Lysophosphatidic acid-induced itch is mediated by signalling of LPA5 receptor, phospholipase D and TRPA1/TRPV1

Structure of the TRPA1 ion channel suggests regulatory mechanisms

(2015) Candice E. Paulsen et al.   NATURE

Tmem100 Is a Regulator of TRPA1-TRPV1 Complex and Contributes to Persistent Pain

(2015) Hao-Jui Weng et al.   NEURON

HTR7 Mediates Serotonergic Acute and Chronic Itch

(2015) Takeshi Morita et al.   NEURON

Itch Mechanisms and Circuits

(2014) Liang Han et al.   Annual Review of Biophysics

Lysophospholipid receptor nomenclature review: IUPHAR Review 8

(2014) Yasuyuki Kihara et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Bile Acid Receptor TGR5 Activates the TRPA1 Channel to Induce Itch in Mice

(2014) TinaMarie Lieu et al.   GASTROENTEROLOGY

Targeting TRP ion channels for itch relief

(2014) Xuming Zhang   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

TRPV4 channel activity is modulated by direct interaction of the ankyrin domain to PI(4,5)P2

(2014) Nobuaki Takahashi et al.   Nature Communications

The Epithelial Cell-Derived Atopic Dermatitis Cytokine TSLP Activates Neurons to Induce Itch

(2013) Sarah R. Wilson et al.   CELL

A sensory neuron–expressed IL-31 receptor mediates T helper cell–dependent itch: Involvement of TRPV1 and TRPA1

(2013) Ferda Cevikbas et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Potentiation of the Transient Receptor Potential Vanilloid 1 Channel Contributes to Pruritogenesis in a Rat Model of Liver Disease

(2013) Majedeline Belghiti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The TGR5 receptor mediates bile acid–induced itch and analgesia

(2013) Farzad Alemi et al.   JOURNAL OF CLINICAL INVESTIGATION

Neural processing of itch

(2013) Tasuku Akiyama et al.   NEUROSCIENCE

New insights into the mechanisms of itch: are pain and itch controlled by distinct mechanisms?

(2013) Tong Liu et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Phosphatidylinositol-4,5-biphosphate-dependent rearrangement of TRPV4 cytosolic tails enables channel activation by physiological stimuli

(2013) Anna Garcia-Elias et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian Phospholipase C

(2012) Ganesh Kadamur et al.   Annual Review of Physiology

Superoxide generation and leukocyte accumulation: key elements in the mediation of leukotriene B4-induced itch by transient receptor potential ankyrin 1 and transient receptor potential vanilloid 1

(2012) Elizabeth S. Fernandes et al.   FASEB JOURNAL

A ménage à trois made in heaven: G-protein-coupled receptors, lipids and TRP channels

(2011) Jyrki P. Kukkonen   CELL CALCIUM

Phospholipase A2Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention

(2011) Edward A. Dennis et al.   CHEMICAL REVIEWS

Phospholipase D: Enzymology, Functionality, and Chemical Modulation

(2011) Paige E. Selvy et al.   CHEMICAL REVIEWS

Lysophosphatidic acid directly activates TRPV1 through a C-terminal binding site

(2011) Andrés Nieto-Posadas et al.   Nature Chemical Biology

TRPA1 is required for histamine-independent, Mas-related G protein–coupled receptor–mediated itch

(2011) Sarah R Wilson et al.   NATURE NEUROSCIENCE

Tricyclodecan-9-yl-Xanthogenate (D609) Mechanism of Actions: A Mini-Review of Literature

(2011) Rao Muralikrishna Adibhatla et al.   NEUROCHEMICAL RESEARCH

Analysis of cellular and behavioral responses to imiquimod reveals a unique itch pathway in transient receptor potential vanilloid 1 (TRPV1)-expressing neurons

(2011) S.-J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LPA Receptors: Subtypes and Biological Actions

(2010) Ji Woong Choi et al.   Annual Review of Pharmacology and Toxicology

Aiming drug discovery at lysophosphatidic acid targets

(2010) Gabor Tigyi   BRITISH JOURNAL OF PHARMACOLOGY

Lysophosphatidic Acid Is a Potential Mediator of Cholestatic Pruritus

(2010) Andreas E. Kremer et al.   GASTROENTEROLOGY

Facial Injections of Pruritogens and Algogens Excite Partly Overlapping Populations of Primary and Second-Order Trigeminal Neurons in Mice

(2010) T. Akiyama et al.   JOURNAL OF NEUROPHYSIOLOGY

Spontaneous itch in the absence of hyperalgesia in a mouse hindpaw dry skin model

(2010) Tasuku Akiyama et al.   NEUROSCIENCE LETTERS

International Union of Basic and Clinical Pharmacology. LXXVI. Current Progress in the Mammalian TRP Ion Channel Family

(2010) L.-J. Wu et al.   PHARMACOLOGICAL REVIEWS

Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation

(2010) H. M. H. G. Albers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms

(2009) N. Imamachi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PIP2 Is a Necessary Cofactor for Ion Channel Function: How and Why?

(2008) Byung-Chang Suh et al.   Annual Review of Biophysics

Intracisternal, But Not Intrathecal, Injection of Naloxone Inhibits Cutaneous Itch-Related Response in Mice

(2008) Yasushi Kuraishi et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Transient receptor potential channels meet phosphoinositides

(2008) Bernd Nilius et al.   EMBO JOURNAL

Phospholipase C Mediated Modulation of TRPV1 Channels

(2008) Tibor Rohacs et al.   MOLECULAR NEUROBIOLOGY

Direct Activation of Transient Receptor Potential Vanilloid 1(TRPV1) by Diacylglycerol (DAG)

(2008) Dong Ho Woo et al.   Molecular Pain

Behavioral differentiation between itch and pain in mouse

(2008) Steven G. Shimada et al.   PAIN

Modulation of the transient receptor potential channel TRPA1 by phosphatidylinositol 4,5-biphosphate manipulators

(2008) Yuji Karashima et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Measurement of plasma lysophosphatidic acid concentration in healthy subjects: strong correlation with lysophospholipase D activity

(2008) S. Hosogaya et al.   ANNALS OF CLINICAL BIOCHEMISTRY