Article
Respiratory System
Guiqin Chen, Qiane Yu, Haifeng Ran, XuHong Li, Tijiang Zhang
Summary: This article reports a rare case of cavitary lymphoepithelioma-like carcinoma of the lung and reviews the clinical and imaging characteristics reported in previous cases, which will be helpful for clinicians and imaging physicians in diagnosing this disease.
BMC PULMONARY MEDICINE
(2023)
Article
Gastroenterology & Hepatology
David J. Hermel, Emma Z. Du, Ray Lin, Catherine T. Frenette, Darren S. Sigal
Summary: LEL-HCC is a rare liver tumor with potential efficacy and safety of immune checkpoint blockade, although current evidence-based practices are lacking. A case report demonstrates successful treatment of LEL-HCC with an immune checkpoint inhibitor. More robust, large-scale analysis is needed for better evaluation of treatment strategies and outcomes for this rare tumor subtype.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2021)
Article
Oncology
Hui-Zhao Hong, Jia-Kang Li, Jia-Tao Zhang, Li-Shan Peng, Yi-Long Wu, Wen-Zhao Zhong
Summary: This study aimed to investigate the effects of neoadjuvant immunotherapy on pulmonary lymphoepithelioma-like carcinomas (LELC). The results showed that neoadjuvant immunotherapy was effective in treating LELC and demonstrated comparable efficacy with respect to different histological subtypes.
Article
Immunology
Xuanye Zhang, Yixin Zhou, Hualin Chen, Chen Chen, Zuan Lin, Li-na He, Wei Du, Tao Chen, Shaodong Hong, Sha Fu
Summary: In patients with advanced PLELC, adding PD-1/PD-L1 inhibitor to platinum-based chemotherapy significantly increased PFS and ORR with a tolerable safety profile.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Liqin Zhang, Tairan Hao, Yuqing Wei, Mo Dong, Yuancheng Xiong
Summary: In this case report, a patient with stage IV PPLELC achieved a pathological complete response after neoadjuvant treatment, demonstrating significant effectiveness and safety.
Article
Oncology
Yi Xiao, Jinyuan He, Shaoning Luo, Min Dong, Wei Li, Gaijiao Liu, Hongjie Chen, Xiongwen Yang, Shaohong Huang
Summary: This study investigated the efficacy and safety of different treatment regimens for advanced pulmonary lymphoepithelioma-like carcinoma (pLELC). The results showed that chemoimmunotherapy had the highest 2-year progression-free survival (PFS) as a first-line treatment, suggesting that it may be the best treatment option for patients with advanced pLELC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Yang Fu, Yue Zheng, Pei-Pei Wang, Yue-Yun Chen, Zhen-Yu Ding
Summary: The study demonstrated that in patients with LELC, immunotherapy showed higher objective response rates and disease control rates compared to chemotherapy. The depth of response was better in the ICI group, with significantly longer progression-free survival and higher 1-year PFS rate.
ONCOTARGETS AND THERAPY
(2021)
Article
Oncology
Zuohong Wu, Xinghong Xian, Ke Wang, Deyun Cheng, Weimin Li, Bojiang Chen
Summary: The study found that immune checkpoint inhibitors may be a promising treatment for advanced PPLELC patients, with most patients showing a positive response to this treatment, and further large clinical trials are needed to support this finding.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Junjun Jia, Hongkai Guo, Jiabin Liu, Qi Sun, Guoqiang Cao, Shao Zhou, Mingqi Shuai, Feng Gao, Shusen Zheng, Min Zhang
Summary: The purpose of this study was to optimize the diagnosis and treatment of lymphoepithelioma-like hepatic carcinoma (LELC). By retrospectively analyzing 16 cases of LELC and using cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC) as control groups, it was found that the diagnosis and treatment of LELC showed better results.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ruizhen Li, Ke Cheng, Xiaofen Li, Chen Chang, Wanrui Lv, Xiaoying Li, Pei Zhang, Heqi Yang, Dan Cao
Summary: Epstein-Barr virus-associated lymphoepithelioma-like intrahepatic cholangiocarcinoma (EBVa LEL-ICC) is a rare tumor that has shown inconsistent response to immunotherapy. We report a case of a 53-year-old woman with EBVa LEL-ICC who initially responded to immunotherapy and chemotherapy but developed resistance. Stereotactic ablative radiotherapy (SABR) was added to the patient's treatment, resulting in successful tumor shrinkage. Surgery and SABR are effective adjuncts to improve the survival rate of patients with EBVa LEL-ICC.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Immunology
Wen-Qing Zou, Wei-Jie Luo, Yan-Fen Feng, Fang Liu, Shao-Bo Liang, Xue-Liang Fang, Ye-Lin Liang, Na Liu, Ya-Qin Wang, Yan-Ping Mao
Summary: In this study, the expression levels and prognostic value of multiple inhibitory checkpoints in head and neck lymphoepithelioma-like carcinoma (HNLELC) were investigated. The results showed that the expression of inhibitory checkpoints and an inhibitory checkpoint-based signature (ICS) may enhance the prognostic value of the TNM staging system and guide personalized inhibitory checkpoint blockade therapy in HNLELC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Biagio Ricciuti, Greg Jones, Mariano Severgnini, Joao Alessi, Gonzalo Recondo, Marissa Lawrence, Tim Forshew, Christine Lydon, Mizuki Nishino, Michael Cheng, Mark Awad
Summary: In patients with advanced NSCLC, changes in ctDNA levels after pembrolizumab treatment may predict treatment response before radiological assessment. Early decreases in ctDNA corresponded with clinical benefit, suggesting a potential role for ctDNA as an early pharmacodynamic biomarker of response or resistance to immunotherapies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Lan-Lan Pang, Jun Liao, Yi-Hua Huang, Jia-Di Gan, Wei-Tao Zhuang, Yi Lv, Wei-Ting Liang, Li Zhang, Wen-Feng Fang
Summary: Pulmonary lymphoepithelioma-like carcinoma (PLELC) is a rare and distinctive subtype of nonsmall cell lung cancer (NSCLC). The potential of immunotherapy for advanced PLELC, characterized by high PD-L1 expression and scarcity of druggable driver mutations, remains unclear due to limited and inconclusive evidence on the clinical impact of immune-checkpoint inhibitors (ICIs).
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Ying Fan, Qianyun Shan, Jiali Gong, Jing Qin, Hongyang Lu
Summary: This study retrospectively reviewed data from 18 patients diagnosed with PPLELC at Zhejiang Cancer Hospital between 2009 and 2020, investigating the correlation between PD-L1 expression, clinicopathological characteristics, and treatment outcomes. The results showed that the prognosis of PPLELC is better than other NSCLC subtypes, and immunotherapy may be a promising approach to extend survival in advanced PPLELC patients.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Oncology
Liming Li, Wenpeng Huang, Ping Hou, Weiwei Li, Menyun Feng, Yiyang Liu, Jianbo Gao
Summary: This study aimed to develop a preoperative risk scoring model based on CT images to distinguish lymphoepithelioma-like gastric carcinoma (LELGC) from non-LELGC. The study found that enhancement pattern, CT-defined lymph node status, and attenuation in the venous phase were independent predictors of LELGC. The risk identification model showed high accuracy in both the training and validation cohorts.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Thierry Landre, Gregoire Justeau, Jean-Baptiste Assie, Kader Chouahnia, Claire Davoine, Cherifa Taleb, Christos Chouaid, Boris Duchemann
Summary: This meta-analysis found that anti-PD-(L)1 with or without chemotherapy was associated with longer overall survival and progression-free survival for patients with KRAS-mutant NSCLCs compared to chemotherapy alone. The benefits were seen in both first- and second-line trials, with patients with KRAS-mutant NSCLCs experiencing significantly longer overall survival than those with wild-type KRAS tumors.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Editorial Material
Critical Care Medicine
Yacine Tandjaoui-Lambiotte, Yanis Akrour, Aude Gibelin, Frederic Gonzalez, Annabelle Stoclin, Anne-Sophie Moreau, Paul Jaubert, Anne Oppenheimer, Boris Duchemann, Stephane Gaudry
Summary: This study retrospectively investigated the use of TKI in ICU for NSCLC patients and explored the potential factors associated with ICU survival.
Article
Oncology
Philippe Wind, Zoe ap Thomas, Marie Laurent, Thomas Aparicio, Matthieu Siebert, Etienne Audureau, Elena Paillaud, Guilhem Bousquet, Frederic Pamoukdjian
Summary: The pre-operative GRADE score, which combines simple geriatric and cancer parameters, can provide a prognosis and help surgeons choose the most suitable treatment strategy for older cancer patients undergoing major surgery for digestive or non-breast gynaecological cancers, thereby avoiding under or over-treatment.
Article
Health Care Sciences & Services
Geraldine Falgarone, Guilhem Bousquet, Arnaud Wilmet, Albert Brizio, Valerie Faure, Celestin Guillouet, Franck Baudino, Isabelle Roque, Samuel Mayol, Frederic Pamoukjian
Summary: This study examined the implementation of the telemedicine device Consult Station in areas with a low density of medical services and evaluated its contribution to health care pathways. The results showed that Consult Station was mainly used by younger women for low-severity seasonal infections, while consultations for hypertension, diabetes, and preventive medicine were less common. The implementation of Consult Station could address the challenge of medical deserts and potentially reduce work absenteeism.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Editorial Material
Rheumatology
Eurydice Angeli, Alexander Ariel Padron Gonzalez, Diaddin Hamdan, Gabriel Pop, Geraldine Falgarone, Guilhem Bousquet
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Correction
Health Care Sciences & Services
Geraldine Falgarone, Guilhem Bousquet, Arnaud Wilmet, Albert Brizio, Valerie Faure, Celestin Guillouet, Franck Baudino, Isabelle Roque, Samuel Mayol, Frederic Pamoukdjian
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Oncology
Timothee Lambert, Kinan El Husseini, Maeva Zysman, Boris Duchemann, Andre Gillibert, Luca Campedel, Edouard Dantoing, Camille Rolland-Debord, Maxime Patout
Summary: This study aimed to assess the characteristics of lung cancer in patients receiving long-term oxygen therapy (LTOT) and compare them with lung cancer patients without LTOT. The results showed that the treatment outcomes and survival rates were similar between the two groups, suggesting that LTOT does not significantly affect lung cancer outcomes.
Review
Biochemistry & Molecular Biology
Burak Gonullu, Eurydice Angeli, Frederic Pamoukdjian, Guilhem Bousquet
Summary: Anti-HER2 therapies greatly improve the prognosis of HER2-overexpressing cancers, but the relationship between HER2 copy number and response rate to treatment is unclear. A meta-analysis was performed on 9 studies, involving 11,238 women with breast cancer, to study the association between HER2 amplification level and pathological complete response (pCR). The analysis showed that higher HER2/CEP17 ratio was associated with higher pCR rates, confirming the potential therapeutic value of considering HER2 amplification level.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Surgery
Sammi Zerrouk, Paolo Casoni, Edoardo Cervi, Rafik Amirat, Guilhem Bousquet, Christophe Leboeuf, Anne Janin, Frederic Pamoukdjian
Summary: This study aimed to compare ultrasound and histological approaches for patients with chronic venous disease (CVD). The results showed that ultrasound assessment of vein wall thickness (VWT) could be a non-invasive tool for diagnosis and follow-up in CVD, and could help optimize treatment plans.
Article
Critical Care Medicine
Anne-Claire Toffart, Anne-Pascale Meert, Florent Wallet, Aude Gibelin, Olivier Guisset, Frederic Gonzalez, Amelie Seguin, Achille Kouatchet, Myriam Delaunay, Didier Debieuvre, Boris Duchemann, Gaelle Rousseau-Bussac, Martine Nyunga, David Grimaldi, Albrice Levrat, Elie Azoulay, Virginie Lemiale
Summary: This study describes immune-related adverse events (irAE) leading to ICU admissions in solid cancer patients treated with immune checkpoint inhibitors (ICI). The results show that half of the ICU admissions were associated with irAE and could be treated with steroids.
ANNALS OF INTENSIVE CARE
(2023)
Article
Oncology
Thuy Thi Nguyen, Diaddin Hamdan, Eurydice Angeli, Jean-Paul Feugeas, Quang Van Le, Frederic Pamoukdjian, Guilhem Bousquet
Summary: Breast cancer brain metastases are a challenging daily practice. This study performed a meta-analysis on genomic data to identify gene alterations associated with metastatic processes in the brain. Six genes with a higher mutation prevalence in brain metastases than in extracerebral metastases were identified, indicating their potential therapeutic implications.
Editorial Material
Oncology
Eurydice Angeli, Guilhem Bousquet
Letter
Oncology
Thi Oanh Bui, Eurydice Angeli, Morad El Bouchtaoui, Guillaume Gapihan, Van Tu Dao, Justine Paris, Christophe Leboeuf, Michael Soussan, Patrick Villarese, Marianne Ziol, Emmanuel Van Glabeke, Thi Huong Le, Jean-Paul Feugeas, Anne Janin, Guilhem Bousquet
Summary: This study identified a frequent pL1575P NOTCH1 mutation as a new biomarker for ccRCC metastases and predictive of response to the CB103 NOTCH1-intracellular domain inhibitor.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2023)
Review
Respiratory System
Ana Oliveira, Gaia Fabbri, Thomas Gille, Elena Bargagli, Boris Duchemann, Rachel Evans, Hilary Pinnock, Anne E. Holland, Elisabetta Renzoni, Magnus Ekstrom, Steve Jones, Marlies Wijsenbeek, Anh Tuan Dinh-Xuan, Guido Vagheggini
Summary: This article summarizes the main needs of patients with progressive pulmonary fibrosis (PF) and their caregivers and proposes a supportive care approach. Personalized care, education, emotional and psychological support, specialized treatments, and better access to information and resources are necessary. Treatment should start at diagnosis and be tailored to the patient's needs, including individualized pharmacological and non-pharmacological interventions such as oxygen therapy and pulmonary rehabilitation.
Article
Cardiac & Cardiovascular Systems
Boris Duchemann, Ana Maria Portela, Pascal Joudiou, Olivia Freynet, Laurent Zelek, Emmanuel Martinod, Marianne Kambouchner
Summary: In locally advanced non-small-cell lung cancer, mediastinal staging is crucial for therapeutic decision-making. This case report presents a rare case of endobronchial involvement by metastatic lymph node cells after endobronchial ultrasound. The need for careful endoscopic control before surgical resection is highlighted in cases of prior positive endobronchial ultrasound with a time interval.
ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
