Apoptin as a Tumor-Specific Therapeutic Agent: Current Perspective on Mechanism of Action and Delivery Systems

Virus-esque nucleus-targeting nanoparticles deliver trojan plasmid for release of anti-tumor shuttle protein

(2020) Suleixin Yang et al.   JOURNAL OF CONTROLLED RELEASE

Cancer statistics, 2019

(2019) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Advancements in small cell lung cancer: the changing landscape following IMPOWER-133

(2019) Jose Pacheco et al.   Clinical Lung Cancer

Is irreversible electroporation safe and effective in the treatment of hepatobiliary and pancreatic cancers?

(2019) Li-Ming Wu et al.   Hepatobiliary & Pancreatic Diseases International

Antitumor effect of a dual cancer-specific oncolytic adenovirus on prostate cancer PC-3 cells

(2019) Chuan-xin Cui et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Transarterial Radioembolization (TARE) Agents beyond 90Y-Microspheres

(2019) C. Bouvry et al.   Biomed Research International

Combining Radiotherapy With Anti-angiogenic Therapy and Immunotherapy; A Therapeutic Triad for Cancer?

(2019) Ruben S. A. Goedegebuure et al.   Frontiers in Immunology

Targeting Innate Immunity to Enhance the Efficacy of Radiation Therapy

(2019) Tahir B. Dar et al.   Frontiers in Immunology

The Evolving Landscape of Immunotherapy-Based Combinations for Frontline Treatment of Advanced Renal Cell Carcinoma

(2019) Asim Amin et al.   Frontiers in Immunology

Deciphering the Mechanism of Action Involved in Enhanced Suicide Gene Colon Cancer Cell Killer Effect Mediated by Gef and Apoptin

(2019) Blanca Cáceres et al.   Cancers

Polyplexes of Functional PAMAM Dendrimer/Apoptin Gene Induce Apoptosis of Human Primary Glioma Cells In Vitro

(2019) Yoonhee Bae et al.   Polymers

Principles of Resistance to Targeted Cancer Therapy: Lessons from Basic and Translational Cancer Biology

(2019) Amit J. Sabnis et al.   TRENDS IN MOLECULAR MEDICINE

MicroRNAs in Cutaneous T-Cell Lymphoma: The Future of Therapy

(2019) Rebecca Kohnken et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

CRISPR/Cas9 technology as a potent molecular tool for gene therapy

(2019) Ansar Karimian et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Progress in the application of exosomes as therapeutic vectors in tumor-targeted therapy

(2019) XUDONG XIE et al.   CYTOTHERAPY

A dual cancer-specific recombinant adenovirus suppresses the growth of liver cancer cells in vivo and in vitro

(2019) Yufei Tian et al.   ANTI-CANCER DRUGS

An enhanced anti-tumor effect of apoptin-cecropin B on human hepatoma cells by using bacterial magnetic particle gene delivery system

(2018) Xi Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

rApoptin induces apoptosis in human breast cancer cells via phosphorylation of Nur77 and Akt

(2018) Zhenhuan Hou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Oncorine, the World First Oncolytic Virus Medicine and its Update in China

(2018) Min Liang   CURRENT CANCER DRUG TARGETS

Apoptin, a Versatile Protein with Selective Antitumor Activity

(2018) Jessica Castro et al.   CURRENT MEDICINAL CHEMISTRY

Poly (amidoamine) (PAMAM) dendrimer mediated delivery of drug and pDNA/siRNA for cancer therapy

(2018) Jun Li et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Recurrent Glioblastoma Treated with Recombinant Poliovirus

(2018) Annick Desjardins et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effect of the oncolytic ECHO-7 virus Rigvir® on the viability of cell lines of human origin in vitro

(2018) Andra Tilgase et al.   Journal of Cancer

The advent of oncolytic virotherapy in oncology: The Rigvir® story

(2018) Pēteris Alberts et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Trial Watch: Oncolytic viro-immunotherapy of hematologic and solid tumors

(2018) Jonathan G. Pol et al.   OncoImmunology

Modeling Heat Transfer in Tumors: A Review of Thermal Therapies

(2018) Assunta Andreozzi et al.   ANNALS OF BIOMEDICAL ENGINEERING

Immunotherapy in LELC: About 1 case and a focused review

(2018) M. Darasson et al.   Clinical Lung Cancer

Overexpression of RYBP inhibits proliferation, invasion, and chemoresistance to cisplatin in anaplastic thyroid cancer cells via the EGFR pathway

(2018) Ai-Hua Tong et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Oncolytic virus immunotherapy: future prospects for oncology

(2018) Junaid Raja et al.   Journal for ImmunoTherapy of Cancer

Novel peptide MT23 for potent penetrating and selective targeting in mouse melanoma cancer cells

(2017) Nan Zhou et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

A truncated apoptin protein variant selectively kills cancer cells

(2017) Santiago Ruiz-Martínez et al.   INVESTIGATIONAL NEW DRUGS

Apoptin Gene Delivery by the Functionalized Polyamidoamine Dendrimer Derivatives Induces Cell Death of U87-MG Glioblastoma Cells

(2017) Yoonhee Bae et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

C-terminal region of apoptin affects chicken anemia virus replication and virulence

(2017) Yongqiang Wang et al.   Virology Journal

Oncolytic viruses: adenoviruses

(2017) Julia Niemann et al.   VIRUS GENES

A peptide derived from apoptin inhibits glioma growth

(2017) Liqiu Zhang et al.   Oncotarget

Review: Oncolytic virotherapy, updates and future directions

(2017) Christos Fountzilas et al.   Oncotarget

Canine Parvovirus ns1 gene and Chicken Anemia vp3 gene induce partial oncolysis of Canine Transmissible Venereal Tumor

(2017) Aubid Hussain Bhat et al.   Scientific Reports

Apoptin Gene Delivery by the Functionalized Polyamidoamine (PAMAM) Dendrimer Modified with Ornithine Induces Cell Death of HepG2 Cells

(2017) Yoonhee Bae et al.   Polymers

A novel anti-CD22 scFv–apoptin fusion protein induces apoptosis in malignant B-cells

(2017) Solmaz Agha Amiri et al.   AMB Express

PTD4-apoptin induces Bcl-2-insensitive apoptosis in human cervical carcinoma in vitro and in vivo

(2016) Xiao-Wen Liu et al.   ANTI-CANCER DRUGS

MDA7 combined with targeted attenuated Salmonella vector SL7207/pBud-VP3 inhibited growth of gastric cancer cells

(2016) Hongdan Cao et al.   BIOMEDICINE & PHARMACOTHERAPY

Paradigm shift in bacteriophage-mediated delivery of anticancer drugs: from targeted ‘magic bullets’ to self-navigated ‘magic missiles’

(2016) Valery A. Petrenko et al.   Expert Opinion on Drug Delivery

Combined administration of the apoptin gene and poly (I:C) induces potent anti-tumor immune response and inhibits growth of mouse mammary tumors

(2016) Shishir Kumar Gupta et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Dipeptide-functionalized polyamidoamine dendrimer-mediated apoptin gene delivery facilitates apoptosis of human primary glioma cells

(2016) Yoonhee Bae et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Activation of the Chicken Anemia Virus Apoptin Protein by Chk1/2 Phosphorylation Is Required for Apoptotic Activity and Efficient Viral Replication

(2016) Thomas J. Kucharski et al.   JOURNAL OF VIROLOGY

Inhibitory effect of genetically engineered mesenchymal stem cells with Apoptin on hepatoma cells in vitro and in vivo

(2016) Jingsi Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Dendrimer Prodrugs

(2016) Soraya da Silva Santos et al.   MOLECULES

Creation of an apoptin-derived peptide that interacts with SH3 domains and inhibits glioma cell migration and invasion

(2016) Weiwei Song et al.   TUMOR BIOLOGY

Human serum albumin-mediated apoptin delivery suppresses breast cancer cell growth in vitro and in vivo

(2016) Fang Wu et al.   Oncology Letters

Efficient therapeutic delivery by a novel cell-permeant peptide derived from KDM4A protein for antitumor and antifibrosis

(2016) Hu Wang et al.   Oncotarget

Location, Location, Location: Five Facts about Tissue Tropism and Pathogenesis

(2016) Laura-Isobel McCall et al.   PLoS Pathogens

Potentiation of Apoptin-Induced Apoptosis by Cecropin B-Like Antibacterial Peptide ABPs1 in Human HeLa Cervical Cancer Cell Lines is Associated with Membrane Pore Formation and Caspase-3 Activation

(2016) Basse Mame Birame et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Enzymatic Prenylation and Oxime Ligation for the Synthesis of Stable and Homogeneous Protein-Drug Conjugates for Targeted Therapy

(2015) Joong-jae Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Apoptin interacts with and regulates the activity of protein kinase C beta in cancer cells

(2015) Jessica Bullenkamp et al.   APOPTOSIS

Apoptin as a Potential Viral Gene Oncotherapeutic Agent

(2015) Prafull Kumar Singh et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Enhanced tumour cell nuclear targeting in a tumour progression model

(2015) Michael S Nastasie et al.   BMC CANCER

Adapted ECHO-7 virus Rigvir immunotherapy (oncolytic virotherapy) prolongs survival in melanoma patients after surgical excision of the tumour in a retrospective study

(2015) Simona Doniņa et al.   MELANOMA RESEARCH

Oncotoxic proteins in cancer therapy: Mechanisms of action

(2015) Yu. N. Lezhnin et al.   MOLECULAR BIOLOGY

Apoptin-modified human mesenchymal stem cells inhibit growth of lung carcinoma in nude mice

(2015) JINGCHUN DU et al.   Molecular Medicine Reports

Mapping of apoptin-interaction with BCR-ABL1, and development of apoptin-based targeted therapy

(2015) Jaganmohan R. Jangamreddy et al.   Oncotarget

Apoptin enhances the oncolytic properties of vaccinia virus and modifies mechanisms of tumor regression

(2015) Galina Kochneva et al.   Oncotarget

Viral genes as oncolytic agents for cancer therapy

(2014) Shishir Kumar Gupta et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Preclinical pharmacology and toxicology study of Ad-hTERT-E1a-Apoptin, a novel dual cancer-specific oncolytic adenovirus

(2014) Yanxin Qi et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Apoptins: selective anticancer agents

(2014) Oscar M. Rollano Peñaloza et al.   TRENDS IN MOLECULAR MEDICINE

Apoptosis and Molecular Targeting Therapy in Cancer

(2014) Mohamed Hassan et al.   Biomed Research International

Experimental research Therapeutic anti-tumor effect of exogenous apoptin driven by human survivin gene promoter in a lentiviral construct

(2013) Feng Ye et al.   Archives of Medical Science

A Novel Double-Enhanced Suicide Gene Therapy in a Colon Cancer Cell Line Mediated by Gef and Apoptin

(2013) Houria Boulaiz et al.   BIODRUGS

Selective apoptosis induction in MCF-7 cell line by truncated minimal functional region of Apoptin

(2013) Lim Shen Ni et al.   BMC CANCER

Salmonella typhimurium Mediated Delivery of Apoptin in Human Laryngeal Cancer

(2013) Guo-fang Guan et al.   International Journal of Medical Sciences

Nonviral gene therapy in vivo with PAM-RG4/apoptin as a potential brain tumor therapeutic

(2013) Jong-Sang Park et al.   International Journal of Nanomedicine

HSPA9 overexpression inhibits apoptin-induced apoptosis in the HepG2 cell line

(2013) CHUANMEI PENG et al.   ONCOLOGY REPORTS

The role of CDK1 in apoptin-induced apoptosis in hepatocellular carcinoma cells

(2013) JING ZHAO et al.   ONCOLOGY REPORTS

λ Phage Nanobioparticle Expressing Apoptin Efficiently Suppress Human Breast Carcinoma Tumor Growth In Vivo

(2013) Alireza Shoae-Hassani et al.   PLoS One

Local non-viral gene delivery of apoptin delays the onset of paresis in an experimental model of intramedullary spinal cord tumor

(2013) W A Pennant et al.   SPINAL CORD

AdHu5-apoptin induces G2/M arrest and apoptosis in p53-mutated human gastric cancer SGC-7901 cells

(2013) Qianqian Li et al.   TUMOR BIOLOGY

The efficacy of combination therapy using adeno-associated virus-mediated co-expression of apoptin and interleukin-24 on hepatocellular carcinoma

(2013) Lijie Yuan et al.   TUMOR BIOLOGY

Mitotic catastrophe triggered in human cancer cells by the viral protein apoptin

(2013) H L Lanz et al.   Cell Death & Disease

Evolutionary dynamics of cancer in response to targeted combination therapy

(2013) Ivana Bozic et al.   eLife

Production of recombinant immunotherapeutics for anticancer treatment

(2013) Maria-Cristina S Pranchevicius et al.   Bioengineered

Proteasomal insensitivity of apoptin in tumor cells

(2012) Henriëtte L. Lanz et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

Molecularly modified VP3 (30–121) induces apoptosis in human bladder cancer (EJ) cells but not in normal (3T3) cells

(2012) Junfeng Yang et al.   CELL BIOLOGY INTERNATIONAL

Cell-penetrating peptides: classes, origin, and current landscape

(2012) Francesca Milletti   DRUG DISCOVERY TODAY

Therapeutic efficacy of an hTERT promoter-driven oncolytic adenovirus that expresses apoptin in gastric carcinoma

(2012) LEI LIU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Systemic delivery of lentivirus-mediated secretable TAT-apoptin eradicates hepatocellular carcinoma xenografts in nude mice

(2012) JIN-LU MA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Modeling of Molecular Interaction between Apoptin, BCR-Abl and CrkL - An Alternative Approach to Conventional Rational Drug Design

(2012) Soumya Panigrahi et al.   PLoS One

Design of a binding scaffold based on variable lymphocyte receptors of jawless vertebrates by module engineering

(2012) S.-C. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apoptin selectively induces the apoptosis of tumor cells by suppressing the transcription of HSP70

(2012) Lijie Yuan et al.   TUMOR BIOLOGY

TAT-Apoptin induces apoptosis in the human bladder cancer EJ cell line and regulates Bax, Bcl-2, caspase-3 and survivin expression

(2012) JUN LI et al.   Experimental and Therapeutic Medicine

Nanoparticle Delivery of Cancer Drugs

(2011) Andrew Z. Wang et al.   Annual Review of Medicine

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

DNA Damage Response Signaling Triggers Nuclear Localization of the Chicken Anemia Virus Protein Apoptin

(2011) T. J. Kucharski et al.   JOURNAL OF VIROLOGY

Survivin knockdown combined with apoptin overexpression inhibits cell growth significantly

(2010) Qin Liu et al.   CANCER BIOLOGY & THERAPY

Specific isoforms of p73 control the induction of cell death induced by the viral proteins, E1A or Apoptin

(2010) Poramaporn Klanrit et al.   CELL CYCLE

PTD4-apoptin protein and dacarbazine show a synergistic antitumor effect on B16-F1 melanoma in vitro and in vivo

(2010) Jia-lu Jin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Targeting of drugs and nanoparticles to tumors

(2010) Erkki Ruoslahti et al.   JOURNAL OF CELL BIOLOGY

Towards novel paradigms for cancer therapy

(2010) V Pavet et al.   ONCOGENE

Advances in mesenchymal stem cell-mediated gene therapy for cancer

(2010) Roisin M Dwyer et al.   Stem Cell Research & Therapy

Apoptin Enhances Radiation-Induced Cell Death in Poorly Responding Head and Neck Squamous Cell Carcinoma Cells

(2009) Remilio A. L. Schoop et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Apoptin, a tumor-selective killer

(2009) Marek Los et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction

(2009) Ji Luo et al.   CELL

Proteins selectively killing tumor cells

(2009) Mathieu H.M. Noteborn   EUROPEAN JOURNAL OF PHARMACOLOGY

PTD4-apoptin protein therapy inhibits tumor growthin vivo

(2009) Jun Sun et al.   INTERNATIONAL JOURNAL OF CANCER

Oncolytic Rat Parvovirus H-1PV, a Candidate for the Treatment of Human Lymphoma: In Vitro and In Vivo Studies

(2009) Assia L Angelova et al.   MOLECULAR THERAPY

Value of apoptin’s 40-amino-acid C-terminal fragment for the differentiation between human tumor and non-tumor cells

(2008) Stefan Heckl et al.   APOPTOSIS

Biodegradable PAMAM ester for enhanced transfection efficiency with low cytotoxicity

(2008) Hye Yeong Nam et al.   BIOMATERIALS

Tumor Cell Metabolism: Cancer's Achilles' Heel

(2008) Guido Kroemer et al.   CANCER CELL

The C-terminus of apoptin represents a unique tumor cell-enhanced nuclear targeting module

(2008) Henna V. Kuusisto et al.   INTERNATIONAL JOURNAL OF CANCER

Unscheduled Akt-Triggered Activation of Cyclin-Dependent Kinase 2 as a Key Effector Mechanism of Apoptin's Anticancer Toxicity

(2008) S. Maddika et al.   MOLECULAR AND CELLULAR BIOLOGY

Induction of apoptosis in Vero cells by Newcastle disease virus requires viral replication, de-novo protein synthesis and caspase activation

(2008) P.V. Ravindra et al.   VIRUS RESEARCH