic messenger RNA

(2016) Dan Dominissini et al.   NATURE

m6A RNA methylation promotes XIST-mediated transcriptional repression

(2016) Deepak P. Patil et al.   NATURE

Transcriptome-wide mapping reveals reversible and dynamic N1-methyladenosine methylome

(2016) Xiaoyu Li et al.   Nature Chemical Biology

Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA

(2016) Chuanzhao Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex

(2016) Hao Du et al.   Nature Communications

N6-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression

(2016) Nagaraja Tirumuru et al.   eLife

Dynamics of the human and viral m6A RNA methylomes during HIV-1 infection of T cells

(2016) Gianluigi Lichinchi et al.   Nature Microbiology

N6-methyladenosine Modulates Messenger RNA Translation Efficiency

(2015) Xiao Wang et al.   CELL

m6A RNA Methylation Is Regulated by MicroRNAs and Promotes Reprogramming to Pluripotency

(2015) Tong Chen et al.   Cell Stem Cell

Coordination of m 6 A mRNA Methylation and Gene Transcription by ZFP217 Regulates Pluripotency and Reprogramming

(2015) Francesca Aguilo et al.   Cell Stem Cell

Structure and Thermodynamics of N6-Methyladenosine in RNA: A Spring-Loaded Base Modification

(2015) Caroline Roost et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural imprints in vivo decode RNA regulatory mechanisms

(2015) Robert C. Spitale et al.   NATURE

N6-methyladenosine-dependent RNA structural switches regulate RNA–protein interactions

(2015) Nian Liu et al.   NATURE

Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly

(2015) Yury S Polikanov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Control of Chromatin Structure by Long Noncoding RNA

(2015) Gudrun Böhmdorfer et al.   TRENDS IN CELL BIOLOGY

The NSD family of protein methyltransferases in human cancer

(2015) Theodore Vougiouklakis et al.   Epigenomics

Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly

(2015) Yury S Polikanov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Histone Lysine Methyltransferase Wolf-Hirschhorn Syndrome Candidate 1 Is Involved in Human Carcinogenesis through Regulation of the Wnt Pathway

(2015) Gouji Toyokawa et al.   NEOPLASIA

The Oncogenic Polycomb Histone Methyltransferase EZH2Methylates Lysine 120 on Histone H2B and Competes Ubiquitination

(2015) Masaharu Kogure et al.   NEOPLASIA

FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis

(2014) Xu Zhao et al.   CELL RESEARCH

Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase

(2014) Xiao-Li Ping et al.   CELL RESEARCH

Dynamic RNA Modifications in Posttranscriptional Regulation

(2014) Xiao Wang et al.   MOLECULAR CELL

N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells

(2014) Yang Wang et al.   NATURE CELL BIOLOGY

Role of tRNA modifications in human diseases

(2014) Adrian Gabriel Torres et al.   TRENDS IN MOLECULAR MEDICINE

Critical role of lysine 134 methylation on histone H2AX for γ-H2AX production and DNA repair

(2014) Kenbun Sone et al.   Nature Communications

Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5′ Sites

(2014) Schraga Schwartz et al.   Cell Reports

Functional diversity of 2-oxoglutarate/Fe(II)-dependent dioxygenases in plant metabolism

(2014) Scott C. Farrow et al.   Frontiers in Plant Science

RNA-Methylation-Dependent RNA Processing Controls the Speed of the Circadian Clock

(2013) Jean-Michel Fustin et al.   CELL

Identification of Wilms' Tumor 1-associating Protein Complex and Its Role in Alternative Splicing and the Cell Cycle

(2013) Keiko Horiuchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N6-methyladenosine-dependent regulation of messenger RNA stability

(2013) Xiao Wang et al.   NATURE

A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation

(2013) Jianzhao Liu et al.   Nature Chemical Biology

Expression and roles of Wilms' tumor 1-associating protein in glioblastoma

(2012) Du-Il Jin et al.   CANCER SCIENCE

Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons

(2012) Kate D. Meyer et al.   CELL

ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

(2012) Guanqun Zheng et al.   MOLECULAR CELL

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

(2012) Dan Dominissini et al.   NATURE

Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B

(2012) Hyun-Soo Cho et al.   Nature Communications

The Histone Demethylase JMJD2B Plays an Essential Role in Human Carcinogenesis through Positive Regulation of Cyclin-Dependent Kinase 6

(2011) G. Toyokawa et al.   Cancer Prevention Research

Inhibition of 2-oxoglutarate dependent oxygenases

(2011) Nathan R. Rose et al.   CHEMICAL SOCIETY REVIEWS

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

(2011) Guifang Jia et al.   Nature Chemical Biology

Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers

(2010) Shinya Hayami et al.   INTERNATIONAL JOURNAL OF CANCER

The YTH Domain Is a Novel RNA Binding Domain

(2010) Zhaiyi Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The spike protein of SARS-CoV — a target for vaccine and therapeutic development

(2009) Lanying Du et al.   NATURE REVIEWS MICROBIOLOGY

Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/ -secretase expression

(2008) S. S. Hebert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA